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Speaker Biographies

Adrian Bird   Claes Lindberg
Marie-Andrée Akimenko   Matthias Mann
Dennis Black   Michael McClung
Jens Bollerslev   Beata Lecka-Czernik
Lynda F. Bonewald   Klaus Olgaard
Roberto Civitelli   Eric Orwoll
Cyrus Cooper   Stuart Ralston
John Cunningham   Frank Rauch
Ove Furnes   Jonathan Reeve
Mark Gurnell   Ruth Ross
Stephen Hill   Kjeld Søballe
Michael Holick   A Francis Stewart
Martin Hrabé de Angelis   J Mark Wilkinson
Markus Ketteler   Klaus Willecke
Irina Kratchmarova   Mona Zaidi

Adrian Bird

Following his PhD at Edinburgh University in 1970, Dr Bird undertook postdoctoral research at the Universities of Yale and Zürich. In 1975 he returned to the MRC Mammalian Genome Unit in Edinburgh, where his research focused on DNA methylation and the existence of CpG islands as markers for mammalian genes. Following 3 years at the Institute for Molecular Pathology in Vienna, he moved back to Edinburgh as Buchanan Professor of Genetics in 1990. During this period he established a mechanistic connection between DNA methylation and chromatin via methyl-CpG binding proteins. His laboratory discovered the first such protein, MeCP2 and generated a mouse model for Rett Syndrome. Since 1995 Dr Bird has been Director of the Wellcome Trust Centre for Cell Biology.

Marie-Andrée Akimenko

Following her PhD at the Institut Pasteur in Paris, Marie-Andrée Akimenko did her postdoctoral training at the University of Oregon, where she developed an interest in using the zebrafish as an animal model to study embryonic development and fin regeneration. In 1992, she joined the Ottawa Health Research Institute (OHRI) affiliated to the University of Ottawa where she is currently Senior Scientist at the OHRI and Professor in the Departments of Medicine and of Cellular and Molecular Medicine. She is one of the pioneers in the molecular analysis of the mechanisms of fin regeneration in zebrafish. Her research focus in the last few years has been aimed at understanding the role of the hedgehog and bone morphogenetic protein signaling pathways in the overall growth of the regenerate and in dermal bone patterning during fin development and regeneration. Recent work has compared the molecular mechanisms of development in dermal bone with those of endochondral bone. She serves as a member of the editorial board of the journal “Developmental Dynamics” since 2003.

Dennis Black

Dennis Black completed his undergraduate work and received his MA and PhD in biostatistics from the University of California, Berkeley. He subsequently joined the faculty of the University of California, San Francisco, where he is currently Professor in the Department of Epidemiology and Biostatistics. Dr Black is active in both teaching and research, with a focus on osteoporosis and clinical trials. He was the lead investigator on the Fracture Intervention Trial (FIT) of alendronate and is currently Principal Investigator for the Long-term Extension of FIT (FLEX), the PTH and Alendronate (PATH) study, the PTH Once Weekly Research (POWR) and the HORIZON PFT trial of IV zoledronic acid. Dr Black has served on the Council of the American Society for Bone and Mineral Research and serves on many professional/governmental committees, including the National Osteoporosis Foundation Committee on Simplification of BMD Reporting and the World Health Organization Task Force for Osteoporosis. He has been an invited speaker at numerous national and international professional meetings and has published extensively in peer-reviewed journals. He is also the author of several book chapters, and currently serves as a reviewer for a number of professional publications, including the New England Journal of Medicine, JAMA and Journal of Bone and Mineral Research.

Bollerslev

Jens Bollerslev is head of Section of Endocrinology at Rikshospitalet in Oslo, Norway and Professor in Endocrinology at the University of Oslo. His scientific interests have primarily been related to monogenetic disorders of bone metabolism (he defended his thesis on human osteopetrosis in 1990) and bone as target tissues for endocrine disorders. For many years he has also been interested in treatment of borderline hypercalcemia due to primary hyperparathyroidism, and took the initiative in a randomized Scandinavian study on the effect of operation versus conservative observation. The first results from this study have recently been published. From the perspective of different mammalian mutations of osteopetrosis, Jens Bollerslev has contributed to international collaborations on the topic of osteoclast dysfunction and the coupling principle. In the bone field, he is currently involved in clinical investigations on bone loss in relation to solid organ transplantation.

Lynda F. Bonewald

Dr Lynda F. Bonewald a Curators’ Professor and the Lee M. and William Lefkowitz Professor in the Department of Oral Biology and directs the Bone Biology Research Program at UMKC. Dr Bonewald has worked in the area of transforming growth factor beta and in the lipoxygenases but is probably best known for her research in osteocyte biology. Osteocytes are the most abundant cell in bone and appear to be responsible for sensing mechanical stress and signaling bone modeling and remodeling. She is Director of a program project entitled “The Effects of Mechanical Strain on Osteocyte Function”. The program involves investigators at UMKC, KUMC, and UTHSC in San Antonio, Texas. Dr Bonewald is presently the Chair of the Advocacy Committee for American Society for Bone Mineral Research. She previously chaired the Board of Scientific Counselors of the NIH’s National Institute of Dental and Craniofacial Research and is Past President of the Association for Biomolecular Resource Facilities. She serves on the editorial boards for the Journal for Biomolecular Techniques and now the Journal for Bone and Mineral Research and is Associate Editor for Experimental Biology and Medicine.
 

Roberto Civitelli

Roberto Civitelli, MD, completed his medical studies and residency in internal medicine at Siena University School of Medicine, Italy, before moving to the Division of Bone and Mineral Diseases at Washington University, in St. Louis, Missouri, where he completed a fellowship in Endocrinology and Metabolism and was appointed full faculty in 1990. He has risen through the ranks to the current position of Professor of Medicine, Orthopaedic Surgery, and Cell Biology and Physiology. His areas of clinical specialty include osteoporosis and bone and mineral diseases. His research interests include cell-cell communication and signaling in bone and regulation of osteoblast differentiation and function.

Dr Civitelli is the author of over 100 peer-reviewed manuscripts and invited publications and 13 book chapters. He has served on the editorial boards of the Journal of Clinical Endocrinology and Metabolism, the Journal of Bone and Mineral Research, and the Journal of Laboratory and Clinical Medicine, and he is the editor of Calcified Tissue International. He is a member of several professional organizations including the American Association of Physicians, the American Society for Bone and Mineral Research and the International Bone and Mineral Society. He has received several industry sponsored and federally funded grants from the National Institutes of Health, and the National Aeronautics and Space Administration.

Cyrus Cooper

Cyrus Cooper is Professor of Rheumatology and Director of the MRC Epidemiology Resource Centre at the University of Southampton Medical School and Southampton General Hospital in the UK. Professor Cooper graduated from the University of Cambridge and St Bartholomew’s Hospital, London in 1980, and completed his residency in 1985 at the Southampton University Hospitals. He then worked in the MRC Environmental Epidemiology Unit as an MRC Training Fellow, and at the University of Bristol as a Senior Registrar in Rheumatology. In 1990, he won an MRC Travelling Fellowship to the Mayo Clinic, USA, where he continued his research in osteoporosis. Cyrus Cooper returned to the UK in 1992 to take up a position as Senior Lecturer in Rheumatology and MRC Senior Clinical Scientist. He was promoted to the foundation Chair in Rheumatology at the University of Southampton in 1997 while continuing as an MRC Senior Clinical Scientist at the MRC Environmental Epidemiology Unit. In 2003, he was appointed Director of the MRC Epidemiology Resource Centre, University of Southampton.

John Cunningham

John Cunningham is currently Professor of Nephrology at University College London Hospitals, The Royal Free Hospital and University College London, London, UK. Earlier he had been Professor of Renal and Metabolic Medicine and Consultant Physician at St Bartholomew’s and The Royal London School of Medicine & Dentistry where he also served as Admissions Sub Dean and as a Special Trustee for many years. His training was in Cambridge (pre-clinical) and Oxford (clinical) and subsequently in London and at Washington University School of Medicune, St Louis, USA. He has remained an active clinician in nephrology and in general internal medicine. He is a teacher and mentor of clinicians and scientists from undergraduate to senior faculty levels.

He runs a research programme examining the following: control by structurally modified vitamin D metabolites of PTH synthesis and release; the synthesis and release of bone cytokines by osteoblast like cells and the regulation of these by vitamin D metabolites; the location and relevance of the extracellular calcium receptor (CaR) in bone cells; the influence of simulated uraemia on the release of cytokines by bone cells; the factors mediating bone loss following renal transplantation and preventative strategies; the factors that control parathyroid function in vivo, including new vitamin D metabolites and calcimimetic agents; the pathogenesis of soft tissue calcification as it affects uraemic patients. Over the past few years his group has found that new structurally modified metabolites of vitamin D differ substantially in the way they influence the behaviour of both parathyroid cells and bone cells. His group has also devised, conducted and published studies of the first effective prophylaxis against bone loss in the post transplant setting and has contributed to the understanding of the roles of calcimimetics and new vitamin D analogues as treatments for uraemic hyperparathyroidism.

John Cunningham frequently lectures nationally and internationally, as well as serving on numerous international expert panels and working groups.
 

Ove Furnes

Chairman Department of Orthopaedic Surgery
Director The Norwegian Arthroplasty Register
Haukeland University Hospital, Bergen, Norway
Associate Professor in Orthopaedic Surgery, Department of Surgical Sciences, University of Bergen, Norway

His PhD thesis titled: "Hip and knee replacement in Norway 1987-2000. The Norwegian Arthroplasty Register", was a register based epidemiology study on knee and hip replacement.

He is a consultant orthopaedic surgeon with a special interest in prostheses surgery in rheumatic patients. Most of his scientific work has been on register based observational studies in hip and knee replacement, working with the ongoing prospective study on joint replacement in Norway from 1987 until today. From 2002 he has been the Director of the Norwegian Arthroplasty Register and from 2006 he became Chairman of the Department of Orthopaedic Surgery at Haukeland Univsersity Hospital in Bergen.
 

Mark Gurnell

Dr Gurnell graduated from St Bartholomew’s Hospital London, and it is here that he first developed his interest in endocrinology under the combined tutelage of Professors GM Besser, JAH Wass & AB Grossman. His interest in the molecular basis of endocrine disorders subsequently took him to Cambridge (St John’s College), as a Wellcome Clinical Training Fellow under the supervision of Professor VK Chatterjee, where he undertook a PhD investigating the roles of the human thyroid hormone b receptor and the peroxisome-proliferator-activated receptor b in human disease. Having completed his clinical training in Cambridge, he was appointed to a University Lectureship in 2004 and now co-directs a research group, with Professor Chatterjee, exploring the roles of nuclear receptors in human endocrine/metabolic disease. In 2000 he was the recipient of the Medical Research Society’s Young Investigator Gold Medal, and in 2001 the Society for Endocrinology’s Young Clinical Endocrinologist of the Year award.
 

Stephen Hill

Stephen Hill is Professor of Molecular Pharmacology and Director of the Institute of Cell Signalling at the University of Nottingham in the UK. He is also Director and Founder of the company CellAura Technologies Ltd. Dr Hill studied at the University of Bristol and gained his PhD at the Department of Pharmacology, University of Cambridge in 1979. His current research interests include:

  • Mechanisms of intracellular cross-talk
  • Desensitisation of G-protein-coupled receptors
  • Agonist trafficking and receptor interactions with multiple G-proteins
  • Constitutive activity of G-protein-coupled receptors
  • Signalling from GPCRs to the nucleus

Michael Holick

Michael F Holick, PhD, MD, is professor of medicine, physiology and biophysics and director of the General Clinical Research Center at Boston University Medical Center

He has made numerous contributions to the field of the biochemistry, physiology, metabolism, and photobiology of vitamin D for human nutrition. He identified 25-hydroxyvitamin D from human blood, and was the first to help structurally identify and chemically synthesize 1,25-dihydroxyvitamin D3. He determined the mechanism for how vitamin D is synthesized in the skin, demonstrated the effect of aging, obesity, latitude, seasonal change, sunscreen use, skin pigmentation, and clothing on this vital cutaneous process, and established global recommendations for exposure to sunlight as a major source of vitamin D. He has helped increase awareness of the pediatric and medical community regarding the extent that vitamin D deficiency exist in the US population, and its role in causing metabolic bone disease, and osteoporosis in adults.
 

Martin Hrabé de Angelis

Martin Hrabé de Angelis studied biology at the Philipps University in Marburg and received his PhD in 1994. He worked as postdoctoral fellow from 94- 97 at the Jackson Laboratory in Bar Harbor/USA studying the Delta/Notch pathway and mouse mutant lines with impaired somitogenesis. He started his own research group in 97 at the GSF National Research Centre in Munich. In 2000 he was recruited as director of the Institute of Experimental Genetics at the GSF. Hrabe de Angelis is full professor at the Technical University in Munich and holds the chair of Experimental Genetics. At the same time he serves as director of the European Mouse Mutant Archive in Monterotondo/Rome Italy. His research focus is on large-scale mutagenesis, functional genomics using mouse models for the understanding of inherited diseases in man, the Delta/Notch pathway and bone related diseases. In 2002 he founded the German Mouse Clinic (GMC) for comprehensive phenotyping of mouse models.

Markus Ketteler

Dr Markus Ketteler is Consultant Nephrologist at the Department of Nephrology and Clinical Immunology, University Hospital of the RWTH Aachen, Germany, responsible for the Haemodialysis and the Renal Transplantation Unit. Before this, Dr Ketteler had worked in the Department of Nephrology at the University Hospital Benjamin Franklin, Free University, Berlin, Germany (1989-1992 and 1994-2000), and in the Department of Nephrology and Hypertension at the University Hospital in Salt Lake City, UT, USA (1992-1994), where he had spending a 2-year Postdoctoral Fellowship working on the role of nitric oxide in inflammatory glomerular diseases. His current research focus is aimed at the understanding of pathomechanisms involved in extra-osseous calcifications and cardiovascular disease in patients with chronic kidney disease (CKD). His research group identified the deficiency of fetuin-A, a circulating calcification inhibitor, as a uraemia- and inflammation-related risk predictor of cardiovascular and all-cause mortality in patients on dialysis.
 

Irina Kratchmarova

Current position (since 2005): Associate Professor at the Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark

Education and Professional Experience: MSc in Molecular Biology, specialization: Animal and Human Physiology, Faculty of Biology, Sofia University, Sofia, Bulgaria, 1991-1997, (supervisor Professor Ignat Minkov); PhD from Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark, 1997-2001, (supervisor Professor Karsten Kristiansen); Assistant Professor in the group of Professor Matthias Mann, Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark, 2001-2005.

Main Research Areas: Cell differentiation, quantitative proteomics, signaling cascades, secreted molecules

Beata Lecka-Czernik

Beata Lecka-Czernik is an Associate Professor in the Department of Geriatrics at the University of Arkansas for Medical Sciences, USA. She obtained her undergraduate degree from the Warsaw University and his PhD from the Institute of Biochemistry and Biophysics Polish Academy of Sciences, both in Warsaw, Poland. She received her postdoctoral training at the University of Arkansas for Medical Sciences and became UAMS faculty in 1995. She has initiated research on the role of nuclear receptor PPARgamma in the maintenance of adult bone mass by demonstrating that PPARgamma plays a key regulatory role in the process of marrow mesenchymal stem cells (MSCs) commitment toward osteoblasts and adipocytes. Dr. Lecka-Czernik’s research interests include: 1) effects of aging and PPARgamma on differentiation potential of MSCs; 2) effects of highly specific PPARgamma agonists and anti-diabetic drugs, thiazolidinediones, on bone. She is the Editor for the PPAR Research inaugural issue, PPARs and Bone Metabolism. Her research has been supported by grants from the National Institute of Health and the American Diabetes Association.

Claes Lindberg

PhD in Organic Pharmaceutical Chemistry, Uppsala University, Sweden (1978).
Assistant Professor, Uppsala University (1990).

Joined Astra Draco in Lund, Sweden, 1979 as team leader and associate director responsible for bioanalytical mass spectrometry. Currently holds a position as Associate Principal Scientist at Translational Sciences within AstraZeneca R&D in Lund.

The research interest is focused on mass spectrometry applied to proteomics with special emphasis on biomarker discovery by combined chromatographic and mass spectrometric techniques.~

Matthias Mann

Matthias Mann (born 1959) is a scientist in the area of mass spectrometry and proteomics. Born 1959 in Germany he studied mathematics and physics at the University of Goettingen. He received his Ph.D. in 1988 at Yale University were he worked in the group of the later Nobel laureate John Fenn. After a postdoctoral fellowship at the University of Southern Denmark in Odense he became group leader at the European Molecular Biology Laboratory (EMBL) in Heidelberg. Later he went back to Odense as a Professor for Bioinformatics. Since 2005 he is a director at the Max Planck Institute of Biochemistry in Munich.

Michael McClung

Dr Michael McClung received his medical degree from the University of Texas Southwestern Medical School in Dallas and completed his residency at Parkland Memorial Hospital in the same city. His fellowship in endocrinology was completed at the National Institutes of Health. He is a Fellow of the American College of Physicians and the American College of Endocrinology. He has served on the Board of the International Society for Clinical Densitometry and the Committee of Scientific Advisors for the International Osteoporosis Foundation. As Founding Director of the Oregon Osteoporosis Center in Portland, Oregon and Assistant Director of the Department of medical Education at Providence Portland Medical Center, he is involved in medical education and clinical practice. His Center has participated in the conduct of and reporting of many clinical trials.
 

Klaus Olgaard

Klaus Olgaard is Professor of Nephrology and Internal Medicine at the University of Copenhagen and at Department of Nephrology, Rigshospitalet, Copenhagen, Denmark. His scientific interests are basic and clinical research in nephrology-endocrinology, especially related to calcium, phosphorus, parathyroid hormone (PTH), PTH related peptide, vitamin D, renal osteodystrophy and post-transplant bone disease.

Professor Olgaard was the President for the ERA-EDTA congress held in Copenhagen in 2002. He is Past President of several national nephrology and transplantation societies including the Danish Society of Nephrology. He is subject editor for Nephrology Dialysis Transplantation, and has been a member of several editorial boards.

Professor Olgaard has authored more than 200 publications in peer-reviewed international journals and is the editor of the K/DIGO guidelines, 2006 on: Bone and Mineral Metabolism in CKD.

Eric Orwoll

Dr Orwoll completed his undergraduate degree at the University of Michigan, received his MD from the University of Maryland School of Medicine and completed his residency in internal medicine at Providence Medical Center. A fellowship in Endocrinology and Metabolism was completed at the Oregon Health Sciences University in Portland.

His appointments at the Oregon Health & Science University are numerous. Dr Orwoll is an Attending Physician, Director, Bone and Mineral Clinic and Densitometry Services; Director, Bone and Mineral Research Unit; Head, Bone and Mineral Section of the Division of Endocrinology, Diabetes, Clinical Nutrition; Professor of Medicine; Director, Clinical and Translational Sciences Institute; Associate Dean for Research in the School of Medicine and OHSU Associate Vice President for Research.

Dr Orwoll’s major research interests include the epidemiology, etiology and therapy of osteoporosis, the effects of sex steroids on skeletal biology and skeletal genetics. He is the principal investigator on several research grants funded by the National Institutes of Health, including Osteoporotic Fractures in Men (MrOS), and is the author of over 150 peer reviewed publications, reviews, book chapters, and books.

He is assigned to several National Committees. For instance, Dr Orwoll is a member of the Board of Trustees, National Osteoporosis Foundation and has been a member of the Orthopedics Study Section, NIH. He is a member of a variety of professional societies, including the American Society for Bone and Mineral Research, Endocrine Society, American Society for Clinical Nutrition and the Federation of American Societies for Experimental Biology.

His editorial posts have included membership on the editorial boards of the Journal of Bone and Mineral Research, the Journal of Clinical Endocrinology and Metabolism, Endocrinology and Clinical Densitometry. Dr Orwoll is a reviewer for many journals, including Endocrinology, Bone, Osteoporosis International, Journal of Clinical Investigation, JAMA, New England Journal of Medicine and Annals of Internal Medicine.

Stuart Ralston

Stuart Ralston graduated in medicine from Glasgow University in 1978 and developed an interest in metabolic bone disease during postgraduate training with Dr Iain T Boyle at Glasgow Royal Infirmary. Professor Ralston trained in general internal medicine and rheumatology in Glasgow between 1981 and 1988. He was appointed as a Wellcome Senior Clinical Research Fellow and Honorary Consultant at the University of Edinburgh between 1988 and 1990 and moved to Aberdeen to take up an appointment as Senior Lecturer in Medicine in 1991. He was appointed as Professor of Medicine and Bone Metabolism in 1996 and was Director of the Institute of Medical Sciences at Aberdeen between 2002 and 2004. Professor Ralston took up the ARC chair of Rheumatology at the University of Edinburgh in February 2005 and was appointed as Head of the School of Molecular and Clinical Medicine in November 2005. He is an Honorary Consultant Rheumatologist with Lothian Health Board and is lead clinician for Osteoporosis services within NHS Lothian.

Professor Ralston has published extensively on several aspects of bone disease including the genetics of osteoporosis; the pathogenesis and management of Paget's disease of bone; the role of Nitric Oxide in bone and the pathogenesis and management of cancer-associated bone disease. He was President of the European Calcified Tissues Society between 1998 and 2005. He is currently joint editor-in-chief of Calcified Tissue International, associate editor of Bone; associate editor of Endocrinology and a member of the Editorial Board of the Journal for Bone and Mineral Research

Frank Rauch

Current Position (since 2001): Assistant Director of Clinical Research at the Shriners Hospital for Children and Assistant Professor at the Department of Pediatrics of McGill University, Montreal, Canada.

Education: MD from Munich Technical University, Germany, in 1991; pediatric training at the Children’s Hospital of Cologne University, Germany, 1991-1997 (supervisor Dr. E. Schoenau); research fellowship in bone development at the Shriners Hospital for Children, Montreal, 1997-1999 (supervisors Dr. R. St-Arnaud and Dr F. H. Glorieux).

Scientific Activity: 105 peer-reviewed publications, 22 book chapters and proceedings contributions.

Main Research Areas: Pediatric bone histomorphometry, musculoskeletal interaction, osteogenesis imperfecta

Editorial Activity: Associate Editor, Journal of Musculoskeletal and Neuronal Interactions; Editorial Board, Osteoporosis International
 

Jonathan Reeve

Jonathan trained at the MRC Clinical Research Centre and the Endocrine Unit Massachusetts General Hospital. His early research interests included the first clinical studies of PTH1-34 in osteoporosis and new techniques in tracer studies and systems biology. His interest in osteocytes was stimulated by a long-standing collaboration with Pierre J Meurnier and Monique Arlot, which led to the first studies of osteocytes apoptosis in sudden estrogen withdrawal with Brendon Noble and Nigel Loveridge. He has also co-ordinated the European Prospective Osteoporosis Study, with over 35 collaborating principal investigators and more than 100 scientific papers including a series of meta-analysis, that give hope for better identification of the patient at risk. His current interests include the genetic epidemiology of osteoportic fractures (as a Principal Investigator in the GENOMOS Consortium) and the regulation of bone formation and resorption by osteocytic signalling in collaboration with colleagues at the Department of Endocrinology in Leiden. Jonathan is currently a Director of Research in the University Department of Medicine at Cambridge.

Ruth Ross

Dr Ruth Ross is a senior lecturer in Pharmacology at The University of Aberdeen in Scotland. Her primary research focus is cannabinoid receptor pharmacology and the pharmacology of the endocannabinoids and related metabolites. This research is directed towards discovery of the role of the endocannabinoids in pain, inflammation, obesity and bone disorders and the development of small molecules, which modulate the various elements of the endocannabinoid system as novel therapeutics.

Kjeld Søballe

Professor, DMSc
Consultant in orthopaedic surgery at University Hospital of Aarhus, DK Section for Hip Surgery

Expertise:
Surgical treatment of osteoarthritis, joint preserving procedures (periacetabular osteotomy), experimental basic research in implant fixation, ceramic coatings, bone grafting, growth factors, cytokines, wear debris, iNANO science, tissue engineering, therapeutic peptides, gene technology, clinical studies of total joints, epidemiology of osteoarthrosis.

A Francis Stewart

Francis Stewart received his PhD from the University of New South Wales, Sydney Australia in 1986 for studies on the molecular biology of lactation. He then pursued post-doctoral work with Guenther Schuetz at the German Cancer Research Centre on chromatin and steroid hormone action.

In 1991 he became a Group Leader in the Gene Expression Program at EMBL, Heidelberg where he combined work on chromatin and epigenetic mechanisms with the development of advanced genome engineering strategies for the mouse and other living systems. These include the now popular ligand (usually tamoxifen) regulated gene switch based on site specific recombination by Cre-steroid hormone receptor fusion proteins; the development of efficient FLP recombination by application of molecular evolution to obtain FLPe; and recombineering the use of homologous recombination by the lambda phage Red operon in E.coli for DNA engineering, particularly for engineering BACs (bacterial artificial chromosomes) and construction of complex targeting vectors. Recent studies of epigenetic mechanisms in chromatin have focused on histone lysine methylation and trithorax-Group action.

Dr. Stewart became the founding Professor for Genomics at the Dresden University of Technology in 2001.
 

J Mark Wilkinson

Mark Wilkinson is a clinical fellow in hip arthroplasty at The University of Sheffield, UK His research interests include the pathogenesis and treatment of aseptic loosening after total hip arthroplasty, for which he has received grant support from the Arthritis Research Campaign, Royal College of Surgeons of England, and the John Charnley Trust. Previously he was the International Arthroplasty Fellow at Wrightington Hospital, Wigan, and a doctoral student with Professor Richard Eastell at The University of Sheffield. He has been awarded the British Orthopaedic Association Robert Jones Gold Medal and Association Prize, the British Hip Society McKee Prize, National Osteoporosis Society Young Investigator Award, and an Orthopaedic Research Society New Investigator Recognition Award.
 

Klaus Willecke

Klaus Willecke, Professor of Genetics at the University of Bonn, Germany, since 1968. Ph.D. in Biochemistry at the University of Munich 1968, Postdoctoral work at Princeton University (USA) 1968-1971, Habilitation in Genetics at the University of Cologne 1973. Associate Professor of Cell Biology at the University of Essen (Medical School) 1977-1986, Sabbatical terms at Yale University, USA, 1973, Stanford University, USA, (1982), Massachusetts Institute of Technology, USA, (1993), and University of Munich (1999).

Current research area: Biological functions of connexin genes, transgenic mice, molecular biology.
 

Mone Zaidi

Professor Mone Zaidi is Professor of Medicine, Geriatrics, and Physiology and Biophysics at The Mount Sinai School of Medicine in New York as well as the Director of The Mount Sinai Bone Program. Professor Zaidi has published over 200 articles including chapters and papers in journals such as Cell, Nature Cell Biology, Journal of Cell Biology, and Journal of Clinical Investigation. His research focuses on the developmental biology of bone and molecular and cellular mechanisms of skeletal remodeling during adult life.

Dr Zaidi has been funded continuously initially by the Medical Research Council (MRC) and Arthritis Research Council in England, and thereafter, in the United States by the National Institutes of Health (NIH) and the Department of Veterans Affairs. Professor Zaidi was elected to the American Society for Clinical Investigation (ASCI), the Association of American Physicians (AAP), the Oslerian Interurban Clinical Club and the Society of Osteobiology. He served as Chair of the Orthopedics and Musculoskeletal Grant Review Committee of the NIH, and for two separate terms, as Chair of the VA’s Endocrine Grant Review Panel. He was admitted to Fellowship of the Royal College of Physicians of London and Dublin, Royal College of Pathologists of London, American College of Endocrinology, American College of Physicians, and Institute of Biologists (London).

Dr Zaidi has been invited internationally to give lectures, and was recently “Invited Speaker” at the Japanese Society for Bone and Mineral Research.

 

   
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