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TUESDAY 28 May 2002

08:00 - 18:00 Registration

PLENARY SESSION 7

GENETICS

08:30 - 09:30 Main Auditorium

08:30 I-20 Treasure your exceptions: genetic mapping of skeletal dysplasias Clair Francomano (Bethesda MD, USA)

09:00 I-21 Progress in mapping osteoporosis genes in mice Robert Klein (Portland OR, USA)

ORAL PRESENTATIONS 6

GENETICS

09:30 - 10:18 Main Auditorium

09:30 O-27 COLIA1 SP1 BINDING SITE POLYMORPHISM PREDISPOSES TO OSTEOPOROTIC FRACTURES BY ALTERING COLLAGEN PRODUCTION AND IMPAIRING BONE MINERALISATION T. L. Stewart¹*, P. Roschger², B. Grabner², P. Fratzl³, V. Mann¹, R. M. Aspden¹, K. Klaushofer², S. H. Ralston^{1 1}Bone Research Group, University of Aberdeen, UK; ²Ludwig Boltzman Institute of Osteology, Vienna, Austria; ³Erich Schmid Institute of Material Science, Leoben, Austria

09:42 O-28 INTERACTION BETWEEN POLYMORPHISMS IN THE METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) GENE AND THE COLLAGEN TYPE I ALPHA 1 (COLIA1) GENE IN BONE MINERAL DENSITY AND FRACTURE RISK J. B. J. van Meurs¹*, P. Arp¹, M. van der Klift², A. Hofman², H. A. P. Pols^1,2, A. G. Uitterlinden^{1,2 1}Department of Internal Medicine, Erasmus University Centre, Rotterdam, The Netherlands; ²Department of Epidemiology and Biostatistics, Erasmus University Centre, Rotterdam, The Netherlands

09:54 O-29 ASSOCIATION STUDY OF THE CDX-2 POLYMORPHISM IN THE 1A PROMOTER REGION OF THE HUMAN VITAMIN D RECEPTOR GENE AND FRACTURE Y. Fang¹*, J. B. J. van Meurs¹, A. Hofman², H. P. T. M. van Leeuwen¹, C. M. van Duijn², H. A. P. Pols^1,2, A. G. Uitterlinden^{1,2 1}Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands; ²Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

10:06 O-30 POLYMORPHISMS OF THE TNFR2 GENE ARE ASSOCIATED WITH BONE MINERAL DENSITY IN WOMEN FROM THE UK O. M. E. Albagha*, P. N. Tasker, F. E. A. Mcguigan, D. M. Reid, S. H. Ralston Dept of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK

10:18 - 10:45 Coffee Break

WORKSHOP 3

CLINICAL CASES

10:45 - 12:15 Main Auditorium

10:45 O-31 CONGENITAL PSEUDARTHROSIS OF THE TIBIA: TREATMENT WITH A BONE MORPHOGENETIC PROTEIN (OP-1 DEVICE) D. Anticevic¹*, Z. Stanec², M. Jelic¹, S. Vukicevic^{3 1}Department of Orthopedic Surgery, Medical School, Zagreb, Croatia; ²Department of Plastic Surgery, Medical School, Zagreb, Croatia; ³Department of Anatomy, Medical School, Zagreb, Croatia

11:05 O-32 OSTEOPETROSIS WITH SPARSE HAIR AND DENTAL DYSPLASIA - AN UNUSUAL PRESENTATION CASE REPORT I. Baric¹*, V. Kusec², V. Sarnavka³, M. Cuk¹, D. Krpan⁴, S. Mutar-Susic⁵, I. Skrinjaric⁵, D. Begovic^{1 1}Department of Pediatrics, Clinical Hospital Centre, Zagreb, Croatia; ²Clinical Institute of Laboratory Diagnosis, Clinical Hospital Centre, Zagreb, Croatia; ³Department of Dermatology, Clinical Hospital Centre, Zagreb, Croatia; ⁴General Hospital 'Sveti Duh', Zagreb, Croatia; ⁵School of Dentistry, Zagreb, Croatia

11:25 O-33 OSTEOPETROSIS - PLAIN FILM RADIOGRAPHS VS MRI - CASE REPORT OF ADOP II TYPE P. Marusic¹*, L. J. Vojnic¹, H. Landeka², B. Brkljacic^{1 1}Department of Radiology, University Hospital 'Dubrava', Zagreb, Croatia; ²Department of Neurology,University Hospital 'Dubrava', Zagreb, Croatia

11:45 O-34 NEUROENDOCRINE TUMOR CAUSING FGF23-INDEPENDENT ONCOGENIC HYPOPHOSPHATEMIC OSTEOMALACIA F. Paglia¹*, A. Corsi^2,3, S. Minisola¹, S. Dionisi¹, S. De Geronimo¹, S. Licci², A. Marzullo², F. Malchiodi⁴, M. Riminucci^2,3, P. Bianco^{2 1}Department of Clinical Science, La Sapienza University, Rome, Italy; ²Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy; ³Department of Experimental Medicine, Laboratory of Pathology, University of L'Aquila, Italy; ⁴Laboratory of Ultrastructure, ISS, Rome, Italy

WORKSHOP 4

FUNCTIONAL GENOMICS

10:45 - 12:15 Small Auditorium

10:45 I-22 Harvesting biological data using bioinformatics:   prediction of human disease genes Jack Leunissen (Nijmegen, The Netherlands)

11:15 I-23 Application of proteomics to elucidate mechanisms of disease Laura Lawrie (Aberdeen, UK)

11:45 I-24 Probing gene function by transgenic approaches Marian Young (Bethesda MD, USA)

12:15 - 14:00 Lunch and Poster Session 3

Between 12:15 and 13:15 all posters will be attended by their presenting author.

PLENARY SESSION 8

OSTEOCYTES / MECHANICAL LOADING

14:00 - 15:00 Main Auditorium

14:00 I-25 Bone cells' responses to mechanical strain: implications for postmenopausal osteoporosis Lance Lanyon (London, UK)

14:30 I-26 What type of exercise protects the skeleton? Ari Heinonen (Tampere, Finland)

ORAL PRESENTATIONS 7

REGULATION OF OSTEOGENESIS

15:00 - 16:12 Main Auditorium

15:00 O-35 VARIATION IN HUMAN BONE CELL RESPONSE TO STIMULATION BY FLUID FLOW OR CYCLIC STRAIN M. Mullender¹*, A. J. El Haj², Y. Yang², J. Magnay², M. A. van Duin¹, J. Klein-Nulend^{1 1}Dept. Oral Cell Biology, ACTA-Vrije Universiteit, Amsterdam, The Netherlands; ²Centre for Science and Technology in Medicine, Dept. Biomedical Eng., Stoke-on-Trent, UK

15:12 O-36 THE BONE-SPECIFIC TRANSCRIPTIONAL REGULATOR CBFA1 IS A TARGET OF MECHANICAL SIGNALS IN OSTEOBLASTIC CELLS P. G. Ziros¹, A-P. Rojas Gil¹, T. Georgakopoulos¹, E. K. Basdra², A. G. Papavassiliou¹* ¹Department of Biochemistry, School of Medicine, University of Patras, GR-26110 Patras, Greece; ²Department of Orthodontics, Heidelberg University, D-69120 Heidelberg, Germany

15:24 O-37 PROTEIN KINASE C ALPHA / ESTROGEN RECEPTOR ALPHA INTERACTION IN OSTEOBLAST DIFFERENTIATION M. Longo¹*, M. Brama¹, M. Marino², K. S. Korach³, W. C. Wetsel⁴, R. Scandurra², T. Faraggiana², R. Baron⁵, A. Teti¹, S. Migliaccio^{1,2 1}Department of Experimental Medicine, University of L'Aquila, Italy; ²University 'La Sapienza', Rome, Italy; ³NIEHS, Research Triangle Park, NC, USA; ⁴Duke University Medical Center, Durham, NC, USA; ⁵Dept Orthop. & Cell Biology, Yale Univ., New Haven, CT, USA

15:36 O-38 METALLOPROTEINASE-14 IS INDUCED AT BEGINNING OF OSTEOGENESIS IN VITRO AND ITS DOWN-REGULATION IS REQUIRED FOR OSTEOGENIC PROGRESSION D. Palmieri, S. Poggi, V. Ulivi, P. Manduca* Dobig, University of Genova, Italy

15:48 O-39 DIFFERENTAL EXPRESSION OF CCN-FAMILY MEMBERS DURING OSTEOGENESIS, CHONDROGENESIS AND ADIPOGENESIS USING PRIMARY HUMAN MESENCHYMAL STEM CELLS N. Schütze*, U. Nöth, J. Schneidereit, C. Hendrich, J. Eulert, F. Jakob Orthopädische UniversitätsklinikClinic, Labor für Molekulare Experimentelle Orthopädie, Würzburg, Germany

16:00 O-40 OP-1 DEVICE IN SURGICAL TREATMENT OF THE SCAPHOID BONE NON-UNION R. Bilic¹*, M. Jelic^1,2, M. Pecina¹, S. Vukicevic^{2 1}Department of Orthopedic Surgery, School of Medicine, University of Zagreb, Croatia; ²Departments of Anatomy, School of Medicine, University of Zagreb, Croatia

Coffee Break

16:12 - 16:30

SATELLITE SYMPOSIUM

BONE FORMING AGENTS: THE NEW PARADIGM FOR OSTEOPOROSIS MANAGEMENT

Sponsored by Eli Lilly & Co

16:30 - 18:00 Small Auditorium

16:30 Introduction: effects of bone active agents on bone cells Graham Russell (Oxford, UK)

16:40 Effects of bone forming agents on bone strength and architecture Juliet Compston (Cambridge, UK)

17:00 Teriparatide and the treatment of osteoporosis: clinical results to date Robert Neer (Boston MA, US)

17:20 Strategy and tactics in the management of severe osteoporosis: who to treat John Kanis (Sheffield, UK)

17:40 Q&A

Chairmen and Panel

20:00 - 23:00 CLOSING PARTY

Wednesday 29 May