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Oral Communications
Day-at-a-glance:
Saturday Sunday
Monday Tuesday
Wednesday
Overview
Timetable [PDF]
Orals 1 Orals
2 Orals 3 Orals
4 Orals 5 Orals
6 Orals 7 |
| |
| Sunday 6 May, 2007 |
09:00-
10:00 |
 |
Oral
Communications 1: Bone Development and Tissue Engineering
Chairs: Richard Eastell (Sheffield, UK)
Kjeld Søballe (Aarhus, Denmark) |
|
| 09:00 |
OC001 |
HIGH BONE MASS LRP5 MUTATION LEADS TO INCREASED BONE
FORMATION AND INHIBITION OF ADIPOGENESIS IN HUMAN MESENCHYMAL STEM
CELLS
W. Qiu*1, T. E. Andersen1, B. M. Abdallah1,
M. Kassem1
1Department of Endocrinology
and Metabolism, University Hospital of Odense, Odense C, Denmark |
|
| 09:12 |
OC002 |
N-CADHERIN INTERACTION WITH LRP5 ANTAGONIZES WNT SIGNALING
AND DELAYS OSTEOBLAST DIFFERENTIATION AND BONE MASS ACQUISITION
E. Hay*1, E. Laplantine1, M. Frain2, V. Geoffroy1,
R. Muller3, P. J. Marie1
1INSERM
U606 and University Paris VII, 2ENS, INSERM U784, Paris, France, 3Institute
for Biomedical Engineering, ETH, Zurich, Switzerland |
|
| 09:24 |
OC003 |
MICE LACKING SCLEROSTIN HAVE INCREASED BONE FORMATION
AND BONE
STRENGTH
X. Li*1, Q. Niu1, N. Sun1, F. J.
Asuncion1, M. Barrero1, M. S. Ominsky1,
K. S. Warmington1, M. Grisanti1, H. Tan1,
Z. Geng1, P. J. Kostenuik1, W. S. Simonet1,
C. Kurahara1, H. Z. Ke1, C. Paszty1
1Metabolic Disorders, Amgen Inc., Thousand Oaks, United
States |
|
| 09:36 |
OC004 |
SKELETAL GROWTH DEFICIT AS RESULT OF ANTAGONISM
BETWEEN HOXA2
EXPRESSION AND CHONDROCYTE DIFFERENTIATION: MORPHOLOGICAL AND DENSITOMETRIC
STUDY
P. Deprez*1, L. Massip2, F. Ectors3,
B. Lengelé1, J. Devogelaer4, C. Nyssen-Behets1,
R. Rezsöhazy5
1Experimental Morphology, Université Catholique
de Louvain, Brussels, Belgium, 2Centre de Recherche en
Cancérologie, Université Laval, Québec, Canada,
3GIGA, Liège, 4Rheumatology, Université
Catholique de Louvain, Brussels, 5Veterinary Sciences,
Université Catholique de Louvain, Louvain-La-Neuve, Belgium
|
|
| 09:48 |
OC005 |
DLX5 REGULATES POSITIVELY OSTEOGENESIS
DURING EMBRYONIC DEVELOPMENT
N. M. Samee*1, V. Geoffroy1, C. Marty1,
C. Schiltz1, G. Levi2, M. de Vernejoul1
1U606, IFR139, 2UMR 5166, CNRS/MNHN, Paris,
France |
|
15:05-
16:05 |
|
Oral Communications
2: Osteoporosis and Genetics
Chairs: Stuart Ralston (Edinburgh, UK)
Henrik Jorgensen (Copenhagen, Denmark) |
|
| 15:05 |
OC006 |
GENETIC VARIATION IN APOLIPOPROTEIN E
IS RELATED TO HIP FRACTURE RISK: 25 YEARS FOLLOW-UP OF 9181 ADULTS
FROM THE GENERAL POPULATION
C. L. Tofteng*1, R. Frikke-Schmidt2, P. Bach-Mortensen1,
A. Tybjærg-Hansen2, L. Hyldstrup1, B. G. Nordestgaard3
1Osteoporosis Research Clinic, Hvidovre University Hospital,
Hvidovre, 2Dept. of Clinical Biochemistry, Rigshospitalet,
Copenhagen University Hospital, Copenhagen, 3Dept. of Clinical
Biochemistry, Herlev University Hospital, Herlev, Denmark |
|
| 15:17 |
OC007 |
A RARE HAPLOTYPE IN THE 5’ FLANK
OF THE COLIA1 GENE IS ENRICHED IN HIP
FRACTURE PATIENTS AND REDUCES BONE STRENGTH INDEPENDENT OF BMD
H. Jin*1, T. L. Stewart2, R. van 't Hof1,
R. M. Aspend2, S. H. Ralston1
1Molecular
Medicine Center, University of Edinburgh, Edinburgh, 2Department
of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United
Kingdom |
|
| 15:29 |
OC008 |
HIGHER PERIMENOPAUSAL BONE MASS AND REDUCED
POSTMENOPAUSAL BONE LOSS IN WOMEN CARRYING THE C161T SNP IN THE PPAR
GAMMA GENE. THE DANISH OSTEPOROSIS PREVENTION STUDY
C. L. Tofteng*1, S. Petersen1, J. Teilmann1,
P. Eiken2, B. Abrahamsen3, B. L. Langdahl4,
J. B. Jensen1
1Osteoporosis Research Clinic, Hvidovre
University Hospital, Hvidovre, 2Dept of Endocrinology,
Hillerød County Hospital, Hillerød, 3Dept
of Endocrinology, Gentofte University Hospital, Gentofte, 4Dept
of Endocrinology, Århus University Hospital, Århus, Denmark
|
|
| 15:41 |
OC009 |
ASSOCIATION BETWEEN BONE TURNOVER MARKERS
AND BONE LOSS OVER 5 YEARS IN RANDOMLY SELECTED ELDERLY WOMEN: THE
MALMÖ OPRA STUDY
K. K. Ivaska*1, P. Gerdhem1, K. Åkesson1,
K. Väänänen2, K. J. Obrant1
1Department of Orthopaedics, Lund University, Malmo, Sweden,
2Department of Anatomy, University of Turku, Turku, Finland
|
|
| 15:53 |
OC010 |
USE OF DXA-BASED STRUCTURAL ENGINEERING
MODELS OF THE PROXIMAL FEMUR TO PREDICT HIP FRACTURE
L. Yang*1, N. Peel2, J. Clowes3,
K. Wilson4, E. V. McCloskey1, R. Eastell1
1Academic Unit of Bone Metabolism, University of Sheffield,
2Metabolic Bone Centre, Northern General Hospital, Sheffield,
United Kingdom, 3Mayo Clinic, Rochester, MN, 4Hologic
Inc., Bedford, MA, United States |
|
16:30-
17:30 |
|
Oral
Communications 3: Hormones, including Estrogen, Vitamin D, PTHRP
Chairs: Hans van Leeuwen (Rotterdam, Netherlands)
Peter Vestergaard (Aarhus, Denmark)
|
|
|
| 16:30 |
OC011 |
DELETION OF THE GHRELIN RECEPTOR GHSR CORRECTS THE
TRABECULAR, BUT NOT THE CORTICAL BONE CHANGES IN THE FEMORAL HEAD
OF OB/OB MICE
M. van der Velde*1, B. C. J. van der Eerden1,
Y. Sun2, P. J. D. Delhanty1, A. van der Lely1,
H. Weinans3, H. A. P. Pols1, R. G. Smith2,
J. P. T. M. van Leeuwen1
1Department of
Internal Medicine, Erasmus MC, Rotterdam, Netherlands, 2Huffington
Centre on Aging, Baylor College of Medicine, Houston, United States,
3Department of Orthopedics, Erasmus MC, Rotterdam, Netherlands
|
|
| 16:42 |
OC012 |
THE SEROTONINERGIC RECEPTOR 5-HT2B REGULATES OSTEOBLAST
FUNCTION AND BONE MASS IN AGEING MICE
C. Collet*1, C. Schiltz2, V. Geoffroy2,
C. Marty2, L. Maroteaux3, J. Launay4,
M. De Vernejoul2
1Service de Biochimie et
Biologie Moléculaire, Lariboisiere Hospital, 2Inserm
U606-IFR139, Lariboisiere Hospital, 3INSERM U616, Pitié-Salpêtrière
Hospital, 4Service de Biochimie et Biologie Moléculaire,
Lariboisiere Hospital, Paris, France |
|
| 16:54 |
OC013 |
USE OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS AND
RISK OF HIP/FEMUR
FRACTURES: A POPULATION-BASED CASE-CONTROL STUDY
B. M. K. S. Thio*1, F. de Vries1, T. C. G. Egberts1,
H. G. M. Leufkens1, T. P. van Staa2
1Pharmacoepidemiology
and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences,
Utrecht, Netherlands, 2Environmental Epidemiology Unit,
Medical Research Council, Southampton General Hospital, Southampton,
United Kingdom |
|
| 17:06 |
OC014 |
ß-ARRESTIN2 INHIBITS PTH-STIMULATED OSTEOCLASTOGENESIS
AND CORTICAL BONE REMODELING IN RESPONSE TO LOW CALCIUM DIET
A. Rufo*1, V. Glatt2, E. Bianchi2,
D. D. Pierroz3, N. Rucci1, R. Rizzoli2,
M. L. Bouxsein2, A. Teti1, S. L. Ferrari2
1Dept. of Experimental Medicine, University of L' Aquila,
L' Aquila, Italy, 2Service of Bone Diseases, Dept. of Rehabilitation
and Geriatrics, WHO Center for Osteoporosis Prevention, Geneva University
Hospital, Geneva, Switzerland, 3Orthopedic Biomechanics
Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical
School, Boston, United States |
|
| 17:18 |
OC015 |
TRANSGENIC DISRUPTION OF GLUCOCORTICOID
SIGNALLING IN MATURE OSTEOBLASTS ATTENUATES KRN SERUM-INDUCED ARTHRITIS
IN VIVO
H. Zhou1, F. Buttgereit2, T. Gaber2,
R. Kalak1, D. Huscher2, J. Modzelewski1,
C. R. Dunstan1, M. J. Seibel*1
1Bone
Research Program, ANZAC Research Institute, Sydney University, Sydney,
Australia, 2Dept. of Rheumatology & Clinical Immunology,
Charité (CCM) and DRFZ, Berlin, Germany |
|
| Monday 7 May, 2007 |
|
09:00-
10:00 |
|
Oral Communications
4: Cell Biology: Osteoblasts, Osteocytes and Bone Formation
Chairs: Ellen Hauge (Aarhus, Denmark)
Tim Skerry (Sheffield, UK)
|
|
|
| 09:00 |
OC016 |
THE BINDING BETWEEN SCLEROSTIN AND LRP5 IS DRASTICALLY
IMPAIRED BOTH IN HIGH-BONE-MASS LRP5 MUTANTS AND IN THE PRESENCE OF
DKK1
W. Balemans*1, E. Cleiren1, M. Ai2,
L. Van Wesenbeeck1, M. L. Warman3, W. Van Hul1
1Dept. of Medical Genetics, University of Antwerp, Antwerp,
Belgium, 2Dept. of Genetics, Case Western Reserve University,
Cleveland, 3Orthopaedic Research Laboratories, Boston Children's
Hospital, Boston, United States |
|
| 09:12 |
OC017 |
IDENTIFICATION OF NOVEL PHOSPHOPROTEINS ON PLASMA MEMBRANES
OF HUMAN MESENCHYMAL STEM CELLS USING TITANIUM DIOXIDE CHROMATOGRAPHY
AND MASS SPECTROMETRY
T. E. Thingholm*1, M. R. Larsen2, L. J. Foster3,
M. Kassem4, O. N. Jensen5
1Institute for
Biochemistry and Molecular Biology, University of Southern Denmark,
2Institute for Biochemistry and Molecular Biology, University
of Southern Denmark, Odense, Odense M, Denmark, 3Institute
for Biochemistry and Molecular Biology, University of British Columbia,
Vancouver, Canada, 4Clinic of Endocrinology Treatment,
University Hospital, 5Institute for Biochemistry and Molecular Biology,
University of Southern Denmark, Odense, Denmark |
|
| 09:24 |
OC018 |
BIPHENYLCARBOXYLATES INHIBIT BONE RESORPTION IN VITRO
AND OVARIECTOMY INDUCED BONE LOSS IN VIVO WITHOUT IMPAIRING PTH INDUCED
BONE FORMATION
A. I. Idris*1, I. R. Greig2, S. H. Ralston1,
R. J. van 't Hof1
1Molecular Medicine Centre,
University of Edinburgh, Edinburgh, 2Medicine and Therapeutics,
University of Aberdeen, Aberdeen, United Kingdom |
|
| 09:36 |
OC019 |
OSTEOCYTES SUBJECTED TO PULSATING FLUID
FLOW INHIBIT OSTEOCLAST
FORMATION AND BONE RESORPTION
D. Tan1, T. J. De Vries1, A. M. Kuijpers-Jagtman2,
C. M. Semeins1, V. Everts1, J. Klein-Nulend*1
1Department of Oral Cell Biology, Acta-Vrije Universiteit
and Universiteit Van Amsterdam, Amsterdam, 2Department
of Orthodontics and Oral Biology, Radboud University Nijmegen Medical
Centre, Nijmegen, Netherlands
|
|
| 09:48 |
OC020 |
OSTEOCYTES AND OSTEOBLASTS EXHIBIT DIFFERENT
GENE EXPRESSION OF PROTEINS INVOLVED IN CANONICAL AND NON-CANONICAL
WNT SIGNALING PATHWAYS AFTER MECHANICAL LOADING
A. Santos*1, B. Zandieh-Doulabi2, C. M. Semeins1,
J. Klein-Nulend1
1Oral Cell Biology, ACTA-Vrije
Universiteit, 2Dept of Orthopaedics, Vrije Universiteit
Medical Center, Amsterdam, Netherlands |
|
15:05-
16:05 |
|
Oral Communications
5: Osteoporosis Treatment
Chairs: Serge Ferrari (Geneva, Switzerland)
Peter Schwarz (Glostrup, Denmark) |
|
| 15:05 |
OC021 |
CLINICAL RISK FACTORS ENHANCE THE PERFORMANCE
OF BMD IN THE PREDICTION OF FRACTURES
H. Johansson*1, E. V. McCloskey2, A. Oden3,
O. Johnell3, C. De Laet4, J. Brown5,
J. Eisman6, S. Fujiwara7, D. Goltzman8,
D. Mellstrom9, J. Melton III10, H. Pols11,
J. Reeve12, A. Silman13, D. Torgerson14,
J. A. Kanis15
1Statistics, WHO Centre,
Stockholm, Sweden, 2WHO Collaborating Centre for Metabolic
Bone Diseases, Sheffield, United Kingdom, 3WHO Collaborating
Centre for Metabolic Bone Diseases, , Sweden, 4WHO Collaborating
Centre for Metabolic Bone Diseases, , Belgium, 5Rheumatology,
Sans Ospedale University Quebec, Quebec, Canada, 6Bone
and Mineral, Garvan Institute, Sydney, Australia, 7Clinical
Studies, Radiation Effects Foundation, Hiroshima, Japan, 8Medicine,
McGill University, Canada, 9Geriatric Medicine, Goteborg
University, Goteborg, Sweden, 10Epidemiology, Mayo Clinic,
Rochester, United States, 11Internal Medicine, Erasmus
University, Rotterdam, Netherlands, 12Medicine, Strangeway's
Research Laboratory, Cambridge, 13Epidemiology Unit, University
of Manchester, Manchester, 14Health Services, York University,
York, 15WHO Collaborating Centre for Metabolic Bone Diseases,
University of Sheffield, Sheffield, United Kingdom |
|
| 15:17 |
OC022 |
EFFECT OF ONCE-YEARLY INFUSION OF ZOLEDRONIC
ACID 5 MG ON BIOCHEMICAL MARKERS OF BONE TURNOVER: DATA FROM HORIZON-PFT
P. D. Delmas1, D. Bauer2, D. Black3,
S. R. Boonen4, F. Cosman5, R. Eastell*6
1Department of Medicine, University Claude Bernard Lyon
1, Lyon, France, 2Department of Medicine, 3Department
of Epidemiology and Biostatistics, University of California, San Francisco,
San Francisco, United States, 4Center for Metabolic Bone
Diseases, Leuven University, Leuven, Belgium, 5Department
of Medicine, Helen Hayes Hospital, West Haverstraw, United States,
6Metabolic Bone Center, Northern General Hospital, Sheffield,
United Kingdom |
|
| 15:29 |
OC023 |
STRONTIUM RANELATE DECREASES VERTEBRAL
FRACTURE RISK WHATEVER THE LEVEL OF PRETREATMENT BONE TURNOVER MARKERS
J. Collette1, J. Y. Reginster*2, O. Bruyère3,
C. Roux4, R. Lorenc5, D. Felsenberg6,
T. D. Spector7
1Department of Clinical Biology,
Bone and Cartilage Markers Laboratory, 2WHO Collaborating
Center for Public Health Aspect of Osteoarticular Disorders, University
of Liège, 3Service de Chimie Médicale, CHU
de Liège, Liège, Belgium, 4Department of
Rheumatology B, Cochin Hospital, Paris, France, 5Osteoporosis
Center, National Center for Osteoporosis, Warsaw, Poland, 6Charité
Campus Benjamin Franklin, Center of Muscle & Bone Research, Free
& Humboldt University, Berlin, Germany, 7Department
of Rheumatology, St Thomas’ Hospital, London, United Kingdom
|
|
| 15:41 |
OC024 |
EFFECTS OF PRIOR ANTIRESORPTIVE THERAPY
ON THE BONE MINERAL DENSITY
RESPONSE TO TWO YEARS OF TERIPARATIDE TREATMENT IN POSTMENOPAUSAL
WOMEN WITH OSTEOPOROSIS: FINAL RESULTS FROM THE EUROFORS TRIAL
E. V. McCloskey*1, F. Marín2, G. B. Obermayer-Pietsch3,
M. E. Simoes4, C. Barker2, G. Lyritis5,
H. Oertel6, T. N. Nickelsen6, S. Boonen7
1Academic Unit of Bone Metabolism, University of Sheffield,
Sheffield, 2Medical Research, Lilly Research Center, Windlesham,
United Kingdom, 3Universitätsklinik Für Innere
Medizin, Medizinische Universität, Graz, Austria, 4Reumatologia,
Instituto Portugues de Reumatologia, Lisbon, Portugal, 5Department
of Orthopedics, University of Athens, Athens, Greece, 6Medical
Research, Lilly Research Center, Bad Homburg, Germany, 7Division
of Geriatric Medicine, Universitaire Ziekenhuizen, Leuven, Belgium
|
|
| 15:53 |
OC025 |
A SOLUBLE ACTIVIN RECEPTOR TYPE IIA (ACTRIIA)
ACTS AS A NOVEL BONE ANABOLIC AGENT
R. Pearsall*1, M. Cornwall-Brady1, J. Lachey2,
L. Mazzolla2, A. Pullen2, D. Smith3,
L. Stadmeyer4, E. Cory5, E. Canalis6,
M. L. Bouxsein5
1Preclinical Pharmacology,
2Acceleron Pharma, Acceleron Pharma, Cambridge, 3St
Francis Hospital, & Medical Center, 4St Francis Hospital
& Medical Center, St. Francis Hospital & Medical Center, Hartford,
CT, 5Beth Israel Deaconess Medical Center, Harvard Medical
School, Boston, MA, 6St Francis Hospital & Medical
Center, University of Connecticut School of Medicine, Hartford, CT,
United States |
|
| Tuesday 8 May, 2007 |
|
09:00-
10:00 |
|
Oral
Communications 6: Cancer and Metabolic Bone Diseases other than Osteoporosis
Chairs: Graham Russell (Oxford, UK)
Jens Erik Beck Jensen (Hvidovre, Denmark) |
|
| |
|
09:00 OC026 LYMPHOCYTIC CELLS, AS THE
MYELOMA B-CELL CLONE, CONTRIBUTES TO THE
FORMATION OF OSTEOCLASTS IN MYELOMA PATIENTS
T. L. Andersen*1, P. Boissy1, T. E. Sondergaard1,
K. Kupisiewicz1, T. Plesner2, T. Rasmussen3,
J. Haaber4, S. Kølvraa5, J. M. Delaisse1
1Department of Clinical Cell Biology, 2Department
of Haematology, Vejle Hospital, Sourthern Denmark University, Vejle,
3Department of Clinical Haematology, Rigshospitalet,
Copenhagen, 4Department of Pathology, Odense University
Hospital, Odense, 5Department of Clinical Genetics, Vejle
Hospital, Sourthern Denmark University, Vejle, Denmark
|
|
| 09:12 |
OC027 |
MICE WITH A TRUNCATING MUTATION AFFECTING
THE UBIQUITIN-ASSOCIATED
DOMAIN OF SQSTM1 EXHIBIT FEMORAL SHAFT EXPANSION AND INCREASED OSTEOBLAST
ACTIVITY IN VIVO AND ABNORMALITIES OF OSTEOBLAST AND OSTEOCLAST FUNCTION
IN VITRO
J. A. Rojas*1, A. Daroszewska1, M. H. Helfrich2,
R. J. van 't Hof1, S. H. Ralston1
1Molecular
Medicine Centre, University of Edinburgh, Edinburgh, 2Medicine
and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
|
|
| 09:24 |
OC028 |
INTERPLAY BETWEEN INTERLEUKIN-6 AND c-SRC
IN THE REGULATION OF
OSTEOBLAST FUNCTION
B. Peruzzi*1, M. Longo1, F. De Benedetti2,
A. Teti1
1Experimental Medicine, University
of l’Aquila, l’Aquila, 2, Ospedale Pediatrico
Bambino Gesù, Rome, Italy |
|
| 09:36 |
OC029 |
STATINS SENSITIZE HUMAN OSTEOSARCOMA CELLS
TO CHEMOTHERAPY AND REDUCE TUMOR CELL INVASION AND MIGRATION
O. Fromigue*1, Z. Hamidouche1, P. J. Marie1
1Laboratory of Osteoblast Biology and Pathology, INSERM
U606 and University Paris VII, Paris, France |
|
| 09:48 |
OC030 |
CANNABINOID RECEPTOR AGONISTS ARE POTENTIAL
BONE ANABOLIC AGENTS WHICH STIMULATE BONE FORMATION IN VITRO AND INCREASE
BONE MASS IN VIVO
A. Sophocleous*1, E. Landao-Bassonga1, R. J.
van 't Hof1, A. I. Idris1, S. H. Ralston1
1Molecular Medicine Centre, University of Edinburgh, Edinburgh,
United Kingdom |
|
15:05-
16:05
|
|
Oral Communications
7: Cell Biology: Osteoclasts and Bone Resorption
Chairs: Niklas Rye Jørgensen (Hvidovre, Denmark)
Anna Teti (L’Aquila, Italy) |
|
| 15:05 |
OC031 |
HEMATOPOIETIC STEM CELL TARGETED NEONATAL
GENE THERAPY CURES OC/OC MICE FROM OSTEOPETROSIS
M. Johansson1, T. De Vries2, M. Ehinger3,
T. Schoenmaker2, S. Karlsson1, V. Everts*2,
J. Richter1
1Molecular Medicine, Lund University,
Lund, Sweden, 2Oral Cell Biology, Academic Centre for Dentistry
Amsterdam, Amsterdam, Netherlands, 3Pathology, Lund University,
Lund, Sweden |
|
| 15:17 |
OC032 |
IN VIVO DIFFERENTIATION OF MURINE DENDRITIC
CELLS INTO OSTEOCLASTS RESCUES THE OSTEOPETROTIC PHENOTYPE OF OC/OC
MICE
C. Blin-Wakkach1, A. Wakkach1, R. Dacquin2,
A. Mansour1, P. Jurdic2, G. F. Carle*1
1Unit K2943 CNRS UNSA, Université de Nice-Sophia
Antipolis, Faculté de Médecine, Nice, 2UMR
5161 CNRS/ENS, Ecole Normale Supérieure, Lyon, France |
|
| 15:29 |
OC033 |
THE BETA-GLUCURONIDASE KLOTHO DIMINISHES
OSTEOCLASTOGENESIS AND
SUBSEQUENT OSTEOCLASTIC BONE RESORPTION
B. C. J. van der Eerden*1, Q. Chang2, J. G.
J. Hoenderop2, H. A. P. Pols1, R. J. M. Bindels2,
J. P. T. van Leeuwen1
1Internal Medicine,
Erasmus MC, Rotterdam, 2Cell Physiology, Nijmegen Centre
for Molecular Life Sciences, Nijmegen, Netherlands |
|
| 15:41 |
OC034 |
SMALL MOLECULE INHIBITORS OF TRAF-DEPENDENT
SIGNALING AS ANTI RESORPTIVE AND ANTI-RHEUMATIC DRUGS
A. I. Idris*1, I. R. Greig2, M. Gray1,
S. H. Ralston1, R. J. van 't Hof3
1Molecular
Medicine Centre, University of Edinburgh, Edinburgh, 2Medicine
and Therapeutics, University of Aberdeen, Aberdeen, 3Molecular
Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom
|
|
| 15:53 |
OC035 |
CHONDROADHERIN IS DECREASED IN YOUNG OSTEOPOROTIC
PATIENTS AND REDUCES BONE RESORPTION BY INHIBITING OSTEOCLAST FUNCTION
AND DIFFERENTIATION
M. Alamanou1, N. Rucci1, O. Kristoffer2,
A. Rufo1, K. Gautvik2, A. Teti*1,
D. Heinegård3
1Dept. of Experimental
Medicine, University of L Aquila, L Aquila, Italy, 2Dept.
of Clinical Chemistry, Ullevaal University Hospital and Institute
of Medical Biochemistry, Oslo, Norway, 3Dept. of Experimental
Medical Science, Lund University, Lund, Sweden |
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