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ECTS AGM
ECTS Training Course - Genetic Approaches in Bone Diseases
Allied Health Professionals Session
Satellite conference: Anabolic pathways into bone

All sesssions take place at:
Prague Congress Center
5 kvetna 65
140 21 Prague 4
Czech Republic

Friday 12 May, 12.30
EUROPEAN CALCIFIED TISSUE SOCIETY (ECTS) AGM

All ECTS members are invited to attend.


Wednesday 10 May, 08.55-18.05
ECTS TRAINING COURSE – GENETIC ASPECTS OF BONE DISEASES: METHODS AND APPLICATIONS
 

Course fee: ECTS Member - € 95, Non-member - € 145

Registration: You can register for this course through the ECTS web site or by selecting the option on the meeting registration form

Course organiser: Stuart Ralston (Edinburgh, UK)

The aim of this ECTS training course is to provide participants who are unfamiliar with the field with an overview of the general approaches that are used for the genetic dissection of bone diseases, and to give practical guidance on topics such as statistical analysis and study design. The workshop will comprise a series of state of the art lectures, given by experts in the field and intermingled with practical sessions when specific issues will be covered in small groups.

Topics:
Family based studies and positional cloning
Meta-analysis
Association studies
Heritability analysis
Use of SOLAR and GENEHUNTER
Genetic mapping in mice
The TDT test
Whole genome association studies
 
Speakers:
Omar Albagha (Edinburgh, UK)
Matt Brown (Brisbane, Australia)
Emma Duncan (Brisbane, Australia)
John Ioannidis (Ioannina, Greece)
Robert Klein (Oregan, USA)
Iain MacKay (Cambridge, UK)
Stuart Ralston (Edinburgh, UK)
André Uitterlinden (Rotterdam, Netherlands)
Wim Van Hul (Antwerp, Belgium)

For further information please see the ECTS website or email admin@ectsoc.org.
 


Wednesday 10 May, 11.30-12.30
ALLIED HEALTH PROFESSIONALS SESSION
 

A new innovation this year will be the introduction of a special session for Allied Health Professionals. The programme will be designed to be of interest in particular to nurses, physiotherapists, radiologists, nutritionists, dieticians and clinical trial co-ordinators working in the field of metabolic bone diseases. The session will include a preview of the main meeting programme to be given by Socrates Papapoulos (Leiden, Netherlands), who will discuss the highlights and explain some of the issues and why they are significant.

Attendance at this session is free of charge to delegates registered for the main meeting. Please tick the box on the registration form to book a place.
 


Sunday 14 May, 12.00-14.00
SATELLITE CONFERENCE: Anabolic pathways into bone: recent discoveries from the ANABONOS and OSTEOGENE European Consortia
 
 

The ANABONOS project, Molecular Mechanisms of Bone Formation and Anabolism:
Osteoporotic fractures are a major healthcare problem in Europe and this is set to increase as the proportion of the elderly individuals in the population expands. Osteoporosis can be treated by drugs that inhibit bone resorption, but these do not restore normal skeletal strength and are incompletely effective at preventing fractures. Consequently, there is an urgent need to develop new treatments for osteoporosis that stimulate bone formation. Such treatments would offer the prospect of greater efficacy by reversing the structural abnormalities of bone in established osteoporosis. This project will advance understanding of the mechanisms responsible for bone formation, with the long-term aim of harnessing this knowledge to develop new anabolic agents for osteoporosis.

These aims will be achieved by drawing leading European academic research groups together with SME’s working in bone metabolism to define the mechanisms of bone formation and uncover pathways that can be targeted for therapeutic intervention. We will define downstream effectors of molecules that regulate bone formation in mice and define signalling pathways that are activated in human genetic diseases characterised by increased bone formation. The mechanisms of action of drugs with known anabolic effects will be investigated and novel genes that regulate bone formation will be uncovered by ENU mutagenesis and genetic mapping studies.

The project will lead to a greater understanding of how bone formation is regulated and will underpin the development of new therapeutic strategies for the prevention and treatment of osteoporosis.

The OSTEOGENE project is focused on improving the understanding of the molecular mechanisms involved in bone homeostasis. A main emphasis is on the anabolic aspects. New knowledge is sought using contemporary array technology and functional genomics building on the recently definition of the human genome. A major target is identification of the mRNAs and proteins that exercise a central role in the building (anabolic) phases of bone metabolism, including but not limited to those regulated by parathyroid hormone (PTH).

Selective stimulation of anabolic effectors, it is argued, form the basis for new treatment modalities that will increase new and fully-functional bone formation. This approach contrasts with many contemporary regimes of treatment that primarily inhibit bone resorption, thus increasing the amount of more or less worn tissue. A special attempt is made to identify genetic markers that can be used for early identification of people at risk for later development of osteoporosis.

The project is undertaken by a multidisciplinary team including medical practitioners, molecular and cellular biologists and biochemists all with an international track record. The long-term aim is a reduction in the impact of osteoporosis in Europe brought about by application of appropriate evidence-based therapeutic and preventive medicine.

There is a charge of €35 for this session, which includes lunch. Please tick the box on the registration form to book a place.

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