P001-Su GENDER DIFFERENCES IN TRABECULAR AND CORTICAL MICROSTRUCTURE OF THE DISTAL RADIUS SHOWN IN AN ELDERLY POPULATION AS ASSESSED BY HIGH-RESOLUTION 3D-PQCT

T. L. Mueller¹, M. Stauber¹, C. Gratzke², F. Eckstein², R. Müller¹

¹Institute for Biomedical Engineering IBT, ETH and University of Zürich, Zürich, Switzerland, ²Musculosceletal Research Group, Institute of Anatomy, Ludwig-Maximilians-Universität, München, Germany

P002-Mo FRACTURE RISK AMONG WOMEN WITH THE LOWEST BONE TURNOVER DURING 10 YEARS OF ALENDRONATE TREATMENT

D. C. Bauer¹, A. C. Santora², M. C. Hochberg³, A. Chattopadhyay², P. Ross²

¹Medicine, Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, ²Clinical Research, Merck Research Laboratories, Rahway, ³Rheumatology, University of Maryland, Baltimore, United States

P003-Tu FRACTURE INDEX VALIDATION IN A POPULATION-BASED SAMPLE OF SWISS ELDERLY WOMEN

O. Lamy¹, M. Krieg¹

¹Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne - CHUV, Switzerland

P004-Su TEN YEAR ABSOLUTE RISK OF OSTEOPOROTIC FRACTURES ACCORDING TO BMD T-SCORE AT MENOPAUSE. THE DANISH OSTEOPOROSIS PREVENTION STUDY.

B. Abrahamsen¹, P. Vestergaard², B. Rud³, O. Bärenholdt⁴, J. B. Jensen³, S. Pors Nielsen⁴, L. Mosekilde², K. Brixen¹

¹Dept of Endocrinology M, Odense University Hospital, Odense C, ²Dept of Endocrinology C, Aarhus University Hospital, Aarhus C, ³Osteoporosis Clinic, HS Hvidovre Hospital, Copenhagen, ⁴Clinical Physiology, Hillerød Hospital, Hillerød, Denmark

P005-Mo INTRAVENOUS IBANDRONATE INJECTIONS ARE AT LEAST AS EFFECTIVE AND SIMILARLY WELL TOLERATED AS DAILY ORAL IBANDRONATE IN POSTMENOPAUSAL OSTEOPOROSIS: 1-YEAR RESULTS FROM DIVA

S. Adami¹, R. Nuti², E. Czerwinski³, C. Hughes⁴, P. Ward⁴, B. Bonvoisin⁴, L. B. Tanko⁵

¹., University of Verona, Verona, ²., University of Siena, Siena, Italy, ³., Krakow Medical Centre, Krakow, Poland, ⁴., F. Hoffmann-La Roche Ltd., Basel, Switzerland, ⁵., CCBR, Ballerup, Denmark

P006-Tu STRONTIUM RANELATE IMPROVES BONE MICROARCHITECTURE AND INTRINSIC BONE QUALITY

P. Ammann¹, S. Barrauld¹, R. Dayer¹, R. Rizzoli¹

¹Division of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital, Geneva, Switzerland

P007-Su AN INDIVIDUALISED MODEL OF COST-EFFECTIVENESS OF BISPHOSPHONATES IN ELDERLY WOMEN

T. P. Van Staa¹, P. Geusens², A. Boonen², H. G. M. Leufkens³, C. Cooper⁴

¹Epidemiology, Procter Gamble Pharma, Egham, United Kingdom, ²Department of Rheumatology, University Hospital, Maastricht, ³Department of Pharmacoepidemiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, ⁴MRC Resource Center in Epidemiology, Southampton Hospital, Southampton, United Kingdom

P008-Mo IN VIVO MONITORING OF BONE FORMATION BY NEAR-INFRARED FLUORESCENCE MEDIATED TOMOGRAPHY

H. Gremlich¹, R. Kneuer¹, S. Kerrad¹, M. Merdes², A. Suter¹, M. Kneissel²

¹Discovery Technology, ²Bone and Cartilage Unit, Novartis Institutes for BioMedical Research, Basel, Switzerland

P009-Tu SERUM CATHEPSIN K LEVELS REFLECT OSTEOCLASTIC ACTIVITY IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS AND PATIENTS WITH PAGET'S DISEASE

C. Meier¹, U. Meinhardt², J. R. Greenfield², C. R. Dunstan³, M. J. Seibel³

¹Clinic for Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland, ²Garvan Institute of Medical Research, University of NSW, ³Bone Research Program, ANZAC Research Institute, University Sydney, Sydney, Australia

P010-Su ADIPONECTIN INCREASES BONE MASS IN MICE BY SUPPRESSING OSTEOCLASTOGENESIS AND ACTIVATING OSTEOBLASTOGENESIS

K. Oshima¹, A. Nampei¹, M. Matsuda², M. Iwaki², A. Fukuhara², J. Hashimoto¹, H. Yoshikawa¹, I. Shimomura³

¹Department of Orthopaedics, Graduate School of Medicine, Osaka University, ²Department of Medicine and Pathophysiology, Graduate School of Frontier Biosciences, Osaka University, ³Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan

P011-Mo PTHR1 POLYMORPHISMS AND THEIR ROLE IN VARIATION IN BONE MINERAL DENSITY

C. Vilarino-Guell¹, P. Y. Woon¹, L. J. Miles¹, E. L. Duncan², F. Consortium³, J. A. Wass², M. A. Brown¹

¹Nuffield Department of Orthopaedic Surgery, Botnar Research Centre,, ²Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, ³, Oxagen Ltd, Abingdon, United Kingdom

P012-Tu PTHRP EXPRESSION IN CARTILAGE CELLS IS REGULATED BY THE HEDGEHOG SIGNALING MOLECULE, GLI2

J. A. Sterling¹, M. Zhao¹, B. O. Oyajobi¹, B. G. Grubbs¹, G. R. Mundy¹

¹Cellular and Structural Biology, University of Texas Health Science Center San Antonio, San Antonio, United States

P013-Su VITAMIN D STATUS AND THE THRESHOLD FOR SECONDARY HYPERPARATHYROIDISM IN THE LONGITUDINAL AGING STUDY AMSTERDAM (LASA)

P. Lips¹, S. M. F. Pluijm², J. H. Smit², N. M. Van Schoor²

¹Endocrinology, ²EMGO Institute, VU University Medical Center, Amsterdam, Netherlands

P014-Mo Y2 RECEPTORS AND THE CENTRAL REGULATION OF CORTICAL BONE: RECIPROCAL ACTIVITY TO LEPTIN.

P. A. Baldock¹, S. Allison¹, A. Sainsbury², R. F. Enriquez¹, H. Herzog², J. A. Eisman¹, E. M. Gardiner¹

¹Bone and Mineral, ²Neurobiology, Garvan Institute of Medical Research, Sydney, Australia

P015-Tu BETA-CATENIN IS A POWERFUL ENHANCER OF BMP-2 GENE EXPRESSION IN OSTEOBLASTS IN VITRO AND IN VIVO

M. Zhao¹, M. Qiao¹, D. Chen², S. E. Harris³, B. O. Oyajobi¹, I. R. Garrett⁴, G. Gutierrez⁴, G. R. Mundy¹

¹Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, ²Orthopaedics, University of Rochester, Rochester, ³Periodontics, University of Texas Health Science Center at San Antonio, ⁴Bone, Osteoscreen Inc., San Antonio, United States

P016-Su SECRETED FRIZZLED-RELATED PROTEIN 1 (SFRP1) REGULATES MESENCHYMAL STEM CELL DIFFERENTIATION TOWARD OSTEOGENIC OR ADIPOGENIC LINEAGE

F. Wang¹, C. Lin², Y. Chen³, K. Yang¹, Y. Huang¹, Y. Sun¹, H. Huang¹

¹Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, ²Department of Nephrology, Cjayi Chang Gung Memorial Hospital, Chayi, ³Department of Orthopedic Surgery, Linko Chang Gung Memorial Hospital, Linko, Taiwan

P017-Mo P53 REPRESSES THE EXPRESSION OF TRANSCRIPTION FACTOR OSTERIX AND FUNCTIONS AS A NEGATIVE REGULATOR OF OSTEOBLASTOGENESIS AND BONE FORMATION

X. Wang¹, H. Kua¹, Y. Hu¹, K. Guo¹, Q. Zeng¹, G. Karsenty², J. Yeh³, B. Li¹

¹IMCB, Institute of Molecular and Cell Biology, Singapore, Singapore, ²Molecular and Human Genetics, Baylor College of medicine, Houston, ³Medicine, Winthrop-University Hospital, Mineola, United States

P018-Tu ROLE OF FIBROBLAST GROWTH FACTOR RECEPTOR-2 IN THE ALTERED OSTEOBLAST PHENOTYPE INDUCED BY TWIST HAPLOINSUFFICIENCY IN THE SAETHRE-CHOTZEN SYNDROME

H. Guénou¹, K. Kaabeche¹, S. Le Mée¹, P. J. Marie¹

¹Osteoblast Biology and Pathology, Inserm U606, Paris cedex 10, France

P019-Su APO2L/TRAIL IS A POTENT ANTI-CANCER AGENT THAT PREVENTS BREAST CANCER –INDUCED BONE DESTRUCTION IN A MOUSE MODEL.

D. M. Findlay¹, A. Evdokiou¹, T. L. Minh¹, A. Labrinidis¹, S. Hay¹, V. Liapis¹, S. Bouralexis¹, K. Welldon¹

¹Orthopaedics and Trauma, The University of Adelaide, Adelaide, Australia

P020-Mo SCLEROSTIN IS A DELAYED SECRETED PRODUCT OF OSTEOCYTES THAT REGULATES BMU WIDTH AND CORTICAL CANAL INFILLING.

K. E. S. Poole ¹, R. L. Van Bezooijen², N. Loveridge¹, S. E. Papapoulos², C. W. Löwik², J. Reeve¹

¹Department of Bone Research, University of Cambridge, Cambridge, United Kingdom, ²Department of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands

index

Age-Related changes in Bone - P021 - P050

P021-Tu LOW BONE TURNOVER AND FUNCTIONAL HYPOPARATHYROIDISM REDUCE MORTALITY IN VITAMIN D DEFICIENT ELDERLY

P. N. Sambrook¹, C. Chen¹, L. March¹, I. Cameron², R. Cumming³, S. Lord⁴, M. Seibel⁵

¹Institute of Bone and Joint Research, Royal North Shore Hospital, ²Rehabilitation Studies Unit, ³School of Public Health, ⁴Prince of Wales Medical Research Institute, ⁵ANZAC Research Institute, University of Sydney, Sydney, Australia

P022-Su BMD MAINTAINED AFTER WITHDRAWAL OF MILK SUPPLEMENT: A FOLLOW-UP STUDY IN POSTMENOPAUSAL CHINESE WOMEN IN MALAYSIA

W. S. S. Chee¹, A. R. Suriah², . G. P. Ting¹, . S. Y. Tan¹, . S. P. Chan³, K. Chinna⁴, Y. Zaitun⁵

¹Nutrition and Dietetics, National University of Malaysia, Kuala Lumpur, ²Food Science Program, National University of Malaysia, UKM Bangi, ³Dept of Medicine, University Malaya, Kuala Lumpur, ⁴Faculty of Information Technology and Science Quantitatives, University Technology Mara, Shah Alam, ⁵Dept of Nutrition and Health Science, Putra University Malaysia, Serdang, Malaysia

P023-Mo HIGH BONE TURNOVER IS AN INDEPENDENT PREDICTOR OF MORTALITY IN THE FRAIL ELDERLY: A PROSPECTIVE COHORT STUDY.

M. J. Seibel¹, C. Chen², L. March², I. Cameron³, R. Cumming⁴, J. Simpson⁴, P. N. Sambrook²

¹Bone Research Program, ANZAC Research Institute, University of Sydney, ²Institute of Bone and Joint Research, Royal North Shore Hospital, ³Rehabilitation Studies Unit, ⁴School of Public Health, University of Sydney, Sydney, Australia

P024-Tu BONE MINERAL DENSITY IN PREMENOPAUSAL WOMEN WITH RHEUMATOID ARTHRITIS

H. O. Hämäläinen¹, H. Kautiainen¹, A. Kotaniemi¹

¹Rheumatology, Rheumatism Foundation Hospital, Heinola, Finland

P025-Su DELAY IN BONE DENSITY GAIN COMPARED WITH HEIGHT GROWTH MAY CAUSE TRANSIENT INCREASE IN FRACTURE IN GROWING JAPANESE CHILDREN

M. Iki¹, J. Tamaki¹, Y. Ikeda¹, Y. Sato², A. Morita¹, H. Naka³

¹Department of Public Health, Kinki University School of Medicine, Osaka-Sayama, ²Department of Nutrition, Tenshi College, Sapporo, ³Department of Physical Education, Kyoto University of Education, Kyoto, Japan

P026-Mo ITALIAN PEDIATRIC REFERENCE CURVES FOR QUANTITATIVE ULTRASOUND BONE MEASUREMENTS AT MULTIPLE SKELETAL SITES

L. Pedrotti¹, R. Mora¹, G. Tuvo¹, M. Miceli¹, C. Livieri², S. Quaglini³

¹Department of Orthopaedics and Traumatology, University of Pavia, Istituto Città di Pavia, ²Department of Health Science, ³Department of Computer Science and Systems, University of Pavia, Pavia, Italy

P027-Tu THE RETROSPECTIVE ANALYSIS OF MINERAL CONTENT IN BONE SAMPLES FROM DONORS AGED 0-99 YEARS LIVING IN THE SOUTHERN URALS OVER THE SECOND HALF OF THE XX CENTURY

E. I. Tolstykh¹, E. E. Tokareva¹, L. M. Peremyslova², N. B. Shagina¹, M. O. Degteva¹

¹Biophysics Laboratory, ²Environmental Laboratory, Urals Research Center for Radiation Medicine, Chelyabinsk, Russian Federation

P028-Su ASSESSMENTS OF THE CORTICAL BONE RESORPTION RATES FOR MEN AND WOMEN AGED 30-80 YEARS IN A LONGITUDINAL (25 YEARS) STUDY USING STRONTIUM-90 AS A RADIOACTIVE TRACER.

N. B. Shagina¹, E. I. Tolstykh¹, O. V. Vyushkova², V. I. Zalyapin³, M. O. Degteva¹

¹Biophysics Laboratory, ²Epidemiological Department, Urals Research Center for Radiation Medicine, ³Department of Mathematical Analysis, Southern Urals State University, Chelyabinsk, Russian Federation

P029-Mo GENE EXPRESSION ANALYSIS OF MAJOR LINEAGE DEFINING FACTORS OF HUMAN BONE MARROW CELLS RELATED WITH AGING AND AGE RELATED DISORDERS IN BONE

Y. Jiang¹, H. Mishima², S. Sakai², H. Kojima³, T. Uemura³

¹ADRC, National Institute of Advanced Industrial Science and Technology, Nantong Univ., Guizhou Acad. Sci., ²Dept. of orthpaedics, Univ. of Tsukuba, ³Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan

P030-Tu FALL MECHANISMS IN A HEALTHY OLDER POPULATION WITH MINIMAL TRAUMA FRACTURES.

P. A. Turner¹

¹Social Futures Institute School of Social Sciences & Law, University of Teesside, Middlesbrough, United Kingdom

P031-Su TARGETED DISRUPTION OF THE SRC SUBSTRATE, SAM68, PROTECTS AGAINST AGE-RELATED BONE LOSS

J. E. HENDERSON¹, S. Richard², G. Tremblay², T. Chen², G. Vogel², M. Tremblay³, W. Li¹, A. Li¹, R. Y. J. Gao¹, . M. Morel²

¹Medicine, Centre for Bone and Peridontal Research, ²Terry Fox Molecular Oncology Group and Bloomfield Centre for Research on Aging, SMBD Jewish General, ³Biochemistry, Cancer Centre, McGill University, Montreal, Canada

P032-Mo AGE CHANGES IN THE MANDIBULAR CONDYLE AND TIBIA IN RATS

Y. Kameyama¹, Y. Suzumura¹, M. Aiba¹, M. Bessho¹, Y. Sugita¹, K. Kubo¹, E. Sato¹, H. Maeda¹

¹Pathology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan

P033-Tu EFFECT OF MECHANICAL COMPONENTS OF PHYSICAL ACTIVITY ON BONE MINERAL DENSITY IN JAPANESE CHILDREN: CROSS-SECTIONAL ANALYSES

J. TAMAKI¹, M. Iki¹, Y. Sato², H. Naka³

P034-Su REPEATED MEASUREMENTS ANALYSIS OF BONE FRAGILITY RISK FACTORS: FIRST RESULTS

G. Livshits¹, I. Malkin¹, G. Bigman¹, E. Kobyliansky¹, M. J. Seibel²

¹Anatomy and Anthropology, Tel Aviv University, Tel Aviv, Israel, ²ANZAC Research Institute, Bone Research Program, University of Sydney, Sydney, Australia

P035-Mo BIOCHEMICAL MARKERS OF BONE METABOLISM AND SERUM LEPTIN IN OBESE POSTMENOPAUSAL WOMEN.

R. S. Filip¹, G. Raszewski², A. Haratym-Maj¹, D. Filip¹

¹Dept of Metabolic Diseases of Bone Tissue, ²Department of Toxicology, Institute of Agricultural Medicine in Lublin, Lublin, Poland

P036-Tu QUANTITATIVE MULTI-SLICE CT STUDY ON LUMBAR VERTEBRAE OF OSTEOPOROTIC ELDERLY WOMEN: COMPARISON OF VOLUMETRIC BMD WITH DXA

S. Wu¹, X. Cheng², J. Qi¹, L. Wen¹, B. Wang³, Y. Wang³

¹Department of Radiology, First Central Hospital of Tianjin Medical University, Tianjin, ²Department of Radiology, Jishuitan Hospital of Beijing University, ³Department of Radiology, First Central Hospital of Tianjin Medical University, Beijing, China

P037-Su THE BACKBONE OF TRABECULAR NETWORK - A NEW APPROACH.

Z. Tabor¹, E. Rokita¹

¹Departhemt of Biophysics, Jagiellonian University, Cracow, Poland

P038-Mo DIFFERENTIAL DIAGNOSIS OF CONNECTIVE TISSUE DISORDERS, MARFAN SYNDROME

V. Vyskocil¹, J. Varvarovska², R. Pikner¹

¹Bone Disease Center Department of Medicine II, ²Of Pediatric, Charles University Hospital, PLZEN, Czech Republic

P039-Tu TWO YEARS EXPERIENCE OF RALOXIFENE THERAPY

B. Miskic¹, D. Bistrovic², V. Cosic³

¹Internal medicine, General hospital Dr. Josip Bencevic, ²Internal medicine, ³Gynecology and obstetrics, General hospital "Dr. Josip Bencevic", Slav.Brod, Croatia

P040-Su THE EXISTING BONE PHENOTYPE OF MICE LACKING TRANSIENT RECEPTOR POTENTIAL CHANNEL 5 (TRPV5) PERSISTS DURING AGING

B. C. J. Van der Eerden¹, L. Ndamba¹, J. H. Waarsing², J. G. J. Hoenderop³, H. Weinans², C. J. Buurman¹, H. A. P. Pols¹, R. J. M. Bindels³, J. P. T. M. Van Leeuwen¹

¹Internal Medicine, ²Orthopedics, Erasmus MC, Rotterdam, ³Cell Physiology, NCMLS, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

P041-Mo THE AGE OF ATTAINMENT OF PEAK BONE MASS IS SITE SPECIFIC IN SWEDISH MEN - THE GOOD STUDY

M. Lorentzon¹, D. Mellström², C. Ohlsson¹

¹Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, ²Department of Geriatric Medicine, University of Gothenburg, Gothenburg, Sweden

P042-Tu PERIOSTEAL APPOSITION RATE WITH AGE IS IDENTICALLY LOW IN BOTH SEXES: CROSS-SECTIONAL MEASUREMENTS OF METACARPAL BONES BY DIGITAL X-RAY RADIOGRAMMETRY

L. Hyldstrup¹, P. Bach-Mortensen¹, T. Jensen¹, S. Sonne-Holm²

¹Osteoporosis Research Unit, Dept. of Endocrinology, ²Dept. of Orthopedic Surgery and Copenhagen City Heart Study, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark

P043-Su YOUNG WOMEN’S BONE MINERAL DENSITY CHANGES AND THEIR LIFESTYLE BEHAVIOURS; A GROUNDED THEORY ANALYSIS

C. Elgán¹, A. Dykes¹, G. Samsioe², B. Fridlund¹

¹Nursing, Nursing, ²Obstetrics and Gyneacology, Obsterics and Gyneacology, Lund, Sweden

P044-Mo THE GENDER DIFFERENCE IN BONE STRENGTH CONTINUES TO INCREASE INTO OLD AGE

G. Sigurdsson¹, G. Sigurdsson², T. Aspelund¹, M. Chang¹, B. Jonsdottir¹, S. Sigurdsson¹, G. Eiriksdottir¹, A. Gudmundsson¹, A. Gudmundsson², T. B. Harris³, V. Gudnason¹, T. F. Lang⁴

¹, Icelandic Heart Association, Kopavogur, ²Landspitali, University Hospital, Reykjavik, Iceland, ³, National Institute on Aging, Bethesda, ⁴, University of California, San Fransisco, United States

P045-Tu HIGH DOSE OF BISPHOSPHONATE ENHANCES THE EFFECT OF PTH ON TRABECULAR BONE IN OVARIECTOMIZED RATS

R. J. Arends¹, . H. N. Chan¹, T. M. C. Van de Klundert¹, H. Van Oudheusden¹, . P. E. J. Langerwerf¹, M. J. A. Van Beuningen - de Vaan¹, A. G. H. Ederveen¹

¹Pharmacology, N.V. Organon, Oss, Netherlands

P046-Su ABSOLUTE MEASUREMENT OF BONE MASS FROM WHOLE BONES OF WOMEN AND MEN, 20 TO 90 YEARS OF AGE

L. Klein¹

¹Dept of Orthopedics, Case Western Reserve University, Ohio, United States

P047-Mo SPINE AND FEMUR BONE MINERAL DENSITY IN HEALTHY TUNISIAN WOMEN

L. Zakraoui¹, A. Laatar¹, S. Kassab¹, R. Nasraoui¹, S. Kerkeni¹, A. Ben Hamida², R. Ben Aissa², B. Zouari³, N. Gueddana²

¹Department of Rheumatology, Mongi Slim Hospital, La Marsa, ²National Office of Family and Population, -, ³Department of Epidemiology, School of Medicine, University of Tunis, Tunis, Tunisia

P048-Tu DUAL FEMUR DENSITOMETRY IN A CZECH POPULATION: EFFECT ON DIAGNOSIS DECISIONS

P. Kasalicky¹, J. Rosa¹

¹Bone Metabolic Unit, DC MEDISCAN, Prague, Czech Republic

P049-Su EXPRESSION OF BMP-3,-7 AND CDMP-1,-2 IN NORMAL AND OSTEOARTHRITIC HUMAN ARTICULAR CARTILAGE

D. Bobinac¹, J. Spanjol¹, S. Zoricic¹, I. Maric¹

¹Department of Anatomy, Medical faculty, University of Rijeka, Rijeka, Croatia

P050-Mo VITAMIN D3 AT THE 1500 IU/DAY DOSE COMPARING DAILY, WEEKLY OR MONTHLY ADMINISTRATION TO ELDERLY

S. Ish-Shalom¹, R. Vieth², T. Salganik³, E. Segal³, B. Raz³, I. Bromberg²

¹Calcium and Bone Metabolism Unit, Rambam Medical Center, Haifa, Israel, ²Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada, ³Metabolic Bone Diseases Unit, Technion Faculty of Medicine, Haifa, Israel

index

Bone Cartilage and Connective Tissue Matrix : Analysis Techniques - P051 - P063

P051-Tu HISTOLOGICAL EXAMINATIONS ON BONE AUGMENTATION BY A COMBINATION OF A BIORESORBABLE PLATE AND BONE FILLING HYDROXYAPATITES

T. Kojima¹, N. Amizuka², A. Suzuki², M. Yoshizawa¹, C. Saito¹, T. Maeda²

¹Division of Reconstructive Surgery for Oral and Maxillofacial Region, ²Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Niigata, Japan

P052-Su QUANTITATIVE FLUORESCENCE ANALYSIS OF BONE DEPOSITION AFTER DOXYCYCLINE ADMINISTRATION DURING ENDODONTIC THERAPY - A PILOT STUDY

D. Snjaric¹, J. Horvat¹, D. Kuis¹, M. Kovacevic¹, T. Tamarut¹, S. Beslic¹, D. Bobinac², N. Jonjic³, G. Djordjevic³

¹Deparment of Dental pathology, School of dentistry, ²Department of anatomy, ³Department of pathology, Medical faculty of Rijeka, Croatia, Rijeka, Croatia

P053-Mo IN VIVO MICRO-CT: OPTIMISING IMAGE QUALITY, SCAN TIME AND RADIATION DOSE: WHAT CAN BE REALISTICALLY AND SAFELY ACHIEVED?

P. L. Salmon¹, A. Y. Sasov¹

¹Application Science, Skyscan NV, Aartselaar, Belgium

P054-Tu A COMPARATIVE STUDY OF ULTRASTRUCTURE OF BONE AND CERAMIC HYDROXYAPATITE BY MEANS OF X-RAY CRYSTAL ANALYSIS

V. I. Luzin¹, E. P. Berezhnoy¹, S. L. Kucherenko¹, V. V. Golovchenko¹

¹Department of normal anatomy, State medical university of Luhansk, Luhansk, Ukraine

P055-Su MANDIBLE AND MAXILLA VOLUMETRIC DENSITOMETRY (VBMD) IN HEALTHY ADULTS ASSESSED BY DENTAL PQCT

R. Capiglioni¹, V. E. Montangero¹, E. J. A. Roldan¹

¹Maxilla Osteology Group -GOM-, Intitute of Neurobiology -IDNEU-, Buenos Aires, Argentina

P056-Mo IDENTIFICATION OF THE ELEMENTAL COMPOSITION OF METAL PARTICLES FROM A FAILED JOINT PROSTHESIS BY LASER ABLATION INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY

A. G. Cox¹, J. Denton², M. Holt³

¹Centre for Analytical Sciences, University of Sheffield, Sheffield, ²Laboratory Medicine Academic Group, University of Manchester, ³Orthopaedic Surgery, Wythenshaw Hospital, Manchester, United Kingdom

P057-Tu NANOSIMS AS AN ANALYTICAL TOOL FOR TRACE METAL DETECTION IN BONE AND LIVER FROM HAEMODIALYSIS PATIENTS

A. G. Cox¹, J. Denton², F. Hillion³, F. Horreard³

¹Centre for Analytical Sciences, University of Sheffield, Sheffield, ²Laboratory Medicine Academic Group, University of Manchester, Manchester, United Kingdom, ³Cameca Instruments, Cameca, Paris, France

P058-Su THE SUITABILITY OF CARTILAGE TURNOVER MARKERS TO ASSESS CHANGES IN CHONDRAL CALLUS TISSUE DURING FRACTURE HEALING

P. Seebeck¹, H. Bail¹, C. Exner¹, H. Schell¹, D. Epari¹, H. Bragulla², G. Duda¹

¹Center for Musculoskeletal Surgery, Charité - University Medicine Berlin, ²Institute for Veterinary Anatomy, Free University Berlin, Berlin, Germany

P059-Mo SIMULTANEOUS DETERMINATION OF DENSITOMETRIC, GEOMETRIC, AND HISTOMORPHOMETRIC PARAMETERS OF FEMORAL NECK FROM PQCT SCANS BY A DEDICATED IMAGE ANALYSIS PROGRAM. IMPLICATIONS FOR THE PREDICTION OF FRACTURE RISK

M. Marenzana¹, F. Colasante¹, U. Di Rauso², G. L. Moro², G. F. Fraschini², A. Rubinacci¹

¹Bone Metabolic Unit, ²Dpt. of Orthopaedics, Scientific Institute H San Raffaele, Milan, Italy

P060-Tu QUANTITATIVE ANALYSIS OF BONE AND CARTILAGE TISSUE STRUCTURES USING BIREFRINGENCE IMAGING SYSTEM

S. Liu¹, Z. Z. Xia², K. K. Pope¹

¹MetriPol, Oxford Cryosystems Ltd, Long Hanborough, ²Botnar Research Centre, Institute of Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

P061-Su PROCESSES USED TO PURIFY HUMAN BONE ALLOGRAFTS ALTER MATRIX SURFACE AND CYTOCOMPATIBILITY

A. Dumas¹, C. Gaudin-Audrain¹, G. Mabilleau¹, P. Massin¹, L. Hubert¹, M. F. Baslé¹, D. Chappard¹

¹INSERM EMI 0335 - LHEA, Faculté de Médecine, Angers, France

P062-Mo RISEDRONATE’S ANTIFRACTURE EFFICACY IS INDEPENDENT OF BASELINE BMD LEVEL

R. Adachi¹, S. Magowan², I. Barton³, D. Felsenberg⁴, R. Lindsay⁵

¹Saint Joseph's Hospital, McMaster University, Hamilton, Canada, ²Medical and Technical Affairs, Procter and Gamble Pharmaceuticals, Mason, United States, ³Medical and Technical Affairs, Procter and Gamble Pharmaceuticals, Egham, United Kingdom, ⁴Department of Radiology, University Hospital Benjamin, Berlin, Germany, ⁵Regional Bone Center, Helen Hayes Hospital, West Haverstraw, United States

P063-Tu HPLC DETERMINATION OF PENTOSIDINE AS A MOLECULAR INDICATOR OF GLYCOXIDATION AND PROTEIN CROSS-LINKING IN DIABETIC PATIENTS

M. Braun¹, M. Adam¹, J. Škrha²

¹Dept. of Bone and Cartilage Metabolism, Institute of Rheumatology, ²Dept. of Endocrinology, 1st Faculty of Medicine, Prague, Czech Republic

index

Bone Cartilage and Connective Tissue Matrix : Calcification - P064 - P076

P064-Su CORONARY ARTERY CALCIFICATION IN DIALYSIS PATIENTS

S. Jeren¹, . B. R. B. Rozman¹, . J. C. J.Crnjakovic-Palmovic¹, . G. J. J. Gudel-Greguric¹, . K. J. K. Juric¹, . Z. B. Z. Borkovic¹

¹Internal Medicine - Hemodialysis, University Hospital, Zagreb , Croatia, Zagreb, Croatia

P065-Mo CLINICAL AND RADIOLOGICAL RESULTS USING PERIOSTEUM-DERIVED OSTEOBLASTS FOR SINUS AUGMENTATION

K. A. n. d. r. e. a. s. Schlegel¹, F. Neukam¹, R. Zimmermann², J. Wiltfang³, J. Park⁴

¹Maxillofacial Surgery Department, ²Department of Transfusion Medicine, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, ³Maxillofacial Surgery Department, Department of Oral and Maxillofacial Surgery of the University of Schleswig-Holstein, Kiel, ⁴Maxillofacial Surgery Department, Department of Oral and Maxillofacial Surgery of the University of Schleswig-Holstein, Erlangen, Germany

P066-Tu ELECTRON MICROSCOPY OF THE EFFECT OF FLUORIDE IONS ON THE APATITE CRYSTAL FORMATION DURING OSTEOGENESIS

M. Kakei¹, T. Sakae², M. Yoshikawa³, N. Tamura⁴, T. Ogawa⁵

¹1st. Dept. of Oral Anatomy, Meikai University School of Dentistry, Sakado, ²Dept. of Anatomy, Nihon Univ. School of Dentistry at Matsudo, Chiba, ³Dept. of Orthodontics, ⁴Dept. of Chemistry, Meikai Univ. School of Dentistry, Sakado, ⁵Dept. Of Dental Hygiene, Saitama Pref. College, Saitama, Japan

P067-Su MINERAL CONTENT AND COMPOSITION OF BONE: SPECIES VARIATION AND THE EFFECTS OF DISEASE

R. M. Aspden¹, L. D. Mkukuma¹, I. R. Gibson², D. W. L. Hukins³, C. T. Imrie⁴, J. M. S. Skakle⁴

¹Orthopaedics, ²Medical Sciences, ³Biomedical Physics, ⁴Chemistry, University of Aberdeen, Aberdeen, United Kingdom

P068-Mo THE NO DONOR SODIUM NITROPRUSSIDE INHIBITS MINERALIZATION IN ATDC5 CELLS

L. F. A. .. Huitema¹, A. B. Vaandrager¹, R. P. Weeren², A. Barneveld², B. J. Helms¹, C. H. A. Lest¹

¹Biochemistry and Celbiology, ²Equine Sciences, Faculty of veterinary sciences, Utrecht University, Utrecht, Netherlands

P069-Tu REMINERALIZATION EFFECTS OF DEMINERALIZED APATITE CRYSTAL IN BOVINE ENAMEL

H. Mishima¹, D. Sugita², Y. Saeki², Y. Miake³, T. Yanagisawa³

¹Health Sciences, Kochi Gakuen College, Kochi, ²Food Material Section, Lotte Co., LTD. Central Laboratory, Sitama, ³Ultrastructural Section, Oral Health Science Center, Tokyo Dental College, Chiba, Japan

P070-Su THE EFFECT OF VITAMIN K2 (MK-4) ON REDUCED “BONE QUALITY” BY MAGNESIUM INSUFFICIENCY

N. Amizuka¹, M. Li¹, M. Kobayashi², S. Akahane³, K. Hara², K. Takeuchi¹, M. Nasu¹, H. Ozawa³, Y. Akiyama², T. Maeda¹

¹Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Niigata, ²Department of Applied Drug Research, Eisai. Co. Ltd., Tokyo, ³Division of Hard Tissue Research, Matsumoto Dental University, Shiojiri, Japan

P071-Mo IDENTIFICATION OF ACTIVE PHOSPHO1 WITHIN MATRIX VESICLES: SUPPORT FOR A ROLE IN HYDROXYAPATITE CRYSTAL FORMATION.

S. J. Roberts¹, D. Harmey², P. J. Sadler³, J. L. Millan², C. Farquharson¹

¹Bone Biology Group, Roslin Institute, Edinburgh, United Kingdom, ²Oncodevelopmental Biology Program, The Burnham Institute, La Jolla, United States, ³School of Chemistry, The University of Edinburgh, Edinburgh, United Kingdom

P072-Tu THE EXPRESSION PATTERN OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN THE PHYSIS

S. Kong¹, S. Kim¹, S. Kim¹, H. Kim¹

¹Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, South Korea

P073-Su ROLE OF PROGRESSIVE ANKYLOSIS GENE (ANK) IN CARTILAGE MINERALIZATION

T. Kirsch¹, J. Xu¹, W. Wang¹

¹Orthopaedics, University of Maryland School of Medicine, Baltimore, United States

P074-Mo HOW MINERALIZATION KINETICS DETERMINE THE BONE MINERAL DENSITY DISTRIBUTION?

D. Ruffoni¹, P. Fratzl¹, P. Roschger², K. Klaushofer², R. Weinkamer¹

¹Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, ²Hanusch Hospital and UKH Meidling, Ludwig-Boltzmann Institute of Osteology and Fourth Medical Department, Vienna, Austria

P075-Tu BONE FORMATION - DOMINANT ROLE OF STRESS CHANGES

M. PETRTYL¹, J. Danesova¹

¹Laboratory of Biomechanics and Biomaterials, Czech Technical University, Faculty of Civil Engineering, Prague 6, Czech Republic

P076-Su FETUIN AND OSTEOCALCIN INFLUENCE CALCOSPHERITE FORMATION IN AN IN VITRO ACELLULAR MODEL OF CALCIFICATION

R. Filmon¹, C. Cincu², M. F. Baslé¹, D. Chappard¹

¹INSERM EMI 0335 - LHEA, Faculté de Médecine, Angers, France, ²Dept. Macromolecular chemistry, University Politehnika, Bucharest, Romania

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Bone Cartilage and Connective Tissue Matrix : Chondrocytes - P077 - P092

P077-Mo PHYSIOLOGICAL DEATH OF HYPERTROPHIC CHONDROCYTES

Y. Ahmed¹, L. Tatarczuch¹, K. Alkhodair¹, C. N. Pagel¹, H. M. S. Davies², M. Mirams¹, E. J. Mackie¹

¹School of Veterinary Science, University of Melbourne, Parkville, ²School of Veterinary Science, University of Melbourne, Werribee, Australia

P078-Tu ESTROGEN RECEPTOR-RELATED RECEPTOR ALPHA, ERRA, INHIBITS THE PROLIFERATIVE TO HYPERTROPHIC CHONDROCYTE TRANSITION IN VITRO AND IS DYSREGULATED IN INFLAMMATORY ARTHRITIS.

E. Bonnelye¹, N. Laurin², P. Jurdic¹, D. Hart³, J. E. Aubin²

¹Laboratoire de Biologie Moleculaire et Cellulaire, CNRS5161 ENS Ecole Normale Superieure de Lyon, Lyon, France, ²Department of Molecular and Medical Genetics, University of Toronto, Toronto, ³Department of surgery, McCaig Center for Joint Injury and Arthritis Research, University of Calgary, Calgary, Canada

P079-Su MELANOCORTIN AND LINEAR GROWTH

J. K. Yeh¹, J. F. Evans¹, Q. T. Niu¹, J. F. Aloia¹

¹Metabolism Laboratory, Winthrop-University Hospital, Mineola, United States

P080-Mo CELLULAR AND MOLECULAR CHARACTERIZATION OF PRIMARY RAT CHONDROCYTES DIFFERENTIATED IN CULTURE.

G. Mailhot¹, A. Gartland², A. Mason-Savas¹, C. A. Mackay¹, P. R. Odgren¹

¹Cell Biology, University of Massachusetts, Worcester, United States, ²Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool, United Kingdom

P081-Tu Cervical Chemonucleolysis Associated to Ventral Slot in Dogs: Clinical-Surgical, Radiological and Histological Evaluation.

A. F. Daibert¹, R. J. Del Carlo², M. I. V. Viloria², B. S. Monteiro², A. C. Tsiomis², L. C. P. Pinheiro², R. R. Filgueiras¹

¹Veterinary Medicine, University of Brasilia - UnB, Brasília, ²Veterinary Medicine, Federal University of Viçosa, Viçosa, Brazil

P082-Su DEVELOPMENT OF A MESENCHYMAL STEM CELL BASED THERAPY FOR REPAIR OF GROWTH PLATE CARTILAGE IN AN OVINE MODEL

R. C. McCarty¹, S. Gronthos², B. K. Foster³, C. J. Xian³

¹Orthopaedic Surgery - Paediatrics - Haematology, Women's and Children's Hospital - University of Adelaide - Institute of Medical and Veterinary Scien, ²Haematology, Institute of Medical and Veterinary Science, ³Orthopaedic Surgery, Women's and Children's Hospital, Adelaide, Australia

P083-Mo BONE MORPHOGENETIC PROTEIN SIGNALING IN CHONDROCYTE PROLIFERATION AND HYPERTROPHY DURING ENDOCHONDRAL BONE FORMATION

T. Iwai¹, M. Horiki¹, J. Murai¹, H. Yoshikawa¹, N. Tsumaki¹

¹Orthopaedics, Osaka University Graduate School of Medicine, Suita, Japan

P084-Tu THE ACCUMULATION OF MUTANT FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) IN THE ENDOPLASMIC RETICULUM OF CHONDROCYTIC CELLS AND THEIR APOPTOSIS

M. Nasu¹, N. Amizuka², M. Li², S. Nomura¹, J. E. Henderson³, T. Maeda²

¹Division of Oral Health in Aging and Fixed Prosthodontics, Department of Oral Health Science, ²Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ³Centre for Bone and Periodontal Research, McGill University, Montreal, Canada

P085-Su CARTILAGE TISSUE FORMATION FROM BONE MARROW DERIVED CELLS USING ROTATING WALL VESSEL (RWV) BIOREACTOR

T. Uemura¹, Y. Ohyabu², N. Kida¹, H. Kojima¹, H. Mishima³, T. Yoshioka³, S. Sakai³, J. Tanaka²

¹Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, ²Biomaterials Center, NIMS, ³Department of Orthopedics, University of Tsukuba, Tsukuba, Ibaraki, Japan

P086-Mo SONIC HEDGEHOG PROMOTES PROLIFERATION AND CHONDROGENIC DIFFERENTIATION OF BONE MARROW-DERIVED MESENCHYMAL STROMAL CELLS IN VITRO

J. J. P. .. Warzecha¹, S. Goettig¹, E. Lucarelli², A. Kurth¹

¹Orthopedics, University Hospital, Frankfurt am Main, Germany, ²Orthopedics, Istituti Rizzoli, Bologna, Italy

P087-Tu ZONES OF EPIPHYSEAL CARTILAGE CLASSIFIED DUE TO CELLULAR MORPHOLOGY AND FUNCTIONAL ACTIVITY STATE

V. G. Koveshnikov¹

¹Department of normal anatomy, State medical university of Luhansk, Luhansk, Ukraine

P088-Su THE PRODUCTION OF PRO-INFLAMMATORY CYTOKINES BY ACTIVATED HUMAN ARTICULAR CHONDROCYTES IS NOT INFLUENCED BY BISPHOSPHONATES.

J. F. Van Offel¹, E. J. Dombrecht¹, C. H. Bridts¹, W. J. Stevens¹, L. S. De Clerck¹

¹Department of Immunology, Allergy and Rheumatology, University of Antwerp, Antwerp, Belgium

P089-Mo ALTERED CELLULAR KINETICS AND EXPRESSION PATTERN OF TYPE X COLLAGEN AND INDIAN HEDGEHOG IN THE PHYSIS OF FEMORAL HEAD OF THE SPONTANEOUSLY HYPERTENSIVE RATS

S. Kong¹, S. Kim², H. Kim³

¹Orthopaedic Surgery, BK21 Graduate school, Yonsei University College of Medicine, ²Orthopaedic Surgery, BK Graduate school, Yonsei University College of Medicine, ³Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, South Korea

P090-Tu ELEVATED EXPRESSION OF HYPOXIA-INDUCIBLE FACTOR-2ALPHA IN TERMINALLY DIFFERENTIATED GROWTH PLATE CHONDROCYTES

A. J. Stewart¹, B. Houston¹, C. Farquharson¹

¹Division of Gene Function and Development, Roslin Institute, Edinburgh, United Kingdom

P091-Su INFLUENCE OF PROTEASE INHIBITORS ON CHONDROGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS

H. Bertram¹, R. Dreier², J. Wachters¹, S. Boehmer¹, W. Richter¹

¹Department of Orthopaedic Surgery, Ruprecht-Karls-University Heidelberg, Heidelberg, ²Institut fuer Physiologische Chemie und Pathobiochemie, University Muenster, Muenster, Germany

P092-Mo HUMAN CHONDROCYTIC LINES PROVIDE A MODEL FOR ACHONDROPLASIA AND THANATOPHORIC DYSPLASIA

L. Legeai-Mallet¹, C. Benoist-Lasselin¹, J. Bonaventure¹, L. Gibbs¹, S. Heuertz¹, A. Munnich¹

¹Unité 393, INSERM, Paris, France

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Bone Cartilage and Connective Tissue Matrix : Gene Identification and Expression - P093 - P098

P093-Tu IDENTIFICATION OF ACID-SENSING ION CHANNELS (ASICS) IN BONE

H. Jahr¹, . M. Van Driel¹, . H. A. Pols¹, . J. A. Verhaar², . H. A. Weinans², . J. P. Van Leeuwen¹

¹Internal Medicine, ²Orthopedics, Erasmus MC, Rotterdam, Netherlands

P094-Su DIFFERENTIAL GENE EXPRESSION OF BONE ANABOLIC FACTORS AND TRABECULAR BONE ARCHITECTURAL CHANGES AT A DISTAL SKELETAL SITE IN PRIMARY HIP OSTEOARTHRITIS

J. S. Kuliwaba¹, J. S. Kuliwaba², J. S. Kuliwaba³, L. Truong¹, L. Truong², L. Truong³, H. Tsangari¹, H. Tsangari², D. M. Findlay⁴, N. L. Fazzalari¹, N. L. Fazzalari², N. L. Fazzalari³

¹Division of Tissue Pathology, Institute of Medical and Veterinary Science, ²Bone and Joint Research Laboratory, Hanson Institute, ³Department of Pathology, ⁴Department of Orthopaedics and Trauma, The University of Adelaide, Adelaide, Australia

P095-Mo HUMAN (FETAL) CARTILAGE - GENE EXPRESSION PROFILES AND SPECIFIC GENE ANALYSIS

C. Stelzer¹, S. Schlaubitz², P. Hermanns², B. Lee², E. Schmidt³, T. Hankeln³, A. Winterpacht⁴, B. Zabel¹

¹Childrens hospital, University of Mainz, Mainz, Germany, ²Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX USA, United States, ³Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, Mainz, ⁴Institut fuer Humangenetik, Friedrich-Alexander Universitaet, Erlangen, Germany

P096-Tu Abstract Withdrawn

P097-Su TRANSCRIPTOME ANALYSIS AND COMPREHENSIVE EXPRESSION PROFILING IN HUMAN TISSUES AND CELLS FOR IDENTIFICATION AND CHARACTERIZATION OF RELEVANT DRUG TARGETS IN BONE METABOLISM.

F. Zolezzi¹, C. Villa¹, P. Guarnieri¹, T. Flak², P. Tarroni¹

¹Target Biology, ²Bioinformatics, Axxam Srl, Milan, Italy

P098-Mo THE PREVALENCE OF OCHRONOSIS IN A ROMANI (GYPSY) POPULATION IN TAMIL NADU, SOUTH INDIA.

I. Jebaraj¹, P. Jebaraj², D. Fleming³

¹Departments of Orthopaedic Surgery, ²Psychiatry, ³Clinical Pharmacology, Christian Medical College, Vellore, India

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Bone Cartilage and Connective Tissue Matrix : General - P099 - P114

P099-Tu OTHER MORE LOGICAL APPROACH TO OSTEOPOROSIS WITH TERIPARATIDE

A. Bazarra-Fernández¹, M. Bazarra-Castro²

¹Obstetrics and Gynecology, Hospital Monforte, La Coruña, ²Medicine, University of Santiago, Santiago, Spain

P100-Su FAT CONTENT AND FATTY ACID PROFILE OF OSTEOARTHRITIC AND OSTEOPOROTIC BONE

R. M. Aspden¹, M. S. Plumb¹

¹Orthopaedics, University of Aberdeen, Aberdeen, United Kingdom

P101-Mo CALCIFIED TISSUES INVOLVED IN TOOTH ANKYLOSIS

P. Carvalho-Lobato¹, M. Manzanares-Céspedes¹, J. Franch-Serracanta², C. Pilipili³, A. Belmonte-Calderón¹, M. Lafuente-Baigorri², I. Serra-Renom¹

¹Human Anatomy and Embryology-Bellvitge, University of Barcelona, L'Hospitalet, ²Veterinary Surgery, Faculty of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Spain, ³École de Médécine dentaire et de Stomatologie, Catholic University of Louvain, Brussels, Belgium

P102-Tu THE UNIQUE GROWTH PROCESS OF THE ULTRATHIN MINERALITES IN BONE-APATITE

S. Sarig¹

¹Chemistry Dept., Hebrew University of Jerusalem, Hod Hasharon, Israel

P103-Su IMMUNOHISTOCHEMICAL LOCALIZATION OF PERLECAN AND HEPARANASE IN HERTWIG’S EPITHELIAL ROOT SHEATH DURING ROOT FORMATION IN MOUSE MOLAR.

A. Hirata¹, H. Nakamura², T. Yamamoto¹

¹Department of Oral Morphology, Okayama University Graduate School of Medicine and Dentistry, Okayama, ²Department of Oral Histology, Matsumoto Dental University, Shiojiri, Japan

P104-Mo BONE DENSITOMETRY IN MODERATE AND SEVERE ASTHMATIC PATIENTS IN KHUZESTAN PROVINCE-IRAN

E. Eidani¹, K. Mowla¹

¹Pulmonary, Ahwaz university of medical sciences, Ahwaz, Iran (Islamic Republic of)

P105-Tu IMPLANTATION OF OCTACALCIUM PHOSPHATE (OCP) STIMULATE BOTH CHONDROGENESIS AND OSTEOGENESIS IN THE TIBIA, BUT ONLY OSTEOGENESIS IN THE MANDIBULAR BONE OF RATS

F. Sargolzaei Aval¹, M. Arab¹, S. Sarani¹

¹Anatomy, Zahedan university of medical Sciences, Zahedan, Iran (Islamic Republic of)

P106-Su STUDY ON BONE MINERAL DENSITY (BMD) AMONG THE MALE BEHCET,S DISEASE(BD)PATIENTS IN KHUZESTAN PROVINCE-IRAN

K. Mowla¹, E. Hajian¹, J. Hashemi¹, M. Sahrae¹

¹Rheumatology, Ahwaz university of medical sciences, Ahwaz, Iran (Islamic Republic of)

P107-Mo ENVIRONMENTAL EFFECTS ON THE BONE TISSUE

Z. Valkusz¹

¹Department of Endocrinology, University of Szeged, Faculty of Medicine, Szeged, Hungary

P108-Tu BEHAVIOUR OF OSTEOSARCOMA AND PRIMARY OSTEOBLASTIC CELLS ON FITC-LABELLED FIBRILLAR AND MONOMERIC COLLAGEN LAYERS

V. M. Muhonen¹, M. Sassi-Puitti¹, R. Heikkinen², P. Lehenkari³, J. Tuukkanen¹

¹Department of Anatomy and Cell Biology, ²Department of Medical Technology, ³Department of Surgery, University of Oulu, Oulu, Finland

P109-Su ENHANCED BONE FORMATION IN HYALURONAN-BASED SCAFFOLD (HYALOGRAFT 3D®) WITH BONE MARROW-DERIVED STEM CELLS

S. Hwang¹, I. I. S. Kim¹, T. T. H. Cho¹, Y. Y. L. Zhang¹, J. J. H. Lee¹

¹Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University, Seoul, South Korea

P110-Mo EFFECTS OF CONTINUOS BRAIN INFUSION ON BONE METABOLISM IN RATS.

F. Guidobono¹, V. Sibilia¹, C. Netti¹, N. Lattuada¹, D. Rapetti¹, E. Mrak², U. Mezzadri², I. Villa², A. Rubinacci², F. Pagani¹

¹Dept. of Pharmacology,Chemotherapy and Medical Toxicology, University of Milan, ²Bone Metabolic Unit, Scientific Institute San Raffaele Hospital, Milan, Italy

P111-Tu NEUROTRANSMITTER, SEROTONIN, AFFECTS CORTICAL BONE ARCHITECTURE IN RAT FEMUR

I. Westbroek¹, B. I. Gustafsson², E. Waarsing³, H. Waldum², H. Weinans³, J. P. T. van Leeuwen⁴, U. Syversen²

¹Department of Internal Medicine and Orthopaedics, Erasmus Medical Centre, Rotterdam, Netherlands, ²Institute for Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway, ³Department of Orthopaedics, ⁴Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, Netherlands

P112-Su PHYSICOCHEMICAL CHARACTERIZATION AND HISTOLOGIC ANALYSIS OF DIFFERENTS XENOGRAFTS IN THE REPAIR OF CRITICAL SIZE DEFECT IN CALVARIA OF RATS

K. B. S. Paiva¹, T. Accorsi-Mendonça², J. M. Granjeiro³, R. Taga⁴, C. M. Bramante²

¹Biochemistry, Biology Institute, State University of Campinas, Campinas, ²Endodontics, Bauru Dental School, University of Sao Paulo, Bauru, ³Molecular and Cellular Biology, Fluminense Federal University, Rio de Janeiro, ⁴Biological Sciences, Bauru Dental School, University of Sao Paulo, Bauru, Brazil

P113-Mo AN ADSORPTION MODEL EXPLAINS THE DIFFERENCES IN HYDROXYAPATITE BINDING AFFINITIES OF IMPORTANT BISPHOSPHONATES IN CLINICAL USE

F. H. Ebetino¹, G. H. Nicollas², Z. Hennerman², P. Emmerling², R. J. Phipps¹, B. L. Barnett³

¹New Drug Development, Procter and Gamble Pharmaceuticals, Mason, ²Chemistry Department, University at Buffalo, SUNY, Buffalo, ³Department of Chemistry, University of Cincinnati, Cincinnati, United States

P114-Tu BIOTOLERATION OF CYCLOOLEFIN COPOLYMER AND ITS BLENDS IN VIVO

H. Hulejová¹, M. Adam¹, V. Barešová¹, Š. Ruzicková², Z. Bastl³, Z. Kruliš⁴, Z. Horák⁴, M. Petrtýl⁵

¹Dept. of Bone and Cartilage Metabolism, ²Dept. of Molecular Biology and Immunogenetics, Institute of Rheumatology, ³, Institute of Physical Chemistry, Academy of Sciences, ⁴, Institute of Macromolecular Chemistry, Academy of Sciences, ⁵, Czech Technical University, Faculty of Civil Engineering, Prague, Czech Republic

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Bone Cartilage and Connective Tissue Matrix : Matrix Proteins - P115 - P121

P115-Su PERIODONTAL TISSUE REGENERATION BY THE APPLICATION OF PHOSPHOPHORYN/COLLAGEN COMPOSITE

T. FUJII¹, Y. TERADA¹, F. KOBAYASHI², T. KOIKE², T. SAITO², T. UEMURA³

¹Institute of Medical Science, ²Dept. of Operative Dentistry, Health Sciences University of Hokkaido, Sapporo, ³Age Dimension Team, National Institute of Advanced Industrial Science and technology, Tokyo, Japan

P116-Mo COLLAGEN REGULATES GROWTH AND DIFFERENTIATION OF HUMAN OSTEOBLASTS

R. HATA¹, Y. Maehata¹, S. Takamizawa¹, Y. Kato¹

¹Dept. Biochem. Mol. Biol., Kanagawa Dent. Coll.,, Yokosuka, Japan

P117-Tu THE EXTRACELLULAR MATRIX 1 GENE IS ESSENTIAL FOR EARLY MOUSE DEVELOPMENT

S. Sercu¹, J. Liekens¹, L. Umans², T. Van De Putte², L. Beek², D. Huylebroeck², J. Merregaert¹, A. Zwijsen²

¹Molecular Biotechnology, University of Antwerp, Wilrijk, ²Developm. Biol, VIB and Lab. Mol. Biol., KU Leuven, Leuven, Belgium

P118-Su REAL TIME QUANTITATION OF SYNDECAN 1-4 EXPRESSION IN A NON-CRITICAL RAT TIBIAL DEFECT MODEL

S. Song¹, D. Hutmacher², V. Nurcombe¹, S. M. Cool¹

¹Stem Cell and Tissue Repair, Institute of Molecular and Cell Biology, ²Division of Bioengineering, National University of Singapore, Singapore, Singapore

P119-Mo CHANGES IN THE COLLAGENOUS MATRIX OF THE BONES FROM TARTRATE-RESISTANT ACID PHOSPHATASE KNOCKOUT MICE

H. C. Roberts¹, L. Knott¹, N. C. Avery¹, T. M. Cox², M. J. Evans³, A. R. Hayman¹

¹Department of Clinical Veterinary Science, University of Bristol, Bristol, ²Department of Medicine, University of Cambridge, Cambridge, ³School of Biosciences, Cardiff University, Cardiff, United Kingdom

P120-Tu CONSERVED FEATURES OF MATRIX AND BONE GAMMA-CARBOXYGLUTAMIC ACID PROTEINS IN VERTEBRATES - AN EVOLUTIONARY POINT OF VIEW

V. Laizé¹, P. Martel², C. S. B. Viegas¹, M. Cancela¹

¹CCMAR - Centre for Marine Sciences, ²CMBE - Centre for Molecular and Structural Biomedicine, University of Algarve, Faro, Portugal

P121-Su OSTEOCALCIN AND MATRIX GLA PROTEIN IN DEVELOPING TELEOST TEETH. IDENTIFICATION OF SITES OF EXPRESSION AND PROTEIN ACCUMULATION

D. C. Simes¹, J. B. Ortiz-Delgado², P. Gavaia¹, C. Sarasquete², L. Cancela¹

¹CCMAR, FCMA-Universidade do Algarve, Faro, Portugal, ²Superior Council for Scientific Investigation, Andalusia Institute of Marine Sciences., Cádiz, Spain

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Bone Cartilage and Connective Tissue Matrix : Mechanical Stress - P122 - P133

P122-Mo ANABOLIC EFFECTS OF PHYSIOLOGICAL STRAIN REGIMEN IN A NEW CANCELLOUS BONE EXPLANT TISSUE CULTURE-LOADING SYSTEM.

V. David¹, A. Guignandon¹, N. Laroche¹, D. Jones², E. L. Smith³, L. Vico¹

¹Inserm E0366, LBTO, Faculté de Médecine, St-Etienne, France, ²Experimental Orthopaedics and Biomechanics, Philipps University, Marburg, Germany, ³Preventive Medicine, Wisconsin University, Madison, United States

P123-Tu OSTEON SWELLING INDUCED BY LOADING

Z. Bechor¹, E. J. Mackie², H. M. S. Davies¹

¹Veterinary Science, The University of Melbourne, Weribbee, ²Veterinary Science, The University of Melbourne, Parkville, Australia

P124-Su TRABECULAR BONE OF PROXIMAL HUMAN FEMUR: DEPENDENCE OF MECHANICAL COMPRESSIVE STRENGTH ON LOCAL VARIATIONS IN BONE MORPHOMETRY

E. Perilli¹, F. Baruffaldi¹, M. Baleani¹, R. Fognani¹, M. Visentin¹, S. Stea¹, F. Traina¹

¹Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy

P125-Mo INTEGRIN SIGNALING IS A MAJOR PATHWAY FOR INTRACELLULAR RESPONSE TO LOW-INTENSITY PULSED ULTRASOUND

M. E. Bolander¹, J. F. Greenleaf², J. T. Bronk¹, R. R. Kinnick²

¹Orthopedic Surgery, ²Physiology, Mayo Clinic, Rochester, United States

P126-Tu GENERATION OF MICROMOTION IN SOFT TISSUE ADJACENT TO FRACTURED BONE BY PULSED ULTRASOUND-GENERATED PRESSURE WAVES

M. E. Bolander¹, J. F. Greenleaf², J. T. Bronk¹, R. R. Kinnick²

¹Orthopedic Surgery, ²Physiology, Mayo Clinic, Rochester, United States

P127-Su EXPRESSION OF A NOVEL ALTERNATIVELY SPLICED UCP2 MRNA IN OSTEOSARCOMA

M. E. Bolander¹, G. Sarkar¹, A. Srivastava¹, C. Rock¹, B. Fuchs¹

¹Orthopedic Surgery, Mayo Clinic, Rochester, United States

P128-Mo PEAK STRAINS IN EQUINE LOCOMOTION

H. M. S. Davies¹

¹Veterinary Science, The University of Melbourne, Weribbee, Australia

P129-Tu FIBROBLAST GROWTH FACTOR RECEPTOR-3 IS UP-REGULATED BY THE INHIBITION OF ERK1/2 PHOSPHORYLATION IN MECHANICALLY STIMULATED OSTEOBLASTS.

R. A. Jackson¹, S. Cool², A. Kumarasuriyar¹, V. Nurcombe²

¹School of Biomedical Sciences, University of Queensland, Brisbane, Australia, ²Stem Cell and Tissue Repair Lab, IMCB, Singapore, Singapore

P130-Su ALTERED CELLULAR KINETICS AND THE EXPRESSION OF HEAT SHOCK PROTEIN IN THE GROWTH PLATE OF UNLOADED RATS

S. Kong¹, J. Park², S. Kim¹, H. Kim²

¹Orthopaedic Surgery, BK21 Graduate school, ²Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, South Korea

P131-Mo FEMORAL BONE TISSUE STRAINS DURING A FALL TO THE SIDE

R. Huiskes¹, B. Van Rietbergen¹, E. Verhulp¹

¹Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

P132-Tu SIMULATION OF TRABECULAR BONE REMODELING AND ITS REGULATION BY MECHANICAL AND BIOLOGICAL FACTORS

R. Weinkamer¹, M. A. Hartmann¹, Y. Brechet², P. Fratzl¹

¹Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, ²LTPCM, ENSEEG, St. Martin d´Heres, France

P133-Su MINERALIZATION VECTOR QUANTIFIES DIFFERENCES IN FRACTURE CALLUS DUE TO LOADING

S. L. Di Jorio¹, M. C. H. van der Meulen², J. H. Kinney³, J. T. Ryaby⁴

¹Harrington Department of Bioengineering, Arizona State University, Tempe, AZ, ²Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, ³Mechanical Engineering, Lawrence Livermore National Laboratory, Livermore, CA, ⁴Research and Development, OrthoLogic Corp., Tempe, AZ, United States

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Bone Cartilage and Connective Tissue Matrix : Proteinases - P134 - P136

P134-Mo CATHEPSIN K DEFICIENT OSTEOCLASTS OF LONG BONE USE MMPS TO RESORB BONE

V. Everts¹, K. A. Hoeben², P. Saftig³, W. Beertsen⁴

¹Dept. Oral Cell Biology, Academic Centre of Dentistry Amsterdam, ²Dept. Cell Biology, Academic Medical Centre, Amsterdam, Netherlands, ³Dept. Biochemistry, University of Kiel, Kiel, Germany, ⁴Dept. Periodontology, Academic Centre of Denistry Amsterdam, Amsterdam, Netherlands

P135-Tu SERUM CATHEPSIN K MEASUREMENTS: REPEATABILITY, INTRA-SUBJECT AND POSTPRANDIAL VARIABILITY

U. Meinhardt¹, C. Meier², J. R. Greenfield³, T. V. Nguyen⁴, J. De Winter², M. J. Seibel²

¹Pituitary Research Unit, Garvan Institute of Medical Research, ²Bone Research Program, ANZAC Research Institute, ³Diabetes and Obesity Program, ⁴Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia

P136-Su PROTEASES CONTROL CHONDROCYTE LATE DIFFERENTIATION AND APOPTOSIS DURING ENDOCHONDRAL OSSIFICATION AND DEGENERATIVE JOINT DISEASES

R. Dreier¹, T. Mainz¹, A. V. Babarina¹, P. Bruckner¹

¹Physiological Chemistry and Pathobiochemistry, Münster University Hospital, Münster, Germany

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Bone Morphogenetic Proteins - P137 - P146

P137-Mo COLLAGEN FIBRIL DIAMETER AT DIFFERENT CORTICAL BONE SITES

M. Tzaphlidou¹, P. Berillis¹

¹Medical Physics, Medical School, Ioannina University, Ioannina, Greece

P138-Tu COLLAGEN BONE AND SKIN STRUCTURE IN HEALTH AND DISEASE. IMAGE PROCESSING AND QUANTITATIVE ULTRASTRUCTURAL STUDIES

M. Tzaphlidou¹

¹Medical Physics, Medical School, Ioannina University, Ioannina, Greece

P139-Su BONE MARROW PERCUTANEUS AUTOGRAFT IN SEGMENTARY DEFECT PRODUCED IN RABBIT RADII.

S. V. S. G. Barros¹, R. Junqueira Del Carlo¹, R. R. Filgueiras², M. I. V. Viloria¹, S. R. Galvão¹, B. S. Monteiro¹

¹Veterinary Medicine, Federal University of Viçosa, Viçosa, ²Veterinary Medicine, University of Brasilia - UnB, Brasilia, Brazil

P140-Mo TYPE OF BONE FORMATION INDUCED BY BMP IN DISTRACTION OSTEOGENESIS: INTRAMEMBRANOUS, ENDOCHONDRAL OR BOTH?

R. Hamdy¹, D. Lauzier¹, F. Rauch¹, M. Mandu¹, T. Haque¹, S. Nakada¹

¹Othopaedics, McGill University, Montreal, Canada

P141-Tu DEMINERALIZED HOMOLOGOUS BONE MATRIX ASSOCIATED WITH AUTOGENOUS BONE MARROW IN THE REPAIR OF RADIAL SEGMENTAL BONE DEFECTS IN RABBITS.

R. R. Filgueiras¹, A. M. Silva², R. J. Del Carlo², S. R. Galvão², D. Rizzo²

¹Veterinary Medicine, University of Brasilia - UnB, Brasilia, ²Veterinary Medicine, University of Viçosa, Viçosa, Brazil

P142-Su EXPRESSION OF BONE MORPHOGENETIC PROTEINS IN HUMAN METASTATIC PROSTATE AND BREAST CANCER

D. Bobinac¹, I. Maric¹, S. Zoricic¹, J. Spanjol², G. Djordjevic³, E. Mustac³, Z. Fuckar²

¹Department of Anatomy, Rijeka University School of Medicine, ²Department of Surgery, Rijeka University Hospital, ³Department of Pathology, Rijeka University School of Medicine, Rijeka, Croatia

P143-Mo PRO-OSTEOGENIC EFFECTS OF FOLLISTATIN ON BONE MORPHOGENETIC PROTEINS IN MESENCHYMAL PROGENITOR CELLS

G. E. Dootson¹, A. J. Scully², P. Genever¹, A. J. Harrison³

¹Biomedical Tissue Research, Department of Biology, University of York, ²Orthopaedics, ³Clinical Therapies, Smith and Nephew Research Centre, York, United Kingdom

P144-Tu BMP-2 AND BMP-7 GENE TRANSFER USING IN VIVO ELECTROPORATION INDUCES RAPID BONE FORMATION ACCOMPANIED BY BMP-4 EXPRESSION

M. Kawai¹, T. Yamamoto¹

¹Oral Morphology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan

P145-Su HOMOLOGOUS DEMINERALIZED BONE MATRIX ASSOCIATED OR NOT TO AUTOLOGOUS BONE MARROW IN A RABBIT LUMBAR SPINAL FUSION.

D. Rizzo¹, R. J. Del Carlo¹, A. S. A. Silva¹, B. S. Monteiro¹, P. S. A. Silva¹, R. R. Filgueiras²

¹Veterinary Medicine, Federal University of Viçosa, Viçosa, ²Veterinary Medicine, University of Brasilia - UnB, Brasilia, Brazil

P146-Mo MANIPULATION OF THE ANABOLIC AND CATABOLIC RESPONSES IN A CRITICAL DEFECT MODEL WITH OP-1 AND ZOLEDRONIC ACID

D. D. Little¹, R. Bransford², M. M. McDonald¹, C. Godfrey¹, N. Amanat¹

¹Orthopaedic Research and Biotechnology, The Children's Hospital at Westmead, Westmead, Australia, ²Department of Orthopaedics, University of Washington, Seattle, United States

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Calcitonin and CGRP - P147 - P149

P147-Tu SENSORY NEUROPEPTIDE INHIBITES ADRENERGIC STIMULATION OF OSTEOCLASTOGENESIS IN MOUSE BONE MARROW CELLS

A. Togari¹, K. Hirukawa¹, A. Kondo¹, M. Arai¹, K. Ishizuka², H. Nakamura²

¹Department of Pharmacology, ²Department of Endodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan

P148-Su A POSSIBLE PREFERENTIAL EFFECT OF SALMON CALCITONIN - NASAL SPRAY (CT-NS) ON REDUCTION OF LUMBAR SPINE COMPRESSION FRACTURES IN ELDERLY OSTEOPOROTIC WOMEN: RESULTS FROM THE PROOF STUDY

S. L. Silverman¹, M. Olson², L. Mindeholm², M. Azria³, C. Chesnut⁴

¹Medicine and Rheumatology, Cedars-Sinai UCLA, Beverly Hills, United States, ²CD and MA, ³EDD, Novartis Pharma, Basel, Switzerland, ⁴Radiology and Medicine, University of Washington, Seattle, Washington, United States

P149-Mo DIMINISHED OSTEOCLAST RESPONSE TO CALCIUM STIMULUS IN POSTMENOPAUSAL OSTEOPOROTIC WOMEN

V. Zikan¹, J. J. Stepan¹, Z. Limanova¹, J. Jiskra¹

¹Department of Internal Medicine 3, Charles University, Faculty of Medicine 1, Prague 2, Czech Republic

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Calcium-Sensing Receptors - P150 - P152

P150-Tu NOVEL MUTATIONS OF THE CALCIUM-SENSING RECEPTOR IN PATIENTS WITH FAMILIAL HYPOCALCIURIC HYPERCALCEMIA AND AUTOSOMAL DOMINANT HYPOCALCEMIA

C. Haag¹, E. Schulze¹, A. Lorenz¹, K. Frank-Raue¹, F. Raue¹

¹Endocrine Practice, Laboratory for molecular genetic analysis, Heidelberg, Germany

P151-Su EXPERIMENTAL HYPERCALCEMIA IN HORSES INDUCES HYPOMAGNESEMIA, HYPOKALEMIA, AND HYPERPHOSPHATEMIA WITH INCREASED URINARY EXCRETION OF ELECTROLYTES

R. E. Toribio¹, C. W. Kohn², K. M. Rourke², A. L. Levine¹, T. J. Rosol¹

¹Department of Veterinary Biosciences, ²Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, United States

P152-Mo CINACALCET AND HYPOCALCIURIC HYPERCALCEMIA (HH)

P. Filipponi¹, G. Pioda², A. Nicasi³, S. Cristallini⁴

¹ASL1 dell'Umbria, Centrol per Osteoporosi e per le Malattie Metaboliche dello Scheletro, Umbertide, ², Servizio Medico Polizia di Stato, ³ASL1 dell'Umbria, Laboratorio Analisi, ⁴ASL1 dell'Umbria, Centrol per Osteoporosi e per le Malattie Metaboliche dello Scheletro, Italy

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Cancer: Cancer and bone - P153 - P180

P153-Tu THE ROLE OF THE CHEMICAL SHIFT MAGNETIC RESONANCE IMAGING IN THE INVESTIGATION OF THE BONE MARROW AFFECTED BY MONOCLONAL GAMMOPATHIES.

P. Rajnics¹, M. Egyed¹, G. Bajzik²

¹Hematology, Kaposi Mor Hospital, ²Diagnostic imaging, University of Kaposvar, Kaposvar, Hungary

P154-Su ZOLEDRONIC ACID SUPPRESSES LUNG METASTASES AND EXTENDS OVERALL SURVIVAL OF OSTEOSARCOMA-BEARING MICE

B. Ory¹, M. Heymann², F. Blanchard¹, A. Kamijo³, F. Gouin¹, D. Heymann¹, F. Rédini¹

¹EA 3822-ERI 7 INSERM, Physiopathologie de la Résorption Osseuse, Faculté de Médecine, Nantes cedex 1, ²Département de Pathologie, Hôpital Nord Laennec, St Herblain 44800, France, ³Department of Orthopaedic Surgery, Yokohama City University, School of medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan

P155-Mo OSTEOCLASTIC MIGRATION AND MATRIX-DEGRADATION IN OSTEOLYTIC METASTASIS.

M. Li¹, N. Amizuka¹, K. Oda², Y. Kawano¹, K. Takeuchi¹, T. Maeda¹

¹Division of Oral Anatomy, Department of Oral Biological Science, ²Division of Biochemistry, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

P156-Tu THE INTRAOSTEAL TUMOURS AND THE MATERIAL “LITAR”

S. D. Litvinov¹, G. G. Nettov², R. F. Khabibullin²

¹General and Inorganic Chemistry, Samara State Technical University, Samara, ²Traumatology, The Scientific and Research Traumatology Centre “Reconstructive Traumatology and Orthopedics”, Kazan, Russian Federation

P157-Su EVALUATION OF THE TARTRATE-RESISTANT ACID PHOSPHATASE 5B AS SERUM MARKER OF BONE RESORPTION IN RADIOTHERAPY OF BREAST CANCER PATIENTS WITH BONE METASTASES

S. Mose¹, C. Menzel², A. A. Kurth³, K. Obert⁴, U. Ramm⁴, H. D. Böttcher⁴, U. Pichlmeier⁵

¹Dept. of Radiotherapy and Radiooncology, Schwarzwald-Baar Klinikum, Villingen-Schwenningen, ²Dept. of Nuclear Medicine, Johann Wolfgang Goethe University Hospital, ³Dept. of Orthopedic Surgery, Stiftung Friedrichsheim, Johann Wolfgang Goethe University Hospital, ⁴Dept. of Radiotherapy and Radiooncology, Johann Wolfgang Goethe University Hospital, Frankfurt-Main, ⁵Dept. of Medical Biometry and Epidemiology, University, Hamburg, Germany

P159-Tu ZOLEDRONIC ACID INHIBITS OSTEOSARCOMA CELL PROLIFERATION VIA CELL CYCLE ARREST AND INHIBITION OF FOCAL ADHESION KINASE PHOSPHORYLATION

B. Ory¹, F. Blanchard¹, F. Gouin¹, F. Rédini¹, D. Heymann¹

¹EA 3822-ERI 7 INSERM, Physiopathologie de la Résorption Osseuse, Faculté de Médecine, 44035 Nantes cedex 1, France

P160-Su POTENTIAL CAPABILITY OF ADOPTIVE TUMOR-INFILTRATING LYMPHOCYTES THERAPY IN PATIENTS WITH OSTEOSARCOMA: PRELIMINARY REPORT.

K. Mori¹, B. Cherrier², S. Theoleyre², F. Gouin², F. Redini², D. Heymann²

¹Universite de Nantes EA 3822, INSERM ERI 7, Physiopathologie de la Resorption Osseuse, Faculte de Medecine, Nantes cedex 1, France, ²Universite de Nantes EA 3822, INSERM ERI 7, Physiopathologie de la Resorption Osseuse, Faculte de Medecine, Nantes cedex 1,

P161-Mo SART3 EXPRESSION IN CAUCASIAN PATIENTS WITH MUSCULOSKELETAL TUMOR.

K. Mori¹, F. Gouin¹, F. Redini¹, D. Heymann¹

¹Universite de Nantes EA 3822, INSERM ERI 7, Physiopathologie de la Resorption Osseuse, Faculte de Medecine, Nantes cedex 1, France

P162-Tu OSTEOPOROSIS AND RATE OF BONE LOSS AMONG POSTMENOPAUSAL SURVIVORS OF BREAST CANCER --- RESULTS FROM A SUBGROUP IN THE WOMEN’S HEALTH INITIATIVE OBSERVATIONAL STUDY

Z. Chen¹, M. Maricic², T. L. Bassford², M. Pettinger³, C. Ritenbaugh², A. Lopez², D. H. Barad⁴, M. Gass⁵, M. S. LeBoff⁶

¹Epidemiology and Biostatistics, ²College of Medicine, University of Arizona, Tucson, ³Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, ⁴WHI Clinic Center, Albert Einstein College of Medicine, Bronx, ⁵WHI Clinic Center, University of Cincinnati, Cincinnati, ⁶Bringham and Women's Hospital, Harvard Medical School, Boston, United States

P163-Su NEPHROTOXIC DIFFERENCES OF BISPHOSPHONATES FOR METASTATIC BONE DISEASE

T. Pfister¹, F. Bauss², J. Body³

¹Pre-clinical Research and Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland, ²Roche Diagnostics, GmbH Pharma Research, Penzberg, Germany, ³Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium

P164-Mo RESULTS OF A LARGE MULTINATIONAL, MULTIDISCIPLINARY SURVEY ON THE MANAGEMENT OF BONE METASTASES

J. Body¹, J. Lagrange², J. Laredo³, M. Tubiana-Hulin⁴

¹Internal Medicine, Institut Jules Bordet, Brussels, Belgium, ²Radiotherapy, Hôpital Henri Mondor, Creteil Cx, ³Service Imagerie, Hôpital Lariboisière, Paris Cx 10, ⁴Medicine C, Centre René Huguenin, Saint-Cloud, France

P165-Tu HYPERCALCEMIA IN CANCER PATIENTS: A REVIEW OF MORE THAN 1000 PATIENTS

M. Soyfoo¹, G. Vogt², J. J. Body¹

¹Internal Medicine, ²Data Centre, Institut Jules Bordet, Brussels, Belgium

P166-Su SAFETY OF INTRAVENOUS (I.V.) AND ORAL IBANDRONATE FOR UP TO 4 YEARS IN PATIENTS WITH BREAST CANCER AND BONE METASTASES

D. Tripathy¹, J. Body², B. Bergström³

¹Komen Center for Breast Cancer Research, University of Texas Southwestern Medical Center, Dallas, United States, ²Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium, ³Clinical Science, Hoffmann-La Roche Inc., Nutley, United States

P167-Mo IMPROVING THE MANAGEMENT OF METASTATIC BONE PAIN: PHASE III TRIALS OF IBANDRONATE IN PATIENTS WITH BREAST CANCER AND BONE METASTASES

J. Body¹, B. Bergström²

¹Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium, ²Clinical Science, Hoffmann-La Roche Inc., Nutley, United States

P168-Tu INTRAVENOUS (I.V.) AND ORAL IBANDRONATE REDUCE THE RISK OF SKELETAL-RELATED EVENTS (SRES) IN PATIENTS WITH BREAST CANCER AND BONE METASTASES

D. Tripathy¹, B. Bergström²

¹Komen Center for Breast Cancer Research, University of Texas Southwestern Medical Center, Dallas, ²Clinical Science, Hoffmann-La Roche Inc., Nutley, United States

P169-Su ORAL IBANDRONATE TREATMENT PRECEDED BY A SINGLE RAPID DOSE OF INTRAVENOUS (I.V.) IBANDRONATE RAPIDLY DECREASES SERUM-CTX A MARKER OF BONE RESORPTION IN PATIENTS WITH METASTATIC BONE DISEASE DUE TO MULTIPLE MYELOMA AND BREAST CANCER

B. Bergström¹, M. Lichinitser², N. Andreeva³, M. Budde⁴, P. Garnero⁵, J. Body⁶

¹Clinical Science, Hoffmann-La Roche Inc., Nutley, United States, ²Clinical Science, NN Blokhin Russian Cancer Research, ³Medical Oncology, Semashko Central Clinical Hospital, Moscow, Russian Federation, ⁴Statistics Division, F. Hoffmann La-Roche AG, Basel, Switzerland, ⁵Clinical Science, Synarc, Lyon, France, ⁶Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium

P170-Mo ORAL IBANDRONATE DECREASES MARKERS OF BONE RESORPTION TO THE SAME EXTENT AS INTRAVENOUS (I.V.) ZOLEDRONIC ACID IN PATIENTS WITH BONE METASTASES FROM BREAST CANCER: RESULTS FROM A COMPARATIVE PHASE III TRIAL

J. Body¹, M. Lichinitser², S. Tjulandin², P. Garnero³, B. Bergström⁴

¹Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium, ²Medical Oncology, NN Blokhin Russian Cancer Research, Moscow, Russian Federation, ³Clinical Science, Synarc, Lyon, France, ⁴Clinical Science, Hoffmann-La Roche Inc., Nutley, United States

P171-Tu EVALUATION OF TARTRATE-RESISTANT ACID PHOSPHATASE MEASUREMENTS IN PATIENTS WITH BREAST CANCER

K. Brenner¹, N. Kheddoumi², F. Journe², G. Vogt³, M. Paesmans³, J. Body¹

¹Department of Internal Medicine, ²Laboratory of Endocrinology and Bone Disease, ³Data Center, Institut Jules Bordet, Brussels, Belgium

P172-Su EFFICACY OF IBANDRONATE FOR THE TREATMENT OF SKELETAL EVENTS IN PATIENTS WITH BONE METASTASES SECONDARY TO COLORECTAL CARCINOMA

P. Heras¹, S. Karagiannis², K. Kritikos², A. Hatzopoulos¹, I. Stavrinadis², D. Mitsibounas²

¹Department of Internal Medicine, General Hospital of Nafplio, Nafplio, ²Psychosomatic Problems, Greek Medical Society, Athens, Greece

P173-Mo RENAL SAFETY OF INTRAVENOUS IBANDRONATE IN BREAST CANCER PATIENTS WITH METASTATIC BONE DISEASE

B. Bergstrom¹, N. V. Lyubimova², M. V. Pashkov², N. E. Kushlinsky², M. R. Lichinitser²

¹Clinical Science, Hoffmann-La Roche Inc, Nutley, United States, ²NN Blokhin Cancer Research Centre, RAMS, Moscow, Russian Federation

P174-Tu A COMPARATIVE STUDY OF IBANDRONATE AND PAMIDRONATE IN PATIENTS WITH BONE METASTASES FROM BREAST OR LUNG CANCER

K. Kritikos¹, P. Heras², A. Hatzopoulos², S. Karagiannis¹, D. Mitsibounas¹

¹Psychosomatic Problems, Greek Medical Society, Athens, ²Internal Medicine Clinic, General Hospital of Nafplio, Nafplio, Greece

P175-Su MICROCOMPUTED TOMOGRAPHY AND TEXTURE ANALYSIS OF RADIOGRAPHS IN RAT BONE METASTASES

S. BLOUIN¹, . M. F. MOREAU¹, . M. F. BASLE¹, . D. CHAPPARD¹

¹INSERM EMI0335, Faculte de medecine, Angers, France

P176-Mo LIMITED VALUE OF HYPERBARIC OXYGEN THERAPY IN THE TREATMENT OF MANDIBULAR OSTEORADIONECROSIS; A CASE REPORT

A. Y. D. . E. Alami¹

¹Surgery department, section of head and neck surgery, King Hussein Cancer Center, Amman, Jordan

P177-Tu IMPAIRED PROTEASOMAL CAPACITY AS THE TARGET OF PROTEASOME INHIBITORS IN MULTIPLE MYELOMA

S. Cenci¹, A. Mezghrani¹, P. Cascio², L. Oliva¹, A. Orsi¹, F. Cerruti², S. Masciarelli¹, L. Mattioli³, E. Pasqualetto¹, R. Sitia¹

¹DIBIT, San Raffaele Scientific Institute and Università Vita-Salute San Raffele, Milano, ²Dept. of Morphophysiology, University of Turin, Turin, ³Dept. of Experimental Medicine, University of Genoa, Genoa, Italy

P178-Su INDUCTION OF PARATHYROID HORMONE-RELATED PROTEIN MESSENGER RNA EXPRESSION IN HUMAN LUNG CARCINOMA BONE METASTASES AND EFFECTS OF ZOLEDRONIC ACID

X. Deng¹, S. Tannehill-Gregg¹, M. Nadella¹, G. He¹, A. Levine¹, T. Rosol¹

¹Veterinary Biosciences, The Ohio State University, Columbus, United States

P179-Mo TARTRATE-RESISTANT ACID PHOSPHATASE (TRACP 5B) AS MARKER OF BONE METASTASES IN BREAST CANCER PATIENTS

A. Honig¹, B. Michler¹, H. Caffier¹, J. Dietl¹

¹Department of Obstetrics and Gynecology, University of Wuerzburg, Wuerzburg, Germany

P180-Tu ADHESION REGULON ALTERATIONS AND OSTEOMIMICRY ARE STRIKING FEATURES OF THE MOLECULAR CROSSTALK BETWEEN PROSTATE TUMOR CELLS AND BONE CELLS

K. Ackermann¹, W. Pyerin¹

¹Biochemische Zellphysiologie A135, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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Cancer: Other - P181 - P185

P181-Su IN VITRO AND IN VIVO ASSESSMENT OF ZOLEDRONATE ON RAT CHONDROSARCOMA MODEL

F. GOUIN¹, B. ORY¹, F. BLANCHARD¹, F. REDINI¹, D. HEYMANN¹

¹EA 3822 - INSERM ERI 7, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses, Medicine Faculty, Nantes cedex 1, France

P182-Mo THE INDUCTION OF APOPTOSIS IN HUMAN BREAST CANCER CELLS BY BISPHOSPHONATES.

H. R. Franke¹, F. Wolbers², I. Vermes²

¹Obstetrics and Gynecology, ²Clinical Chemistry, Medisch Spectrum Twente Hospital Group, Enschede, Netherlands

P183-Tu BONE MASS DENSITY IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY

K. F. Vartanian¹, F. F. Krotkov¹, D. I. Levchuk¹

¹Medical Radiology, Russian Academy for Advanced Medical Studies, Moscow, Russian Federation

P184-Su SEQUENTIAL COMBINATION BETWEEN IBANDRONATE AND TAMOXIFEN EXHIBIT SYNERGISTIC EFFECTS ON THE INHIBITION OF BREAST CANCER CELL GROWTH

F. Journé¹, C. Chaboteaux¹, G. Laurent², J. Body¹

¹Laboratory of Endocrinology and Bone Diseases, Institut Jules Bordet, Brussels, ²Laboratory of Histology, Université de Mons-Hainaut, Mons, Belgium

P185-Mo USE OF BISPHOSPHONATE ANALOGS OF RISEDRONATE TO ELUCIDATE ANTIANGIOGENIC MECHANISMS OF BISPHOSPHONATES IN VIVO

F. H. Ebetino¹, P. G. Fournier², V. Castronovo³, P. Clezardin²

¹New Drug Development, Procter and Gamble Pharmaceuticals, Mason, United States, ²INSERM U.403, Laennec School of Medicine, Lyon, ³Tumor Biology Laboratory, University of Liège Sart Tilman, Liège, France

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Cancer: Prostate cancer - P186 - P190

P186-Tu RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B LIGAND, PARATHYROID HORMONE-RELATED PROTEIN AND CELL PROLIFERATION DISCRIMINATE POORLY AND WELL-DIFFERENTIATED PROSTATE CARCINOMA

F. C. Pérez-Martínez¹, J. L. Sarasa², V. Alonso³, J. J. Granizo⁴, F. Manzarbeitia², P. Esbrit³, F. J. Calahorra¹

¹Urology Department, ²Pathology Department, ³Bone and Mineral Metabolism Laboratory, ⁴Epidemiology Unit, Fundación Jiménez Díaz, Madrid, Spain

P187-Su EFFECTS OF SOYBEAN PHYTOESTROGENS ON CELL VIABILITY AND SOME BONE-RELATED CYTOKINES IN HUMAN PROSTATE CANCER CELLS

V. Alonso¹, A. R. De Gortázar¹, F. C. Pérez-Martínez², F. J. Calahorra², P. Esbrit¹

¹Bone and Mineral Metabolism Laboratory, ²Urology Department, Fundación Jiménez Díaz, Madrid, Spain

P188-Mo BIOCHEMICAL MARKERS OF BONE TURNOVER IN PATIENTS WITH LOCALIZED AND METASTASIZED PROSTATE CANCER

A. Hegele¹, . H. G. Wahl², R. Hofmann¹, S. Sevinc¹, . I. Herzum², L. Koliva¹, P. Olbert¹

¹Urology, ²Clinical Chemistry, Medical School, Philipps-University, Marburg, Germany

P189-Tu TISSUE-TYPE SPECIFIC ANTI-CANCER EFFECTS AND VITAMIN K-DEPENDENT GAMMA-GLUTAMYL CARBOXYLASE ACTIVITY OF VITAMIN K COMPOUNDS

K. Nakagawa¹, Y. Mizuguchi¹, A. Murakami¹, T. Okano¹

¹Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan

P190-Su OSTEOPROTEGERIN TREATMENT INHIBITS THE GROWTH OF LYTIC PROSTATE CANCER LESIONS IN BONE.

J. M. Blair¹, L. A. Perryman¹, H. Y. Pwint¹, J. Lelliott¹, J. De Winter², P. J. Russell¹, C. R. Dunstan², M. J. Seibel²

¹Oncology Research Centre, UNSW Department of Clinical Medicine, Prince of Wales Hospital, Randwick, ²Bone Research Program, Anzac Research Institute, University of Sydney at Concord Hospital, Concord, Australia

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Clinical Parathyroid Disease and Hypercalcemia of Malignancy - P191 - P193

P191-Mo INTRAVENOUS ZOLENDRONIC ACID EFFECTIVELY DECREASES SERUM CALCIUM IN PRIMARY HYPERPARATHYROIDISM.

W. Misiorowski¹, L. Papierska¹, S. Zgliczynski¹

¹Endocrinology Clinic, Medical Centre for Postgraduate Education, Warsaw, Poland

P192-Tu DO SERUM MEASUREMENTS OF RANKL AND OPG REFLECT THE INCREASED BONE METABOLISM IN PRIMARY HYPERPARATHYROIDISM?

L. S. Stilgren¹, L. Hegedüs¹, A. R. Madsen¹, B. Abrahamsen¹

¹Dept. of Endocrinology, Odense University Hospital, Odense C, Denmark

P193-Su SISTERS WITH FAMILIAL ISOLATED HYPERPARATHYROIDISM

K. Nakayama¹, A. Sato¹, M. Watanabe¹, K. Inukai¹, K. Takeichi¹, T. Sawa¹, K. Yoshimoto², S. Uchino³, T. Izumida¹, S. Wada⁴, A. Itabashi⁵, S. Katayama¹

¹Department of Endocrinology and Diabetes, Saitama Medical School, Iruma-gun, ²Molecular Pharmacology, Tokushima Universithy, Tokushima, ³Department of Surgery, Noguchi Hospital, Beppu, ⁴Faculty of Pharmacology, Josai International University, Togane, ⁵Department of Labratory Medicine, Saitama Medical School, Iruma-gun, Japan

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Diseases of Bone (Other Than Osteoporosis) : Congenital/Genetic Bone Disease - P194 - P201

P194-Mo GENETIC, CELLULAR AND CLINICAL ANALYSIS OF FOURTY-TWO PATIENTS AFFECTED BY OSTEOPETROSIS

A. Del Fattore¹, B. Peruzzi¹, C. Di Giacinto¹, A. Cappariello¹, D. Fortunati¹, M. Iacobini¹, M. Luciani¹, E. Lanino¹, C. Messina¹, S. Cesaro¹, H. Fryssira¹, C. Letizia¹, G. Bianchini¹, A. Taranta¹, S. Migliaccio¹, A. Teti¹

¹Experimental Medicine, University of L'Aquila, L'Aquila, Italy

P195-Tu RISEDRONATE PHARMACOKINETICS IN CHILDREN WITH OSTEOGENESIS IMPERFECTA

G. A. Thompson¹, D. E. Burgio², D. A. Russell¹, L. A. Sun¹, N. Bishop³

¹Clin Pharmacology and Pharmocokenetics, ²New Drug Development-Bone, Procter and Gamble Pharmaceuticals, Mason, United States, ³Head of Academic Unit of Child Health, University of Sheffield, Sheffield, United Kingdom

P196-Su A LRP5 MISSENSE MUTATION IN AN EXTENDED FAMILY RESULTS IN AUTOSOMAL DOMINANT OSTEOSCLEROSIS IN ASSOCIATION WITH CRANIOSYNOSTOSIS AND MILD DEVELOPMENTAL DELAY

W. Balemans¹, M. Kwee², E. Cleiren¹, J. J. P. Gille², F. Van der Blij³, J. M. Sepers⁴, W. Van Hul¹

¹Dept. Medical Genetics, University of Antwerp, Antwerp, Belgium, ²Dept. Clinical Genetics and Human Genetics, VU University Medical Center, Amsterdam, ³Dept. Pediatrics, ⁴Dept. Internal Medicine, Medical Center Alkmaar, Alkmaar, Netherlands

P197-Mo CHAPERONE-PROCOLLAGEN INTERACTIONS DIFFER WITH MUTATION LOCATION IN OSTEOGENESIS IMPERFECTA

A. Ashok¹, A. M. Barnes¹, J. C. Marini¹

¹BEMB, NICHD, National Institutes of Health, Bethesda, United States

P198-Tu DISRUPTION OF INTRAMEMBRANOUS AND ENDOCHONDRAL BONE DEVELOPMENT IN TR ALPHA 2 NULL MICE

J. H. D. Bassett¹, P. J. O'Shea¹, K. Nordstrom², B. Vennstrom², G. R. Williams¹

¹Molecular Endocrinology Group, Imperial College London, Hammersmith Hospital, London, United Kingdom, ²Department of Molecular Biology, Karolinska Institute, Stockholm, Sweden

P199-Su THE ROSI STUDY (RISEDRONATE IN ADULTS WITH OSTEOGENESIS IMPERFECTA TYPE 1):

E. L. Duncan¹, L. A. Bradbury², S. Barlow³, F. Geoghenan⁴, A. Blumsohn⁵, P. Schofield⁶, J. A. H. Wass¹, R. G. Russell², M. A. Brown⁷

¹Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford Radcliffe Hospital Trust, ²Nuffield Department of Surgery, ³Radiology Department, Nuffield Orthopaedic Centre, ⁴Department of Biochemistry, John Radcliffe Hospital, Oxford, ⁵Bone Metabolism Unit, Northern General Hospital, ⁶Procter and Gamble, Nuffield Orthopaedic Centre, Sheffield, ⁷Botnar Centre, Nuffield Orthopaedic Centre, Oxford, United Kingdom

P200-Mo FAILURE OF A SUCCESSFUL BONE MARROW TRANSPLANT TO RESCUE OSTEOCLAST DEFICIENT AUTOSOMAL RECESSIVE OSTEOPETROSIS

P. S. Grabowski¹, N. J. Shaw², P. J. Darbyshire², D. Hughes³, N. J. Bishop¹

¹Academic Unit of Child Health, University of Sheffield, Sheffield, ², Birmingham Children's Hospital, ³Musculoskeletal Pathology, Royal Orthopaedic Hospital, Birmingham, United Kingdom

P201-Tu ALENDRONATE 70 MG ON PATIENTS AFFECTED WITH THALASSEMIA MAJOR: AN OBSERVATIONAL STUDY

S. T. Bucchieri¹, N. Napoli¹, D. Bruno¹, F. Giordano¹, C. Sferrazza¹, F. De Nicola¹, R. Malizia², M. Capra³, G. Rini¹, G. Di Fede¹

¹Internal Medicine, University of Palermo, ²Hoematology, Villa Sofia Hospital, ³Hoematology, ARNAS Opedale dei Bambini, palermo, Italy

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Diseases of Bone (Other Than Osteoporosis) : Metabolic Bone Disease - P202 - P213

P202-Su BONE PATHOLOGIES IN FREE-FLYING CAPTIVE BATS

C. E. Evans¹, A. Fidgett², S. Sanderson², J. Denton¹

¹Laboratory and Regenerative Medicine, University of Manchester, Manchester, ²Other, Chester Zoo, Chester, United Kingdom

P203-Mo HYPERCALEAMIA: A HOSPITAL-BASED SURVEY

A. I. Al-Bahrani¹, W. D. Fraser¹

¹Clinical Biochemistry, The Royal Liverpool and Broadgreen University Hospital, Liverpool, United Kingdom

P204-Tu ANALYSIS OF BONE TURNOVER IN ANOREXIA NERVOSA PATIENTS

D. Smith¹, B. F. Murray², M. Doyle³, C. Y. Tan¹, K. Malone⁴, M. Darby⁴, D. O'Shea¹, M. J. McKenna¹, T. J. McKenna¹

¹Department of Investigative Endocrinology, ²Department of Bone Metabolism, ³Department of Nutrition, ⁴Department of Psychiatry, St Vincent's University Hospital, Dublin, Ireland

P205-Su TIMING OF RESUMPTION OF BONE REMODELING IN CHILDREN FOLLOWING SEVERE BURNS

G. L. Klein¹, D. J. Sherrard², D. N. Herndon³

¹Pediatrics, University of Texas Medical Branch, Galveston, ²Medicine, VA Medical Center and University of Washington School of Medicine, Seattle, ³Surgery, Shriners Burns Hospital and University of Texas Medical Branch, Galveston, United States

P206-Mo MYCOBACTERIUM TUBERCULOSIS HSP 60.1, BUT NOT HSP 60.2, DIRECTLY INHIBITS OSTEOCLASTIC BONE RESORPTION BY BLOCKING RANKL ACTIVITY

S. Meghji¹, V. R. Winrow², C. J. Morris², J. Mesher¹, A. R. M. Coates³, P. Tormay³, D. R. Blake², B. Henderson¹

¹Eastman Dental Institute, UCL, London, ²School of Health and Rheumatic Diseases, University of Bath, Bath, ³Department of Medical Microbiology, St George's Hospital Medical School, London, United Kingdom

P207-Tu EFFECTS OF THYAMAZOL ON BONE METABOLISM IN HYPERTHYREOTIC PREMENOPAUSAL WOMEN

V. Altabas¹, M. Misjak², N. Vrkic³, M. Berkovic⁴, G. Mirosevic⁴, B. Milanovic⁵

¹Department of Endocrinology, Diabetes and Metabolic Diseases, University Hospital Sestre milosrdnice, ²Department of Endocrinology, Diabetes and Metabolic Diseases, University Hospital "Sestre milosrdnice", ³Department of Medical Biochemistry, ⁴Department of Endocrinology, Diabetes and Metabolic Diseases, University Hospital, ⁵Department of Medical Biochemistry, University Hospital "Sestre milosrdnice", Zagreb, Croatia

P208-Su RISK FACTORS FOR LOW TURNOVER RENAL OSTEODYSTROPHY IN DIALYSIS PATIENTS.

Z. Nowak¹, M. Konieczna², Z. Wankowicz¹

¹Department of Nephrology, ²Center of Nuclear Medicine, Military Institute of Medicine, Warsaw, Poland

P209-Mo COMPARISON TWO ASSAYS FOR FIBROBLAST GRWOTH FACTOR-23

S. Fukumoto¹, N. Ito¹, Y. Takeuchi², Y. Frishberg³, J. Silver⁴, Y. Yamazaki⁵, T. Yamashita⁵, T. Fujita¹

¹Department of Internal Medicine, University of Tokyo Hospital, ²Department of Internal Medicine, Toranomon Hospital, Tokyo, Japan, ³Division of Pediatric Nephrology, Shaare Zedek Medical Center, ⁴Minerva Center for Calcium and Bone Metabolism, Hebrew University Hadassah Medical Center, Jerusalem, Israel, ⁵Pharmaceutical Research Laboratories, Kirin Brewery, Takasaki, Japan

P210-Tu DEVELOPMENT OF BONE REMODELLING BALANCE AND TURNOVER INDICES IN PATIENTS WITH METABOLIC BONE DISEASE

D. Smith¹, B. F. Murray², D. O'Shea¹, M. J. McKenna¹, T. J. McKenna¹

¹Department of Investigative Endocrinology, ²Bone Metabolism Laboratory, St Vincent's University Hospital, Dublin, Ireland

P211-Su ALTERED MRNA EXPRESSION OF MEMBRANE TRANSPORTERS IN THE KIDNEYS OF X-LINKED HYPOPHOSPHATEMIC (HYP) MICE

M. H. Meyer¹, R. A. Meyer¹

¹Orthpaedic Research Laboratory, Carolinas Medical Center, Charlotte, United States

P212-Mo IDENTIFICATION OF METABOLIC BONE DISEASE IN PATIENTS UNDERGOING HEARTH TRANSPLANTATION.

L. Gil-Fraguas¹, E. Jodar², G. Martínez², J. Vara¹, J. Delgado³, M. Gomez³, F. Hawkins²

¹Rehabilitation, ²Endocrinology, ³Cardiology, University Hospital 12 de Octubre, Madrid, Spain

P213-Tu VALPROATE HAS STRAIN-SPECIFIC EFFECTS ON BONE MINERAL CONTENT IN MICE

S. Senn¹, S. Kantor¹, S. Andrikopoulos², T. J. O'Brien¹, M. J. Morris³, J. D. Wark¹

¹Medicine, ²Medicine, Austin and Repatriation Hospitals, ³Pharmacology, The University of Melbourne, Parkville, Australia

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Diseases of Bone (Other Than Osteoporosis) : Osteomalacia - P214

P214-Su 25-VITAMIN D AND PARATHYROID HORMONE LEVELS MEASURED IN PATIENTS FROM PRIMARY AND SECONDARY CARE CLINICS

S. Patel¹, J. Barron², S. Hyer³

¹Department of Medicine and Rheumatology, ²Department of Clinical Chemistry, ³Department of Endocrinology, St Helier Hospital, Carshalton, United Kingdom

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Diseases of Bone (Other Than Osteoporosis) : Other - P215 - P237

P215-Mo EFFECT OF ETANERCEPT ON BONE RESORPTION IN PSORIATIC ARTHRITIS

M. Massarotti¹, A. Celant¹, R. Cossutta¹, B. Marasini¹

¹Rheumatology Unit, Humanitas Clinical Institute, Rozzano, Italy

P216-Tu THE ANALYSIS OF BONE MINERAL DENSITY, OSTEOCALCIN AND BIOCHEMICAL INDEX OF SKELETAL FLUOROSIS'S PATIENT AND TREATMENT BY ADDING SELENIUM IN GUIZHOU PROVINCE, CHINA.

Z. G. Luo¹, X. Q. Gao², H. Y. Dong³, H. Li⁴, W. M. Liang², G. Huang¹, Y. S. Niu¹

¹Department of Bioengineering,Life Science College, Shenzhen University, Shenzhen, ²Department of Histology and Embryology, Guiyang Medical College, Guiyang, ³Department of Cardiology, Peking University Shenzhen Hospital, ⁴Department of Healing, Second Peaple Hospital, Shenzhen, China

P217-Su THE OPG/TRAIL COMPLEX IN AN IN VITRO OSTEOCLASTOGENESIS MODEL DERIVED FROM HUMAN MULTIPLE MYELOMA-BONE DISEASE.

S. Colucci¹, G. Brunetti¹, R. Rizzi², G. Mori¹, G. Colaianni¹, A. Oranger¹, A. Liso³, S. Capalbo², A. Zallone¹, V. Liso², M. Grano¹

¹Human Anatomy and Histology, ²Hematology, University of Bari, Bari, ³Hematology, University of Foggia, Foggia, Italy

P218-Mo T CELLS SUPPORT OSTEOCLASTOGENESIS IN AN IN VITRO MODEL DERIVED FROM HUMAN PSORIATIC ARTHRITIS

M. Grano¹, S. Colucci¹, G. Brunetti¹, A. Oranger¹, G. Mori¹, L. Quarta², A. Corrado², R. Rizzi³, F. P. Cantatore²

¹Human Anatomy and Histology, University of Bari, Bari, ²Clinica Reumatologica "M Carrozzo", University of Foggia, Foggia, ³Hematology, University of Bari, Bari, Italy

P219-Tu HIGHER BONE MINERAL DENSITY IN REPRODUCTIVE AGED, CAUCASIAN, HIRSUTE PATIENTS. POSITIVE CORRELATION OF TESTOSTERONE LEVELS TO BONE MINERAL DENSITY IN HIRSUTISM.

D. Glintborg¹, M. Andersen¹, C. Hagen¹, A. P. Hermann¹

¹Endocrinology, Odense University Hospital, Odense, Denmark

P220-Su BIOLOGICAL AND MECHANICAL CHANGES OF THE BONE-GRAFT-CEMENT INTERFACE AFTER IMPACTION ALLOGRAFTING

H. Frei¹, J. O’Connell², B. A. Masri³, C. P. Duncan³, T. R. Oxland³

¹Biomedical Research Centre, University of British Columbia, Vancouver, ², Surrey Memorial Hospital, Surrey, ³Department of Orthopeadics, University of British Columbia, Vancouver, Canada

P221-Mo EFFECTS OF ELECTROGENE-TRANSFER WITH WNT3A EXPRESSION VECTOR ON FRACTURED MICE.

Y. Negishi¹, C. Soga², H. Sekiya³, M. Yamamoto⁴, T. Yoshimoto⁵, Y. Izumi⁵, K. Seto³, Y. Aramaki¹, M. Tamura⁶, K. Kawashima²

¹School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, ²Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, ³First Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Kanagawa, ⁴Research Center for Life Science Resources, Kagoshima University, ⁵Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, ⁶Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine Hokkaido University, Hokkaido, Japan

P222-Tu IMBALANCED EXPRESSION OF RANKL AND OSTEOPROTEGERIN MRNA IN PANNUS TISSUE OF RHEUMATOID ARTHRITIS

M. Ainola¹, J. Mandelin¹, M. Liljeström¹, S. Santavirta², Y. T. Konttinen³

¹Biomedicine, Anatomy, University of Helsinki, ²Orthopaedic and Traumatology, ³Department of Medicine,Invärtes medicin, Helsinki University Central Hospital, Helsinki, Finland

P223-Su RISK FACTORS FOR FALLS IN TURKISH ELDERLY

Z. Ulger¹, M. Halil², M. Cankurtaran², B. Yavuz², D. Dede¹, N. Özkayar², S. Ariogul²

¹Department of Internal Medicine, ²Department of Internal Medicine, Division of Geriatric Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey

P224-Mo DIAGNOSTIC VALUE OF MICRO-CT FOR THE ASSESSMENT OF RARE HUMAN BONE PATHOLOGIES

F. J. Rühli¹, M. Schultz², R. L. Evison³, R. Müller³

¹Institute of Anatomy, University of Zürich, Zürich, Switzerland, ²Department of Anatomy, Georg-August-University, Göttingen, Germany, ³Institute for Biomedical Engineering, ETH and University of Zürich, Zürich, Switzerland

P225-Tu P1NP, B-CROSSLAPS AND OSTEOCALCIN AS BIOCHEMICAL MARKERS OF BONE TURNOVER IN HAEMODIALYSIS PATIENTS

D. Pavlovic¹, N. Vrkic²

¹Department of Nephrology and Dialysis, University Hospital Sestre milosrdnice, ²Department of Clinical Chemistry, University Hospital "Sestre milosrdnice", Zagreb, Croatia

P226-Su DENTAL PQCT SCANS OF PATIENTS WITH DIFFERENT MECHANICAL AND HORMONAL DISTURBANCES. PRACTICAL EXAMPLES OF A NEW DIAGNOSTIC TOOL

V. E. Montangero¹, L. Maffei², G. Tubert¹, A. Aymond¹, R. Guelman³, E. J. A. Roldan¹

¹ERMES-BO, Maxilla Osteology Group -GOM-, ²Endocrinology, CAE, ³Endocrinology, DyTEMe, Buenos Aires, Argentina

P227-Mo CLINICAL EVALUTION OF COX2 INHIBITORS VS. INDOMETACIN IN THE PREVENTION OF HETEROTOPIC CALCIFICATIONS (HC) AFTER TOTAL HIP-REPLACEMENT

M. H. Brem¹, M. Kerl¹, A. Brenning², K. Gelse¹, F. F. Hennig¹, O. A. Schmid¹

¹Orthopedic Surgery, ²Institut für Medizininformatik, Biometrie und Epidemiologie, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

P228-Tu EFFECT OF LIPOPOLYSACCHARIDE ON MIGRATION OF OSTEOCLAST PRECURSORS

Y. Yoo¹, S. Taeg¹, H. Lee¹

¹Dept of Oral Biology, College of Dentistry, Yonsei University, Seoul, South Korea

P229-Su INCREASED ARTERIAL CALCIFICATIONS IN PAGET'S DISEASE

M. M. Laroche¹, A. A. Delmotte¹

¹Rheumatology, CHU Rangueil, Toulouse, France

P230-Mo BONE CHANGES DEPEND ON BONE DENSITY IN MURINE OSTEOARTHRITIS

S. M. Botter¹, G. J. V. van Osch², J. Day², E. Waarsing², N. Kops², J. A. N. Verhaar², H. A. P. Pols¹, H. Weinans², J. P. T. van Leeuwen¹

¹Dept. of Internal Medicine, ²Dept. of Orthopaedics, Erasmus Medical Centre, Rotterdam, Netherlands

P231-Tu INCREASED BONE FRACTURE RISK IN UNTREATED POSTMENOPAUSAL, POLLEN-ALLERGIC WOMEN

V. Ferencz¹, E. Csupor², E. Toth³, S. Meszaros¹, C. Horvath¹

¹1st Department of Internal Medicine, Semmelweis University Budapest, ²Health Service, Budapest Local Authorities, Budapest, ³Department of Rheumatology, Ferenc Flor Country Hospital, Kerepestarcsa, Hungary

P232-Su BONE-SPECIFIC ALKALINE PHOSPHATASE IN MEN WITH COELIAC DISEASE

M. Worsfold¹, S. F. Evans¹, M. W. J. Davie¹, D. E. Powell¹, C. A. Sharp¹

¹Charles Salt Centre, Robert Jones and Agnes Hunt Hospital NHS Trust, Oswestry, United Kingdom

P233-Mo CORRELATION OF NANOMECHANICAL PROPERTIES AND BONE ORGANIC/INORGANIC COMPONENTS IN OSTEOLATHYRITIC TREATED RAT BONES.

I. Manjubala¹, P. Roschger², E. Paschalis², R. Zoehrer², H. S. Gupta¹, K. Klaushofer², P. Fratzl¹

¹Department of Biomaterials, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany, ²4th Medical Department, LBIO, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Vienna, Austria

P234-Tu CHANGES OF JOINT FORCES DUE TO SUBLUXATION OF THE THUMB PROVOKE BONE ADAPTATION IN TRAPEZIAL BONE

J. Goldhahn¹, P. Nufer¹, T. Kohler², V. Kuhn³, D. Herren⁴, R. Müller²

¹Musculoskeletal Research, Schulthess Clinic, ²Institute for Biomedical Engineering, Swiss Federal Institute of Technology and University of Zurich, Zurich, Switzerland, ³Research Department, Clinic for Traumatology and Sportsmedicine of the University Innsbruck, Innsbruck, Austria, ⁴Department for Hand Surgery, Schulthess Clinic, Zurich, Switzerland

P235-Su POLYETHYLENE WEAR INFLUENCES PROGRESSION OF PELVIC PERI-PROSTHETIC OSTEOLYSIS

D. M. Findlay¹, D. W. Howie¹, M. A. McGee², R. Stamenkov², S. Neale², J. D. Taylor³, S. Callary², S. Pannach², G. Kourlis³

¹Orthopaedics and Trauma, The University of Adelaide, ²Orthopaedics and Trauma, ³Radiology, Royal Adelaide Hospital, Adelaide, Australia

P236-Mo SOFT TISSUE UPTAKE ON SKELETAL SCINTIGRAM

L. D. Petrovic-Rackov¹

¹Clinic of Reumathology, Military Medical Academy, Belgrade, Yugoslavia

P237-Tu ENZYME IMMUNOASSAY FOR N-TERMINAL C-TYPE NATRIURETIC PEPTIDE (NT-PROCNP)

G. Hawa¹, S. Maitzen¹, W. Woloszczuk²

¹Research and Development, BIOMEDICA Group, ²., Ludwig Boltzmann Institut für experimentelle Endokrinologie, Vienna, Austria

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Estrogen - P238 - P243

P238-Su BONE EFFECTS OF RALOXIFENE IN A MAN WITH ESTRADIOL DEFICIENCY

L. E. Maffei¹, P. B. Antunez¹, C. Aranda², M. Vasquez², M. Stivel³, V. Rochira⁴, G. Caffagni⁴, P. M. Chavassieux⁵, P. Meunier⁵, C. Carani⁴

¹Investigacion Clinica Aplicada, Consultorios Asociados de Endocrinologia, ²TCBA, Tomografia Computada Buenos Aires, ³Servicio de Endocrinologia, Hospital Durand, Buenos Aires, Argentina, ⁴Chair of Endocrinology, Dpt. of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy, ⁵INSERM Unité 403, Faculté Laennec, Lyon, France

P239-Mo ESTROGEN AND BONE METASTASES IN BREAST CANCER

A. S. Levenson¹, L. A. Simons¹, T. E. Thurn¹, R. L. Satcher¹

¹Orthopaedic Surgery Department, Northwestern University's Feinberg School of Medicine, Chicago, United States

P240-Tu FREE TESTOSTERONE IS A POSITIVE WHILE FREE ESTRADIOL IS A NEGATIVE PREDICTOR OF CORTICAL BONE SIZE IN YOUNG SWEDISH MEN - THE GOOD STUDY

M. Lorentzon¹, C. Swanson¹, D. Mellström², C. Ohlsson¹

¹Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, ²Department of Geriatric Medicine, University of Gothenburg, Gothenburg, Sweden

P241-Su CHROMATIN DYNAMICS AT INFLAMMATORY, BONE-WASTING GENES SUPPRESSED BY ESTROGEN

E. Benasciutti¹, L. Oliva¹, S. Cenci¹

¹DIBIT, San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, Milano, Italy

P242-Mo INVESTIGATION OF CENTRAL VERSUS PERIPHERAL EFFECTS OF ESTRADIOL IN OVARIECTOMIZED MICE

N. Andersson¹, U. Islander¹, E. Egecioglu², E. Löf³, M. K. Lindberg¹, H. Carlsten¹, C. Ohlsson¹

¹Department of Internal Medicine, ²Department of Physiology, ³Department of Pharmacology, Göteborg University, Göteborg, Sweden

P243-Tu BONE PHENOTYPE OF NERKI MICE

O. K. Oz¹, U. Coskun¹, A. Thomas¹, A. Hajibeigi¹, S. Ozturk², J. Anderson¹, D. S. Perrien³, L. Jameson⁴, L. J. Suva⁵

¹Radiology, ²Plastic and Reconstructive Surgery, UT Southwestern Medical Center, Dallas, ³Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, ⁴Medicine, Northwestern University, Chicago, ⁵Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, United States

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Genetics : General Studies - P244

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Genetics : Polymorphisms - P245 - P261

P245-Mo THE METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) C677T POLYMORPHISM AND BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN IN MALTA

C. Vidal¹, M. Brincat², A. Xuereb-Anastasi³

¹Department of Pathology, ²Department of Obstetrics and Gynaecology, ³Institute of Health Care, University of Malta, G'Mangia, Malta

P246-Tu IMPACT OF MULTIPLE CANDIDATE GENES ON BONE MINERAL DENSITY IN CHINESE WOMEN

H. Zhao¹, J. Liu¹, G. Ning¹, L. Zhang¹, H. Song¹, Y. Chen¹, L. Jiang¹, M. Dai¹, M. Xu¹, J. Chen¹

¹Department of Endocrine and Metabolic Diseases,Ruijin Hospital, Shanghai Institute of Endocrinology and Metabolism, Shanghai, China

P247-Su RELATIONSHIP BETWEEN KLOTHO POLYMORPHISMS WITH BONE MINERAL METABOLISM AND CARDIOVASCULAR RISK FACTORS IN KOREAN WOMEN

K. Oh¹, E. Yun², E. Rhee³, W. Lee³, K. Baek⁴, M. Kang⁴, S. Kim¹, C. Park¹, S. Ihm¹, S. Park¹

¹Internal Medicine, Hallym University, Sacred Heart Hospital, Anyang, ²Radiology, Hallym University, Kang-Dong Sacred Heart Hospital, ³Internal Medicine, Sungkyunkwan University School of Medicine, ⁴Internal Medicine, The Catholic University of Korea, Seoul, South Korea

P248-Mo RELATIONSHIP BETWEEN OSTEOPROTEGERIN POLYMORPHISMS WITH AORTIC CALCIFICATION AND BONE MINERAL METABOLISM IN KOREAN WOMEN

E. Yun¹, K. Oh², E. Rhee³, W. Lee³, K. Baek⁴, M. Kang⁴, C. Park², S. Ihm², S. Park², C. Choi¹

¹Radiology, Hallym University, Kang-Dong Sacred Heart Hospital, Seoul, ²Internal Medicine, Hallym University, Sacred Heart Hospital, Anyang, ³Internal Medicine, Sungkyunkwan University School of Medicine, ⁴Internal Medicine, The Catholic University of Korea, Seoul, South Korea

P249-Tu POLYMORPHISMS IN THE PROMOTER REGION OF THE ESTROGEN RECEPTOR BETA GENE ARE ASSOCIATED WITH HIGHER RISKS OF OSTEOPOROSIS IN BOTH MEN AND WOMEN

A. W. K. Kung¹, B. M. H. Lai¹, H. H. L. Lau¹, V. Chan¹

¹Department of Medicine, The University of Hong Kong, Hong Kong, China

P250-Su ASSOCIATIONS BETWEEN THE NOVEL CANDIDATE GENES FOR OSTEOPOROSIS AND CIRCULATING 25-OH VITAMIN D IN WHITE POSTMENOPAUSAL WOMEN

I. V. Zofkova¹, K. Zajickova¹, M. Hill²

¹Department of Clinical Endocrinology, ²Steroid Hormone Unit, Institute of Endocrinology, Prague, Czech Republic

P251-Mo FUNCTIONAL GENE VARIANT WITHIN PAI-1, BUT NOT WITHIN TGF-BETA1, IS ASSOCIATED WITH BONE MINERAL DENSITY IN CZECH WOMEN.

J. A. Hubacek¹, R. Bohuslavova², V. Adamkova³, M. Weichetova⁴

¹Centre for Experimental medicine, ²Centre for Experimental Medicine, ³Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, ⁴III. Internal Clinic, Charles University, Prague, Czech Republic

P252-Tu VITAMIN D RECEPTOR GENE HAPLOTYPE IS ASSOCIATED WITH BODY HEIGHT

Y. Fang¹, J. B. J. van Meurs¹, M. Jhamai¹, F. Rivandeneira¹, J. P. T. Van Leeuwen¹, H. A. P. Pols¹, H. A. P. Pols², A. G. Uitterlinden¹, A. G. Uitterlinden²

¹Internal Medicine, ²Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands

P253-Su ANALYSIS OF THE PPAR-GAMMA3 PROMOTER POLYMORPHISM (681 C/G TRANSVERSION) IN SPANISH POSTMENOPAUSAL WOMEN

J. M. Quesada¹, A. Casado², R. Cuenca Acevedo³, L. Barrios⁴, G. Dorado⁵

¹Sanyres XXI Prasa. Unidad de Metabolismo Mineral, Hospital Universitario Reina Sofía, ²Sanyres XXI Prasa. Unidad de Metabolismo Mineral, Hospital Universitario Reina Sof, ³Unidad de Metabolismo Mineral, Hospital Universitario Reina Sofía, ⁴Unidad de Metabolismo Mineral, ⁵Dp Bioquímica y Biología Molecular, Universidad de Córdoba, Córdoba, Spain

P254-Mo POLYMORPHISM OF VITAMIN D RECEPTOR GENE IS ASSOCIATED TO THE PHENOTYPE AND THE BONE MINERAL DENSITY IN PATIENTS WITH TURNER SYNDROME

N. G. Tolosa de Talamoni¹, A. Perez¹, L. Silvano², L. Muñoz², M. Binci¹, G. Sobrero², M. Moore², E. Pretel¹, A. Boyanovsky², M. Ulla³, V. Centeno¹, M. Miras²

¹Biochemistry and Molecular Biology, National University of Cordoba, ²Servicio de Endocrinología, Hospital de Niños de la Santisima Trinidad, ³Servicio de Endocrinología, CEOM, Cordoba, Argentina

P255-Tu ESTROGEN RECEPTORS POLYMORPHISMS: RELATION WITH BONE MINERAL DENSITY AND LIPID PROFILE AND RESPONSE TO HORMONE REPLACEMENT THERAPY IN POSTMENOPAUSAL WOMEN

S. Silvestri¹, A. Bloch Thomsen², A. Gozzini¹, Y. Bagger², C. Christiansen², M. Brandi¹

¹Internal Medicine, University of Florence, Firenze, Italy, ²Center for Clinical and Basic Research, CCBR, Ballerup, Denmark

P256-Su THE COMT VAL158MET POLYMORPHISM IS ASSOCIATED WITH BONE MINERAL DENSITY AND BODY FAT IN ELDERLY SWEDISH MEN – MR OS SWEDEN

A. Eriksson¹, D. Mellström², E. S. Orwoll³, Ö. Ljunggren⁴, O. Johnell⁵, C. Ohlsson⁶

¹Center for Bone Research at the Sahlgrenska Academy and Division of Clinical Pharmacology, Department of Internal Medicine, ²Department of Geriatrics, Göteborg University, Göteborg, Sweden, ³Bone and Mineral Research Unit, Department of Medicine Oregon Health Sciences University and Portland Veterans Affairs Medical Cente, Portland Oregon, United States, ⁴Department of Medical Sciences, University of Uppsala, Uppsala, ⁵Department of Orthopaedics, Malmö University Hospital, Malmö, ⁶Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Göteborg, Sweden

P257-Mo ASSOCIATION OF TUMOUR NECROSIS FACTOR-ALPHA PROMOTER POLYMORPHISMS WITH PERIPROSTHETIC OSTEOLYSIS

L. T. Bakiyeva¹, R. A. Brooks¹, D. C. Ireland², M. Polli³, M. Porteous³, T. R. Fanshawe⁴, N. Rushton¹

¹Orthopaedic Research Unit, ²Department of Medicine, University of Cambridge, Cambridge, ³Trauma Orthopaedic Surgery, West Suffolk NHS Trust, Bury St.Edmunds, ⁴Centre for Applied Medical Statistics, University of Cambridge, Cambridge, United Kingdom

P258-Tu THE LOW ACTIVITY 158MET VARIANT OF THE COMT GENE IS ASSOCIATED WITH INCREASED FRACTURE RISK IN ELDERLY MEN

L. Stolk¹, J. B. J. Van Meurs¹, A. Hofman², H. A. P. Pols¹, A. G. Uitterlinden¹

¹Internal Medicine, ²Epidemiology and Biostatistics, Erasmus MC, Rotterdam, Netherlands

P259-Su OSTEOPOROSIS AND GENETIC DISPOSITION FOR PRIMARY ADULT LACTOSE INTOLERANCE IN MEN

B. M. Obermayer-Pietsch¹, M. Gugatschka¹, A. Strele², A. Fahrleitner-Pammer¹, H. Dobnig¹, S. Kudlacek³, P. Pietschmann⁴, W. Renner⁵

¹Internal Medicine, ²Clinical Research Center, Medical University Graz, Graz, ³Internal Medicine, Krankenhaus Barmherzige Brüder, Vienna, ⁴Institute of Pathology, University Vienna, Wien, ⁵Institute of Molecularbiological Analyses, Graz, Austria

P260-Mo LARGE-SCALE POPULATION BASED STUDY SHOWS NO EVIDENCE OF ASSOCIATION BETWEEN COMMON POLYMORPHISM OF THE VDR GENE AND BMD IN BRITISH WOMEN

F. E. A. McGuigan¹, H. M. Macdonald¹, A. Stewart², A. J. Black², W. D. Fraser³, S. H. Ralston¹, D. M. Reid¹

¹Medicine and Therapeutics, University Of Aberdeen, ²Osteoporosis Research Unit, Woolmanhill Hospital, Aberdeen, ³Clinical Biochemistry and Metabolic Medicine,, Royal Liverpool University Hospital, Liverpool, United Kingdom

P261-Tu RELATIONSHIPS BETWEEN PVUII AND XBAI POLYMORPHISMS OF ER ALPHA GENE AND ULTRASOUND BONE PARAMETERS IN POLISH POPULATION - THE EPOLOS STUDY

M. Kruk¹, M. Jaworski¹, J. Lukaszkiewicz², E. Karczmarewicz¹, P. Bilinski³, E. Czerwinski⁴, A. Lewinski⁵, E. Marcinowska-Suchowierska⁶, A. Milewicz⁷, M. Spaczynski⁸, A. G. Uitterlinden⁹, R. S. Lorenc¹

¹Dept. of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, ²Dept. of Biochemistry, Pharmaceutical Division, Medical University, Warsaw, ³Orthopaedic and Traumatology Clinic, The Ludwig Rydygier Medical University, Bydgoszcz, ⁴Dept. of Orthopaedics, Jagiellonian University, Cracow, ⁵Regional Centre of Menopause and Osteoporosis, Dept. of Thyroidology, Clinical Hospital No 3, Lodz, ⁶Dept. of Internal Medicine, Postgraduate Medical Education Centre, Orlowski Hospital, Warsaw, ⁷Dept. and Clinic of Endocrinology and Diabetology, Wroclaw University of Medicine, Wroclaw, ⁸Dept. of Gynecology and Obstetrics, Division of Gynecological Oncology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland, ⁹Dept. of Internal Medicine, Erasmus University, Rotterdam, Netherlands

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Growth Factors and Cytokines - P262 - P278

P262-Su THE EFFECT OF LOW INTENSITY PULSED ULTRASOUND ON EXPRESSION OF BASIC FGF DURING LENGTHENING OF DISTRACTION OSTEOGENESIS

C. Chan¹, K. Lee², L. Qin¹, W. Cheung¹, K. Leung¹

¹Orthopaedics and Traumatology, ²Lee Hysan Clinical Research Laboratories, Chinese University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region of China

P263-Mo RANKL DIRECTLY INDUCES BONE MORPHOGENETIC PROTEIN-2 EXPRESSION IN RANK-EXPRESSING POS-1 OSTEOSARCOMA CELLS.

Y. Wittrant¹, K. Mori¹, A. Riet¹, A. Kamijo², D. Heymann¹, F. Rédini¹

¹EA 3822-ERI 7 INSERM, Physiopathologie de la Résorption Osseuse, Faculté de Médecine, Nantes cedex 1, France, ²Department of Orthopaedic Surgery, Yokohama City University, School of medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan

P264-Tu STATIN INDUCES MINERALIZED TISSUE FORMATION IN CULTURED RAT DENTAL PULP CELLS

H. Seto¹, H. Ohba¹, H. Hama¹, M. Horibe¹, T. Nagata¹

¹Department of Periodontology and Endodontology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

P265-Su BONE PHENOTYPE OF IL-6 TRANSGENIC MICE MIMICKING HUMAN CHRONIC INFLAMMATORY DISEASES IN CHILDREN

E. Spica¹, F. DeBenedetti², C. DiGiacinto¹, A. DelFattore¹, R. Paro¹, S. Berni¹, P. Ballanti³, N. Rucci¹, A. Teti¹

¹Department of Experimental Medicine, University of L'Aquila, L'Aquila, ²Ospedale Bambino Gesù, Ospedale Bambino Gesù, ³Department of Experimental Medicine and Pathology, University of Rome "La Sapienza", Rome, Italy

P266-Mo HYPERPROLACTINEMIA STIMULATED DUODENAL ACTIVE CALCIUM ABSORPTION IN OVARIECTOMIZED RATS

N. Krishnamra¹, K. Tudpor¹, N. Charoenphandhu¹

¹Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

P267-Tu THE EFFECTS OF EXTRACELLULAR NUCLEOTIDES ON EGF-INDUCED C-FOS GENE EXPRESSION

A. Gartland¹, W. D. Fraser², J. A. Gallagher³, R. A. Hipskind⁴

¹Human Anatomy and Cell Biology, Clinical Biochemistry, ²Clinical Biochemistry, ³Human Anatomy and Cell Biology, The University of Liverpool, Liverpool, United Kingdom, ⁴IGMM, CNRS, Montpellier, France

P268-Su BLOOD SERUM RANKL IN RATS DRINKING STRONTIUM CHLORIDE WATER

M. Jablonski¹, M. Gorzelak¹, M. Patyra¹, A. Chodkowska², E. Jagiello-Wojtowicz²

¹Orthopedics, ²Toxicology, Medical University, Lublin, Poland

P269-Mo INFLUENCE OF LOW CONCENTRATIONS OF STRONTIUM CHLORIDE IN DRINKING WATER ON MINERAL DENSITY OF THE RAT SKELETON

M. Jablonski¹, M. Gorzelak¹, M. Patyra¹, E. Jagiello-Wojtowicz²

¹Orthopedics, ²Toxicology, Medical University, Lublin, Poland

P270-Tu BONE DEVELOPMENT, PHYSICAL GROWTH AND SEX STEROIDS IN ADOLESCENT GIRLS

W. Furmaga-Jablonska¹, B. Kulik-Rechberger², M. Jablonski³, M. Kozlowska², A. Kosciesza², M. Patyra³, J. Walawski³

¹Neonates, Infants' Pathology and Cardiology, ²Developmental Pediatrics, ³Orthopedics, Medical University, Lublin, Poland

P271-Su RINSING AFTER IMPACTION DOES NOT INFLUENCE OSTEOINDUCTIVITY OF MORSELIZED CANCELLOUS BONE GRAFTS

G. Hannink¹, E. Piek², P. Van der Kraan³, W. Schreurs¹, P. Buma¹

¹Orthopaedic Research Lab, Radboud University Medical Center, ²Department of Cellular Biology and Applied Biology, ³Experimental Rheumatology and Advanced Therapeutics, Radboud University, Nijmegen, Netherlands

P272-Mo MODULATION OF EXOGENOUS OPG BIO-DISPONIBILITY BY MEMBRANOUS RANKL EXPRESSING CELLS.

S. Kwan Tat¹, Y. Fortun¹, S. Couillaud-Battaglia¹, D. Heymann¹, M. Padrines¹

¹PATHOPHYSIOLOGY OF BONE RESORPTION LABORATORY -EA 3822 - INSERM ERI 7, Medicine Faculty, 44 035 NANTES cedex 1, France

P273-Tu THE CIRCADIAN RHYTHM OF OSTEOPROTEGERIN AND ITS ASSOCIATION WITH PARATHYROID HORMONE SECRETION IN NON-OSTEOPOROTIC ELDERLY POSTMENOPAUSAL WOMEN

F. Joseph¹, B. Y. Chan², H. D. White¹, A. M. Ahmad¹, B. H. Durham², A. Joshi¹, Y. Cheng², S. Vinjamuri³, J. A. Gallagher⁴, J. P. Vora¹, W. D. Fraser²

¹Dept. of Diabetes and Endocrinology, ²Dept. of Clinical Biochemistry, ³Dept. of Nuclear Medicine, Royal Liverpool University Hospital, Liverpool, ⁴Dept. of Human Anatomy and Cell Biology, University of Liverpool, United Kingdom

P274-Su QUANTIFICATION OF DIFFERENT GROWTH FACTORS IN REAMING ASPIRATE, ILIAC CREST, BLOOD AND PRP

G. Schmidmaier¹, S. Herrmann¹, T. Ohly¹, M. Schäfer¹, J. Green², T. Weber³, N. Haas¹, B. Wildemann¹

¹Center for Musculoskeletal Surgery, Charité, Berlin, Germany, ², Synthes, Paoli, ³Trauma, Methodist Hospital, Indianapolis, United States

P275-Mo Analyzing the growth factor quantity in commercially available Demineralized bone matrix (DBX)

B. Wildemann¹, A. Kadow¹, N. Haas¹, G. Schmidmaier¹

¹Center for Musculoskeletal Surgery, Charité, Berlin, Germany

P276-Tu SERUM FGF 23 IS ELEVATED IN THE EARLY PHASE OF BONE HEALING

S. Goebel¹, J. Seufert², R. Ebert³, J. Lienau⁴, G. Duda⁴, F. Jakob³

¹Dept. of Orthopaedics, König-Ludwig-Haus, ²Endocronology and Molecular Medicine, Medizinische Klinik II, ³Osteology, König-Ludwig-Haus, Würzburg, ⁴Center for Muskuloskeletal chirurgy, Freie Universität, Berlin, Germany

P277-Su EARLY CYR61 PROTEIN EXPRESSION IN FRACTURE CALLUS IS INFLUENCED BY FIXATION STABILITY

J. Lienau¹, H. Schell¹, D. R. Epari¹, N. Schütze², F. Jakob², H. J. Bail¹, G. N. Duda¹

¹Center for Musculoskeletal Surgery, Charité - University Medicine Berlin, Free and Humboldt-University of Berlin, Berlin, ²Clinical Research Group on Musculoskeletal Diseases, Orthopaedic Department, University of Würzburg, Würzburg, Germany

P278-Mo PATTERN OF MINERALIZATION AFTER PERIODONTAL TISSUE ENGINEERING WITH ENAMEL MATRIX PROTEINS

D. D. Bosshardt¹, A. Sculean², N. P. Lang¹

¹Periodontology and Prosthodontics, University of Berne, School of Dental Medicine, Berne, Switzerland, ²Periodontology, University Medical Center Nijmegen, Nijmegen, Netherlands

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Insulin-like Growth Factors and Binding Proteins - P279 - P281

P279-Tu OSTEOPROTEGERIN IN UMBILICAL BLOOD AS A MARKER OF BONE DEVELOPMENT IN NEWBORNS

W. Furmaga-Jablonska¹, M. Jablonski², A. Kosciesza³

¹Neonates, Infants' Pathology and Cardiology, ²Orthopedics, ³Developmental Pediatrics, Medical University, Lublin, Poland

P280-Su LIVER-DERIVED INSULIN-LIKE GROWTH FACTOR I IS PERMISSIVE FOR OVARIECTOMY-INDUCED BONE LOSS

N. Andersson¹, M. K. Lindberg¹, S. Movérare-Skrtic¹, J. Svensson¹, T. Chavoshi¹, K. Venken², D. Vanderschueren², H. Carlsten¹, C. Ohlsson¹

¹Department of Internal Medicine, Göteborg University, Göteborg, Sweden, ²Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium

P281-Mo CONGENITAL AROMATASE DEFICIENCY CAUSES ABNORMAL PUBERTAL GROWTH AND GROWTH HORMONE SIGNALING IN MICE

O. K. Oz¹, A. M. Thomas¹, L. E. Nanu¹, E. R. Simpson²

¹Radiology, UT Southwestern Medical Center, Dallas, United States, ²Prince Henry's Institute, Monash Medical Centr, Clayton, Australia

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Osteoblasts : Apoptosis and Cell Cycle - P282 - P290

P282-Tu CBL-MEDIATED UBIQUITINATION OF ALPHA 5 INTEGRIN SUBUNIT MEDIATES FIBRONECTIN-DEPENDENT OSTEOBLAST DETACHMENT AND APOPTOSIS INDUCED BY FIBROBLAST GROWTH FACTOR RECEPTOR 2 ACTIVATION.

K. Kaabeche¹, H. Guénou¹, D. Bouvard², N. Didelot¹, A. Listrat¹, P. J. Marie¹

¹Osteoblast Biology and Pathology, Inserm U606, Paris cedex 10, ²LEDAC, UMR CNRS UJF 5538, La Tronche, France

P283-Su VASCULAR ENDOTHELIAL GROWH FACTOR (VEGF) ACTS AS A SURVIVAL FACTOR IN HUMAN OSTEOBLASTIC CELLS

A. R. De Gortázar¹, V. Alonso¹, P. Esbrit¹, M. V. Alvarez-Arroyo²

¹Bone and Mineral Metabolism Laboratory, ²Renovascular Metabolism Laboratory, Fundación Jiménez Díaz, Madrid, Spain

P284-Mo ONCOSTATIN M SENSITIZES OSTEOSARCOMA CELLS TO APOPTOSIS VIA THE MITOCONDRIAL PATHWAY

F. Blanchard¹, C. Chipoy¹, P. Juin², F. Rédini¹, D. Heymann¹

¹EA 3822 - INSERM ERI7, Faculty of Medicine, ²U601, INSERM, Nantes, France

P285-Tu REGULATION OF OSTEOBLAST APOPTOSIS BY CYTOKINES

C. Garcia-Moreno¹, M. Montero¹, C. De la Piedra¹, A. Ortiz²

¹Bone Pathophysiology Laboratory, ²Nephrology Laboratory, Jimenez-Diaz Foundation, Madrid, Spain

P286-Su ALPHA-LIPOIC ACID INHIBITS TNF-ALPHA-INDUCED APOPTOSIS IN HUMAN BONE MARROW STROMAL CELLS

J. Koh¹, C. Byun², Y. Chung³, K. Lee¹, G. Kim¹

¹Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, ²Asan Institute for Life Sciences, Asan Medical Center, ³Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea

P287-Mo CYCLOOXYGENASE-2 MEDIATES THROMBIN’S INHIBITION OF OSTEOBLAST APOPTOSIS BY A PAR-1-INDEPENDENT MECHANISM.

C. N. Pagel¹, L. Loh¹, S. Merlin¹, E. Tudor², R. N. Pike³, E. J. Mackie¹

¹School of Veterinary Science, ²Department of Pharmacology, University of Melbourne, ³Deprtment of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia

P288-Tu THE BH3-ONLY PROTEIN BIM IS UPREGULATED IN OSTEOBLASTS IN RESPONSE TO DEXAMETHASONE TREATMENT, GROWTH FACTOR DEPRIVATION AND ANOIKIS

B. Espina¹, R. Conradie², G. Russell³, P. Hulley³

¹Nuffield Department of Orthopaedic Surgery, Botnar Research Centre, Oxford, United Kingdom, ²Dept Internal Medicine, University of Stellenbosch, Cape Town, South Africa, ³Nuffield Department of Orthopaedic Surgery, Botnar Reserach Centre, Oxford, United Kingdom

P289-Su RESPONSE OF THE MURINE BONE CELL LINES TO IONIZING RADIATION

C. E. Hellweg¹, P. Lau¹, S. Kirchner¹, A. Arenz¹, C. Baumstark-Khan¹

¹Institute for Aerospace Medicine, Radiobiology, DLR, German Aerospace Center, Koeln, Germany

P290-Mo ROLE OF THE INHIBITORS OF HYDROXY-METHYL-GLUTARYL-COA INHIBITORS (STATINS) IN THE OSTEOSARCOMA CELL BEHAVIOR.

N. E. Cabrera-Benítez¹, O. Hernández-Perera¹, R. G. Díaz-Peñate¹, A. Arín-Martínez¹, M. García-Chicano¹, R. Pérez-Machín¹, J. M. García-Castellano¹

¹Laboratory of Molecular Oncology. Research Unit, Hospital Dr. Negrín, Las Palmas, Spain

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Osteoblasts : Coupling to Bone Resorption - P291 - P293

P291-Tu EFFECT OF STATINS ON OSTEOPROTEGERIN PRODUCTION BY BONE CELLS

H. L. Smith¹, J. H. H. Williams², M. J. Marshall¹

¹Charles Salt Research Centre, RJAH Orthopaedic Hospital, ²Chester Centre for Stress Research, University College of Chester, Shropshire, United Kingdom

P292-Su APOPTOTIC BODIES FROM DYING OSTEOCYTES INDUCE SPECIFIC AND UNIQUE RESPONSES IN DIFFERENT PHAGOCYTES.

G. Kogianni¹, V. Mann¹, A. Devitt², C. D. Gregory², S. Brown², H. A. H. Simpson³, B. S. Noble³

¹Scottish Mechanotransduction Consortium, ²MRC Centre for Inflammation, ³Scottish Mechanotransduction Consortium and Musculoskeletal Research Unit, University of Edinburgh, Edinburgh, United Kingdom

P293-Mo THE EFFECT OF TEMPERATURE ON BONE CELL FUNCTION

J. C. Utting¹, A. Brandao-Burch¹, I. R. Orriss¹, P. J. Whatling¹, T. R. Arnett¹

¹Anatomy and Developmental Biology, University College London, London, United Kingdom

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Osteoblasts : Gene Expression and Transcription Factors - P294 - P300

P294-Tu LONG WAVE ULTRASOUND MAY ENHANCE BONE REGENERATION BY ALTERING OPG/RANKL RATIO IN HUMAN OSTEOBLAST-LIKE CELLS.

A. Maddi¹, K. Ho², S. Ong³, M. Harris⁴, L. Sharp¹, S. Meghji¹

¹Eastman Dental Institute, UCL, London, United Kingdom, ²Oral and Maxillofacial Surgery, National University of Singapore, Singapore, Singapore, ³Oral and Maxillofacial Surgery, University of Malaya, Kuala Lumpur, Malaysia, ⁴Oral and Maxillofacial Surgery, Barts and The London School of Medicine and Dentistry, London, United Kingdom

P295-Su GENE ARRAY ANALYSIS OF SHOCK WAVE–INDUCED CHANGES OF GENE EXPRESSION IN HUMAN OSTEOBLAST CULTURES FROM PATIENT WITH FRACTURE NON-UNIONS

U. Ritz¹, J. D. Rompe², A. Ackermann¹, J. Heine², P. M. Rommens³, A. Hofmann³

¹Department of Orthopaedic Surgery and Accident Surgery, ²Department of Orthopaedic Surgery, ³Department of Accident Surgery, Johannes Gutenberg University School of Medicine, Mainz, Germany

P296-Mo CCAAT/ENHANCER BINDING PROTEIN (C/EBP) BETA IS INVOLVED IN BONE FORMATION

J. J. Smink¹, V. Begay¹, A. Leutz¹

¹Tumorigenesis and Differentiation, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany

P297-Tu DOWN-REGULATION OF TSG101 EXPRESSION DURING OSTEOBLAST DIFFERENTIATION

S. Hung¹, S. Hsu², C. Chen³, Y. Cheng³, D. Chao⁴, S. Hung⁴

¹Orthopedic Sugery Department, Fooyin University Hospital, Tungkang, Pingtung Hsan, ²Nursing Department, Tsuhui Institute of Technology, Pingtung Hsan, ³Orthopedic Sugery Department, Kaohsiung Medical University Hospital, ⁴Biological Sciences, National Sun Yat-sen University, Kaohsiung City, Taiwan

P298-Su MOLECULAR DISSECTION OF KROX20 GENE REGULATION IN BONE: NFAT AND/OR SRF DEPENDENCE?

M. Frain¹, P. Charnay¹

¹INSERM U368, Ecole Normale Supérieure, Paris, France

P299-Mo OVEREXPRESSION OF CBFA1/RUNX2 IN OSTEOBLASTS RESULTS IN STRIKING REDUCTION OF SOST EXPRESSION IN BONE

H. Keller¹, V. Geoffroy², B. Fournier¹, P. Matthias³, M. Kneissel¹

¹Bone and Cartilage Unit, Novartis Institutes for BioMedical Research, Basel, Switzerland, ²Hopital Lariboisiere, INSERM, Paris, France, ³Friedrich-Miescher Institute, For Biomedical Research, Basel, Switzerland

P300-Tu THE OSTEOBLAST TRANSCRIPTION FACTOR OSTERIX IN OSTEOBLASTS FROM PATIENTS WITH METABOLIC BONE DISEASES CORRELATES TO CLINICAL OSTEOPOROTIC MARKERS

M. Giesen¹, T. Eidner², G. Hein², G. Lehmann², M. L. Ponce¹, M. Huefner¹, H. Siggelkow¹

¹Gastroenterology and Endocrinology, University of Goettingen, Göttingen, ²Internal Medicine IV, Friedrich-Schiller-University, Jena, Germany

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Osteoblasts : Genes and Markers - P301

P301-Su RAPID IN VIVO MONITORING OF SOST REGULATION IN BONE

B. Kinzel¹, C. Schnell², M. Lavicky³, H. Keller³, M. Mueller¹, M. Kneissel³

¹Models of Diseases Center, ²Oncology, ³Bone and Cartilage Unit, Novartis Institutes for BioMedical Research, Basel, Switzerland

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Osteoblasts : Hormonal Effects - P302 - P305

P302-Mo GHRELIN AND BONE METABOLISM

N. Fukushima¹, K. Hiraoka¹, M. Zenmyo¹, M. Kojima², K. Nagata¹

¹Department of Orthopedic Surgery, Kurume University School of Medicine, ²Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Japan

P303-Tu 25 HYDROXY- VITAMIN D3- 1ALPHA; HYDROXYLASE IS EXPRESSED IN CULTURED HUMAN BONE CELLS AND IS MODULATED BY ESTRADIOL AND PHYTOESTROGENS

D. Somjen¹, S. Katzburg¹, F. Kohen², B. Gayer³, R. Limor¹, O. Sharon¹, N. Jaccard⁴, D. Hendel⁵, A. M. Kaye⁶, Y. Weisman⁴

¹Endocrine Unit, Tel-Aviv Medical Center, Tel-Aviv, ²Biological Regulation, The Weizmann Institute of Science,, ³Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, ⁴Metabolic Bone Disease Unit, Tel-Aviv Medical Center, Tel-Aviv, ⁵Department of Orthopaedic Surgery, Shaarei-Zedek Medical Center, Jerusalem, ⁶Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel

P304-Su VITAMIN D ANALOG JKF 1624F2-2 AND HYPERGLYCEMIA MODULATE CULTURED HUMAN BONE CELLS RESPONSE TO ESTROGENS BY DIFFERENTIALLY ALTERING ER MRNA EXPRESSION AND BINDING ACTIVITY OF ER

D. Somjen¹, S. Katzburg¹, F. Kohen², B. Gayer², G. H. Posner³, O. Sharon¹, D. Hendel⁴, A. M. Kaye⁵

¹Endocrine Unit, Tel-Aviv Medical Center, Tel-Aviv, ²Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel, ³Department of Chemistry, The Johns Hopkins University, Baltimore, MD., United States, ⁴Department of Orthopaedic Surgery, Shaarei-Zedek Medical Center, Jerusalem, ⁵Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel

P305-Mo EFFECTS OF GROWTH HORMONE ON OSTEOPROTEGERIN PRODUCTION IN HUMAN OSTEOBLAST-LIKE CELLS.

E. Mrak¹, I. Villa¹, R. Lanzi², U. DiRauso³, F. Guidobono⁴, A. Rubinacci¹

¹Bone Metabolic Unit, ²Endocrinology Unit, ³Orthopaedic Division, Scientific Institute H San Raffaele, ⁴Dept of Pharmacology, Chemotherapy, Medical Toxicology, University of Milano, Milano, Italy

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Osteoblasts : Mechanical Strain - P306 - P310

P306-Tu RESPONSES OF OSTEOCYTES TO FLUID FLOW-INDUCED SHEAR STRESS: ANALYSIS OF GENE EXPRESSION BY SUBTRACTIVE HYBRIDIZATION

T. J. Heino¹, K. Kurata², K. Büki¹, K. Väänänen¹

¹Department of Anatomy, University of Turku, Turku, Finland, ²Department of Mechanical Engineering, Kyushu Sangyo University, Fukuoka, Japan

P307-Su IN VITRO MECHANICAL STIMULATION EFFECTS ON OSTEOBLASTIC RELEASE OF OSTEOPROTEGERIN

M. M. Saunders¹, A. F. Taylor¹, C. Du¹, H. J. Donahue¹

¹Orthopaedics and Rehabilitation, Penn State University College of Medicine, Hershey, United States

P308-Mo LONG TERM MAINTENANCE OF LIVING HUMAN CANCELLOUS BONE EXPLANTS EX VIVO.

C. M. Davies¹, P. I. Jaggi¹, D. B. Jones², C. W. Archer³, R. G. Richards¹

¹Interface Biology Group, AO Research Institute, Davos Platz, Switzerland, ²Experimental Orthopaedics and Biomechanics, Phillips University, Marburg, Germany, ³Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom

P309-Tu THE EFFECTS OF GREEN TEA CATECHIN ON THE EXPRESSION OF OSTEOPROTEGERIN (OPG) AND MACROPHAGE-COLONY STIMULATING FACTOR (M-CSF) IN A CULTURED BONE MARROW MESENCHYMAL STEM CELL LINE

C. Chen¹, M. Ho², S. Hung³, J. Chang¹, G. Wang¹

¹Departments of Orthopedics, ²Departments of Physiology, ³Orthopedic Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan

P310-Su MORPHOLOGICAL CHANGES IN ACTIN CYTOSKELETON INDUCED BY TENSILE STRESS IN MOUSE CRANIAL SUTURE

M. Ikegame¹, S. Ejiri², T. Yamamoto¹

¹Oral Morphology, Okayama University Graduate School of Medicine and Dentistry, Okayama, ²Anatomy of the Hard Tissue, Niigata University School of Medical and Dental Science, Niigata, Japan

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Osteoblasts : Progenitor Cells Prostaglandins Nitric Oxide - P311 - P312

P311-Mo EXPOSURE OF MC3T3-E1 OSTEOBLAST-LIKE CELLS TO ARACHIDONIC ACID AND DOCOSAHEXAENOIC ACID MODULATES PROSTAGLANDIN SYNTHESIS AND SECRETION OF OSTEOPROTEGERIN

M. Coetzee¹, M. Haag², M. C. Kruger³

¹Department of Physiology, University of Pretoria, Pretoria, South Africa, ²Department of Physiology, University of Pretoria, Pretoria, SouthAfrica, ³Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand

P312-Tu GLUTAMATE SIGNALING DETERMINES THE PROLIFERATION AND DIFFERENTIATION STATUS OF MESENCHYMAL STEM CELLS

G. J. Spencer¹, N. A. Matthews¹, P. G. Genever¹

¹Biology, University of York, York, United Kingdom

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Osteoblasts : Proliferation and Differentiation - P313 - P339

P313-Su THE EFFECT OF STATINS ON THE PROCESS OF CERVIAL INTERVERTIBRAL FUSION WITH ALLOGENOUS CORTICAL BONE TRASNPLANTATION

Y. Yang¹, J. Hu², X. Li³, L. Zhang², Z. Zhang⁴

¹Department of orthopedics, ²Department of anatomy, Shandong university, ³Department of orthopedics, Qianfoshan hospital, ⁴Department of orthopedics, Shandong provincial hospital, jinan, China

P314-Mo COMBINATION OF BONE MORPHOGENETIC PROTEIN -2 AND TROGLITAZONE INDUCES DIFFERENTIATION OF MULTIPOTENT TBR31-2 CELLS INTO ADIPOCYTES.

N. Nishii¹, C. Itami¹, M. Arai², N. Yanai³, A. Togari², T. Nakabayashi¹

¹School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, ²School of Dentistry, Aichi-Gakuin University, Nagoya, ³Faculty of Liberal Arts, Miyagi Gakuin women's University, Sendai, Japan

P315-Tu THE EFFECT OF OXIDATIVE STRESS ON THE PROLIFERATION AND DIFFERENTIATION OF HUMAN BONE MARROW STROMAL CELL-DERIVED OSTEOBLASTS

M. I. Kang¹, K. H. Baek¹, W. Y. Lee², E. S. Oh³, K. W. Oh⁴, H. S. Kim⁵, J. H. Han⁶, K. W. Lee¹

¹Internal Medicine, Endocrinology, St. Mary's Hospital, The Catholic University Medical College, ²Internal Medicine, Endocrinology, Sungkyunkwan University, ³Internal Medicine, Endocrinology, MizMedi Hospital, ⁴Internal Medicine, Endocrinology, Hallym University, Seoul, ⁵Internal Medicine, Endocrinology, St. Mary's Hospital, The Catholic University Medical College, Taejeon, ⁶Internal Medicine, Endocrinology, St. Mary's Hospital, The Catholic University Medical College, Incheon, South Korea

P316-Su HUMAN FETAL BONE CELLS ASSOCIATED WITH BIORESORBABLE PLA COMPOSITE SCAFFOLDS FOR TISSUE ENGINEERING

M. Montjovent¹, L. Mathieu², B. Hinz³, L. L. Applegate⁴, P. Bourban², P. Zambelli⁵, J. Manson², D. P. Pioletti¹

¹Centre de Recherche en Orthopédie, ²Laboratoire de Technologie des Composites et Polymères, ³Laboratoire de Biophysique Cellulaire, Ecole Polytechnique Fédérale de Lausanne, ⁴Laboratoire de Médecine Foetale, ⁵Hôpital Orthopédique de la Suisse Romande, CHUV, Lausanne, Switzerland

P317-Mo STUDY OF OSTEOBLAST FUNCTION THROUGH CELLULAR CULTURES IN PRIMARY OSTEOPOROTIC MEN

S. Ruiz-gaspa¹, M. Ciria², J. Blanch², L. Perez-edo², G. Salo³, X. Nogues⁴, A. Diez-perez⁴, P. Benito², J. Carbonell²

¹Urfoa, ²Rheumatology, ³Orthopedic, ⁴Internal medicine, Imim-imas.hospital del mar, barcelona, Spain

P318-Tu CHARACTERIZATION OF BONE CELLS CULTURED FROM THE HUMAN MAXILLARY ALVEOLAR RIDGE

C. Clausen¹, N. Hermund², O. Donatsky², H. Nielsen²

¹Interface Biotech, Glostrup University Hospital, Glostrup, ²Department of Oral Surgery, Hillerød Hospital, Hillerød, Denmark

P319-Su OSTEOBLAST-LIKE CELL RESPONSE TO CALCIUM PHOSPHATE COATING CHEMISTRY AND MORPHOLOGY

F. G. Horgan¹, G. A. Burke¹, B. J. Meenan¹

¹Bio-ceramics, Bio-polymers and Bio-mechanics, NIBEC, University of Ulster, Belfast, United Kingdom

P320-Mo VITAMIN K2 INHIBITED IL-1BETA-INCREASED PROLIFERATION OF HUMAN OSTEOBLASTS

A. Morita¹, T. Matsuda¹, A. Togari¹

¹Department of Pharmacology, Aichi-Gakuin Unv., Sch. Dent., Nagoya, Japan

P321-Tu C-SRC INHIBITS ER ALPHA GENE TRANSCRIPTION IN DIFFERENTIATING HUMAN OSTEOBLASTS-LIKE CELLS

M. Longo¹, D. Fortunati¹, B. Peruzzi¹, V. De Luca¹, S. Denger², G. Caselli³, S. Migliaccio⁴, A. M. Teti¹

¹Experimental Medicine, University of l'Aquila, L'Aquila, Italy, ²EMBL, European Molecular Biology Laboratories, Heidelberg, Germany, ³Dompé, Dompé SpA, L'Aquila, ⁴Medical Physiopathology, University "La Sapienza", Rome, Italy

P322-Su PURINERGIC RECEPTOR EXPRESSION CHANGES WITH OSTEOBLAST DIFFERENTIATION AND MATURATION.

I. R. Orriss¹, G. E. Knight¹, S. Ranasinghe¹, G. Burnstock¹, T. R. Arnett¹

¹Anatomy and Developmental Biology, University College London, London, United Kingdom

P323-Mo EXPRESSION AND FUNCTIONAL ANALYSIS OF GAMMA-SECRETASE COMPONENTS IN OSTEOBLASTS.

J. McLeod¹, H. D. Lewis², G. J. Spencer¹, P. G. Genever¹

¹Biology, University of York, York, ²Molecular and Cellular Neuroscience, Merck Sharp and Dohme Laboratories, Harlow, United Kingdom

P324-Tu DIVERGENT ROLES FOR CANONICAL AND NON-CANONICAL WNT SIGNALLING IN HUMAN MESENCHYMAL STEM CELLS

L. Etheridge¹, G. J. Spencer¹, P. G. Genever¹

¹Biology, University of York, York, United Kingdom

P325-Su OSTEOBLASTIC INTERACTION ON CALCIUM PHOSPHATE SURFACE TOPOGRAPHY AT THE SUB-MICRON LEVEL

P. O'Hare¹, G. A. Burke¹, B. J. Meenan¹

¹Biomaterials, Biomechanics and Bioceramics, NIBEC, University of Ulster, Belfast, United Kingdom

P326-Mo INTERACTIONS BETWEEN TRANSMEMBRANE MATRIX METALLOPROTEINASE-1 AND ALKALINE PHOSPHATASE IN MATURE OSTEOBLASTS DETERMINE THE FORMATION OF NODULES AND DEPOSITION OF MINERAL.

P. Manduca¹, S. S. Soldano¹, D. Lombardini¹, V. Ulivi¹

¹Genetics-Dept.Biology, University of Genova, Genova, Italy

P327-Tu EVALUATION OF OSTEOGENIC POTENTIAL OF CULTURED HUMAN ORAL PERIOSTEUM-DERIVED CELLS.

T. Ueno¹, T. T. Kagawa¹, J. Fukunaga¹, M. Kanou¹, N. Mizukawa¹, T. Sugahara¹

¹Oral and maxillofacial reconstructive surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

P328-Su CRITICAL REGULATION OF BMP-INDUCED OSTEOBLASTIC DIFFERENTIATION BY DELTA1/JAGGED1-ACTIVATED NOTCH1 SIGNALING

M. Nobuta¹, T. Tsukazaki¹, K. Sakamoto², K. Katsube², A. Yamaguchi²

¹Division of Orthopaedic Pathomechanism and Division of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, ²Section of Oral Pathology, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan

P329-Mo FIBROBLAST GROWTH FACTOR 8 IS A NOVEL, POTENT REGULATOR OF MESENCHYMAL STEM CELL DIFFERENTIATION INTO MATURE OSTEOBLASTS

T. A. Hentunen¹, M. P. Vainiomäki¹, K. Väänänen¹, P. L. Härkönen²

¹Anatomy, University of Turku, Institute of Biomedicine, Turku, Finland, ²Laboratory Medicine, Lund University, MAS University Hospital, Lund, Sweden

P330-Tu OPTIMIZATION OF MESENCHYMAL STEM CELL CULTURE CONDITIONS FOR 3-D CULTURE

T. A. Hentunen¹, J. Yrjans², H. Aro², K. Väänänen¹

¹Anatomy, University of Turku, Institute of Biomedicine, ²Orthopaedics and Traumatology, University of Turku, Orthopaedic Research Unit, Turku, Finland

P331-Su REGULATION OF OSTEOBLAST ATTACHMENT AND MORPHOLOGY ON CALCIUM PHOSPHATE COATINGS BY SURFACE CHEMISTRY AND PRE-ADSORPTION OF FIBRONECTIN

M. L. Cairns¹, G. A. Burke¹, B. J. Meenan¹

¹Biomaterials and Tissue Engineering, NIBEC, University of Ulster, Belfast, United Kingdom

P332-Mo ROLE OF ENDOTHELIN-1 AND VEGF IN A CO-CULTURE MODEL OF MICROVASCULAR ENDOTHELIAL CELLS AND FETAL RAT CALVARIAL CELLS

B. Weyand¹, H. Von Schroeder²

¹Bonelab, Department of Dentistry, ²University Health Network and Bonelab, Department of Dentistry, University of Toronto, Toronto, Canada

P333-Tu ECTOPIC OVEREXPRESSION OF ADIPOGENIC TRANSCRIPTION FACTORS INDUCES TRANSDIFFERENTIATION OF MC3T3-E1 OSTEOBLASTS

C. Shin¹, S. Kim¹, S. Her¹, D. Kim¹, S. Kim¹

¹Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

P334-Su OSTEOBLASTIC CELL DIFFERENTIATION AND P38 MAP KINASE

R. Dziak¹, M. Dahman¹, J. Lampasso¹

¹Oral Biology, Unversity at Buffalo, State University of NY, Buffalo, United States

P335-Mo C-ABL AUGMENTS BMP2 INDUCED ID1 EXPRESSION AND PARTICIPATES IN SENESCENCE OF OSTEOBLASTS

H. Kua¹, Y. H. Y. Hu¹, X. W. X. Wang¹, S. Boast², S. Goff³, B. Li¹

¹IMCB, Institute of Molecular and Cell Biology, Singapore, Singapore, ²Biochemistry, Columbia university, New York, United States, ³Biochemistry, Institute of Molecular and Cell Biology, Singapore,

P336-Tu HISTONE DEACETYLASES ARE INVOLVED IN THE TRANSCRIPTIONAL REGULATION OF SIBLINGS DURING OSTEOBLAST DIFFERENTIATION

M. Chaplet¹, C. Detry¹, V. Castronovo¹, A. Bellahcene¹

¹Metastasis Research Laboratory, University of Liege, Liege, Belgium

P337-Su INDIRECT ACTION OF VEGF ON OSTEOBLAST BEHAVIOUR: PROSTAGLANDIN-MEDIATED REGULATION OF ENDOTELIAL CELL: OSTEOBLAST CROSS-TALK

C. E. Clarkin¹, A. A. Pitsillides¹, C. Wheeler-Jones¹

¹Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom

P338-Mo THE INFLUENCE OF IMPLANTS SURFACE PROPERTIES ON CELLULAR ADHESION, PROLIFERATION AND SYNTHETIC ACTIVITY

V. Pesáková¹, H. Hulejová¹, L. Himmlová², D. Kubies³

¹Dept. of Bone and Cartilage Metabolism, Institute of Rheumatology, ², GFH Institute of Dental Research, ³, Institute of Macromolecular Chemistry, Academy of Sciences, Prague, Czech Republic

P339-Tu IMPROVED BONE CELLULAR ACTIVITY THROUGH THE USE OF CALCIUM PHOSPHATE COATED POLYMERIC SCAFFOLDS

C. S. N. Choong¹, J. T. Triffitt¹

¹Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, United Kingdom

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Osteoblasts : Signal Transduction - P340 - P341

P340-Su RAPID ACTIVATION OF CREB AND ELK-1 AND ACTINE REORGANIZATION IN FEMALE OSTEOBLASTS IN RESPONSE TO A LOW DOSE OF DAIDZEIN

M. Lieberherr¹, A. De Wilde¹, G. Chaumaz¹, C. Heberden¹, C. Bordat¹

¹Laboratoire de Nutrition et de Sécurité Alimentaire, Institut National de la Recherche Agronomique et Centre National de la Recherche Scientifique, Jouy-en-Josas, France

P341-Mo EXPOSURE OF MOUSE PRE-OSTEOBLAST CELLS TO PULSED ELECTRO-MAGNETIC FIELDS RAPIDLY ACTIVATES THE MTOR SIGNALING PATHWAY

T. E. Patterson¹, Y. Sakai², M. O. Ibiwoye³, R. J. Midura³, M. Zborowski³, M. D. Grabiner⁴, A. Wolfman¹

¹Cell Biology, Cleveland Clinic Foundation, Cleveland, United States, ²Orthopaedic Surgery, Kobe University School of Medicine, Kobe, Japan, ³Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, ⁴Movement Sciences, University of Illinois, Chicago, Chicago, United States

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Osteoblasts : Stromal Cells - P342 - P352

P342-Tu GENE ARRAY ANALYSIS OF ADIPOGENIC TRANSDIFFERENTIATION OF COMMITTED OSTEOBLASTS

T. Schilling¹, U. Noeth², F. Jakob³, N. Schuetze¹

¹Molecular Orthopaedics, ²Division of Tissue Engineering, ³Osteology Center, Orthopaedic Institute, Wuerzburg, Germany

P343-Su INCREASED BONE FORMATION ASSOCIATED TO DECREASED ADIPOGENESIS PARTICIPATES TO MECHANICAL LOADING-INDUCED BONE ADAPTATION.

V. David¹, A. Guignandon¹, M. Lafage-Proust¹, A. Rattner¹, L. Vico¹

¹InsermE0366,LBTO, Faculte de Medecine, St-Etienne, France

P345-Tu EVALUATION OF DIFFERENT METHODOLOGIES TO GENERATE MESENCHYMAL STEM CELLS (MSC) FROM HUMAN BONE MARROW.

A. Casado¹, G. Dorado², C. Herrera³, A. Torres³, J. M. Quesada⁴

¹Sanyres XXI Prasa. Unidad de Metabolismo Mineral, Hospital Universitario Reina Sofía, ²Dp Bioquímica y Biología Molecular, Universidad de Córdoba, ³Servicio de Hematología, ⁴Sanyres XXI Unidad de Metabolismo Mineral, Hospital Universitario Reina Sofía, Cordoba, Spain

P346-Su RALOXIFEN AND TAMOXIFEN ACT AS ANTI-ESTROGEN ON OSTEOBLASTIC DIFFERENTIATION BUT ESTROGEN-LIKE ON ADIPOCYTIC DIFFERENTIATION OF BONE MARROW STROMAL CELLS.

R. Okazaki¹, T. Hayashi¹, T. Ishikawa¹

¹Third Department of Medicine, Teikyo University Shcool of Medicine, Ichihara, Japan

P347-Mo MINIPIG BONE CELLS FOR BONE TISSUE-ENGINEERING PURPOSES

M. Aaboe¹, K. K. b. Bire¹, Z. Z. h. Henriksen², H. H. t. Terheyden³, Y. Y. a. Acil³

¹Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Copenhagen, ²The osteoporosis and Bone Metabolic Unit, Departments of Endocrinology and Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ³Department of Oral and Maxillofacial Surgery, University of Kiel, Kiel, Germany

P348-Tu DIFFERENTIAL CHANGES OF FUNCTION AND GENE EXPRESSION OF BONE MARROW STROMAL CELLS AFTER EXTRACORPOREAL SHOCK WAVE APPLICATION (SWA)

A. Hofmann¹, U. Ritz², A. Ackermann², M. Hessmann¹, P. Rommens¹, J. Heine², J. Rompe²

¹Department of Trauma Surgery, ²Department of Orthopaedic Surgery, Johannes Gutenberg University of Mainz, Mainz, Germany

P349-Su (-)-EPIGALLOCATECHIN-3-GALLATE (EGCG) EHNAHCES OSTEOGENIC DIFFERENTIATION IN A MURINE BONE MARROW MESENCHYMAL STEM CELL LINE

C. Chen¹, M. Ho², S. Hung³, J. Chang¹, G. Wang¹

¹Departments of Orthopedics, ²Departments of Physiology, ³Orthopedic Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan

P350-Mo OSTEOGENICALLY INDUCED BONE MARROW STEM CELLS HEAL MOUSE CRANIOFACIAL BONE WOUNDS

J. Tang¹, Q. Tu¹, J. Chen¹

¹General Dentistry, Tufts University School of Dental Medicine, Boston, United States

P351-Tu OSTEOPROGENITOR REGULATION BY OXYGEN TENSION, HEPATOCYTE GROWTH FACTOR AND 1,25-DIHYDROXYVITAMIN D

G. A. Howard¹, K. Chen¹, G. D'Ippolito¹, P. C. Schiller¹, B. A. Roos²

¹GRECC and Research Service, VA Medical Center and University of Miami Miller School of Medicine, ²GRECC and Research Service, VA Medical Center and Univ of Miami Miller School of Medicine and Stein Gerontological Institute, Miami FL, United States

P352-Su THE LEVEL OF ADIPOGENESIS OCCURRING DURING OSTEOBLAST DIFFERENTIATION OF HUMAN BONE MARROW CELLS CAN BE CONTROLLED BY CULTIVATION PROTOCOLS

K. Maniura¹, F. Baumgartner¹, P. Wick¹, A. Bruinink¹

¹MaTisMed, Empa St. Gallen, St. Gallen, Switzerland

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Osteoclasts : Cathepsins and Other Proteinases - P353 - P355

P353-Mo SERUM LEVELS OF CATHEPSIN K DECREASE WITH AGE BOTH IN WOMEN AND IN MEN

P. Pietschmann¹, G. Hawa², S. Kudlacek³, W. Woloszczuk⁴, K. Kerschan-Schindl⁵

¹Pathophysiology, Medical University of Vienna, ²Research and Development, Biomedica, ³Medicine, Hospital Barmherzige Brueder, ⁴, Ludwig Boltzmann-Institute of Experimental Endocrinology, ⁵Physical Medicine and Rehabilitation, Medical University of Vienna, Vienna, Austria

P354-Tu INVOLVEMENT OF THE UROKINASE RECEPTOR IN BONE HOMEOSTASIS

F. Furlan¹, N. Jorgensen², J. Jemsen², A. Rubinacci³, E. Mrak³, M. Marenzana³, F. Blasi¹

¹Molecular Genetics, DIBIT, H San Raffaele, Milan, Italy, ²Endocrinology, Osteoporosis Unit, Copenhagen, Denmark, ³Bone Metabolic Unit, H San Raffaele, Milan, Italy

P355-Su SERUM CATHEPSIN K: A NOVEL BONE RESORPTION MARKER IN THE EVALUATION OF POSTMENOPAUSAL WOMEN TREATED WITH ALENDRONATE

R. Reyes¹, D. Fernández-García¹, M. De la Higuera¹, G. Alonso¹, P. Mezquita-Raya¹, M. E. Ruiz-Requena², M. Muñoz-Torres²

¹Bone Metabolic Unit. Endocrinology Division, ²Biochemistry Unit, University Hospital San Cecilio, Granada, Spain

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Osteoclasts : Cell Adhesion - P356 - P358

P356-Mo EXPRESSION OF RAB GENES IN BONE RESORBING HUMAN OSTEOCLASTS

M. Heikonen¹, K. Büki¹, H. Vuorikoski¹, J. Vääräniemi¹, H. K. Väänänen¹

¹Institute of Biomedicine, Department of Anatomy, University of Turku, Turku, Finland

P357-Tu TRANSMIGRATION, A NEW PROPERTY OF MATURE OSTEOCLASTS, IS DEPENDENT ON C-SRC, MMPS AND IS REGULATED BY RISEDRONATE.

E. Bonnelye¹, F. Saltel¹, A. Chabadel¹, M. Lafage Proust², P. Jurdic¹

¹Laboratoire de Biologie Moleculaire et Cellulaire, CNRS5161 ENS Ecole Normale Superieure de Lyon, Lyon, ² Faculté de Médecine, INSERM E366, Saint Etienne, France

P358-Su CONSTITUTIVE EXPRESSION OF SPARUS AURATA OSTEOCALCIN IN A CHONDROCYTIC-LIKE (VSA13) AND OSTEOBLASTIC-LIKE CELL LINE (VSA16): EFFECT ON MINERALIZATION RATE AND LEVELS OF CALCIFICATION-RELATED GENE EXPRESSION

S. M. P. Marques¹, D. C. Simes¹, S. I. Cavaco¹, M. L. Cancela¹

¹CCMAR, Universidade do Algarve, Faro, Portugal

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Osteoclasts : Cytokines and Growth Factors - P359 - P363

P359-Mo GENE EXPRESSION OF MONOCYTES AFTER EXPOSURE TO METAL IONS

K. Jost-Albrecht¹, J. Portenier¹, W. Hofstetter¹

¹Department Clinical Research, Group for Bone Biology, University of Berne, Berne, Switzerland

P360-Tu RANKL ACTS UPSTREAM OF CASPASES TO PREVENT BISPHOSPHONATE-INDUCED OSTEOCLAST APOPTOSIS IN VITRO

K. A. McConachie¹, H. L. Rogers¹, M. J. Rogers¹

¹Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom

P361-Su TUMOR NECROSIS FACTOR-ALPHA AND VITAMIN D TOGETHER INHIBIT THE DEVELOPMENT OF OSTEOCLASTS IN VITRO

R. Balga¹, J. Portenier¹, C. Mueller², W. Hofstetter¹

¹Group for Bone Biology, Department Clinical Research, ²Institute for Pathology, University of Berne, Berne, Switzerland

P363-Tu THE CHEMOKINE CCL-9 IS HIGHLY EXPRESSED BY DIFFERENTIATING OSTEOCLASTS IN VIVO AND PROMOTES OSTEOCLASTOGENESIS IN VITRO

M. Yang¹, C. A. MacKay¹, A. Mason-Savas¹, J. Aubin¹, P. R. Odgren¹

¹Cell Biology, University of Massachusetts Medical School, Worcester, United States

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Osteoclasts : Differentiation - P364 - P368

P364-Su CHARACTERIZATION OF THE GREY-LETHAL PROTEIN AND ITS ROLE IN OSTEOCLAST MATURATION AND ACTIVATION

J. Beauregard¹, M. Pata², J. Vacher²

¹Cellular Interactions and Development, ²Cellular interactions and Development, Clinical Research Institute of Montreal, Montreal, Canada

P366-Tu EFFECT OF PPAR AGONISTS, ON HUMAN OSTEOCLAST FORMATION AND ACTIVITY IN VITRO

B. Y. Y. Chan¹, K. A. Buckley², P. J. Wilson², N. Wherly¹, J. Y. Cheng¹, J. P. Dillon², A. Gartland¹, W. D. Fraser¹, J. A. Gallagher²

¹Department of Clinical Chemistry, ²Human Bone Cell Research Group, Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool, United Kingdom

P367-Su APOPTOTIC OSTEOCYTES SUPPORT OSTEOCLASTOGENESIS

G. Kogianni¹, V. Mann¹, H. A. H. Simpson¹, B. S. Noble¹

¹Scottish Mechanotransduction Consortium and Musculoskeletal Research Unit, University of Edinburgh, Edinburgh, United Kingdom

P368-Mo IDENTIFICATION OF THE GENES DIFFERENTIALLY EXPRESSED IN HUMAN OSTEOCLASTS, DENDRITIC CELLS, ENDOTHELIAL CELLS AND MACROPHAGES FROM A COMMON PRECURSOR BY MICROARRRAY ANALYSIS

H. J. Vuorikoski¹, M. Husheem¹, M. E. Rönnemaa¹, T. A. Hentunen¹, K. H. Väänänen¹

¹Anatomy, Biomedicine, University of Turku, Turku, Finland

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Osteoclasts : Inhibition of Resorption - P369 - P385

P369-Tu PHYSIOLOGICAL ROLE OF MELATONIN IN THE SCALE OF TELEOST

N. Suzuki¹, S. Yashima², S. Iwamuro², A. Hattori³

¹Noto Marine Laboratory, Kanazawa University, Ishikawa, ²Biology, Toho University, ³Biology, Tokyo Medical and Dental University, Chiba, Japan

P370-Su SIRNAS DESIGNED BY SIRNA_PROFILE TO SILENCE HUMAN TARTRATE RESISTANT ACID PHOSPHATASE

P. Muhonen¹, A. Seppänen¹, K. Buki¹, H. K. Väänänen¹

¹Department of Anatomy, Institution of Biomedicine, University of Turku, Turku, Finland

P371-Mo CYTOSOLIC ENTRY OF BISPHOSPHONATES INTO MACROPHAGES AND OSTEOCLASTS REQUIRES FLUID-PHASE ENDOCYTOSIS AND ENDOSOMAL ACIDIFICATION

K. Thompson¹, F. P. Coxon¹, D. M. Scheven¹, M. J. Rogers¹, J. C. Crockett¹

¹Bone Research Group, University of Aberdeen, Aberdeen, United Kingdom

P372-Tu INITIATION OF BONE RESORPTION REGULATED BY MECHANICALLY DAMAGED OSTEOCYTES

K. Kurata¹, H. Higaki²

¹Department of Biorobotics, Faculty of Engineering, ²Department of Mechanical Engineering, Faculty of Engineering, Kyushu Sangyo University, Fukuoka, Japan

P373-Su RISEDRONATE AND OTHER NITROGEN-CONTAINING BISPHOSPHONATES ARE EFFICIENTLY INTERNALISED FROM MINERALISED SURFACES BY OSTEOCLASTS, BUT NOT OTHER CELL TYPES, IN VITRO AND IN VIVO

F. P. Coxon¹, K. Thompson¹, A. Hughes¹, F. H. Ebetino², M. J. Rogers¹

¹Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom, ²Health Care Research Center, Procter and Gamble Pharmaceuticals, Mason, United States

P374-Mo CONTINUOUS SUPPRESSION OF TARTRATE-RESISTANT ACID PHOSPHATASE ISOFORM 5B (REFLECTING OSTEOCLAST ACTIVITY) IN PATIENTS WITH MULTIPLE MYELOMA RECEIVING BISPHOSPHONATE TREATMENT

M. Koenigsmann¹, K. Scheinpflug¹, K. Jentsch-Ullrich¹, G. Redemann¹, A. Lux², A. Franke¹

¹Hematology and Oncology, ²Institute for Biometry and Medical Informatics, University Hospital Magdeburg, Magdeburg, Germany

P375-Tu OSTEOCLASTS FROM GUNMETAL MICE ARE DEFECTIVE IN RAB PRENYLATION BUT NOT IN BONE RESORPTION

F. P. Coxon¹, A. Taylor¹, E. H. Mules², M. C. Seabra², M. J. Rogers¹

¹Medicine and Therapeutics, University of Aberdeen, Aberdeen, ²Cell and Molecular Biology, Imperial College, London, United Kingdom

P376-Su ESTROGEN AND TESTOSTERONE USE DIFFERENT CELLULAR PATHWAYS TO INHIBIT OSTEOCLASTOGENESIS AND BONE RESORPTION

T. A. Hentunen¹, H. Michael¹, P. L. Härkönen², K. Väänänen¹

¹Anatomy, University of Turku, Institute of Biomedicine, Turku, Finland, ²Laboratory Medicine, Lund University, MAS University Hospital, Lund, Sweden

P377-Mo ZOLEDRONIC ACID TREATMENT ENHANCES HARD CALLUS FORMATION WITHOUT DELAYING ENDOCHONDRAL REPAIR IN A RAT FRACTURE MODEL

M. McDonald¹, S. Dulai¹, C. Godfrey¹, B. Hamilton¹, D. G. Little¹

¹Orthopaedic Research Department, The Children's Hospital Westmead, Westmead, Australia

P378-Tu CHARACTERIZATION OF DRAK1 IN OSTEOCLASTS BY FLUORESCENCE MICROSCOPY

J. Vääräniemi¹, T. Uemura², H. Kojima²

¹ADRC, AIST , Japan, University of Turku , Finland, ²ADRC, AIST, Tsukuba, Japan

P379-Su INDEPENDENT PATHWAYS IN THE MODULATION OF OSTEOCLASTIC RESORPTION BY INTERMEDIATES OF THE MEVALONATE BIOSYNTHETIC PATHWAY: THE ROLE OF THE RETINOIC ACID RECEPTOR

E. R. Van Beek¹, M. Karperien¹, C. W. G. M. Lowik¹, S. E. Papapoulos¹

¹Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, Netherlands

P380-Mo MODIFICATIONS TO THE PHOSPHONATE GROUPS OF BISPHOSPHONATES AFFECTS THEIR POTENCY AND TARGET ENZYME SPECIFICITY

J. Rojas Navea¹, M. J. Rogers¹, F. H. Ebetino², C. E. McKenna³, B. A. Kashemirov³, I. Mallard³, F. P. Coxon¹

¹Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom, ²Health Care Research Center, Procter and Gamble Pharmaceuticals, Mason, ³Dept. of Chemistry, University of Southern California, Los Angeles, United States

P381-Tu ENDOSTATIN INHIBITS VEGF-A INDUCED OSTEOCLASTIC BONE RESORPTION IN VITRO

A. Sipola¹, K. Malinen¹, T. Hautala², J. Ilvesaro¹, J. Tuukkanen¹

¹Anatomy and Cell Biology, ²Internal Medicine, University of Oulu, Oulu, Finland

P382-Su DISSOLUTION OF THE INORGANIC PHASE OF BONE IS IMPORTANT FOR OSTEOCLAST SURVIVAL AND THE NORMAL COUPLING OF BONE FORMATION TO BONE RESORPTION

M. A. Karsdal¹, R. H. Nielsen¹, M. G. Soerensen¹, J. Gram², C. Christiansen³, M. H. Dziegiel⁴, S. Schaller¹, J. Bollerslev⁵, K. Henriksen¹

¹Pharmacology, Nordic Bioscience, Herlev, ²Medical Endocrinology, Ribe County Hospital, Esbjerg, ³Centre for Clinical and Basic Research, CCBR, Ballerup, ⁴HS Blodbank, Rigshospitalet, Copenhagen, Denmark, ⁵Department of Medical Endocrinology, National University Hospital, Oslo, Norway

P383-Mo THE USE OF HYDROXYAPATITE COLUMN CHROMATOGRAPHY AS A NOVEL METHOD TO REVEAL DIFFERENCES IN RELATIVE BINDING AFFINITIES OF BISPHOSPHONATES

M. A. Lawson¹, J. T. Triffitt¹, F. H. Ebetino², R. J. Phipps², D. J. White², R. G. G. Russell¹

¹Institute of Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²New Drug Development, Procter and Gamble Pharmaceuticals, Mason OH, United States

P384-Tu OSTEOCLAST FUNCTION RELIES ON RAFT-DEPENDENT VESICLE TRAFFICKING BETWEEN THE RUFFLED BORDER AND THE FUNCTIONAL SECRETORY DOMAIN

M. T. K. Mulari¹, M. Nars¹, T. Kaisto², K. Metsikkö², T. Laitala-Leinonen¹, K. Väänänen¹

¹Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, ²Department of Cell Biology and Anatomy, University of Oulu, Oulu, Finland

P385-Su INHIBITORY EFFECT OF RIBBON TYPE NFKB DECOY DEOXYOLIGONUCLEOTIDES ON OSTEOCLAST INDUCTION AND ACTIVITY

Y. KUNUGIZA¹, T. Tomita¹, N. Tomita², T. Kizawa¹, R. Morishita², H. Yoshikawa¹

¹Orthopaedic Surgery, ²Clinical Gene Therapy, Osaka University, Osaka, Japan

index

Osteoclasts : Isolation and Lineage - P386

P386-Mo STEMPRO34 MEDIUM, IL-3, IL-6 AND STEM CELL FACTOR ENHANCE THE YIELD OF OSTEOCLAST PROGENITORS FROM HUMAN ADULT PERIPHERAL BLOOD

A. Cappariello², A. Del Fattore¹, B. Peruzzi¹, M. Longo¹, A. Ugazio², G. F. Bottazzo², A. C. Berardi², A. Teti¹

¹Experimental Medicine, University of L'Aquila, L'Aquila, ²Ospedale Bambino Gesù, Rome, Italy

index

Osteoclasts : Signal Transduction - P387 - P391

P387-Tu MECHANICALLY INDUCED OSTEOCYTE SIGNALS EXPLAIN MODELING AND REMODELING OF TISSUE STRUCTURE IN CORTICAL AND TRABECULAR BONE

R. Ruimerman¹, R. Van Oers¹, P. Hilbers¹, R. Huiskes¹

¹Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

P388-Su DAP12 AND THE FC-RECEPTOR GAMMA-CHAIN REGULATE OSTEOCLAST DIFFERENTIATION AND FUNCTION

A. Mocsai¹, M. Humphrey², J. A. G. Van Ziffle³, L. L. Lanier⁴, C. A. Lowell³, M. C. Nakamura²

¹Dept. of Physiology, Semmelweis University School of Medicine, Budapest, Hungary, ²Dept. of Medicine, ³Dept. of Laboratory Medicine, ⁴Dept. of Microbiology and Immunology, University of California, San Francisco, San Francisco, United States

P389-Mo BSP AND RANKL ACT SYNERGISTICALLY TO INDUCE OSTEOCLASTOGENESIS AND BONE RESORPTION

J. Chen¹, P. Valverde¹

¹General Dentistry, Tufts University School of Dental Medicine, Boston, United States

P390-Tu MODULATION OF MAPK SIGNALLING AND RHO GTPASE ACTIVATION IN OSTEOCLASTS BY PASTEURELLA MULTOCIDA TOXIN (PMT) RESULTS IN DIFFERENTIAL EFFECTS ON DIFFERENTIATION AND ACTIVATION OF MURINE AND HUMAN OSTEOCLASTS

N. W. A. McGowan¹, D. Harmey², J. E. Dunford³, M. J. Rogers³, A. E. Grigoriadis¹

¹Dept Craniofacial Development, King's College London, London, United Kingdom, ²The Burnham Institute, La Jolla, CA, United States, ³Bone Research Group, University of Aberdeen, Aberdeen, United Kingdom

P391-Su WHAT IS THE FUNCTION OF GLUTAMATE TRANSPORTER VARIANTS IN OSTEOCYTES?

D. Mason¹, J. Huggett¹, S. Daniels²

¹Connective Tissue Research laboratories, School of Biosciences, Cardiff University, ²Welsh School of Pharmacy, Cardiff University, Cardiff, United Kingdom

index

Osteoporosis Diagnosis : Bone Mineral Density - P392 - P415

P392-Mo FOREARM SINGLE X-RAY ABSORPTIOMETRY IN THE IDENTIFICATION OF POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS AT THE HIP AND SPINE: A CORRELATION STUDY

M. A. Boyanov¹

¹Endocrinology Clinic, Alexandrovska Hospital, Sofia, Bulgaria

P393-Tu PREVALENCE OF LOW CENTRAL BONE MINERAL DENSITY IN A BULGARIAN FEMALE REFERRAL POPULATION: A PILOT STUDY

M. A. Boyanov¹, V. G. Christov¹

¹Endocrinology Clinic, Alexandrovska Hospital, Sofia, Bulgaria

P394-Su PROTECTIVE EFFECT OF VITAMIN D3 ON METHYLPREDNISOLONE ACTAE INDUCED LOSS OF BONE METABOLISM MARKERS AND BONE MINERAL DENSITY IN THE LUMBAR SPINE OF RAT.

A. Sobhani¹, F. Moradi¹, P. Pasbakhsh¹, I. Ragerdi kashani¹

¹Dept. of Anatomy, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of)

P395-Mo DUAL-ENERGY X-RAY ABSORPTIOMETRIC IN VIVO BONE DENSITOMETRY -- BOON OR BETE NOIRE?

H. H. BOLOTIN¹

¹School of Medical Sciences, RMIT University, Bundoora, Australia

P396-Tu PREVENTING FRACTURES: AN INTEGRATED HOSPITAL SERVICE

G. P. R. Clunie¹, S. Stephenson¹, A. Clark¹

¹Rheumatology, The Ipswich Hospital NHS Trust, Ipswich, United Kingdom

P397-Su BMD AND FRACTURE RISK IN WOMEN STOPPING HRT

G. P. R. Clunie¹, A. Clark¹

¹Rheumatology, The Ipswich Hospital NHS Trust, Ipswich, United Kingdom

P398-Mo BONE MINERAL DENSITY FAILS TO PREDICT THE PRESENCE OF SIGNIFICANT VERTEBRAL DEFORMITIES IN TYPE 2 DIABETIC WOMEN

J. P. Sheehan¹, M. M. Ulchaker¹

¹Osteoporosis Diagnostic Center, North Coast Institute of Diabetes and Endocrinology, Inc., Westlake, United States

P399-Tu PQCT ACCURACY AND PREDICTION OF BONE STRENGTH AT THE DISTAL RADIUS

M. C. Ashe¹, K. M. Khan¹, P. Guy¹, H. A. McKay¹

¹Orthopaedic Engineering Family Practice, University of British Columbia, Vancouver, Canada

P400-Su BONE MINERAL DENSITY IN HEMODIALYSIS PATIENTS

T. Nakai¹, K. Masuhara², N. Kanbara³

¹Orthopaedic Suregery, Osaka Police Hospital, ²Orthopaedic Suregery, Osaka Kosei-nenkin Hospital, ³Internal Medicine, Kanbara Hospital, Osaka, Japan

P401-Mo THE IMPACT OF OBVIOUS VERTEBRAL DEGENERATIVE LESIONS ON THE DIAGNOSTIC VALUE OF BONE MINERAL DENSITY MEASUREMENTS

D. Hadjidakis¹, I. Androulakis¹, A. Mylonakis¹, A. Papaefstathiou¹, S. A. Raptis¹

¹2nd Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University, «Attikon» and «Evgenidion» University Hospitals, Athens, Greece

P402-Tu DISCREPANCIES BETWEEN INDIVIDUAL VERTEBRAL BONE MINERAL DENSITY VALUES IN HEALTHY MALES

A. Mylonakis¹, D. Hadjidakis¹, I. Androulakis¹, A. Papaefstathiou¹, S. A. Raptis¹

¹2nd Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, «Attikon» and «Evgenidion» University Hospitals, Athens University, Athens, Greece

P403-Su ASSESSMENT OF BONE MASS CHANGE BY DXA VS.DXR IN POSTMENOPAUSAL WOMEN TREATED WITH ALENDRONATE

C. Galesanu¹, R. G. Galesanu²

¹Endocrinology, University of Medicine and Pharmacy, ²Osteodensitometry, Centre of Imaging and Radiologic Diagnosis, IASI, Romania

P404-Mo EFFECTS OF TECHNOLOGY AND OPERATOR EXPERIENCE ON BONE DENSITOMETRY PRECISION ERROR

K. G. Faulkner¹, L. S. Weynand¹, H. S. Barden¹, W. K. Wacker¹

¹Product Development, GE Healthcare, Madison, United States

P405-Tu BONE MINERAL DENSITY MEASUREMENT IN CALCANEUS WITH DXA: PREVALENCE OF OSTEOPOROSIS IN FEMALE GENERAL POPULATION

J. L. Perez-Castrillon¹, J. C. Martin-Escudero¹, F. Perez-Fernandez¹, R. Lopez-Izquierdo¹, T. Alonso-Ares¹, I. Gonzalez-Manzano¹, I. Sanchez-Lite¹, J. Rodriguez-Nuñez¹, R. Perez-Martin¹, R. Frutos-Llanos¹

¹Medicine, University Hospital Rio Hortega, Valladolid, Spain

P406-Su IDENTIFICATION OF WOMEN WITH SPINE OR HIP OSTEOPOROSIS USING BONE MINERAL DENSITY AT THE CALCANEUS

J. L. Pérez-Castrillón¹, J. C. Martin-Escudero¹, J. Del Pino², M. Herrero-Baladron¹, R. Prado-Berrocal¹, M. Alegre-Climent¹, S. Otero¹, C. Burgos-Diaz¹

¹Medicine, University Hospital Rio Hortega, Valladolid, ²Medicine, Hospital Clínico, Salamanca, Spain

P407-Mo AN INVESTIGATION OF THE DIFFERENCES IN GEOMETRY OF PROXIMAL FEMUR ACCORDINDG TO SEXUALITY AND ITS RELATION TO FEMORAL BONE MINERAL DENSITY

S. Hepgüler¹, C. Ozturk¹, J. Oncu¹

¹Physical Medicine and Rehabilitation, Ege University, IZMIR, Turkey

P408-Tu HIP OR SPINE FOR DXA MEASUREMENT IN A CZECH POPULATION OVER AGE 65 - IS HIP BMD REALLY MORE SENSITIVE FOR DETECTION OF OSTEOPOROSIS?

P. Kasalicky¹, J. Rosa¹

¹Bone Metabolic Unit, DC MEDISCAN, Prague, Czech Republic

P409-Su COMPARISON BETWEEN LEFT AND RIGHT HIP DEXA MEASUREMENTS

G. T. Sakellariou¹, M. Arvanitakis², E. Spyropoulou¹, P. Tryfonidis¹, I. Chatzigiannis¹

¹Rheumatology, ²Radiology, St. Paul's Hospital, Thessaloniki, Greece

P410-Mo THE LATERAL DISTAL FEMUR: AND ALTERNATIVE DXA SITE FOR CHILDREN WITH CEREBRAL PALSY

H. H. Kecskemethy¹, H. T. Harcke², S. J. Bachrach³

¹Research, ²Medical Imaging, ³Pediatrics, A. I. duPont Hospital for Children, Wilmington, United States

P411-Tu DO ALL ELDERLY HIP FRACTUES HAVE OSTEOPOROSIS?

P. J. Ryan¹, K. O'Neill¹, G. Worcester¹

¹Osteoporosis Unit, Medway Maritime Hospital, Gillingham, United Kingdom

P412-Su COMPARISON OF THE LUNAR DPX-IQ AND PRODIGY DUAL ENERGY X-RAY ABSORPTIOMETERS IN ASSESSMENT OF TOTAL BODY COMPOSITION

P. Böhme¹, S. Jellimann¹, D. Quilliot¹, O. Ziegler¹

¹Diabetology and Nutrition, CHU Nancy, TOUL, France

P413-Mo THE IMPACT OF NICE GUIDANCE ON AN OSTEOPOROSIS SERVICE.

H. J. Veevers¹

¹Rheumatology, South Shore Hospital, Blackpool, United Kingdom

P414-Tu YOUNG NORMAL REFERENCE VALUES FOR DXA BMD IN EUROPEAN MEN AND WOMEN. RESULTS FROM THE NETWORK FOR MALE OSTEOPOROSIS (NEMO) STUDY.

S. Kaptoge¹, . J. A. Da Silva², . J. M. Kaufman³, . J. Reeve⁴, . NEMO Study Group⁵

¹Medicine, University of Cambridge, Cambridge, United Kingdom, ², Clinica Reumatologica, Coimbra, Portugal, ³, University Hospital, Ghent, Belgium, ⁴, University of Cambridge, Cambridge, ⁵, , United Kingdom

P415-Su BLOOD PRESSURE AND BMD IN A SPANISH EARLY POSTMENOPAUSAL WOMEN POPULATION

J. A. Blázquez¹, L. L. Navarro², F. F. Mateos¹, M. M. Cháfer², J. J. Del Pino³

¹Internal Medicine, ²Clinical Chemistry, University Hospital, Albacete, ³Medicine, University Hospital, Salamanca, Spain

index

Osteoporosis Diagnosis : Bone Structure - P416 - P434

P416-Mo VOLUMETRIC SPATIAL DECOMPOSITION OF TRABECULAR BONE – A NEW METHOD FOR LOCAL BONE MORPHOMETRY

M. Stauber¹, R. Müller¹

¹Institute for Biomechanical Engineering, Swiss Federal Institute of Technology, ETH and University of Zürich, Zürich, Switzerland

P417-Tu DISSOCIATION BETWEEN TIBIA STRESS-STRAIN INDEXES (RESISTOMETRY) WITH BONE MINERAL CONTENT (DENSITOMETRY). EXAMPLE-CASES REVEALED WITH A PQCT SYSTEM

E. J. A. Roldan¹, R. Capiglioni², A. Aymond², G. Tubert², R. Guelman², V. E. Montangero¹

¹Scientific Direction, Gador SA, ²Department of Musculoskeletal Research, Institute of Neurobiology -IDNEU-, Buenos Aires, Argentina

P418-Su ELECTRON MICROSCOPY FOR INVESTIGATION OF ORDER/DISORDER IN BONE STRUCTURE.

E. I. Suvorova¹, P. P. Petrenko², P. A. Buffat³

¹Russian Academy of Sciences, Institute of Crystallography, Moscow, ²Russian Academy of Sciences, 2Research Institute of Traumatology and Orthopaedics, Novosibirsk, Russian Federation, ³EPFL, CIME, Lausanne, Switzerland

P419-Mo BONE QUALITY OF THE 3RD PHALANX ASSESSED BY TWO DIFFERENT ULTRASOUND DEVICES - THE OMNISENSE AND THE DBM SONIC 1200.

O. Rintek Madsen¹, C. Suetta², O. H. Sørensen³, C. Egsmose²

¹Dept. of Rheumatology, Gentofte University Hospital, ²Dept. of Rheumatology, Bispebjerg University Hospital, ³Osteoporosis Research Centre, Hvidovre University Hospital, Copenhagen, Denmark

P420-Tu "XTREMECT" A NEW DIMENSION IN BONE MICRO ARCHITECTURE EVALUATION IN VIVO IN HUMANS

M. Dambacher¹, M. Neff², S. Hämmerle³, R. Rizzoli⁴, P. Delmas⁵, L. Qin⁶

¹Rheumatology and Rehabilitation, University Clinic Balgrist, ²Osteoporosis analysis, Center for Osteoporosis, ³Biomedical Engineering, University of Zürich, Zürich, ⁴Internal Medicine, Universitiy Hospital, Geneva, Switzerland, ⁵Bone Diseases, Hopital E. Herriot, Lyon, France, ⁶Orthopaedics and Traumatology, Chinese University, Hong Kong, Region of China

P421-Su MULTI-DETECTOR-ROW CT IMAGING OF VERTEBRAL MICROSTRUCTURE FOR EVALUATION OF FRACTURE RISK

M. Ito¹, K. Ikeda², M. Nishiguchi³, T. Hosoi⁴, H. Orimo⁵

¹Radiology, Nagasaki University, Nagasaki, ²Bone and Joint Disease, The Research Institute, National Center for Geriatrics and Gerontology, Obu, ³Orthopedic Surgery, Zeshin-kai Hospital, Nagasaki, ⁴Internal Medicine, Tokyo Metropolitan Institute of Gerontology and Geriatric Hospital, ⁵Internal Medicine, Health Science University, Tokyo, Japan

P422-Mo SEVERITY OF VERTEBRAL FRACTURE REFLECTS DETERIORATION OF TRABECULAR BONE MICROARCHITECTURE

J. San Martin¹, P. Chen¹, H. K. Genant², Y. Jiang³, P. Delmas⁴, G. P. Dalsky¹, E. F. Eriksen¹

¹Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, ²Osteoporosis and Arthritis Research Group, University of California and Synarc, ³Osteoporosis and Arthritis Research Group, University of California, San Francisco, San Francisco, United States, ⁴Claude Bernard University, INSERM Research Unit 403, Lyon, France

P423-Tu AGE-RELATED CHANGES IN VOLUMETRIC BONE MINERAL DENSITY AND FEMORAL NECK GEOMETRY

J. A. Riancho¹, C. Valero¹, J. L. Hernandez¹, A. L. Zarrabeitia¹, M. T. Zarrabeitia², N. Peña³, J. Gonzalez-Macias¹

¹Internal Medicine, Hospital U.M. Valdecilla, University of Cantabria, ²Legal Medicine, University of Cantabria, ³Medicine, Residencia de Mayores, Santander, Spain

P424-Su PRECISE ALIGNMENT OF MURINE FEMORA IS MANDATORY FOR ACCURATE ASSESSMENT OF BONE STRENGTH

H. van Lenthe¹, R. Voide¹, R. Müller¹

¹Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland

P425-Mo DETECTION OF TRABECULAR DISCONTINUITIES IN THE CT IMAGES OF TRABECULAR BONE.

Z. Tabor¹, E. Rokita¹

¹Departhemt of Biophysics, Jagiellonian University, Cracow, Poland

P426-Tu AN EFFICIENT FINITE ELEMENT MODEL FOR ACCURATE PREDICTION OF TRABECULAR BONE MECHANICAL PROPERTIES IN MAN

H. van Lenthe¹, M. Stauber¹, R. Müller¹

¹Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland

P427-Su COMBINING BONE SHAPE, DENSITY AND TRABECULAR STRUCTURE TO IMPROVE IDENTIFICATION OF HIP FRACTURE: A PILOT STUDY.

J. S. Gregory¹, A. Stewart², P. E. Undrill³, D. M. Reid², R. M. Aspden¹

¹Department of Orthopaedics, ²Department of Medicine and Theraputics, ³Department of Biomedical Physics and Bioengineering, University of Aberdeen, Aberdeen, United Kingdom

P428-Mo COMPARISON OF MEASURES OF COMPLEXITY DERIVED FROM PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY IMAGES WITH STATIC HISTOMORPHOMETRY AND WITH BONE STRENGTH PERFORMED ON HUMAN LUMBAR VERTEBRAL BODIES

J. S. Thomsen¹, P. Saparin², G. Beller³, W. Gowin⁴

¹Department of Connective Tissue Biology, University of Aarhus, Århus, Denmark, ²Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, ³Center of Muscle and Bone Research, Charité – University Medicine Berlin, Campus Benjamin Franklin, ⁴, Berlin, Germany

P429-Tu BIOMECHANICAL ANALYSIS OF PQCT INDICATORS OF BONE HEALTH IN FOREARMS AND LEGS OF 200 NORMAL MEN AND PRE- AND POST-MENOPAUSAL WOMEN

R. F. Capozza¹, G. R. Cointry¹, S. E. Ferretti¹, S. Feldman¹, N. M. Fracalossi¹, M. Morosano², A. Massoni², R. Tozzini², J. L. Ferretti¹

¹Center for P-Ca Metabolism Studies, ²Internal Medicine, Faculty of Medicine, Rosario, Argentina

P430-Su INTERRELATIONSHIPS BETWEEN PQCT-ASSESSED INDICATORS OF BONE MASS, GEOMETRY OR STRENGTH AND MUSCLE STRENGTH IN FOREARMS AND LEGS OF NORMAL, HEALTHY ADULTS

R. F. Capozza¹, G. R. Cointry¹, S. E. Ferretti¹, S. Feldman¹, N. M. Fracalossi¹, P. Reina¹, M. V. Ferretti¹, M. C. Ferullo¹, G. Marchetti¹, J. L. Ferretti¹

¹Center for P-Ca Metabolism Studies, Faculty of Medicine, Rosario, Argentina

P431-Mo GENDER-RELATED DIFFERENCES AND POST-MENOPAUSAL CHANGES IN THE CROSS-SECTIONAL DISTRIBUTION OF PQCT-ASSESSED VBMD OF RADIAL AND TIBIAL DIAPHYSEAL BONE IN HEALTHY ADULTS

G. R. Cointry¹, R. F. Capozza¹, S. Feldman¹, N. M. Fracalossi¹, S. E. Ferretti¹, P. Reina¹, M. V. Ferretti¹, M. C. Ferullo¹, G. Marchetti¹, J. L. Ferretti¹

¹Center for P-Ca Metabolism Studies, Faculty of Medicine, Rosario, Argentina

P432-Tu INTERRELATIONSHIPS BETWEEN PQCT INDICATORS OF CORTICAL BONE VOLUMETRIC DENSITY (VBMD) AND CROSS-SECTIONAL GEOMETRY (DISTRIBUTION/QUALITY CURVES) IN RADII AND TIBIAE OF NORMAL ADULTS

G. R. Cointry¹, R. F. Capozza¹, S. Feldman¹, N. M. Fracalossi¹, S. E. Ferretti¹, P. Reina¹, M. V. Ferretti¹, M. C. Ferullo¹, G. Marchetti¹, J. L. Ferretti¹

¹Center for P-Ca Metabolism Studies, Faculty of Medicine, Rosario, Argentina

P433-Su ASSESSMENT OF THE MICROSTRUCTURE OF HUMAN VERTEBRAE USING VOLUME CT: A FEASIBILITY STUDY

C. Graeff¹, V. Rasche², T. Istel², R. Koppe², W. Timm¹, C. C. Glueer¹

¹Medical Physics, University Clinic Schleswig-Holstein, Kiel, ²Philips Research Laboratories, Hamburg, Germany

P434-Mo PHYSICOCHEMICAL PROPERTIES OF TRABECULAR BONE IN INTRACAPSULAR FRACTURED HIPS: ANALYSIS OF THE DIFFERENT TYPES OF ALTERATIONS AND THEIR DISTRIBUTION BY RAMAN SPECTROSCOPY.

S. Dapia¹, J. Caeiro Rey², E. Vazquez-Fernandez³, P. Carpintero⁴, A. Oteo⁵, M. Blanco-Ramos⁶

¹Innova Auria S.L., Institute of Design and Development of Health Technological Applications, S. Cibrao das Viñas, ²Servicio de Cirugía Ortopédica y Traumatología, Complexo Hospitalario de Ourense, Ourense, ³Unidad de Espectroscopía IR-Raman, RIAIDT, Santiago de Compostela, ⁴Servicio de Traumatologia, Hospital Reina Sofia, Cordoba, ⁵Servicio de Traumatologia, Hospital Virgen de La Torre, Madrid, ⁶Unidad de Investigacion Atencion Primaria, Complexo Hospitalario de Ourense, Ourense, Spain

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Osteoporosis Diagnosis : Markers - P435 - P450

P435-Tu SIGNIFICANCE OF OSTEOPROTEGERIN, OB-RE AND TRAP FOR PREDICTION OF BONE DENSITY

D. Stejskal¹

¹Laboratory Medcicine, Hospital Sternberk, Sternberl, Czech Republic

P436-Su OSTEOPROTEGERIN RELATES TO BONE MARKERS DURING OSTEOPOROSIS TREATMENT

V. Kusec¹, D. Besic², D. Krpan³

¹Clinical institute of laboratory diagnosis, Clinical Hospital Centre Zagreb, ²Dept rheumatolgy and rehabilitation, ³Department of Internal Medicine, General Hospital Sv Duh, Zagreb, Croatia

P437-Mo IMMOBILITY IS ASSOCIATED WITH HIGH BONE TURNOVER IN THE FRAIL ELDERLY

C. N. Chen¹, P. Sambrook¹, L. March¹, I. Cameron², R. Cumming³, J. Simpson³, M. Seibel⁴

¹Institute of Bone and Joint Research, Royal North Shore Hospital, ²Rehabilitation Studies Unit, ³School of Public Health, ⁴ANZAC Research Institute, University of Sydney, Sydney, Australia

P438-Tu RANDOM CALCIUM/CREATININE RATIO VS 24-HOUR URINARY CALCIUM OUTPUT IN THE ASSESSMENT OF PATIENTS WITH METABOLIC BONE DISEASE (MBD)

A. I. Al-Bahrani¹, W. D. Fraser¹

¹Clinical Biochemistry, The Royal Liverpool and Broadgreen University Hospital, Liverpool, United Kingdom

P439-Su NTX IN 500 PATIENTS IN CLINICAL PRACTICE

P. J. Ryan¹

¹Osteoporosis Unit, Medway Maritime Hospital, Gillungham, United Kingdom

P440-Mo REFERENCE INTERVAL OF SERUM TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5B ACTIVITY WITH A NOVEL ASSAY OF JAPANESE SUBJECTS

Y. Nishizawa¹, M. Inaba¹, M. Ishii², H. Yamashita³, T. Miki⁴, H. Goto¹, O. Chaki⁵, K. Kurasawa⁵, Y. Mochizuki⁶

¹Internal Medicine Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, ²Orthopedics, Yoro Orthopedic Clinic, Gifu, ³, Noguchi Thyroid Clinic and Hospital Foundation, Oita, ⁴Geriatric Medicine, Osaka City University Graduate School of Medicine, Osaka, ⁵Obstetrics and Gynecology, Yokohama City University School of Medicine, Kanagawa, ⁶Obstetrics and Gynecology, Dokkyo University School of Medicine, Tochigi, Japan

P441-Tu IS THERE ANY RELATION BETWEEN OSTEOPOROSIS AND C-REACTIVE PROTEIN IN ELDERLY PATIENTS?

D. Dede¹, M. Halil², M. Cankurtaran², B. Yavuz², Z. Ulger¹, N. Ozkayar¹, S. Ariogul²

¹Department of Internal Medicine, Hacettepe University, Faculty of Medicine, ²Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Division of Geriatric Medicine, Ankara, Turkey

P442-Su DAY-TO-DAY AND DIURNAL VARIATIONS OF SERUM TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5B WITH NEWLY DEVELOPED TRAP5B KIT AND THEIR COMPARISON TO OTHER BONE RESORPTION MARKERS

Y. Mochizuki¹, Y. Nishizawa², A. Oishi¹, R. Otsu¹, Y. Igarashi³, T. Miura⁴, N. Inaba¹

¹Obsterics and Gynecology, Dokkyo University School of Medicine, Tochigi, ²Internal Medicine Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, ³Basic Medicine, Dokkyo University School of Medicine, Tochigi, ⁴Biochemical Laboratory, Nitto Boseki Co., Ltd., Fukushima, Japan

P443-Mo DYNAMIC OF BONE TURNOVER MARKERS IN CHRONIC DIABETIC CHARCOT NEUROARTHROPATHY

A. P. Shepelekevich¹, Z. V. Zabarovskaya¹, D. I. Romeiko², J. V. Tolkachev³

¹Endocrinology, Belarusian State Medical University, ²Endocrinology, Minsk-city endocrinology center, ³Radiology, Republic Reabilitation Clinical Hospital, Minsk, Belarus

P444-Tu BIOCHEMICAL MARKERS OF BONE TURNOVER AND RESPONSE OF BONE MINERAL DENSITY TO MENOPAUSE IN SAUDI WOMEN

M. M. Ardawi¹, T. M. Bahksh², H. A. N. Nasrat³, A. A. Maimani⁴, A. Y. Syamik⁵

¹Clinical Biochemistry, King Abdulaziz University Hospital, Faculty of Medicine,Saudi Osteoporosis Research Group, ²Surgery, King Abdulaziz University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, ³Obtetrics and Gynecology, King Abdulaziz University Hospital, Saudi Osteoporosis Research Group, ⁴Radiology, ⁵Physiology, King Abdulaziz University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, Jeddah, Saudi Arabia

P445-Su THE NEWLY-DEVELOPED BONE SPECIFIC TARTRATE-RESISTANT ACID PHOSPHATASE (TRAP5B) KIT IS USEFUL FOR THE MONITORING OF BONE METABOLIC CHANGES BY OSTEOPOROSIS TREATMENT WITH RISEDRONATE

T. Miki¹, H. Naka¹, H. Masaki¹, T. Koumo², Y. Tomiyoshi¹, Y. Imanishi², M. Inaba², Y. Nishizawa²

¹Geriatric Medicine, ²Internal Medicine Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan

P446-Mo BONETRAP® ASSAY: A ROUTINE DIAGNOSTIC IMMUNOASSAY FOR THE QUANTITATIVE DETERMINATION OF TARTRATE-RESISTANT ACID PHOSPHATASE 5B (TRACP 5B) ACTIVITY IN HUMAN SERA

B. I. Schenk¹, M. Radtke¹, D. Franke¹

¹Diagnostik, medac GmbH, Wedel, Germany

P447-Tu FOUR MOLECULAR MARKERS FOR ASSESSMENT OF BONE METABOLISM

A. Tamm¹, S. Leedo², K. Rohtla³, M. Keps²

¹Laboratory Medicine, University of Tartu, ²United Labs, Clinicum of the University, ³Lab. Medicine, University of Tartu, Tartu, Estonia

P448-Su BONE MARKERS AND BLOOD PRESSURE RELATIONSHIP IN EARLY POSTMENOPAUSAL WOMEN

L. Navarro¹, J. A. Blazquez², M. Cháfer¹, F. Mateos², J. Del Pino³

¹Clinical Chemistry, ²Internal Medicine, University Hospital, Albacete, ³Medicine, University Hospital, Salamanca, Spain

P449-Mo BONE ALP LEVEL IS ASSOCIATED WITH AORTIC CALCIFICATION

K. Iba¹, J. Takada¹, N. Hatakeyama¹, T. Yamashita¹

¹Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan

P450-Tu URINARY GAMMA-GLUTAMYL TRANSPEPTIDASE ACTIVITY MEASUREMENT IS USEFUL AS A NOVEL BIOCHEMICAL MARKER OF BONE TURNOVER

I. Kodama¹, M. Sanada², M. Tsuda², Y. Kudo²

¹Obstetrics and Gynecology, Graduate School of Biomedical Sciences, ²Obstetrics and Gynecology Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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Osteoporosis Diagnosis : Miscellaneous - P451 - P458

P451-Su RELATION OF HOMOCYSTEINE, BIOCHEMICAL BONE MARKERS AND BONE MINERAL DENSITY IN PERI- AND POSTMENOPAUSAL WOMEN

M. Herrmann¹, M. Kränzlin², G. Pape¹, M. Sand-Hill¹, W. Herrmann¹

¹Abteilung für Klinische Chemie und Laboratoriumsmedizin - Zentrallabor, Universitätsklinikum des Saarlandes, Homburg - Saar, Germany, ²Abteilung für Endokrinologie, Diabetologie und klinische Ernährung, Kantonsspital Basel, Basel, Switzerland

P452-Mo THE ASSESSMENT OF PROCESS FACTORS INVOLVED IN CONDUCTING THE CANADIAN QUALITY CIRCLE (CQC) PILOT PROJECT FOR THE CARE OF PATIENTS AT RISK FOR OSTEOPOROSIS (OP)

B. Kvern¹, G. Ioannidis², A. Papaioannou², A. Hodsman³, D. Johnstone⁴, C. Crowley⁵, A. Baldwin⁶, M. Doupe⁶, L. Salach⁷, S. Glezer⁸, J. D. Adachi²

¹Family Medicine, University of Manitoba, Winnipeg, ²Medicine, McMaster University, Hamilton, ³Medicine, University of Western Ontario, London, ⁴National Professional Relations Manager, ⁵Medical and Technical Affairs, Procter and Gamble Pharmaceuticals, Toronto, ⁶Primary Health Care Research Unit, University of Manitoba, Winnipeg, ⁷Research and Professional Development, Ontario College of Family Physicians, Toronto, ⁸Therapeutic Group Leader, Aventis Pharma, Laval, Canada

P453-Tu CONTRIBUTION OF THE NEW METHOD OF LATERAL VERTEBRAL ASSESSMENT (LVA) BY DUAL X-RAY ABSORPTIOMETRY (DXA) IN THE DETECTION OF VERTEBRAL FRACTURES.

A. C. Melazzi¹, M. B. Fernandes¹, P. G. S. Lacativa¹, G. S. Leite¹, L. H. Gregorio¹, L. A. T. Russo¹

¹Osteoporosis, Center for Clinical and Basic Research - CCBR Brasil, Rio de Janeiro, Brazil

P454-Su HISTORY OF FRACTURES AND MECHANISM OF FRACTURE: AN EASY WAY TO IDENTIFY PATIENTS WITH POSSIBLE OSTEOPOROSIS

C. Garcés¹, J. Del Pino², J. L. Pérez-Castrillón³, J. A. Blázquez⁴, J. A. Riancho⁵, J. García-Aparicio⁶, L. Quiroga⁷, Á. Valero¹, P. Polavieja¹

¹Osteoporosis, Lilly, Madrid, ²Internal Medicine, Hospital Clínico, Salamanca, ³Internal Medicine, Hospital Río Hortega, Valladolid, ⁴Internal Medicine, Hospital General, Albacete, ⁵Internal Medicine, Hospital Valdecilla, Santander, ⁶Internal Medicine, Hospital Cee, La Coruña, ⁷Internal Medicine, Hospital Montes de San Isidro, León, Spain

P455-Mo INSTANT VERTEBRAL ASSESSMENT (IVA) IN CASE-FINDING FOR OSTEOPOROSIS IN PATIENTS OF 50 YEARS AND OLDER WITH A RECENT FRACTURE

N. O. Kuchuk¹, D. Uyl den¹, J. H. Smit², F. C. Bakker³, J. C. Roos⁴, J. Burcksen⁴, P. Lips¹

¹Endocrinology, ²Sociology and Social Gerontology, ³Surgery, ⁴Radiology, VU University Medical Centre, Amsterdam, Netherlands

P456-Tu EVALUATION OF CA-41 AS A NEW ISOTOPIC TOOL TO ASSESS THE IMPACT OF INTERVENTIONS ON BONE HEALTH

E. Denk¹, T. Walczyk¹, D. J. Hillegonds², J. Vogel², H. Synal³, C. Geppert⁴, K. Wendt⁴, K. Cashman⁵, M. Harrington¹, H. Häuselmann⁶, K. Fattinger⁷, R. F. Hurrell¹

¹Institute of Food Science and Nutrition, ETH Zurich, Zurich, Switzerland, ²Lawrence Livermore National Laboratory, Center for Accelerator Mass Spectrometry, Livermore, United States, ³Laboratory of Particle Physics, ETH Zurich, Zurich, Switzerland, ⁴Institute for Physics, University of Mainz, Mainz, Germany, ⁵Department of Food Science and Technology, University College, Cork, Ireland, ⁶Centre of Rheumatology and Bone Diseases, Klinik Im Park, ⁷Department for Internal Medicine, University Hospital Zurich, Zurich, Switzerland

P457-Su LDL-CHOLESTEROL, TRIGLICERYDES, HDL-CHOLESTEROL AND BONE DENSITY (QUS) IN POSTMENOPAUSAL WOMEN

J. M. Radosavljevic¹, B. J. Kovacev¹, M. K. Medic-Stojanoska¹, M. J. Djeric², I. A. Bajkin¹

¹Clinic of endocrinology, diabetes and metabolic disorders, Institute for internal medicine, Clinical centre, ²Institute for laboratory medicine, Clinical centre, Novi Sad, Yugoslavia

P458-Mo ARE PLASMA LEPTIN LEVELS PREDICTIVE FOR THE BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN?

C. Poiana¹, C. Cucu¹, A. M. Stefanescu², L. Stoian²

¹Endocrinology, Carol Davila University of Medicine, ²Endocrinology, "C.I.Parhon" Institute of Endocrinology, Bucharest, Romania

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Osteoporosis Diagnosis : Ultrasound - P459 - P467

P459-Tu QUANTITATIVE ULTRASOUND AT THE HAND PHALANGES IN 2850 FEMALES AGED 7-77 YEARS: A CROSS-SECTIONAL STUDY

B. Drozdzowska¹, W. Pluskiewicz², Z. Halaba³, H. Misiolek⁴, B. Beck⁵

¹Department and Chair of Pathomorphology, ²Metabolic Bone Diseases Unit, Department and Clinic of Internal Diseases, Diabetology and Nephrology, Silesian School of Medicine in Katowice, ³Outpatient Medical Care, NZOZ "Nasza Rodzina", ⁴Department of Anesthesiology and Intensive Care, ⁵Department of Biochemistry, Silesian School of Medicine in Katowice, Zabrze, Poland

P460-Su BONE MINERAL DENSITY LOSS AND BACK PAIN SYMPTOMS IN PREGNANCY

W. W. K. To¹, M. W. N. Wong²

¹Dept of Obstetrics and Gynaecology, United Christian Hospital, ²Dept of Orthopaedics and Traumatology, Prince of Wales Hospital, Hong Kong, Hong Kong Special Administrative Region of China

P461-Mo ESTIMATION OF FEMORAL BONE DENSITY USING SITE SPECIFIC QUANTITATIVE ULTRASOUND – RESULTS ON EXCISED SPECIMENS

R. Barkmann¹, P. Laugier², U. Moser³, S. Dencks¹, G. Haiat², F. Padilla², C. Glüer¹

¹Medizinische Physik, Diagnostische Radiologie UKSH Kiel, Kiel, Germany, ²Laboratoire d’Imagerie Paramétrique, Université Pierre et Marie Curie, Paris, France, ³, Sulzer Innotech, Winterthur, Switzerland

P462-Tu MULTISITE ULTRASOUND AND VERTEBRAL DEFORMITY: FINDINGS FROM THE CANADIAN MULTICENTRE OSTEOPOROSIS STUDY (CAMOS).

W. P. Olszynski¹, J. D. Adachi², G. Ioannidis², D. A. Hanley³, J. P. Brown⁴, K. S. Davison⁴

¹Medicine, Saskatoon Osteoporosis Centre, Saskatoon, ²Medicine, McMaster University, Hamilton, ³Medicine, University of Calgary, Calgary, ⁴Medicine, University of Laval, Quebec, Canada

P463-Su ABILITY OF ULTRASOUND CALCANEAL BONE DENSITY MEASUREMENT TO DIAGNOSE SPINE OSTEOPOROSIS IN WOMEN

G. T. Sakellariou¹, P. Vounotrypidis², C. Berberidis²

¹Rheumatology, St. Paul's Hospital, ²Rheumatology, 424 General Army Hospital, Thessaloniki, Greece

P464-Mo ULTRASOUND MEASUREMENTS AT THE PROXIMAL PHALANGES RELATED TO METACARPAL RADIOGRAMMETRY IN WOMEN WITH LOW-TRAUMA HIP FRACTURE

J. D. Pedrera-Zamorano¹, F. J. Calvo-Chacón², M. L. Canal-Macías¹, C. Costa-Fernández¹, M. L. Morales-Jiménez¹, J. M. Lavado-García¹

¹Department of Nursing, University of Extremadura, ²Emergency Department - Complejo Hospitalario de Cáceres, Servicio Extremeño de Salud, Cáceres, Spain

P465-Tu HOW DOES ESTROGEN USE IN EARLY POSTMENOPAUSAL WOMEN AFFECT THE DIAGNOSTIC PERFORMANCE OF THE OSTEOPOROSIS SELF-ASSESSMENT TOOL AND QUANTITATIVE ULTRASONOGRAPHY?

B. Rud¹, B. Abrahamsen², L. Rejnmark³, J. B. Jensen¹

¹The Osteoporosis Unit 545, Department of Endocrinology, Hvidovre University Hospital, Hvidovre, ²Department of Endocrinology, Odense University Hospital, Odense, ³University Department of Endocrinology, Aarhus Amtssygehus, Aarhus, Denmark

P466-Su MULTISITE QUANTITATIVE ULTRASOUND AS FIRST PARAMETER FOR THE DIAGNOSTIC SCREENING OF POSTMENOPAUSAL OSTEOPOROSIS

R. Rossetto¹, V. Gasco¹, S. Rovere¹, L. Marafetti¹, M. Seardo¹, C. Tamone², G. Isaia¹, T. Schwartz³, E. Ghigo¹

¹Internal Medicine Division of endocrinology, ²Internal Medicine Metabolic Bone Deseases, University of Turin, Turin, Italy, ³Diagnostic Bone Deseases, Sunlight Medical Ltd, Tel Aviv, Israel

P467-Mo ASSOCIATION OF ULTRASOUNDS AND FRACTURES IN ADULT MEN AND WOMEN IN POLISH POPULATION - THE EPOLOS STUDY

M. Kruk¹, M. Jaworski¹, E. Karczmarewicz¹, P. Bilinski², E. Czerwinski³, A. Lewinski⁴, E. Marcinowska-Suchowierska⁵, A. Milewicz⁶, M. Spaczynski⁷, R. S. Lorenc¹

¹Dept. of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, ²Orthopaedic and Traumatology Clinic, The Ludwig Rydygier Medical University, Bydgoszcz, ³Dept. of Orthopaedics, Jagiellonian University, Cracow, ⁴Regional Centre of Menopause and Osteoporosis, Dept. of Thyroidology, Clinical Hospital No3, Lodz, ⁵Dept. of Internal Medicine, Postgraduate Medical Education Centre, Orlowski Hospital, Warsaw, ⁶Dept. and Clinic of Endocrinology and Diabetology, Wroclaw University of Medicine, Wroclaw, ⁷Dept. of Gynecology and Obstetrics, Division of Gynecological Oncology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland

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Osteoporosis Epidemiology : Diet and Environmental Factors - P468 - P470

P468-Tu DEVELOPMENT OF DIRECT ASSAY OF SERUM PHYTOESTROGENS WITH ELISA; ASSOCIATION OF PHYTOESTROGENS LEVELS WITH BONE METABOLISM IN JAPANESE POSTMENOPAUSAL WOMEN

T. Horiuchi¹, T. Hosoi¹, T. Minekawa², H. Kakishima³, T. Onouchi⁴

¹Endocrinology, Tokyo Metropolitan Geriatric Hospital, ²Product planning and development, Eiken Chemical, ³Product planning and development, Eiken Chemical Co.Ltd., Tokyo, ⁴Clinical Research, Teikyo University School of Medicine, Ichiharashi, Japan

P469-Su WEIGHT-BEARING EXERCISE OVERRIDES IMPACT OF DIETARY PROTEIN ON BONE GROWTH – RESULTS FROM A 3-YEAR LONGITUDINAL STUDY

J. A. Nurmi-Lawton¹, A. Baxter-Jones², C. Cooper³, S. A. New¹

¹School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom, ²College of Kinesiology, University of Saskatchewan, Saskatoon, Canada, ³MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, United Kingdom

P470-Mo LYCOPENE CONSUMPTION SIGNIFICANTLY DECREASES OXIDATIVE STRESS AND BONE RESORPTION MARKERS IN POSTMENOPAUSAL WOMEN AT RISK FOR OSTEOPOROSIS

L. G. Rao¹, E. S. Collins¹, R. G. Josse², A. Strauss², A. V. Rao³

¹Calcium Research Laboratory Division of Endocrinology and Metabolism, Dept of Medicine, ²Division of Endocrinology and Metabolism, Dept of Medicine, St. Michael's Hospital, ³Department of Nutritional Sciences, University of Toronto, Toronto, Canada

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Osteoporosis Epidemiology : Fracture - P471 - P485

P471-Tu FEMUR FRACTURE INCIDENCE IN VENICE (ITALY) IN YEAR 2003: AN ATTEMPT OF HISTORICAL COMPARISON WITH YEAR 1857

A. Bonazza¹, R. Mameli¹, P. Sambo², S. Gravili¹

¹Nuclear Medicine, ²Orthopaedics, General Hospital, Venezia, Italy

P472-Su A REANALYSIS OF TWO STUDIES THAT REPORTED CONTRASTING RESULTS ON THE ASSOCIATION BETWEEN STATIN USE AND RISK OF FRACTURE IN THE SAME DATASOURCE

F. De Vries¹, C. De Vries², H. G. M. Leufkens³, C. Cooper⁴, T. Van Staa³

¹Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands, ²Postgraduate Medical Schoool, University of Surrey, Guildford, United Kingdom, ³Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands, ⁴Medical Research Council Environmental Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, United Kingdom

P473-Mo NO DECREASING HIP FRACTURE INCIDENCE IN OLDER WOMEN

R. F. Gass¹

¹University of Zurich, Institute of Social and Preventive Medicine, Zurich, Switzerland

P474-Tu BIOMECHANICAL PROPERTIES OF 10 DIFFERENT HIP PROTECTORS, AND THE INFLUENCE OF SOFT TISSUE

N. M. Van Schoor¹, A. J. Veen², L. A. Schaap¹, T. Smit², P. Lips³

¹EMGO Institute, ²Department of Physics and Medical Technology, ³Department of Endocrinology, VU University Medical Center, Amsterdam, Netherlands

P475-Su RECOGNIZING OSTEOPOROSIS AND ITS CONSEQUENCES IN QUÉBEC (ROCQ): FRAGILITY FRACTURE RATE AMONG WOMEN WHO SUSTAINED A FRACTURE

J. P. Brown¹, L. Bessette¹, M. Beaulieu², L. Sauriol³, S. Jean¹, S. K. Davison¹, L. Ste-Marie⁴

¹Département de médecine, Université Laval, Ste-Foy, ²Patient Health, Merck Frosst Canada, ³Health Economics, Aventis Pharma, ⁴Département de médecine, Université de Montréal, Montreal, Canada

P476-Mo PREVALENCE AND CUMULATIVE INCIDENCE OF VERTEBRAL FRACTURES IN A RURAL JAPANESE COMMUNITY: THE MIYAMA STUDY

N. Yoshimura¹, T. Takijiri¹, H. Kinoshita², H. Oka³, T. Takeshita¹

¹Department of Public Health, Wakayama Medical University School of Medicine, ²Department of Orthopaedic Surgery, Wakayama Medical University Kihoku Hospital, Wakayama, ³Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan

P477-Tu ITALIAN PRELIMINARY REFERENCE DATA OF NORMAL VERTEBRAL DIMENSIONS FOR MORPHOMETRIC X-RAY ABSORPTIOMETRY (MXA): NORMAL MORPHOMETRIC DEXA (NORMODEXA) STUDY

D. Diacinti¹, C. Francucci², C. Fiore³, M. Rossini⁴, M. Gibilaro⁵, M. Zappi⁶, R. Del Fiacco¹, E. D'Erasmo¹, G. Mazzuoli¹

¹Department of Clinical Sciences, University La Sapienza of Rome, Roma, ²Clinic of Endocrinology, University Politecnic of Marche, Ancona, ³Clinic of Internal Medicine, University of Catania, Catania, ⁴Centro Osteoporosi, University of Verona, Verona, ⁵Centro Osteoporosi, Clinic of Osteoporosis, Catania, ⁶Centro Osteoporosi, Azienda Sanitaria Locale, Imola, Italy

P478-Su COST EFFECTIVENESS ANALYSIS OF SYSTEMATIC PROPHYLAXIS OF FRACTURES IN PATIENTS WITH RECENT HIP FRACTURE AND OSTEOPOROSIS - RESULTS OF A MARKOV ANALYSIS.

J. Ryg¹, P. M. Christensen², J. Gram³, S. Overgaard⁴, K. Brixen¹, J. Sorensen⁵

¹Department of Endocrinology, Odense University Hospital, ²The Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, ³Department of Internal Medicine, Ribe County Hospital, Esbjerg, ⁴Department of Orthopedic Surgery, Odense University Hospital, ⁵Centre for Applied Health Services Research and Technology Assessment, University of Southern Denmark, Odense, Denmark

P479-Mo ICARO STUDY (INCIDENCE AND CHARACTERIZATION OF “INADEQUATE TREATMENT RESPONDER PATIENTS” IN OSTEOPOROSIS): BASELINE CHARACTERISTICS OF STUDY POPULATION, FINAL CROSS-SECTIONAL REPORT.

N. Iori¹, R. Nuti², G. Luisetto³, R. Gentilella¹, V. Lo Cascio⁴, S. Minisola⁵, N. Frisina⁶, . On behalf of⁷

¹Medical Dept., Eli Lilly Italy, Sesto f.no, ²Internal Medicine, Endocrinology Division Le Scotte Hospital, Siena, ³Endocrinology Dept., University Hospital, Padova, ⁴Internal Medicine Dept., G.B. Rossi Borgo Roma Hospital, Verona, ⁵Internal Medicine, Umberto I Hospital - La Sapienza University, Roma, ⁶Internal Medicine, University Hospital, Messina, ⁷The ICARO, Study, Group, Italy

P480-Tu IS EBM BASED ANTIRESORPTIVE TREATMENT OF BONE ENOUGH TO PREVENT FRACTURES IN ELDERLY WOMEN ?

O. Bock¹, H. Boerst¹, F. E. Thomasius², C. Degner¹, G. Armbrecht¹, R. Legeler¹, K. Baumgarten¹, L. Mueller¹, E. Mih¹, R. Bowitz¹, C. Schnepper³, J. Semler⁴, D. Felsenberg¹

¹Center for Muscle and Bone Research, Charité - Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, ²Osteoporosis Study Society, Frankfurt a.M., ³Kuratorium Knochengesundheit e.V., Sinsheim, ⁴Immanuel-Krankenhaus, Berlin, Germany

P481-Su THE FEMUR STRENGTH INDEX PREDICTS HIP FRACTURES INDEPENDENT OF BONE DENSITY AND HIP AXIS LENGTH

P. Hadji¹, V. Ziller², E. Mann², M. Schnabel², D. Mann², M. Bauer²

¹Dept. of Gyn., Endocrinology, Reproductive Medicine and Osteoporosis, ²Dept. of gyn. Endocrinology, Reproductive medicine and Osteoporosis, Philipps-University of Marburg, Marburg, Germany

P482-Mo CHARACTERISTICS OF THE PROXIMAL FEMUR IN FRACTURED LEBANESE SUBJECTS: HIP AXIS LENGTH PREDICTS HIP FRACTURE RISK

G. Maalouf¹, J. Wehbe¹, A. Nehme¹, R. Moucharafieh², M. Gannage³, R. Chidiac¹, Y. Yaghi⁴

¹Orthopaedic Department - Saint George Hospital, Balamand University - Faculty of Medicine, ²Orthopaedic Department, American University of Beirut, ³Endocrinology Department, Hotel Dieu de France, Beirut, ⁴Endocrinology Department, Hammoud University Hospital, Saida, Lebanon

P483-Tu OSTEOPOROSIS AND VERTEBRAL FRACTURE IN PATIENTS WITH COLLES FRACTURE

A. J. Martin¹, N. Fallon¹, D. Byrne¹, M. Healy², C. Walsh³, M. Casey¹, B. Walsh¹

¹Mercers Institute for Research in Ageing, ²Dept of Biochemistry, St James Hospital, ³Dept of Statistics, Trinity College, Dublin, Ireland

P484-Su RETROSPECTIVE STUDY OF HIP AND DISTAL FOREARM FRACTURES INCIDENCE IN MOSCOW REGION

L. A. Marchenkova¹, A. V. Dreval¹, I. V. Kryukova¹

¹Endocrinologic department, Moscow Regional Research Clinical Institute, Moscow, Russian Federation

P485-Mo THE EVALUATION OF QUALITY AND COST OF EARLY MEDICAL CARE FOR HIP AND DISTAL FOREARM FRACTURES IN MOSCOW REGION

A. V. Dreval¹, L. A. Marchenkova¹, I. V. Kryukova¹

¹Endocrinologic department, Moscow Regional Research Clinical Institute, Moscow, Russian Federation

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Osteoporosis Epidemiology : Fracture Outcome - P486 - P487

P486-Tu PYRMONTER ASSESSMENT OF COMPLAINTS IN OSTEOPOROSIS

H. W. Minne¹, C. C. Hinz¹, S. S. Schmitt², D. D. Lazarescu¹

¹Endocrinology, Metabolic Diseases, Clinic DER FÜRSTENHOF, Bad Pyrmont, ²Medizinische Abteilung, Procter und Gamble Pharmaceuticals Germany, Weiterstadt, Germany

P487-Su FACTORS AFFECTING AMBULATORY STATUS AND SURVIVAL OF OSTEOPOROSIS PATIENTS 90 YEARS AND OLDER WITH HIP FRACTURES

Y. Ishida¹, T. Taguchi¹

¹Department of Orthopaedic Surgery, Yamaguchi University School of Medicine, Ube-City, Japan

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Osteoporosis Epidemiology : Risk Factors - P488 - P506

P488-Mo RELATIONSHIP BETWEEN RENAL FUNCTION AND BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN THAT WERE EVALUATED FOR BONE MASS

A. L. Negri¹, C. Lombas¹, J. R. Zanchetta¹

¹Nephrology, Instituto de Investigaciones Metabólicas, Buenos Aires, Argentina

P489-Tu FRACTURE RISK ASSOCIATED WITH ORAL AND TOPICAL CORTICOSTEROIDS

P. Vestergaard¹, L. Rejnmark², L. Mosekilde²

¹The Osteoporosis Clinic, ²Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus, Denmark

P490-Su DIABETES AND FRACTURE RISK - EFFECTS OF ANTIDIABETIC MEDICATION

P. Vestergaard¹, L. Rejnmark², L. Mosekilde²

¹The Osteoporosis Clinic, ²Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus, Denmark

P491-Mo FAMILY PHYSICIANS’ AWARENESS OF OSTEOPOROSIS RISK FACTORS AND UTILIZATION OF BONE MINERAL DENSITY (BMD) SCREENING FOLLOWING A MULTIFACETED OSTEOPOROSIS INTERVENTION STRATEGY: CANADIAN QUALITY CIRCLE (CQC) PILOT PROJECT

A. Papaioannou¹, G. Ioannidis¹, B. Kvern², A. Hodsman³, D. Johnstone⁴, C. Crowley⁵, M. Doupe⁶, A. Baldwin⁶, J. D. Adachi¹

¹Medicine, McMaster University, Hamilton, ²Family Medicine, University of Manitoba, Winnipeg, ³Medicine, University of Western Ontario, London, ⁴National Professional Relations Manager, ⁵Medical and Technical Affairs, Procter and Gamble Pharmaceuticals, Toronto, ⁶Primary Health Care Research Unit, University of Manitoba, Winnipeg, Canada

P492-Tu THE RISK FACTORS CONTRIBUTING TO DISTAL CANCELLOUS BONE LOSS IN RHEUMATOID ARTHRITIS

I. Adamsone¹, D. Babarykin¹

¹Department of Dialysis and Transplantation, Medical Academy of Latvia, Riga, Latvia

P493-Su FALL RELATED RISK FACTORS IN MEN COMPARED TO WOMEN REFERRED FOR OPEN ACCESS BONE DENSITOMETRY

S. Patel¹, N. Pursey², K. Pursey²

¹Department of Medicine and Rheumatology, St Helier Hospital, Carshalton, ²Department of Rheumatology, St George's Hospital, London, United Kingdom

P494-Mo BONE MINERAL DENSITY OF ARABIAN WOMEN: RELATION TO ANTHROPOMETRIC AND LIFESTYLE FACTORS AND TO VITAMIN D STATUS

H. F. Saadi¹, A. I. Al-Suhaili², M. Mohammadiyeh², R. Reed³, M. Agarwal⁴, S. Benedict¹

¹Internal Medicine, Faculty of Medicine and Health Sciences, UAE University, ²Nuclear Medicine, Tawam Hospital, ³Family Medicine, ⁴Pathology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates

P495-Tu RISK FACTORS OF OSTEOPOROSIS IN URBAN ASIAN INDIAN WOMEN PRESENTING FOR A PREVENTIVE HEALTH CHECK-UP

A. Keramat¹, A. Chopra², A. Mithal³, D. Chakravarty⁴, B. Patwardhan¹

¹Health Sciences, Pune University, ²Rheumatology, CRD, Pune, ³Endocrinology, Indrapradesh Apollo Hospital, ⁴Radiology, Max Medical Center, New Delhi, India

P496-Su FACTORS INFLUENCING BONE MASS IN UNIVERSITY STUDENTS

Y. Chung¹, S. Ahn¹, Y. Kim¹, S. Lee¹, K. Song¹, M. Lee¹, H. Song¹, D. Kim¹, K. Lee¹, M. Kim², C. Sung³

¹Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, ²Food and Nutrition, Samcheok National University, Samcheok, ³Food and Nutrition, Sookmyung Women's University, Seoul, South Korea

P497-Mo PILOT CASE CONTROL INVESTIGATION OF RISK FACTORS FOR OSTEOPOROSIS IN AN URBAN INDIAN POPULATION

R. M. Jha¹, A. Mithal¹, E. M. Brown²

¹Endocrinology, Indraprastha Apollo Hospital, New Delhi, India, ²Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States

P498-Tu DIFFERENCES IN MARKERS OF BONE TURNOVER BETWEEN OLDER CHINESE AND BRITISH ADULTS

L. Yan¹, A. Prentice¹, B. Zhou², X. Wang²

¹Nutrition and Bone Health Group, MRC Human Nutrition Research, Cambridge, United Kingdom, ²Department of Preventive Medicine, Shenyang Medical College, Shenyang, China

P499-Su SERUM LEPTIN AND BMD IN OBESE POSTMENOPAUSAL WOMEN.

R. S. Filip¹, J. Szchabowski², D. Filip¹

¹Dept of Metabolic Diseases of Bone Tissue, ²Department of Internal and Occupational Diseases, Institute of Agricultural Medicine in Lublin, Lublin, Poland

P500-Mo THE EVALUATION OF RISK FACTOR AFFECTING BONE MINERAL DENSITY IN MENOPAUSAL JORDANIAN WOMAN

H. A. Z. KAYLANI¹

¹NUCLEAR MEDICINE DEPARTMENT, KING HUSSEIN MEDICAL CENTER, AMMAN, Jordan

P501-Tu RELATIONSHIP BETWEEN MORTALITY AND BASELINE BONE MINERAL DENSITY, BONE LOSS, WEIGHT LOSS AND WEIGHT FLUCTUATION IN ELDERLY MEN AND WOMEN

N. D. Nguyen¹, J. Center¹, J. Eisman¹, T. Nguyen¹

¹Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia

P502-Su IN OSTEOPOROTIC MEN AND WOMEN A LOW CREATININE CLEARANCE OF <65ML/MIN SIGNIFICANTLY INCREASES THE RISK FOR FALLS AND FRACTURES

L. C. Dukas¹, H. B. Stähelin¹, E. Schacht²

¹Acute Geriatric University Clinic, Universitätsspital, Basel, ²Dept. of Rheumatology and Rehabilitation, University Clinic Balgrist, Zurich, Switzerland

P503-Mo BIPHASIC RELATIONSHIP BETWEEN BONE MINERAL DENSITY AND WEEKLY RUNNING DISTANCE IN HEALTHY MALES

O. Deriaz¹, C. Gobelet¹, A. Crettenand¹, M. Praz¹, R. Rizzoli², G. Gremion³

¹Recherche Médicale, Clinique romande de réadaptation, SUVAcare, Sion, ²Service des maladies osseuses, Hôpital Cantonal, Genève, ³Hôpital orthopédique de Suisse romande, Université de Lausanne, Lausanne, Switzerland

P504-Tu OSTEOPOROTIC RISK IN WOMEN WITH CORONARY ARTHERIOSCLEROSIS

M. J. Montoya¹, E. Peral¹, M. A. Vázquez-Gámez¹, R. Moruno¹, M. J. Gómez-Tejada¹, M. J. Miranda¹, M. Giner¹, R. Pérez-Temprano¹, R. Pérez-Cano¹

¹Department of Internal Medicine, University Hospital Virgen Macarena., Seville, Spain

P505-Su SELECTION OF POSTMENOPAUSAL WOMEN FOR BONE DENSITOMETRY: CAN WE USE THE SAME SCREENING TOOLS AT DIFFERENT AGES?

P. F. DARGENT¹, S. Piault¹, G. Bréart¹

¹Unit 149, INSERM, Villejuif cedex, France

P506-Mo INDICATORS OF POOR HEALTH AND PHYSICAL FRAILTY PREDICT BONE LOSS AT THE HIP

J. Finigan¹, D. M. Greenfield², R. A. Hannon¹, A. Blumsohn¹, N. F. A. Peel¹, R. Eastell¹

¹Academic Unit of Bone Metabolism, ²Clinical Oncology, University of Sheffield, Sheffield, United Kingdom

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Osteoporosis Pathophysiology : Bone Mineral Density - P507 - P513

P507-Tu RELATIONSHIP BETWEEN ANTHROPOMETRICS VARIABLES WITH BONE MINERAL CONTENT (BMC) IN AN URBAN POPULATION. PRELIMINARY STUDY.

A. L. Misiunas¹, V. Ilera², M. Hevia¹, M. G. Loto¹, C. J. Herrera¹, N. G. Rella¹, M. V. Moran¹, G. Roccatagliata¹, M. Curria¹, G. Rovira¹, D. Martino³, C. Fitzsimons³, C. Almeida³, . N. Llacer⁴, . C. Baistrocchi⁴

¹Endocrinolgy, Metabolism and Nutrition Service, ²Endocrinolgy , Metabolism and Nutrition Service, ³Nuclear Medicine Service, ⁴Gynecology Service, Hospital Britanico de Buenos Aires, Buenos Aires, Argentina

P508-Su SOFT TISSUE COMPOSITION AND FEMORAL BONE MINERAL DENSITY IN HIP-FRACTURE WOMEN

M. Di Monaco¹, F. Vallero¹, R. Di Monaco², R. Tappero¹, A. Cavanna¹

¹Osteoporosis Research Center, Presidio Sanitario San Camillo, ²SRF, Società Ricerca e Formazione, Torino, Italy

P509-Mo CALCIUM HOMEOSTASIS AND BONE METABOLISM DURING LACTATION AND POST WEANING

U. K. MØLLER¹, L. REJNMARK¹, L. MOSEKILDE¹

¹Dept. of Endocrinology C, Aarhus University Hospital , Aarhus Sygehus, Aarhus, Denmark

P510-Tu RELATIONSHIPS BETWEEN FAT MASS, LEAN MASS AND BONE MINERAL DENSITY IN HEALTHY EUGONADAL ROMANIAN WOMEN

C. E. Georgescu¹, S. Naumescu¹, O. Manaila¹, I. Duncea¹

¹Department of Endocrinology, University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania

P511-Su BONE MINERAL DENSITY AND LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN SAUDI POSTMENOPAUSAL WOMEN

M. M. Ardawi¹, H. A. N. Nasrat², T. M. Bahksh³, A. A. Maimany⁴, A. Y. Syamik⁵, W. A. Milaat⁶

¹Clinical Biochemistry, King Abdulaziz University Hospital,Faculty of Medicine, Saudi Osteoporosis Research Group, ²Obstetrics and Gynecology, ³Surgery, ⁴Radiology, ⁵Physiology, King Abdulaziz University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, ⁶Family and Community Medicine, Ing Abdulaziz University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, Jeddah, Saudi Arabia

P512-Mo GROWTH RETARDATION AND OSTEOPENIA IN ADOLESCENTS AND YOUNG ADULTS TREATED WITH HEMODIALYSIS

S. O. Mazurenko¹, M. V. Erman², R. K. Kuanshkaliev³, A. A. Enkin⁴

¹Center of Osteoporosis, Medical and Sanitary Unit 122, Sokolov Hospital, ²Medical Faculty, Saint Petersburg State University, ³Division of Hemodyalysis, Saint Magdalene Pediatrics Hospital, ⁴Department of Hemodialysis, Leningrad Regional Hospital, Saint Petersburg, Russian Federation

P513-Tu EFFECT OF IMMOBILIZATION AND NEURAL INFLUENCE ON TIBIAL FRACTURE IN RATS

W. Lam¹, X. Guo¹, K. S. C. Kwong¹, . K. S. Leung²

¹Rehabilitation Sciences, The Hong Kong Polytechnic University, ²Orthopaedics and Tramatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region of China

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Osteoporosis Pathophysiology : Bone Structure - P514 - P517

P514-Su EFFECTS OF CYCLOSPORIN A ON THE REMODELING OF ALVEOLAR BONE IN RATS

C. Wada¹, H. Seto¹, T. Nagata¹

¹Department of Periodontology and Endodontology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

P515-Mo REGULATION OF BONE BALANCE - SEQUENTIAL MICRONUTRITION

M. LUGAND¹, A. CORNELY¹

¹Research, BIORESEARCH, MONTHEY, Switzerland

P516-Tu DENSITOMETRIC AND TEXTURAL ANALYSIS ON DIGITIZED X-RAYS OF TRABECULAR BONE AND ITS RELATIONSHIP WITH BIOMECHANICAL PROPERTIES

J. Caeiro Rey¹, S. Dapia², M. Blanco-Ramos³, F. Fernandez-Lopez²

¹Servicio de Cirugía Ortopédica y Traumatología, Complexo Hospitalario de Ourense, Ourense, ²Innova Auria S.L., Institute of Design and Development of Health Technological Applications, S. Cibrao das Viñas, ³Unidad de Investigacion Atencion Primaria, Complexo Hospitalario de Ourense, Ourense, Spain

P517-Su PATTERNS OF MINERALIZATION IN CHILDREN WITH SECONDARY AND SYNDROME ASSOCIATED OSTEOPOROSIS

M. Grynpas¹, O. Makitie², K. Pritzker¹, E. Sochett³

¹Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada, ²Metabolic Bone Clinic, Hospital for Children and Adolescents, Helsinki, Finland, ³Pediatric Endocrinology, Hospital for Sick Children, Toronto, Canada

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Osteoporosis Pathophysiology : Corticosteroid - P518 - P521

P518-Mo CORTICOSTERONE TREATMENT PRODUCES RAPID AND PROFOUND REDUCTIONS IN CIRCULATING OSTEOCALCIN LEVELS IN MICE

K. Brennan¹, J. DeWinter¹, H. Zhou¹, C. R. Dunstan¹, M. J. Seibel¹

¹Bone Research Program, ANZAC Research Institute, Sydney, Australia

P519-Tu GLUCOCORTICOID-INDUCED LOW BONE MASS IN CHILDREN AND ADOLESCENTS: A LONGITUDINAL STUDY ON A LARGE SAMPLE.

M. Bianchi¹, S. Saraifoger¹, C. Limonta¹, C. Colombo², F. Corona², L. Morandi³, A. Edefonti², G. Nebbia², A. Colombini⁴, L. Ghio²

¹Bone Metabolism Unit, Istituto Auxologico Italiano, IRCCS, ²Clinica Pediatrica, Università di Milano, ³Clinica Neurologica, Istituto Besta, Milano, ⁴Clinica Pediatrica, Ospedale San Gerardo, Monza, Italy

P520-Su THE INFLUENCE OF TREATMENT WITH GLUCOCORTICOIDS ON CORTICAL BONE STRUCTURE AND VERTEBRAL FRAGILITY: COMPARISON BETWEEN MENSTRUAL AND POSTMENOPAUSAL WOMEN

M. Yamauchi¹, H. Kaji², T. Tobimatsu², J. Naito², M. Iu², K. Chihara², T. Sugimoto¹

¹Department of Endocrinology, Metabolism and Hematological Oncology, Shimane University School of Medicine, Izumo, ²Division of Endocrinology,Metabolism, Neurology and Hematology,Oncology, Kobe University Graduate School of Medicine, Kobe, Japan

P521-Mo A MULTI-CENTRE SECONDARY CARE BASED NATIONAL AUDIT OF BONE PROPHYLAXIS IN GLUCOCORTICOID INDUCED OSTEOPOROSIS

H. Gunawardena¹, M. Javaid¹, D. Speden¹, A. Saharia¹, R. Wickramasuriya², J. Potter³, J. E. Compston⁴

¹Department of General Medicine and Rheumatologyment of Medicine, Frenchay Hospital, Bristol, ²Information Technology, Procter and Gamble Pharmaceuticals, Egham, ³Clinical Effectiveness and Evaluation Unit, Royal College of Physicians, London, ⁴Department of Medecine, Addenbrooke Hospital, Cambridge, United Kingdom

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Osteoporosis Pathophysiology : Dietary Factors - P522 - P530

P522-Tu RELATIONSHIP BETWEEN SERUM PARATHYROID HORMONE AND BONE MASS AMONG BLACK AND WHITE ADOLESCENT GIRLS

S. A. Talwar¹, J. Yeh¹, S. Pollack¹, J. F. Aloia¹

¹Bone Mineral Research Center, Winthrop-University Hospital, Mineola, United States

P523-Su EARLY SERUM IGF-I RESPONSE TO ORAL PROTEIN SUPPLEMENTS IN ELDERLY WOMEN WITH A RECENT HIP FRACTURE

T. Chevalley¹, P. Hoffmeyer², J. Bonjour¹, R. Rizzoli¹

¹Service of Bone Diseases, ²Service of Orthopaedic Surgery, University Hospitals Geneva, Geneva, Switzerland

P524-Mo GLUCURONIC ACID INCREASES THE BONE MINERAL DENSITY IN THE DIABETIC RATS

M. Watanabe¹, Y. Makita², D. Miura², Y. Nomura²

¹Rehabilitation, Koseikai Hospital, ²Applied Protein Chemistry, Tokyo University of Agriculture and Technology, Tokyo, Japan

P525-Tu SODIUM AND POTASSIUM EFFECTS ON BONE MASS IN RATS

M. Saric¹, J. Z. Ilich², M. Piasek¹, M. Blanusa¹, S. Cvijetic³, K. Kostial¹

¹Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia, ²School of Allied Health, University of Connecticut, Storrs, United States, ³Occupational Health and Environmental Medicine, Institute for Medical Research and Occupational Health, Zagreb, Croatia

P526-Su EFFECT OF CARTHAMUS TINCTORIUS L. EXTRACTS ON BONE RESORPTION IN OVARIECTOMIZED RATS

A. Quintin¹, I. Nielsen¹, J. Clough¹, J. Moulin², B. Lemaure³, A. Touché³, D. Courtois³, M. Horcajada⁴, W. Chee¹, G. Williamson¹, E. Offord¹

¹Nutrition and Health, ²Bioanalytical Sciences, Nestlé Research Center, Lausanne, Switzerland, ³Plant Sciences, Nestlé Research Center, Tours, ⁴Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Theix, St Genes Champanelle, France

P527-Mo FAT SOLUBLE VITAMINS AND BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN: RESULTS OF A CROSS-SECTIONAL STUDY

J. M. Mata Granados¹, R. Cuenca Acevedo², L. Barrios², F. J. Caballero Villarraso³, M. D. Luque de Castro⁴, J. M. Quesada⁵

¹Sanyres XXI Prasa. Unidad de Metabolismo Mineral, Hospital Universitario Reina Sofía, ²Unidad de Metabolismo Mineral, Hospital Universitario Reina Sofía, Córdoba, ³Servicio de Análisis Clínicos Unidad de Metabolismo Mineral, Hospital Universitario Reina Sofía, Cordoba, ⁴Dep. Química Analítica, Universidad de Córdoba, ⁵Sanyres XXI Prasa. Unidad de Metabolismo Mineral, Hospital Universitario Reina Sofía, Córdoba, Spain

P528-Tu VITAMIN DEFICIENCY AND BONE LOSS IN INFLAMMATORY BOWEL DISEASE

K. Tanaka¹, Y. Nakanishi¹, H. Tsuji², K. Shide², H. Nakase³, S. Kido¹, T. Okano⁴

¹Department of Nutrition, Kyoto Women's University, ²Department of Clinical Nutrition, ³Department of Gastroenterology, Kyoto University Hospital, Kyoto, ⁴Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan

P529-Su PROTEIN INTAKE: EFFECTS ON PHALANGEAL BONE ULTRASOUND IN HEALTHY WOMEN

J. D. Pedrera-Zamorano¹, M. L. Canal-Macías¹, C. Costa-Fernández¹, T. Rodríguez-Domínguez¹, S. Postigo-Mota¹, J. M. Lavado-García¹

¹Department of Nursing, University of Extremadura, Cáceres, Spain

P530-Mo ISOCALORIC LOW-PROTEIN DIET HAS A MAJOR NEGATIVE IMPACT ON BONE MASS AND MICROARCHITECTURE OF THE MANDIBULAR ALVEOLAR BONE IN THE RAT

A. Mavropoulos¹, R. Rizzoli², P. Ammann²

¹Department of Orthodontics, Section of Dental Medicine, ²Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva, Switzerland

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Osteoporosis Pathophysiology : Male Osteoporosis - P531 - P533

P531-Tu EVALUATION OF SEX STEROIDS, BONE TURNOVER MARKERS, AND BONE MINERAL DENSITY IN SAUDI MEN WITH OSTEOPOROSIS

T. M. Bahksh¹, M. S. M. Ardawi², A. A. Maimany³, H. A. N. Nasrat⁴, A. Y. Syamik⁵, W. A. Milaat⁶

¹Surgery, King Abdulaziz University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, ²Clinical Biochemistry, King Abdulaziz University, Faculty of Medicine, Saudi Osteoporosis Research Group, ³Radiology, King Abdulazizi University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, ⁴Obstetrics and Gynecology, ⁵Physiology, ⁶Family and Community Medicine, King Abdulaziz University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, Jeddah, Saudi Arabia

P532-Su IN MEN WITH VERTEBRAL FRACTURE CANCELLOUS BONE IS MORE AFFECTED THAN CORTICAL BONE BUT IS NOT ASSOCIATED WITH INCREASED BONE BREAKDOWN

M. W. J. Davie¹, C. A. Sharp², H. L. Davies², S. F. Evans²

¹Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, ²Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Gobowen, United Kingdom

P533-Mo LARGE POPULATION-BASED GEOGRAPHIC VARIATIONS IN DXA BMD IN MEN AND WOMEN ACROSS EUROPE. RESULTS FROM THE NETWORK FOR MALE OSTEOPOROSIS (NEMO) STUDY.

S. Kaptoge¹, . J. M. Kaufman², . J. Reeve¹, . NEMO Study Group³

¹Medicine, University of Cambridge, Cambridge, United Kingdom, ², University Hospital, Leuven, Belgium, ³, , United Kingdom

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Osteoporosis Pathophysiology : Mechanical Loading - P534 - P540

P534-Tu COMPARISON OF DEXA, PQCT AND QUANTITATIVE USG IN ASSESSMENT OF INTERVAL BONE MINERAL DENSITY CHANGES IN ADOLESCENT DANCERS AND NON-DANCERS

M. W. N. Wong¹, W. W. K. To²

¹Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, ²Department of Obstetrics and Gynaecology, United Christian Hospital, Hong Kong, Hong Kong Special Administrative Region of China

P535-Su DEVELOPMENT OF A COST-EFFECTIVE SMALL-SCALE LOADING MACHINE FOR IN VIVO, EX VIVO AND IN VITRO OSTEOPOROSIS RESEARCH

M. M. Saunders¹

¹Orthopaedics and Rehabilitation, Penn State University College of Medicine, Hershey, United States

P536-Mo ASSOCIATION OF AMOUNT OF PHYSICAL ACTIVITY WITH CORTICAL BONE SIZE AND TRABECULAR VOLUMETRIC BONE MINERAL DENSITY IN YOUNG ADULT MEN - THE GOOD STUDY

M. Lorentzon¹, D. Mellström², C. Ohlsson¹

¹Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, ²Department of Geriatric Medicine, University of Gothenburg, Gothenburg, Sweden

P537-Tu REGIONAL CHANGES IN BODY COMPOSITION 3 MONTHS TO 30 YEARS AFTER TRAUMATIC SPINAL CORD INJURY (SCI): RESULTS OF A CROSS SECTIONAL STUDY IN 100 PARAPLEGIC MEN.

O. Franta¹, A. W. E. Popp¹, D. Michel², H. Knecht³, R. Perrelet¹, Y. Zehnder³, G. A. Zaech³, K. Lippuner¹

¹Osteoporosis Policlinic, University Hospital, ²Institute for Physical- Pain- and Rehabilitation Medicine, Salem Spital Hirslanden, Berne, ³Swiss Paraplegic Center, Nottwil, CH-6207 Nottwil, Switzerland

P538-Su LONG PERIODS OF DISUSE RESCUE THE OSTEOGENIC RESPONSE TO MECHANICAL LOADING THAT IS SUPRESSED BY AGING

R. L. De Souza¹, M. Maiko², F. Eckstein², L. E. Lanyon¹, C. Chenu¹, A. A. Pitsillides¹

¹Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom, ²Institue of Anatomy, Ludwig-Maximillians Universitat, Munich, Germany

P539-Mo INFLUENCE OF SPASTICITY ON BODY COMPOSITION OF PARAPLEGIC MEN AFTER TRAUMATIC SPINAL CORD INJURY (SCI): RESULTS OF A CROSS SECTIONAL STUDY IN 100 PARAPLEGIC MEN

N. Von Tscharner¹, D. Michel², A. W. E. Popp¹, H. Knecht³, R. Perrelet¹, G. A. Zaech³, K. Lippuner¹

P540-Tu RELATIONSHIPS BETWEEN BODY WEIGHT AND VERTEBRAL BONE ARCHITECTURE IN PRIMATES THAT EXHIBIT A 48-FOLD RANGE IN BODY WEIGHT

R. J. Fajardo¹, J. M. De Silva², L. M. MacLatchy², M. L. Bouxsein¹

¹Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, ²Anthropology, University of Michigan, Ann Arbor, United States

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Osteoporosis Pathophysiology : Miscellaneous - P541 - P551

P541-Su EFFECT OF LONG TERM ADMINISTRATION OF ANTIEPILEPTIC DRUGS ON BONE HEALTH PARAMETERS IN OUTPATIENT POPULATION: HIGH PREVALENCE OF OSTEOPENIA AND VITAMIN D DEFICIENCY

R. Khadgawat¹, T. Srivastav², N. Tandon¹, N. Gupta¹, M. Bihari², A. C. Ammini¹

¹Dept of Endocrinology, ²Dept of Neurology, All India Institute of Medical Sciences, New Delhi, India

P543-Tu REDUCED OSTEOCYTE DENSITY AT THE ILIAC CREST IN FRAGILITY HIP FRACTURE PATIENTS

J. S. Kuliwaba¹, J. S. Kuliwaba², J. S. Kuliwaba³, J. P. Cowan¹, J. P. Cowan², J. P. Cowan³, N. Pan¹, N. Pan², N. Pan³, N. L. Fazzalari¹, N. L. Fazzalari², N. L. Fazzalari³

¹Division of Tissue Pathology, Institute of Medical and Veterinary Science, ²Bone and Joint Research Laboratory, Hanson Institute, ³Department of Pathology, The University of Adelaide, Adelaide, Australia

P544-Su OXIDATIVE STRESS INDUCES BONE LOSS IN OVARIECTOMIZED MICE THROUGH INDUCTION OF BONE MARROW RESTRICTED ACTIVATION OF DENDRITIC CELLS AND T CELL ACTIVATION

F. Grassi¹, J. Leavey¹, W. Qian¹, M. Weitzmann¹, R. Pacifici¹, K. Page¹

¹Medicine Endocrinology, Metabolism and Lipids, EMORY UNIVERSITY, ATLANTA, United States

P545-Mo GENDER DIFFERENCES IN SERUM LEPTIN AND GHRELIN: RELATIONSHIP TO BODY COMPOSITION AND BONE MINERAL MEASURES – A CROSS-SECTIONAL OPPOSITE SEX TWIN STUDY

P. N. Sambrook¹, J. Makovey¹, V. Naganathan², M. Seibel³

¹Institute of Bone and Joint Research, Royal North Shore Hospital, ²Geriatrics, Concord Hospital, ³Bone Research Program, ANZAC Res Institute, University of Sydney, Sydney, Australia

P546-Tu BONE MINERAL DENSITY AND FUNCTIONAL ELECTRICAL STIMULATION IN ACUTE SPINAL CORD INJURY

M. Nery¹, J. Middleton², R. Crameri³, P. Clifton-Bligh¹

¹Northern Metabolic Bone Centre, ²Spinal Injuries Unit, Royal North Shore Hospital, St. Leonards, ³School of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Lidcombe, Australia

P547-Su PRIMARY AMENORRHEA AND BONE TURNOVER

I. N. Charopoulos¹, G. P. Trovas², P. P. Kokkinou³, S. T. Tournis⁴, G. P. Lyritis⁴

¹Laboratory for the Research of Musculoskeletal System, University of Athens, ATHENS, ²Laboratory for the Research of Musculosceletal System, University of Athens, ³Genetics, Sismanoglio Hospital, ⁴Laboratory for the Research of Musculoskeletal System, University of Athens, Athens, Greece

P548-Mo CALCITONIN INFLUENCES BONE BLOOD FLOW IN RATS

J. Zak¹

¹Dept. of occupational diseases, Charles University Prague, Prague, Czech Republic

P549-Tu CYCLASE ACTIVATING PARATHORMONE (CAP) AND CAP/CIP RATIO ARE INCREASED IN ELDERLY WOMEN WITH LOW BONE MINERAL DENSITY (BMD) OF THE RADIUS

E. Franek¹, I. Piwowarska², M. Bulanowski³, F. Kokot³, A. Wiecek³

¹Dept of Internal Diseases and Endocrinology, Central Clinical Hospital of Ministry for Int Affairs, ²Dept of Internal Diseases and Endocrinology, Central Clinical Hosp of Ministry for Int Affairs, Warszawa, ³Dept of Nephrology, Endocrinology and Metabolic Diseases, Silesian Univ School of Medicine, Katowice, Poland

P550-Su EVALUATION OF BONE MINERAL DENSITY IN HYPOGONADIC WOMEN

C. Eduard¹

¹Endocrinology, County Hospital Constanta, Constanta, Romania

P551-Mo PREVALENCE AND DETERMINANTS OF OSTEOPOROSIS IN ADULTS WITH ANOREXIA NERVOSA

A. Trombetti¹, B. Penalosa², S. Lopez², A. Andreoli², R. Rizzoli¹

¹Department of Rehabilitation and Geriatrics, ²Psychiatry Service, University Hospital of Geneva, Geneva, Switzerland

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Osteoporosis Pathophysiology : Sex Hormone - P552 - P554

P552-Tu EVALUATION OF SEX STEROIDS, BONE TURNOVER MARKERS, BONE MINERAL DENSITY IN SAUDI POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS

M. M. S. M. Ardawi¹, H. A. N. Nasrat², T. M. Bahksh³, A. A. Maimany⁴, A. Y. Syamik⁵, W. A. Milaat⁶

¹Clinical Biochemistry, ²Ostetrics and Gynecology, ³Surgery, King Abdulaziz University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, ⁴Radiology, King Abdulaziz University Hospital, Saudi Osteoporosis Research Group, ⁵Physiology, King Abdulaziz University Hospital, Faculty of Medicine, Saudi Osteoporosis Research Group, ⁶Family and Community Medicine, King Abdulaziz University Hospital, Saudi Osteoporosis Research Group, Jeddah, Saudi Arabia

P553-Su RELATION OF HOMOCYSTEIN, FOLATE, VITAMIN B12 AND METHYLENETETRAHYDROFOLATE REDUCTASE C667T POLYMORPHISM TO BONE MINERAL DENSITY IN SAUDI POSTMENOPAUSAL WOMEN

M. M. S. M. Ardawi¹, M. H. Qari², A. A. Rouzi³

¹Clinical Biochemistry, ²Hematology, ³Obstetrics and Gynecology, King Abdulaziz University Hospital, Faculty of Medicine, Jeddah, Saudi Arabia

P554-Mo FREE TESTOSTERONE IS A POSITIVE WHILE FREE ESTRADIOL IS A NEGATIVE PREDICTOR OF BONE AREA IN ELDERLY SWEDISH MEN – MR OS SWEDEN

D. Mellström¹, A. Eriksson², M. Lorentzon³, E. S. Orwoll⁴, Ö. Ljunggren⁵, O. Johnell⁶, C. Ohlsson³

¹Department of Geriatrics, ²Center for Bone Research at the Sahlgrenska Academy and Division of Clinical Pharmacology, Göteborg University, ³Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Göteborg, Sweden, ⁴Bone and Mineral Research Unit, Department of Medicine Oregon Health Sciences University and Portland Veterans Affairs Medical Cente, Portland Oregon, ⁵Department of Medical Sciences, University of Uppsala, Uppsala, United States, ⁶Department of Orthopaedics, Malmö University Hospital, Malmö, Sweden

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Osteoporosis Pathophysiology: Animal Models - P555 - P565

P555-Tu RELATIONSHIP BETWEEN OSTEOPENIA AND LUMBAR INTERVERTEBRAL DISC DEGENERATION IN OVARIECTOMIZED RATS

T. Wang¹, L. Zhang²

¹Department of orthopaedic surgery, General Hospital of China Civil Aviation, Beijing, ²Department of orthopaedic surgery, North China Coal Medical College, Tangshan, China

P556-Su BIOCHEMICAL MARKERS OF BONE TURNOVER IN DOGS

M. Belic¹, V. Kusec², A. Svetina¹, R. Turk¹

¹Department of pathophysiology, Faculty of Veterinary Medicine, University of Zagreb, ²Clinical Institute of Laboratory Diagnosis, Clinical Hospital Centre Zagreb, Zagreb, Croatia

P557-Mo CHARACTERIZATION AND ASSESSMENT OF CHRONIC PAIN IN A RAT FRACTURE MODEL

S. D. Bain¹, K. Haynes¹, T. Panzitta¹, J. Wiley¹, M. Brot², M. Roudier¹

¹Bone and CNS Biology, ²CNS Biology, SkeleTech, Inc., Bothell, United States

P558-Tu AN OVARY-INTACT MOUSE MODEL TO STUDY BONE LOSS INDUCED BY ESTROGEN DEFICIENCY

M. L. Bouxsein¹, P. J. Christian², V. Glatt¹, C. J. Rosen³, P. B. Hoyer²

¹Orthopedic Surgery, Beth Israel Deaconess Medical Center, Boston, ²Physiology, University of Arizona, Tucson, ³MECORE, St. Joseph's Hospital, Bangor, United States

P559-Su ACTIVATION OF PPAR-GAMMA BY ROSIGLITAZONE INDUCES BONE LOSS DUE TO CHANGES IN THE PHENOTYPE AND FUNCTION OF BONE MESENCHYMAL CELLS

B. Lecka-Czernik¹, O. P. Lazarenko¹, L. J. Suva², K. Teng¹

¹Geriatrics, ²Orthopaedics, University of Arkansas for Medical Sciences, Little Rock, United States

P560-Mo ISOCALORIC LOW PROTEIN INTAKE DECREASES TITANIUM IMPLANT OSSEOINTEGRATION

R. Dayer¹, R. Rizzoli¹, A. Kaelin², P. Ammann¹

¹Division of Bone Diseases, Department of Rehabilitation and Geriatrics, ²Division of PediatricsOrthopedics, Department of Pediatrics, Geneva, Switzerland

P561-Tu CHEMICAL MODIFICATION OF SMOOTH TITANIUM IMPLANT SURFACE BY COATING WITH PROPYLENE-TETRA-PHOSPHONIC ACID INCREASES THEIR OSSEOINTEGRATION

R. Dayer¹, R. Rizzoli¹, P. Péchy¹, T. Vig², B. O. Aronson³, P. Descouts⁴, P. Ammann¹

¹Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva, ²Swiss Federal Institut of Technology, EPFL, Lausanne, ³Suriasis, SA, ⁴Departement of Physics, University of Geneva, Geneva, Switzerland

P562-Su ACCELERATED BONE AGEING AND ALTERED ESTRADIOL LEVELS IN DNA REPAIR DEFICIENT TRICHOTHIODYSTROPHY MICE.

K. Diderich¹, . J. H. Waarsing², . C. J. Buurman³, . J. Day², . R. M. C. Brandt¹, . F. H. De Jong³, . M. Amling⁴, . J. H. J. Hoeijmakers¹, . H. Weinans², . G. T. J. Van der Horst¹, . J. P. Van Leeuwen³

¹Cell Biology and Genetics, ²Orthopedics, ³Internal Medicine, Erasmus MC, Rotterdam, Netherlands, ⁴School of Medicine, Hamburg University, Hamburg, Germany

P563-Mo AGE-RELATED CHANGES IN VERTEBRAL SIZE AND MICROARCHITECTURE IN MALE MICE

V. Glatt¹, R. J. Fajardo¹, M. L. Bouxsein¹

¹Orthopedics, Beth Israel Deaconess Medical Center, Boston, United States

P564-Tu CENTRAL CONTROL OF BONE REMODELING BY THE VESTIBULAR SYSTEM.

R. Levasseur¹, J. Sabatier², O. Etard³, J. Corvisier³, E. Legrand¹, M. Audran¹, P. Denise³, D. Chappard⁴

¹Rheumatology Department, Angers University Hospital, Angers, ²Nuclear Medicine, ³Physiology, Caen University Hospital, Caen, ⁴Inserm 0335, Medicine Faculty, Angers, France

P565-Su DEVELOPMENT OF AN EXPERIMENTAL MODEL TO STUDY OF OSTEOPOROSIS.

P. S. Santos¹, M. I. V. Viloria¹, R. J. Del Carlo¹, T. T. Oliveira¹, F. Valente¹, R. R. Filgueiras²

¹Veterinary Medicine, Federal University of Viçosa, Viçosa, ²Veterinary Medicine, University of Brasilia - UnB, Brasilia, Brazil

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Osteoporosis Pathophysiology: Bone Growth and Peak Bone Mass - P566 - P571

P566-Mo MECHANISMS FOR BONE GROWTH ARREST AND OSTEOPOROSIS IN YOUNG RATS SECONDARY TO ACUTE 5-FLUOROURACIL CHEMOTHERAPY

C. J. Xian¹, J. Cool¹, B. K. Foster¹

¹Department of Orthopaedic Surgery, Women's and Children's Hospital, North Adelaide, Australia

P567-Tu LYSINE DOSE-RESPONSE ON MICROARCHITECTURE OF TRABECULAR BONE AND GENE EXPRESSION OF CALCIUM TRANSPORTERS IN GROWING RATS

G. Soon¹, P. Ammann², G. Williamson¹, F. Ginty³, E. Offord¹

¹Nutrient Bioavailability, Nestlé Research Centre, Lausanne, ²Division of Bone Diseases, WHO Collaborating Centre for Osteoporosis Prevention, Department of Rehab, University Hospital of Geneva, Geneva, Switzerland, ³MRC Human Nutrition Research, The Elsie Widdowson Laboratory, Cambridge, United Kingdom

P570-Tu SMOKING IS ASSOCIATED WITH LOW PEAK BONE MASS IN MEN

M. F. Nielsen¹, T. Nielsen¹, B. Abrahamsen¹, M. Andersen¹, C. Hagen¹, K. Brixen¹

¹Endocrinology, Odense University Hospital, Odense, Denmark

P571-Su VITAMIN D SUPPLEMENTATION AIDS BONE MINERAL ACCRETION IN ADOLESCENT GIRLS

H. T. Viljakainen¹, A. Natri¹, M. Kärkkäinen¹, M. M. Huttunen¹, A. Palssa¹, J. Jakobsen², K. D. Cashman³, C. Mølgaard⁴, C. Lamberg-Allardt¹

¹Dep. of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland, ²Danish Institute for Food and Veterinary Research, -, Söborg, Denmark, ³Department of Food and Nutritional Sciences, -, Cork, Ireland, ⁴Research Department of Human Nutrition, Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark

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Osteoporosis Pathophysiology: Genetic Factors - P572 - P581

P572-Mo ASSOCIATION OF GENETIC POLYMORPHISMS WITH BONE MINERAL DENSITY AND FRACTURE RISK IN OSTEOPOROTIC WOMEN

S. Clausmeyer¹, C. Haag¹, E. Schulze¹, K. Frank-Raue¹, F. Raue¹

¹Endocrine Practice, Prof. Raue, Heidelberg, Germany

P573-Tu CYP19-AROMATASE HAPLOTYPES AND BONE MASS

J. A. Riancho¹, M. T. Zarrabeitia², C. Valero¹, C. Sañudo¹, J. L. Hernandez¹, J. A. Amado³, A. L. Zarrabeitia¹, J. Gonzalez-Macias¹

¹Internal Medicine, Hospital U.M. Valdecilla, University of Cantabria, ²Legal Medicine, University of Cantabria, ³Endocrinology, Hospital U.M. Valdecilla, University of Cantabria, Santander, Spain

P574-Su THE ROLE OF COLLAGEN I ALPHA1 SP1 POLYMORPHISM AND ULTRASOUND TRANSMISSION VELOCITY IN COLLES´ FRACTURE PREDICTION DEPENDS ON BODY WEIGHT

M. Weichetova¹, J. J. Stepan¹, D. Michalska¹, T. Haas¹

¹Department of Internal Medicine 3, Charles University, Faculty of Medicine, Prague, Prague, Czech Republic

P575-Mo LRP5 POLYMORPHISMS ARE ASSOCIATED WITH OSTEOPOROSIS IN MALES

A. M. Koay¹, C. Vilarino-Guell¹, M. A. Brown¹, P. R. Ebeling²

¹Institute of Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ²Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Melbourne, Australia

P576-Tu A POLYMORPHISM IN THE GENE CODING FOR ESTROGEN RECEPTOR BETA IS ASSOCIATED WITH BONE MINERAL DENSITY IN ELDERLY SWEDISH MEN – MR OS SWEDEN

A. Eriksson¹, D. Mellström², E. S. Orwoll³, Ö. Ljunggren⁴, O. Johnell⁵, C. Ohlsson¹

¹Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, ²Department of Geriatrics, Göteborg University, Göteborg, Sweden, ³Bone and Mineral Research Unit, Department of Medicine Oregon Health Sciences University and Portland Veterans Affairs Medical Cente, Portland Oregon, United States, ⁴Department of Medical Sciences, University of Uppsala, Uppsala, ⁵Department of Orthopaedics, Malmö University Hospital, Malmö, Sweden

P577-Su LRP5 GENE POLYMORPHISMS INFLUENCE BONE MINERALIZATION AND GROWTH IN CHILDREN.

A. M. Koay¹, C. Vilarino-Guell¹, S. D. Leary², C. D. Steer², M. A. Brown¹, J. H. Tobias³

¹Institute of Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, ²Avon Longitudinal Study of Parents and Children, ALSPAC, ³Rheumatology Unit, Bristol Royal Infirmary, Bristol, United Kingdom

P578-Mo A REPEAT POLYMORPHISM IN THE CLCN7 GENE INFLUENCES BONE DENSITY IN PATIENTS WITH AUTOSOMAL DOMINANT OSTEOPETROSIS (ADO) TYPE II AND IN POST-MENOPAUSAL WOMEN

U. Kornak¹, S. Branger², A. Ostertag², O. Benichou², M. De Vernejoul²

¹Institute for Medical Genetics, Charite University Hospital, Campus Virchow, Berlin, Germany, ²INSERM 606, Hôpital Lariboisière, Paris, France

P579-Tu OSTEOPOROSIS PSEUDOGLIOMA SYNDROME : A NOVEL LRP5 MUTATION

R. Levasseur¹, Y. Allanore², M. Abi Fadel³, M. Varret⁴, A. Marques⁴, C. Cormier², A. Kahan², C. Boileau⁴

¹Rheumatology Department, Angers University Hospital, Angers, ²Rheumatology Department, Cochin University Hospital, Paris, ³Inserm U 383, Necker University Hospital, Angers, ⁴Inserm U 383, Necker University Hospital, Paris, France

P580-Su IDENTIFICATION OF POLYMORPHISMS IN THE MKP1 GENE AND THEIR ASSOCIATION WITH BONE MINERAL DENSITY IN MEN WITH ASTHMA

A. Bassiti¹, F. E. A. McGuigan¹, C. Wong², A. E. Tattersfield², P. A. Hulley³, S. H. Ralston¹

¹Bone Research Group, University of Aberdeen, Aberdeen, ²Division of Respiratory Medicine, City Hospital, Nottingham, ³Botnar Reseach Unit, University of Oxford, Oxford, United Kingdom

P581-Mo ANALYSIS OF MURINE CHROMOSOMES 11 AND 13 LOCI THAT CONTROL PEAK BONE MASS

M. Shimizu¹, R. Nakanishi¹, B. Otsuki¹, T. Nakamura¹, M. Hosokawa², M. Mori³, K. Higuchi³, T. Tsuboyama⁴

¹Department of Orthopaedic and Musculoskeletal Surgery, Graduate School of Medicine, Kyoto University, Kyoto, ²Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, ³Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, ⁴School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto, Japan

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Osteoporosis Treatment : Anabolic Agents and Other Agents - P582 - P592

P582-Tu THE RANKL INHIBITOR OSTEOPROTEGERIN CAUSES RAPID AND SIGNIFICANT INCREASES IN BONE DENSITY IN RATS CO-TREATED WITH PARATHYROID HORMONE

X. Li¹, C. Capparelli¹, S. Morony¹, S. Adamu¹, F. Asuncion¹, K. Hoffman¹, M. Grisanti¹, H. L. Tan¹, P. J. Kostenuik¹

¹Metabolic Disorders, Amgen Inc., Thousand Oaks, United States

P583-Su PHARMACOKINETICS (PK), PHARMACODYNAMICS (PD), AND SAFETY OF AMG 162, A FULLY HUMAN MONOCLONAL ANTIBODY TO RANKL, FOLLOWING A SINGLE SUBCUTANEOUS DOSE TO HEALTHY MEN AGED 50 YEARS AND OLDER

M. C. Peterson¹, L. Ni², M. Salfi², J. Green³, D. Burns¹, E. Gurrola¹, D. Padhi³

¹Pharmacokinetics and Drug Metabolism, ²Biostatistics, ³Early Development, Amgen Inc., Thousand Oaks, United States

P584-Mo STRONTIUM RANELATE PROMOTES CHEMOTAXIS, STIMULATES PROLIFERATION AND INDUCES GENES INVOLVED IN THE DIFFERENTIATION OF RAT PRIMARY OSTEOBLASTS.

N. Chattopadyay¹, S. Yano¹, J. Tfelt-Hansen¹, E. M. Brown¹

¹Endocrine-Hypertension Division, Brigham and Women's Hospital, Boston, United States

P585-Tu STRONTIUM RANELATE DECREASES IN VITRO HUMAN OSTEOCLASTIC DIFFERENTIATION

A. Wattel¹, A. Hurtel-Lemaire², C. Godin², R. Mentaverri², S. Kamel², M. Brazier²

¹Laboratoire de Pharmacie et Biologie Cliniques, UMRO, Université de Picardie Jules Verne, ²Laboratoire de Pharmacie et Biologie Cliniques, Faculté de Pharmacie, Amiens, France

P586-Su PROTEIN KINASE C ARE INVOLVED IN STRONTIUM RANELATE-INDUCED OSTEOCLAST APOPTOSIS.

A. Hurtel-Lemaire¹, R. Mentaverri², A. Wattel², S. Kamel², M. Brazier²

¹Laboratoire de Pharmacie et Biologie Cliniques, UMRO, Université de Picardie Jules Verne, ²Laboratoire de Pharmacie et Biologie Cliniques, Faculté de Pharmacie, Amiens, France

P587-Mo SEVELAMER PREVENTS BONE LOSS IN OVARIECTOMIZED RATS

S. Vukicevic¹, P. Simic¹, N. Draca¹, A. Blair², S. Burke², K. Sampath²

¹Department of Anatomy, School of Medicine, Zagreb, Croatia, ²Drug Discovery and Development, Genzyme, Waltham, United States

P588-Tu EFFECT OF ATORVASTATIN TO RANKL/OPG SYSTEM IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

J. L. Pérez-Castrillon¹, L. Abad¹, G. Vega¹, A. Sanz-Cantalapiedra¹, A. SanMiguel¹, A. Mazón¹, A. Mazón¹, S. Sanchez², G. Hernandez², A. Dueñas-Laita¹

¹Medicine, University Hospital Rio Hortega, Valladolid, ²Medicine, Pfizer, Madrid, Spain

P589-Su OSEINE-HIDROXIAPATITE VERSUS CALCIUM CARBONATE EFFECTS IN BONE METABOLISM IN PRIMARY SENILE OSTEOPOROSIS

M. Ciria¹, L. Perez-Edo¹, J. Blanch¹, M. Lisbona¹, M. Coll¹, A. Diez-Perez², X. Nogués², J. Carbonell¹

¹Rheumatology, ²Internal Medicine, Hospital del Mar, Barcelona, Spain

P590-Mo MONONFLUOROPHOSPHATE AND HORMONE REPLACEMENT THERAPY: A RANDOMIZED CONTROLLED TRIAL

T. Cundy¹, A. Grey¹, G. Gamble¹, J. Clearwater¹, A. Horne¹, R. Ames¹, B. Orr-Walker¹, F. Wu¹, M. Evans¹, A. King², I. R. Reid¹

¹Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, ²Department of Pathology, Middlemore Hospital, Auckland, New Zealand

P591-Tu STRONTIUM RANELATE REDUCES THE RISK OF VERTEBRAL FRACTURES IN OSTEOPOROTIC POSTMENOPAUSAL WOMEN WHATEVER THE BASELINE VERTEBRAL FRACTURE STATUS.

P. Fardellone¹, C. Roux², J. Fechtenbaum², S. Kolta², H. P. Kruse³, A. Sawicki⁴, K. Hoszowski⁵, J. Padrino⁶, O. Sorensen⁷, J. Reginster⁸, P. Meunier⁹

¹Department of Rheumatology, Hôpital Nord, Amiens, ²Department of Rheumatology, Cochin Hospital, Paris, France, ³Med. Universitätsklinik, Hamburg, Germany, ⁴, Warsawian Center of Osteoporosis and Calcium Metabolism, ⁵Department of Internal Medicine, Railway Hospital, Warsaw, Poland, ⁶, Hospital 12 de Octubre, Madrid, Spain, ⁷, Osteoporosis Research Center, Hvidovre University Hospital, Hvidovre, Denmark, ⁸, University of Liège, Liège, Belgium, ⁹, Faculty Laennec, Lyon, France

P592-Su CALCIUM-SENSING RECEPTOR MEDIATES STRONTIUM RANELATE-INDUCED OSTEOCLASTS APOPTOSIS.

R. Mentaverri¹, A. Hurtel¹, A. Wattel¹, S. Kamel¹, E. M. Brown², M. Brazier¹

¹UMRO, Université de Picardie Jules verne, Amiens, France, ²Endocrine-Hypertension Division, Brigham and Women's Hospital, Boston, United States

index

Osteoporosis Treatment : Analogs and Metabolites - P593 - P595

P593-Mo EXPERIMENTAL COMPARISON OF BONE-INVIGORATIVE HERBAL MEDICINE AND KIDNEY-INVIGORATIVE HERBAL MEDICINE IN TREATING RAT OSTEOPOROSIS BY OVARIECTOMY

Z. K. Zheng¹, Z. G. Luo², Y. Zhao³, J. Ma⁴, J. P. Wang⁵, W. S. Yu², P. Hu², Q. N. Jiang²

¹Department of Chemistry, Shenzhen University, ²Department of Bioengineering, Shenzhen University, Shenzhen, ³Department of Pharmacology, Guangdong Pharmacology College, Guangzhou, ⁴Hospital, Shenzhen University, ⁵Deparment of Respiratory Medcine, Traditional Chinese Medicine Hospital, Shenzhen, China

P594-Tu WHAT IS THE BASIS FOR THE DISTINCT DIFFERENCES IN THE THERAPEUTIC EFFICACY OF ALFACALCIDOL AND PLAIN VITAMIN D ?

J. D. Ringe¹, P. Farahmand¹, E. Schacht²

¹Klinikum Leverkusen, Medizinische Klinik 4 Rheumatology Osteology, University of Cologne, Leverkusen, Germany, ²Department of Rheumatology and Rehabilitation, University Clinic Balgrist, Zurich, Switzerland

P595-Su THE EFFECT OF ORAL TRANSFER FACTOR ON DEVELOPMENT OF OSTEOPENIA IN OVARIECTOMIZED RATS

K. Svik¹, J. Rovensky¹, R. Istok¹, P. Masaryk¹, M. Stancikova¹

¹Connective tissue, National Institute of Rheumatic Diseases, Piestany, Slovakia

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Osteoporosis Treatment : Bisphosphonates - P596 - P639

P596-Mo THE RATE THAT FAMILY PHYSICIANS PRESCRIBE OSTEOPOROSIS MEDICATIONS TO THEIR PATIENTS: CANADIAN QUALITY CIRCLES (CQC) PROJECT

A. Hodsman¹, G. Ioannidis², A. Papaioannou², B. Kvern³, D. Johnstone⁴, C. Crowley⁵, M. Doupe⁶, A. Baldwin⁶, J. D. Adachi²

¹Medicine, University of Western Ontario, London, ²Medicine, McMaster University, Hamilton, ³Family Medicine, University of Manitoba, Winnipeg, ⁴National Professional Relations Manager, ⁵Medical and Technical Affairs, Procter and Gamble Pharmaceuticals, Toronto, ⁶Primary Health Care Research Unit, University of Manitoba, Winnipeg, Canada

P597-Tu TREATMENT OF CHARCOT ARTHROPATHY WITH ORAL BISPHOSPHONATE

A. Jamieson¹, R. Drummond¹, D. S. Stang¹

¹Diabetes and Metabolism, Hairmyres Hospital, East Kilbride, United Kingdom

P598-Su COMPARISON OF RALOXIFENE AND BISPHOSPHONATES ON ADHERENCE, HEALTH OUTCOMES AND TREATMENT SATISFACTION IN POSTMENOPAUSAL ASIAN WOMEN

A. W. C. Kung¹, E. G. Pasion², D. K. S. Sivananthan³, S. Chen⁴, B. Tay⁵, G. Shah⁶, F. Tam⁷, C. M. Markey⁸, D. Thiebaud⁸

¹Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China, ²Department of Orthopedics, University of the Philippines, Philippine General Hospital, Manila, Philippines, ³, Hospital Fatimah, Perak, Malaysia, ⁴Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ⁵Department of Orthopedic Surgery, Singapore General Hospital, Singapore, ⁶, Doctor's Hospital, Lahore, Pakistan, ⁷, Eli Lilly Canada, Toronto, Canada, ⁸, Eli Lilly Australia, Sydney, Australia

P599-Mo THE EFFICACY OF RISEDRONATE FOR JAPANESE WOMEN WITH OSTEOPOROSIS.

J. Takada¹, K. Iba¹, G. Katahira², M. Takahashi³, M. Nakajima³, H. Hashimoto⁴, T. Ohno⁵, N. Hatakeyama¹, T. Yamashita¹

¹Orthopedic Surgery, Sapporo Medical University, ²Orthopedic Surgery, Sapporo Kiyota Orthopedic Hospital, Sapporo, ³Orthopedic Surgery, Chitose Municipal Hospital, Chitose, ⁴Orthopedic Surgery, Fushimi-Keimei Orthopedic Clinic, Sapporo, ⁵Orthopedic Surgery, Haboro Prefectural Hospital, Haboro, Japan

P600-Tu IMPROVEMENT OF PERIDENTAL BONE DENSITY AND QUALITY WITH BISPHOSPHONATE. A PQCT ANALYSIS OF REGIONAL AND THRESHOLD CLUSTERED DATA

V. E. Montangero¹, S. Pérez Lloret¹, M. A. Beneites¹, R. Demarchi¹, E. J. A. Roldan¹

¹ERMES-BO, Maxilla Osteology Group -GOM-, Buenos Aires, Argentina

P601-Su MECHANICALLY INDUCED DENTAL RESORPTION HALTED WITH SHORT-TERM ORAL PAMIDRONATE. A PRELIMINARY CLINICAL STUDY

V. E. Montangero¹, M. C. Escala¹, A. Santizo¹, R. Capiglioni¹

¹ERMES-BO, Maxilla Osteology Group -GOM-, Buenos Aires, Argentina

P602-Mo IN VITRO PHARMACEUTICAL AND BIOLOGICAL EVALUATION OF ZOLEDRONATE-LOADED CALCIUM PHOSPHATE CERAMICS : AN INNOVATIVE STRATEGY FOR THE LOCAL TREATMENT OF BONE PATHOLOGICAL RESORPTION

C. Faucheux¹, S. Josse², G. Grimandi¹, A. Soueidan¹, M. Arshad¹, P. Janvier², G. Daculsi¹, B. Bujoli², J. Bouler¹, J. J. Guicheux¹

¹INSERM EMI 9903, School of dental surgery, ²CNRS UMR 6513, Faculty of sciences, Nantes, France

P603-Tu RESTORATION AND MAINTENANCE OF BONE DENSITY WITH ALENDRONATE IN CHILDREN WITH OSTEOPOROSIS

C. B. Langman¹, A. L. Arwady¹, H. Price¹

¹Kidney Diseases, Childrens Memorial Hospital, Chicago, United States

P604-Su ADHERENCE WITH BISPHOPHONATE TREATMENT FOR OSTEOPOROSIS IN UK PATIENTS

W. Cowell¹, A. Fulford-Smith², S. Poultney³

¹Health Economics, Roche Ltd, Welwyn Garden City, ²Medical, ³Business Information, GSK, London, United Kingdom

P605-Mo EFFECT OF ALENDRONATE ON BONE MINERAL DENSITY AND CA-P METABOLISM IN SENILE AND POSTMENOPAUSAL OSTEOPOROSIS

S. S. Rodionova¹, A. F. Kolondaev¹

¹Bone Pathology, Central Institute of Traumatology and Orthopaedics, Moscow, Russian Federation

P606-Tu EFFECTS OF ALENDRONATE TREATMENT ON SERUM LEVELS OF OSTEOPROTEGERIN AND TOTAL RANKL IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS

R. Reyes-García¹, D. Fernández-García¹, P. Mezquita-Raya¹, M. De la Higuera¹, G. Alonso¹, M. E. Ruiz-Requena², F. Escobar-Jiménez², M. Muñoz-Torres²

¹Bone Metabolic Unit. Endocrinology Division, ²Biochemistry Unit, University Hospital San Cecilio, Granada, Spain

P607-Su EFFECTS OF ALENDRONATE ON BONE MINERAL DENSITY AND BONE METABOLIC MARKERS IN PATIENTS WITH LIVER TRANSPLANTATION

F. Atamaz¹, S. Hepguler¹, Z. Karasu², M. Kilic³

¹Physical Therapy and Rehabilitation, ²Hepatology and Gastroenterology, ³Surgery, Medical Faculty of Ege University, Izmir, Turkey

P608-Mo COST-EFFECTIVENESS OF RISEDRONATE THERAPY IN POSTMENOPAUSAL WOMEN WITH VARYING RISK OF OSTEOPOROTIC FRACTURES: A SWISS ANALYSIS

O. Lamy¹, M. Krieg¹, J. Wasserfalllen¹, R. Greiner², W. Russ³

¹Department of Internal Medicine, University Hopital of Lausanne, Lausanne, Switzerland, ²Consultant, Health Economics, Lörrach, Germany, ³Medical Affairs, Aventis Pharma, Zürich, Switzerland

P609-Tu A NEW MECHANISM OF ACTION FOR BISPHOSPHONATES: A N-BP-INDUCED ENDOGENOUS ATP-ANALOG (APPPI) CAUSES MITOCHONDRIA-MEDIATED APOPTOSIS

H. Mönkkönen¹, S. Auriola², P. Lehenkari³, M. Kellinsalmi³, I. E. Hassinen⁴, J. Vepsäläinen⁵, J. Mönkkönen¹

¹Department of Pharmaceutics, ²Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio, ³Department of Surgery, ⁴Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, ⁵Department of Chemistry, University of Kuopio, Kuopio, Finland

P610-Su PERSISTENCE TO BISPHOSPHONATE TREATMENT IN ACTUAL CLINICAL PRACTICE

T. P. Van Staa¹, P. Geusens², H. G. M. Leufkens³, C. Cooper⁴

P611-Mo INTRAVENOUS ZOLEDRONATE FOR OSTEOPOROSIS THERAPY

P. J. Ryan¹

¹Osteoporosis Unit, Medway Maritime Hospital, Gillingham, United Kingdom

P612-Tu EFFECTS OF COMBINED AGENT OF ALENDRONATE & CALCITRIOL(MAXMARVIL®) ON BONE METABOLISM IN KOREAN POSTMENOPAUSAL WOMEN: MULTICENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY

Y. Rhee¹, M. Kang², Y. Min³, D. Byun⁴, Y. Chung⁵, C. Ahn¹, K. Baek², J. Mok⁴, D. Kim⁵, D. Kim¹, H. Kim³, Y. Kim¹, S. Lim¹

¹Internal Medicine, College of Medicine, Yonsei University, ²Internal Medicine, College of Medicine, Catholic University of Korea, ³Internal Medicine, College of Medicine, Sungkunkwan University, Seoul, ⁴Internal Medicine, College of Medicine, Soonchunhyang University, Bucheon, ⁵Internal Medicine, Ajou University School of Medicine, Suwon, South Korea

P613-Su ZOLEDRONATE REDUCES EARLY ACUTE BONE LOSS AT THE HIP FOLLOWING SPINAL CORD INJURY

J. S. Bubbear¹, A. Gall², F. R. I. Middleton², M. Ferguson-Pell³, R. W. Keen¹

¹Metabolic Unit, ²Spinal Injuries Unit, ³Aspire Centre for Disability Services, Royal National Orthopaedic Hospital, Stanmore, United Kingdom

P614-Mo BIPHOSPHONATES THERAPY OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN WITH CALCIUM OXALATE NEPHROLITHIASIS

S. O. Mazurenko¹, D. G. Baltachi²

¹Center of Osteoporosis, ²Department of Urology, Medical and Sanitary Unit 122, Sokolov Hospital, Saint Petersburg, Russian Federation

P615-Tu CLINICAL EXPERIENCE WITH PAMIDRONATE TREATMENT IN CHILDREN WITH SPASTIC QUADRIPLEGIC CEREBRAL PALSY - A RETROSPECTIVE REVIEW

H. Harcke¹, H. H. Kecskemethy², S. J. Bachrach³

¹Medical Imaging, ²Research, ³Pediatrics, A. I. duPont Hospital for Children, Wilmington, United States

P616-Su TREATMENT OF ESTABLISHED PRIMARY OSTEOPOROSIS IN MEN WITH RISEDRONATE VERSUS ETIDRONATE: 1-YEAR RESULTS OF A PROSPECTIVE STUDY

B. E. Gerbert¹, H. Heinze¹, J. Schulze¹

¹Universitätsklinikum Dresden, Medizinische Klinik III, Dresden, Germany

P617-Mo BISPHOSPHONATE RELEASE FOLLOWING CESSATION OF LONG-TERM TREATMENT OF CHILDREN WITH OSTEOPOROSIS

S. Papapoulos¹, C. Brumsen¹, N. Hamdy¹, S. Cremers²

¹Endocrinology and Metabolic Diseases, ²Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands

P618-Tu ONCE-MONTHLY DOSING OF ORAL IBANDRONATE IS AT LEAST AS EFFECTIVE AS DAILY DOSING IN POSTMENOPAUSAL OSTEOPOROSIS: 1-YEAR RESULTS FROM MOBILE

J. Y. Reginster¹, V. Zikan², R. Lorenc³, C. Hughes⁴, N. Mairon⁴, B. Bonvoisin⁴, J. A. Stakkestad⁵

¹., University Of Liege, Liege, Belgium, ²., Charles University, Prague, Czech Republic, ³., The Children's Memorial Institute, Warsaw, Poland, ⁴., F. Hoffmann-La Roche Ltd, Basel, Switzerland, ⁵., CECOR AS, Haugesund, Norway

P619-Su COMPARISON OF ANALGESIC EFFICACY OF PAMIDRONATE AND HUMAN CALCITONIN IN VERTEBRAL OSTEOPOROTIC FRACTURE PAINS : A DOUBLE-BLIND STUDY

M. M. Laroche¹, S. S. Cantogrel¹, B. B. Jamard¹, A. A. Constantin¹, L. L. Zabraniecki¹, B. B. Mazieres¹

¹Rheumatology, CHU Rangueil, Toulouse, France

P620-Mo ADHERENCE TO TREATMENT AND CHANGES IN VITAMIN D STATUS IN HIP FRACTURE PATIENTS – PARTICIPANTS OF POST-SURGICAL TREATMENT PROGRAM.

E. Segal¹, C. Zinman², B. Raz¹

¹Metabolic Bone Diseases Unit, Rambam Medical Center, ²Ortopedic Surgery Department, Ramabam Medical Center, Haifa, Israel

P621-Tu MONTHLY ORAL IBANDRONATE IS AT LEAST AS EFFECTIVE AS DAILY ORAL IBANDRONATE IN INCREASING HIP BMD IN POSTMENOPAUSAL OSTEOPOROSIS: 1-YEAR RESULTS FROM MOBILE

C. Cooper¹, J. J. Stepan², R. Lorenc³, C. Hughes⁴, N. Mairon⁴, F. Sedarati⁴, J. Y. Reginster⁵

¹MRC Epidemiology Resource Centre, University of Southampton, Southhampton, United Kingdom, ²., Charles University, Prague, Czech Republic, ³., The Children's Memorial Institute, Warsaw, Poland, ⁴., F. Hoffmann-La Roche Ltd, Basel, Switzerland, ⁵., University of Liege, Liege, Belgium

P622-Su STRONG PATIENT PREFERENCE FOR ONCE-MONTHLY OVER WEEKLY ORAL BISPHOSPHONATE DOSING IN POSTMENOPAUSAL OSTEOPOROSIS

K. Akesson¹, K. Beusterien², A. Hebborn³, N. Kline Leidy²

¹Department of Orthopedics, Malmo University Hospital, Malmo, Sweden, ²Center for Health Outcomes Research, MEDTAP International Inc., Bethesda, MD, United States, ³., F. Hoffmann-La Roche Ltd, Basel, Switzerland

P623-Mo PAMIDRONATE PREVENTS BONE LOSS AND DECREASED BONE STRENGTH IN ADULT FEMALE AND MALE RATS FED AN ISOCALORIC LOW PROTEIN DIET

S. Mekraldi¹, A. Toromanoff¹, R. Rizzoli¹, P. Ammann¹

¹Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva, Switzerland

P624-Tu FAVOURABLE SAFETY PROFILE OF ONCE-MONTHLY ORAL IBANDRONATE IN POSTMENOPAUSAL OSTEOPOROSIS: 1-YEAR RESULTS FROM MOBILE

R. Nuti¹, J. A. Stakkestad², E. Czerwinski³, C. Leigh⁴, N. Mairon⁴, B. Bonvoisin⁴, C. Cooper⁵

¹., University of Sienna, Sienna, Italy, ²., CECOR AS, Haugesund, Norway, ³., Krakow Medical Centre, Krakow, Poland, ⁴., F. Hoffmann-La Roche Ltd, Basel, Switzerland, ⁵MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom

P625-Su URINARY EXCRETION AND EFFICACY OF ORAL ALENDRONATE IN PATIENTS WITH CROHN'S DISEASE AND OSTEOPOROSIS

N. A. T. Hamdy¹, S. Cremers², D. Banffer¹, J. Den Hartigh², P. Vermeij², R. Van Hogezand³, S. Papapoulos¹

¹Endocrinology and Metabolic Diseases, ²Clinical Pharmacy and Toxicology, ³Gastroenterology, Leiden University Medical Centre, Leiden, Netherlands

P626-Mo FAVOURABLE RENAL SAFETY PROFILE OF INTRAVENOUS IBANDRONATE INJECTIONS IN POSTMENOPAUSAL OSTEOPOROSIS: 1-YEAR RESULTS FROM DIVA

P. Delmas¹, D. Reid², D. Felsenberg³, C. Leigh⁴, P. Ward⁴, F. Sedarati⁴, C. Christiansen⁵

¹., Claude Bernard University and INSERM Research Unit 403, Lyon, France, ²Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom, ³., Charite-University Medicine Berlin, Berlin, Germany, ⁴., F.Hoffmann-La Roche Ltd, Basel, Switzerland, ⁵., CCBR, Ballerup, Denmark

P627-Tu EFFECT OF 3- AND 5-YEAR TREATMENT WITH RISEDRONATE ON THE BONE MINERALIZATION DENSITY DISTRIBUTION OF TRABECULAR BONE IN HUMAN ILIAC CREST BIOPSIES

R. Zoehrer¹, P. Roschger¹, E. Durchschlag¹, P. Fratzl², E. Paschalis¹, R. Recker³, R. Phipps⁴, K. Klaushofer¹

¹Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna, Austria, ²Department of Biomaterials, Max Plank Institute of Colloids and Interfaces, Potsdam, Germany, ³Osteoporosis Research Center, Creighton University, Omaha, ⁴New Drug Development, Procter and Gamble Pharmaceuticals, Mason, United States

P628-Su EFFECTS OF 3- AND 5-YEAR TREATMENT WITH RISEDRONATE ON THE BONE MINERAL MATURITY/CRYSTALLINITY AND COLLAGEN CROSS-LINKS AS A FUNCTION OF TRABECULAR SURFACE ACTIVITY

E. Paschalis¹, E. Durchschlag¹, R. Zoehrer¹, P. Roschger¹, P. Fratzl², R. Recker³, R. Phipps⁴, K. Klaushofer¹

¹Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna, Austria, ²Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, ³Osteoporosis Research Center, Creighton University, Omaha, ⁴New Drug Development, Procter and Gamble Pharmaceuticals, Mason, United States

P629-Mo HEAD-TO-HEAD CLINICAL TRIALS COMPARING OSTEOPOROSIS TREATMENTS: DESIGN CONSIDERATIONS

D. Hosking¹, P. Miller²

¹Consultant Physician, Nottingham City Hospital, Nottingham, United Kingdom, ²Director, Colorado Center for Bone Research, Lakewood, United States

P630-Tu FRACTURE RISK AND GASTROINTESTINAL EFFECTS OF BISPHOSPHONATES: LIMITATIONS OF OBSERVATIONAL DATA IN COMPARING TREATMENTS

R. Rizzoli¹, P. N. Sambrook², T. J. Schnitzer³

¹Division of Bone Diseases, University Hospital, Geneva, Switzerland, ²Rheumatology, University of Sydney, Sydney, Australia, ³Internal Medicine, Northwestern University School of Medicine, Chicago, United States

P631-Su FACTS-INTERNATIONAL: GREATER INCREASES IN BMD WITH ALENDRONATE ONCE WEEKLY COMPARED TO RISEDRONATE ONCE WEEKLY

D. M. Reid¹, D. J. Hosking², D. L. Kendler³, N. Verbruggen⁴, K. A. Gaines⁵, M. E. Melton⁵

¹, University of Aberdeen, Aberdeen, ², Nottingham City Hospital, Nottingham, United Kingdom, ³, St. Vincent's Hospital, Vancouver, Canada, ⁴, Merck and Co., Inc., Brussels, Belgium, ⁵, Merck and Co., Inc., Whitehouse Station, NJ, United States

P632-Mo DIFFERENCES IN EARLY DYNAMICS OF SERUM BONE MARKERS IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS TREATED BY ALENDRONATE OR RISEDRONATE

C. Sferrazza¹, N. Napoli¹, V. Cannone¹, G. Cusumano¹, G. Rini¹, G. Di Fede¹

¹Internal Medicine, University of Palermo, Palermo, Italy

P633-Tu EFFECT OF AMINOBIPHOSPHONATES ON ACTIVATION AND DIFFERENTIATION OF T GAMMA DELTA LYMPHOCYTES: AN IN VIVO STUDY

C. C. S. Sferrazza¹

¹Department of Internal Medicine, University of Palermo, Palermo, Italy

P634-Su IN VITRO EFFECTS OF BISPHOSPHONATES ON GAMMA DELTA CELL ACTIVATION AND DIFFERENTIATION.

V. V. f. Ferlazzo¹

¹DEPARTMENT OF INTERNAL MEDICINE, UNIVERSITY OF PALERMO, 90129, Italy

P635-Mo THE IMPACT OF BACKGROUND OP MEDS ON BASELINE FRACTURE RISK FROM THE HORIZON PFT WITH ZOLEDRONIC ACID

J. Zhang¹, P. D. Delmas², R. Eastell³, I. R. Reid⁴, T. Rosario-Jansen¹, M. Flood¹, K. Tong¹, J. Caminis¹, D. M. Black⁵

¹Clinical Research, Novartis Pharmaceuticals, East Hanover, United States, ²Medicine, Hôpital Edouard Herriot, Lyon, France, ³Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, ⁴Clinical Research, University of Auckland, Auckland, New Zealand, ⁵Epidemiology and Biostatistics, University of California San Francisco, San Francisco, United States

P636-Tu IBANDRONATE IMPROVES OSSEOINTEGRATION OF CEMENTLESS METAL IMPLANTS TO A SIMILAR EXTENT WHETHER GIVEN CONTINUOUSLY OR AS A SINGLE EQUIVALENT CUMULATIVE DOSE

A. A. Kurth¹, M. Schwarz², J. Brahnkamp¹, C. Eberhardt¹

¹Department of Orthopaedic Surgery, University Hospital Frankfurt, Frankfurt, ²Department of Orthopaedic Surgery, University Hospital Mannheim, Mannheim, Germany

P637-Su INCIDENCE OF INFLUENZA-LIKE SYMPTOMS WITH INTERMITTENT INTRAVENOUS IBANDRONATE INJECTIONS: 1-YEAR RESULTS FROM DIVA

D. M. Reid¹, L. B. Tankó², D. Felsenberg³, S. Adami⁴, C. Leigh⁵, P. Ward⁵, D. Masanauskaite⁵, P. D. Delmas⁶

¹., University of Aberdeen, Aberdeen, United Kingdom, ²., CCBR, Ballerup, Denmark, ³., Charité-University Medicine Berlin, Berlin, Germany, ⁴., Unversity of Verona, Verona, Italy, ⁵., F. Hoffmann-La Roche Ltd, Basel, Switzerland, ⁶., Claude Bernard University and INSERM Research Unit 403, Lyon, France

P638-Mo LESS FREQUENT ORAL BISPHOSPHONATE DOSING IMPROVES THERAPEUTIC PERSISTENCE IN POSTMENOPAUSAL OSTEOPOROSIS

P. Orcel¹, A. Gilmore², A. Hebborn³, S. Takemoto²

¹., Hôpital Lariboisiere, Paris, France, ²., Health Benchmarks, Inc, Woodland Hills, United States, ³., F. Hoffmann-La Roche Ltd, Basel, Switzerland

P639-Tu DOSE- AND TIME-DEPENDENT APOPTOSIS OF HUMAN SARCOMA CELLS BY IBANDRONATE AND CLODRONATE IN VITRO

U. Stumpf¹, S. Goettig², M. Schoenherr¹, R. Henschler², A. A. Kurth¹

¹Department of Orthopaedic Surgery, University Hospital Frankfurt, ²Institute of Transfusion Medicine and Immune Haematology, Johann Wolfgang Goethe University, Frankfurt, Germany

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Osteoporosis Treatment : Calcitonin - P640

P640-Su SITE-SPECIFIC VARIATIONS IN THERAPEUTIC EFFECTS OF SALMON CALCITONIN-NASAL SPRAY (CT-NS) ON BONE QUALITY (BQUAL) (TRABECULAR MICROARCHITECTURE (TMA) AND BONE QUANTITY (BQUANT) (BMD): RESULTS FROM THE QUEST STUDY.

C. H. Chesnut¹, S. Majumdar², D. Newitt², A. Shields³, M. Olson⁴, M. Azria⁵, L. Mindeholm⁶

¹Radiology and Medicine, University of Washington Medical Center, Seattle, ²Radiology, U Cal San Francisco, San Francisco, Cal, ³Radiology, U of Washington Medical Center, Seattle, Washington, United States, ⁴Biostatistics, ⁵Pharmacology, ⁶Clinical research, Novartis Pharma, Basel, Switzerland

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Osteoporosis Treatment : Dietary Factors - P641 - P646

P641-Mo THE EFFECT OF HIGH CALCIUM FORTIFIED MILK SUPPLEMENTATION ON BIOCHEMICAL MARKERS OF BONE RESORPTION AND FORMATION IN PREMENOPAUSAL WOMEN.

M. C. Kruger¹, L. M. Schollum², C. L. Booth¹, B. Kuhn-Sherlock²

¹Institute of Food, Nutrition and Human Health, Massey University, ², Fonterra Research Centre, Palmerston North, New Zealand

P642-Tu ACIDIC PROTEIN FRACTIONS FROM WHEY OR MILK LIMIT BONE LOSS IN THE FEMALE OVARIECTOMISED RAT.

M. C. Kruger¹, G. G. Plimmer¹, R. C. Poulsen¹, L. M. Schollum², N. Haggarty², S. Ram², K. Palmano²

¹Institute of Food, Nutrition and Human Health, Massey University, ², Fonterra Research Centre, Palmerston North, New Zealand

P643-Su DOSE-RESPONSE OF HESPERIDIN, A CITRUS FLAVONOID, ON BONE MASS IN YOUNG INTACT RATS

M. Horcajada¹, C. Morand¹, P. Lebecque¹, C. Puel¹, J. Mathey¹, M. Davicco¹, G. Williamson², V. Coxam¹, E. Offord²

¹Unité des Maladies Métaboliques et Micronutriments, INRA, St Genes Champanelle, France, ²Nutrition and Health, Nestlé Research Center, Lausanne, Switzerland

P644-Mo ZINC INCREASES THE EFFECTS OF PROTEIN SUPPLEMENTS ON SERUM IGF-I AND BONE TURNOVER IN FRAIL ELDERLY.

A. Rodondi¹, P. Ammann¹, R. Rizzoli¹

¹Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva, Switzerland

P645-Tu EFFECTS OF PHYTOESTROGENS AND THEIR METABOLITES, EQUOL, ON ESTROGENIC ACTIVITY AND OSTEOCLAST FORMATION

C. Hwang¹, Y. Kang¹, I. Moon¹, C. Lim², H. Yoon², I. Han², H. Hur³, K. Han²

¹Laboratory of endocrinology, ²Medicine, Samsung cheil hospital, women's healthcare center, Sungkyunkwan University School of Medicine, seoul, ³Environmental Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea

P646-Su DIETARY INTAKE OF KEY BONE HEALTH NUTRIENTS IN SWISS ELDERLY WOMEN - RESULTS FROM EVANIBUS

E. Wynn Dumartheray¹, M. Krieg¹, J. Cornuz¹, D. R. Whittamore², S. A. New², P. Burckhardt³

¹Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland, ²Centre for Nutrition and Food Safety, University of Surrey, Guildford, United Kingdom, ³Osteology, Bois-Cerf Clinic, Lausanne, Switzerland

index

Osteoporosis Treatment : Estrogen (HRT) and Related Components - P647 - P651

P647-Mo LONG TERM CHANGES ON OPG-RANKL SYSTEM, HORMONAL PROFILE AND BONE MINERAL DENSITY IN PATIENTS WITH POSTMENOPAUSAL OSTEOPOROSIS PATIENTS TREATED WITH RALOXIFENE

D. J. Fernández-García¹, P. Mezquita Raya¹, M. De la Higuera¹, R. Reyes García¹, G. Alonso¹, M. E. Ruiz Requena², M. Muñoz-Torres¹

¹Bone Metabolism Unit. Endocrinology Division., ²Biochemistry Division, University Hospital San Cecilio., Granada, Spain

P648-Tu EFFECT OF RALOXIFENE ON CLINICAL FRACTURES IN ASIAN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS

T. Nakamura¹, J. Liu², H. Morii³, Q. Huang⁴, H. Zhu⁵, Y. Qu⁶, E. Hamaya⁶, D. Thiebaud⁶

¹,, University of Occupational and Environmental Health, Kitakyushu, Japan, ²,, General Hospital of PLA, Beijing, China, ³,, Osaka City University, Osaka, Japan, ⁴,, Shanghai No. 6 People's Hospital, ⁵,, Shanghai Huadong Hospital, Shanghai, China, ⁶Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, United States

P649-Su CHANGE OF BIOCHEMICAL BONE MARKERS AFTER TIBOLONE IN KOREAN POSTMENOPAUSAL WOMEN

B. M. o. o. n. Kang¹, H. Choi², H. M. Park³, S. H. Seo⁴, B. S. Lee⁵, B. I. Lee⁶, J. G. Kim⁷, B. G. Yoon⁸, K. H. Park⁵

¹Obstetrics and gynecology, Asan medical center, Ulsan University Medical School, ²Obstetrics and gynecology, Inje University Medical School, ³Obstetrics and gynecology, ChoongAng University Medical School, ⁴Obstetrics and gynecology, Hanlim University Medical School, ⁵Obstetrics and gynecology, Yonsei University Medical School, ⁶Obstetrics and gynecology, InhaUniversity Medical School, ⁷Obstetrics and gynecology, Seoul National University Medical School, ⁸Obstetrics and gynecology, Seongkyunkwan university medical school, Seoul, South Korea

P650-Mo IMPACT OF THE WOMEN’S HEALTH INITIATIVE (WHI)TRIAL ON OSTEOPOROSIS PREVENTION

G. Phillipov¹, P. J. Phillips¹

¹Endocrinology, The Queen Elizabeth Hospital, Woodville, Australia

P651-Tu A TWIN STUDY OF HIP STRENGTH ASSOCIATED WITH HORMONE REPLACEMENT THERAPY

J. D. Wark¹, L. M. Paton¹, T. J. Beck², L. Semanic², C. A. Nowson³, C. Margerison³, S. Kantor¹

¹Medicine, The University of Melbourne, Parkville, Australia, ², The Johns Hopkins Outpatients Center, Baltimore, United States, ³School of Health Sciences, Deakin University, Burwood, Australia

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Osteoporosis Treatment : Exercise and Physical Factors - P652 - P658

P652-Su THE INFLUENCE OF MELATONIN ON PREVENTION OF OSTEOPOROSIS IN OVARIECTOMIZED RAT BY ROTATING MAGNETIC FIELD

Z. G. Luo¹, J. G. Qi², W. Zhang², X. Q. Gao³, W. M. Liang³, G. Huang¹, Y. S. Niu¹

¹Department of Bioengineering, Shenzhen University, Shenzhen, ²Department of Histology and Embryology, West China Center of Medical Sciences, Chengdu, ³Department of Histology and Embryology, Guiyang Medical College, Guiyang, China

P653-Mo THE OPTIMAL INTENSITY FOR EXERCISE TO PREVENT FROM DECREASING BONE MASS IN OVARIECTOMIZED MICE

A. Minematsu¹

¹Physical Therapy, Health Science, Nara, Japan

P654-Tu EFFECTS OF TREADMILL RUNNING EXERCISE ON TRABECULAR ARCHITECTURE DURING REMOBILIZATION AFTER SUSPENSION-INDUCED OSTEOPENIA IN YOUNG RATS: THREE-DIMENSIONAL OBSERVATION USING MICRO-CT

Y. Joo¹, T. Sone², T. Okamoto¹, K. Miyashita¹, M. Fukunaga², S. Onodera¹

¹Health and Sports Sciences, Kawasaki University of Medical Welfare, ²Nuclear Medicine, Kawasaki Medical School, Kurashiki, Japan

P655-Su EFFECTS OF JUMP EXERCISE ON TRABECULAR ARCHITECTURE DURING REMOBILIZATION AFTER SUSPENSION-INDUCED OSTEOPENIA IN YOUNG RATS: COMPARISON WITH TREADMILL RUNNING

T. Sone¹, Y. Joo², T. Okamoto², K. Miyashita², M. Fukunaga¹, S. Onodera²

¹Nuclear Medicine, Kawasaki Medical School, ²Health and Sports Sciences, Kawasaki University of Medical Welfare, Kurashiki, Japan

P656-Mo INTENSITY OF PHYSICAL ACTIVITY IS A PREDICTOR OF BONE DENSITY CHANGE IN PREMENOPAUSAL WOMEN

A. Vainionpää¹, R. Korpelainen², E. Vihriälä¹, A. Rinta-Paavola³, J. Leppäluoto⁴, T. Jämsä¹

¹Department of Medical Technology, University of Oulu, ²Department of Sports Medicine, Deaconess Institute of Oulu, ³, Newtest Ltd., ⁴Department of Physiology, University of Oulu, Oulu, Finland

P657-Tu EFFECT OF WHOLE BODY VIBRATION EXERCISE ON LUMBAR BONE MINERAL DENSITY, BONE TURNOVER, AND CHRONIC BACK PAIN IN POSTMENOPAUSAL OSTEOPOROTIC WOMEN TREATED WITH ALENDRONATE

J. Iwamoto¹, T. Takeda¹, M. Uzawa²

¹Department of Sports Medicine, Keio University, Tokyo, ²Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, Japan

P658-Su BONE GEOMETRIC ADAPTATION AFTER A RADIUS FRACTURE: A PQCT STUDY

M. C. Ashe¹, J. C. Davis¹, K. M. Khan¹, P. Guy¹, H. A. McKay¹

¹Orthopaedic Engineering Family Practice, University of British Columbia, Vancouver, Canada

index

Osteoporosis Treatment : Follow up and Miscellaneous - P659 - P678

P659-Mo RALOXIFENE THERAPY DECREASES THE RISK OF NEW CLINICAL VERTEBRAL FRACTURES AT 6 MONTHS

Y. Qu¹, J. L. Stock¹, M. Wong¹, D. Thiebaud¹

¹Women's Health Reproductive Medicine, Eli Lilly and Company, Indianapolis, United States

P660-Tu BODY MASS INDEX AFFECTS THE FUNCTIONAL OUTCOME AFTER HIP FRACTURE IN ELDERLY WOMEN.

M. Di Monaco¹, F. Vallero¹, R. Di Monaco², R. Tappero¹, A. Cavanna¹

¹Osteoporosis Research Center, Presidio Sanitario San Camillo, ²SRF, Società Ricerca e Formazione, Torino, Italy

P661-Su EFFECT OF RALOXIFENE ON INCIDENCE OF INVASIVE BREAST CANCER IN POSTMENOPAUSAL WOMEN HAVING A HISTORY OF PRIOR HORMONE THERAPY USE: RESULTS OF THE CORE TRIAL

T. Powles¹, J. A. Cauley², D. Disch³, R. J. Secrest³, J. Mershon³, D. W. Purdie⁴

¹Institute of Cancer Research, Parkside Oncology Clinic, Wimbledon, United Kingdom, ²Department of Epidemiology, University of Pittsburgh, Pittsburgh, ³Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, United States, ⁴Obstetrics and Gynecology, Edinburgh Osteoporosis Centre, Edinburgh, United Kingdom

P662-Mo BREAST CANCER RISK REDUCTION OVER 8 YEARS IN POSTMENOPAUSAL WOMEN WITH OSTEOPENIA OR OSTEOPOROSIS RECEIVING RALOXIFENE

P. D. Delmas¹, J. A. Cauley², A. L. Burshell³, R. J. Secrest⁴, J. Song⁴, P. Cantor⁴

¹University Claude Bernard of Lyon and INSERM Research Unit 403, Hopital Edouard Herriot, Lyon, France, ²Department of Epidemiology, University of Pittsburgh, Pittsburgh, ³Encocrinology Department, Ochsner Clinic Foundation, New Orleans, ⁴Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, United States

P663-Tu META-ANALYSIS OF THE EFFICACY OF RALOXIFENE ON REDUCTION OF VERTEBRAL FRACTURE RISK

E. Seeman¹, G. Crans², E. V. Glass², A. Diez-Perez³, P. D. Delmas⁴

¹Department of Endocrinology, University of Melbourne, Melbourne, Australia, ²Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, United States, ³Department of Internal Medicine and Infectious Diseases, Hospital de Mar. Autonomous University of Barcelona, Barcelona, Spain, ⁴University Claude Bernard of Lyon and INSERM Research Unit 403, Hopital Edouard Herriot, Lyon, France

P664-Su A MULTI-DICIPLINARY PATIENT EDUCATION PROGRAMME INCREASES PATIENTS DIETARY INTAKE OF CALCIUM - INTERIM ANALYSIS FROM A RANDOMIZED PROSPECTIVE TRIAL

D. Nielsen¹, B. Knold¹, N. Nissen¹, J. Ryg¹, K. Brixen¹

¹Endocrinology, Odense University Hospital, Odense, Denmark

P665-Mo URINARY NTX ,SERUM CTX,BONE ALP AND OSTEOCALCIN EVALUATION DURING THREE YEARS OF RISEDRONATE TREATMENT

I. C. h. Koulouris¹, G. C. h. Koulouris², G. Skarantavos³, L. Anadiotis⁴, . E. Kataxaki⁵, I. Kouris⁶, E. Konstantellou⁷

¹Orthopaedic, IKA Egaleo, ²Psychiatry, Eginition Hospital, ³Orthopaedic, A University Orthopaedic Clinic-Attikon hospital, ⁴Biochemistry, Evangelismos General Hospital, ⁵Rheumatology, IKA Hospital, ⁶A UniversityOrthopaedic Clinic, Attikon Hospital, Athens, ⁷Biochemistry, Agios Panteleimon General Hospital Nikea, Pireus, Greece

P666-Tu PATIENT COMPLIANCE WITH RALOXIFENE (DAILY), ALENDRONATE (DAILY AND WEEKLY) AND RISEDRONATE (DAILY) IN THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS

J. D. Ringe¹, G. E. Christodoulakos², D. Mellström³, S. P. Singh⁴, H. Petto⁵, B. Wagemaker⁶, T. Nickelsen⁷, F. Marin⁸, I. Pavo⁵

¹Medizinische Klinik IV, Klinikum Leverkusen, University of Cologne, Leverkusen, Germany, ²Second Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece, ³Department of Geriatrics, Göteborg University, Göteborg, Sweden, ⁴Lordswood Health Centre, Lordswood Health Centre, Kent, United Kingdom, ⁵Area Medical Center Vienna, Lilly Research Laboratories, Vienna, Austria, ⁶Eli Lilly South Africa, Lilly Research Laboratories, Johannesburg, South Africa, ⁷Eli Lilly Germany, Lilly Research Laboratories, Bad Homburg, Germany, ⁸Eli Lilly Spain, Lilly Research Laboratories, Madrid, Spain

P667-Su RALOXIFENE INCREASES INTESTINAL CALCIUM ABSORPTION IN ELDERLY POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS

J. Vokrouhlicka¹, J. Sysalova², J. J. Stepan¹

¹3rd Department of Internal Medicine, Charles University Faculty of Medicine, ²Lab.of AAS, Institute of Chemical Technology, Prague, Czech Republic

P668-Mo CHANGES IN BMD OF THE SPINE, HIP AND HAND IN PATIENTS WITH RHEUMATOID ARTHRITIS DURING ONE YEAR TREATMENT WITH ANTI-TNF.(OSLO-TRURO-AMSTERDAM (OSTRA) COLLABORATIVE STUDY)

M. Vis¹, E. Haavardsholm², T. Uhlig², T. Kvien², A. Woolf³, B. Dijkmans¹, G. Haugeberg⁴, W. Lems¹

¹Rheumatology, VU University Medical center, Amsterdam, Netherlands, ²Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom, ⁴Rheumatology, Diakonhjemmet Hospital, Truro, Norway

P669-Tu CHANGES IN MARKERS OF BONE METABOLISM IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS DURING ONE YEAR TREATMENT WITH INFLIXIMAB. (OSLO-TRURO-AMSTERDAM (OSTRA) COLLABORATIVE STUDY)

M. Vis¹, E. Haavardsholm², T. Uhlig², G. Haugeberg², A. Woolf³, T. Kvien², B. Dijkmans¹, W. Lems¹

¹Rheumatology, VU University Medical center, Amsterdam, Netherlands, ²Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom

P670-Su COMPLIANCE AND EFFECT OF BONE PROTECTIVE TREATMENT IN ELDERLY FEMALES: 5 YEAR FOLLOW-UP STUDY

S. M. Doherty¹, A. Goodby¹, S. A. Steel¹

¹Centre for Metabolic Bone Disease, Hull Royal Infirmary, Hull, United Kingdom

P671-Mo ESOPHOGEAL TRANSIT TIME OF THE FILM-COATED RISEDRONATE 35MG TABLET IN OSTEOPOROTIC PATIENTS WITH VARIABLE DEGREES OF KYPHOSIS

A. C. Perkins¹, M. Frier², P. E. Blackshaw², R. C. Spiller³, K. Fairbairn⁴, R. J. Dansereau⁵, T. Kinghorn⁶, P. San⁴, D. Hosking⁷

¹Department of Medical Physics, Queen's Medical Centre, ²Department of Medical Physics, ³Department of Gastroenterology, Medical School, Queen's Medical Centre, ⁴Department of Radiology, Nottingham City Hospital, Nottingham, United Kingdom, ⁵Process Development, ⁶Biometrics and Statistical Sciences, Procter and Gamble Pharmaceuticals, Mason, United States, ⁷Medical Research Center, Nottingham City Hospital, Nottingham, United Kingdom

P672-Tu IMPROVING THE QUALITY OF OSTEOPOROSIS MANAGEMENT IN DAILY CLINICAL PRACTICE. THE IMPORTANCE OF AUDIT.

C. Egsmose¹

¹Dept. of Rheumatology, Bispebjerg University Hospital, Copenhagen, Denmark

P673-Su RISEDRONATE 15MG/DAY FOR 2 YEARS EXHIBITS AN EXCELLENT SAFETY PROFILE OVER A WIDE RANGE OF RENAL FUNCTION

S. Adami¹, S. H. Magowan², I. Barton³, J. F. Beary⁴, C. O. Bingham, III⁵, P. D. Miller⁶

¹Rheumatologic Rehabilitation Unit, University of Verona, Verona, Italy, ²Medical and Technical Affairs, Procter and Gamble Pharmaceuticals, Mason, United States, ³Medical and Technical Affairs, Procter and Gamble Pharmaceuticals, Egham, United Kingdom, ⁴Clinical Development, Procter and Gamble Pharmaceuticals, Mason, ⁵NYU Hospital for Joint Diseases, New York University, New York, ⁶Colorado Center for Bone Research, University of Colorado Medical Center, Lakewood, United States

P674-Mo EFFECT OF OSTEOPOROSIS TREATMENTS ON RISK OF NON-VERTEBRAL FRACTURES: A REVIEW AND META-ANALYSIS OF INTENTION-TO-TREAT POPULATIONS

S. Boonen¹, R. Laan², I. Barton³, N. B. Watts⁴

¹Center for Metabolic Bone Disease, Leuven University, Leuven, Belgium, ²Department of Rheumatology, University Hospital Nijmegen, Nijmegen, Netherlands, ³Medical and Technical Affairs, Procter and Gamble Pharmaceuticals, Egham, United Kingdom, ⁴Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, United States

P675-Tu FRAGILITY FRACTURES IN ORTHOPAEDICS, ASSESSMENT & TREATMENT

T. A. SYED¹

¹Trauma & Orthopaedic Surgery, Milton Keynes General NHS Trust, Milton Keynes, United Kingdom

P676-Su BRIDGING THE LITERACY GAP

M. Camerlain¹, N. Richard²

¹Service de Rhumatologie, Centre Hospitalier Universitaire de l'Estrie, Sherbrooke, ²Health Education, Merck Frosst Canada Ltd, Kirkland, Canada

P677-Mo PREVALENCE OF VISUAL IMPAIRMENT IN PATIENTS WITH EITHER A FIRST OR SECOND HIP FRACTURE.

N. Maher¹, N. Fallon¹, C. O'Dwyer¹, M. Lam¹, C. Kirby¹, M. C. Casey¹, J. B. Walsh¹

¹Department of Medicine for the Elderly, St James Hospital, Dublin, Ireland

P678-Tu AN UK ECONOMIC EVALUATION OF THE EFFECTS OF CALCIUM AND VITAMIN D IN REDUCING FALLS AND FRACTURES

O. S. Sahota¹, T. H. Sach¹, S. Howard²

¹HCE, QMC, University Hospital, Nottingham, ²Abacus Int, Oxford, Oxford, United Kingdom

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Osteoporosis Treatment : Parathyroid Hormone - P679 - P684

P679-Su A COMPARISON OF TERIPARATIDE AND CALCITONIN THERAPY IN POST-MENOPAUSAL WOMEN WITH OSTEOPOROSIS

A. W. C. Kung¹, E. G. Pasion², M. Sofiyan³, E. M. C. Lau⁴, B. K. Tay⁵, K. S. Lam⁶, K. Wilawan⁷, F. Tam⁸, D. Thiebaud⁹

¹Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong Special Administrative Region of China, ², Our Lady of Lourdes Hospital, Philippines, ³Institute of Orthopaedics and Traumatology, Hospital Kuala Lumpur, Malaysia, ⁴, The Chinese University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region of China, ⁵Dept of Orthopaedic Surgery, Singapore General Hospital, ⁶, Changi General Hospital, Singapore, ⁷Dept of Obstetric and Gynecology, Pramongkutklao Hospital of the Royal Thai Army, Thailand, ⁸ Clinical Outcomes and Research Institute, Eli Lilly Australia Pty Limited, ⁹, Eli Lilly and Company, Australia

P680-Mo TERIPARATIDE EFFECTS AT HIGH BONE-TURNOVER SITES. EXAMPLE OF A CASE MONITORED THROUGH JAW QUANTITATIVE TOMOGRAPHY

V. E. Montangero¹, R. Guelman²

¹Maxilla Osteology Group -GOM-, IDNEU, ²Endocrinology, DyTEMe, Buenos Aires, Argentina

P681-Tu UNEXPECTED INDUCTION OF ANABOLIC GENES FOLLOWING SINGLE LOW DOSE EXPOSURE OF OSTEOBLASTS TO PTH

K. A. Buckley¹, J. P. Dillon¹, J. M. Curran², B. Y. Y. Chan³, W. D. Fraser³, J. A. Gallagher¹

¹Human Anatomy and Cell Biology, ²Clinical Engineering, ³Clinical Chemistry, University of Liverpool, Liverpool, United Kingdom

P682-Su EARLY BMD RESPONSE AT THE LUMBAR SPINE TO TERIPARATIDE: SIX-MONTH RESULTS FROM THE EUROFORS TRIAL

H. Minne¹, R. Eastell², T. Nicholson³, K. Brixen⁴, B. Obermayer-Pietsch⁵, J. Farrerons⁶, C. Garces⁷, F. Marin⁷, P. Ochs⁸, T. Nickelsen⁸

¹Klinik, Der Fürstenhof', Bad Pyrmont, Germany, ²Clinical Sciences Centre, University of Sheffield, Sheffield, ³Department of Biostatistics, Eli Lilly and Company, Windlesham, United Kingdom, ⁴Endocrinology Department, Universitetshospital, Odense, Denmark, ⁵Endocrinology Department, Med. Universitaetsklinik, Graz, Austria, ⁶Internal Medicine, Hospital Santa Creu i Sant Pau, Barcelona, ⁷Medical Department, Eli Lilly and Company, Madrid, Spain, ⁸Medical Department, Eli Lilly and Company, Bad Homburg, Germany

P683-Mo THE SAFETY AND EFFICACY OF PTH IN WOMEN RECEIVING HORMONE THERAPY

I. Fogelman¹, . J. N. Fordham², . J. Fraser³, . T. Spector⁴, . C. Christiansen⁵

¹Nuclear Medicine, New Guy´s Hospital, London, ²The James Cook, University Hospital, Middlesbrough, ³Synexus Ltd., Wigan Centre, Lancashire, ⁴St. Thomas, Hospital, London, United Kingdom, ⁵University of Copenhagen, DK, Glostrup, Denmark

P684-Tu FIRST EXPERIENCE WITH TERIPARATIDE AS TREATMENT OF SEVERE OSTEOPOROSIS IN DAILY ROUTINE IN SWITZERLAND

M. Krieg¹, O. Lamy¹, S. Cuenot¹, M. D. Wagener²

¹Internal medicine, University Hospital, Lausanne, ²Research, Eli Lilly CH, Geneva, Switzerland

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Osteoporosis Treatment : Quality of Life Issues - P685 - P689

P685-Su SELF-ASSESSMENT OF HEALTH IN RELATION TO PREVIOUS FALLS AMONG GENERAL POPULATION AND OSTEOPOROSIS PATIENTS.

T. Tsuboyama¹, T. Takemura¹, M. Shimizu², T. Nakamura²

¹School of Health Sciences, Faculty of Medicine, ²Department of Orthopaedic and Musculoskeletal Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

P686-Mo WHAT DEGREE OF HEIGHT LOSS AFFECTS HEALTH-RELATED QOL IN THE ELDERLY?

S. Fujiwara¹, N. Masunari¹

¹Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan

P687-Tu THE EFFECT OF 1 YEAR OF ALENDRONATE FOLLOWING 1 YEAR OF PTH 1-84: SECOND YEAR RESULTS FROM THE PTH AND ALENDRONATE (PATH) TRIAL.

D. M. Black¹, . C. J. Rosen², . L. Palermo³, . T. Hue³, . K. E. Ensrud⁴, . S. L. Greenspan⁵, . T. F. Lang³, . J. A. McGowan⁶, . J. P. Bilezikian⁷

¹University of California, SF, CA, San Francisco, ²ME Ctr. for Osteo. Res., Bangor, ME, ³SF, CA, U of CA, San Francisco, ⁴U of MN and MVAMC, Minn, MN, ⁵U of Pitt, Pitt, PA, ⁶NIAMS, NIH, Bethesda, MD, ⁷Columbia U, New York, NY, United States

P688-Su MEASUREMENT OF QUALITY OF LIFE (QOL) IN PATIENTS WITH SEVERE OSTEOPOROSIS: THE ICARO STUDY (INCIDENCE AND CHARACTERIZATION OF “INADEQUATE TREATMENT RESPONDER PATIENTS” IN OSTEOPOROSIS), FINAL CROSS-SECTIONAL REPORT

N. Iori¹, G. Isaia², S. Adami³, L. Sinigaglia⁴, R. Gentilella¹, M. Calitro⁵, A. Matina⁶, . On behalf of⁷

¹Medical Dept., Eli Lilly Italy, Sesto f.no, ²Endocrinology Dept., San G. Battista Hospital, Torino, ³Rheumatology Dept., Valeggio sul Mincio Hospital, Verona, ⁴Orthopedic Institute, G. Pini, Milano, ⁵Geriatric Dept., Caduti in Guerra Hospital Canosa, Bari, ⁶Orthopedic Dept., University Hospital, Palermo, ⁷The ICARO, Study, Group, Italy

P689-Mo SECONDARY OSTEOPOROSIS THERAPY BY GENERATING MAGNETIC FIELD

M. R. Nekrasova¹

¹Postgraduate Endocinology Course, Medical Academy, Tyumen, Russian Federation

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Osteoporosis Treatment : Vitamin D - P690 - P691

P690-Tu LOW RATE OF USE OF VITAMIN D SUPPLEMENTS IN OSTEOPOROTIC WOMEN

S. Gaugris¹, A. W. Wertheimer², S. Bolge³, S. S. Sen⁴

¹Ernest Mario School of Pharmacy, Rutgers University, Piscataway, ²School of Pharmacy, Temple University, Philadelphia, ³CHS, Consumer Health Sciences, Princeton, ⁴Outcomes Research, Merck and Co., Inc., Whitehouse Station, United States

P691-Su SUPERIORITY OF ALFACALCIDOL COMPARED TO VITAMIN D PLUS CALCIUM CARBONATE IN LUMBAR BMD IN POST MENOPAUSAL OSTEOPOROSIS

R. Nuti¹, G. Bianchi², M. L. Brandi³, R. Caudarella⁴, E. D'Erasmo⁵, C. Fiore⁶, G. Isaia⁷, G. Luisetto⁸, M. Muratore⁹, P. Oriente¹⁰, S. Ortolani¹¹

¹Internal Medicine, University of Siena, Siena, ²Rheumatology, La Colletta Hospital, Genoa, ³Internal Medicine, University of Florence, Florence, ⁴Medicine, University of Bologna, Bologna, ⁵Medicine, University La Sapienza, Rome, ⁶Medicine, University of Catania, Catania, ⁷Medicine, University of Turin, Turin, ⁸Medicine, University of Padua, Padua, ⁹Rheumatology, Cascione-Galateo Hospital, Lecce, ¹⁰Rheumatology, University of Naples, Naples, ¹¹Medicine, Istituto Auxologico, Milan, Italy

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Paget's Disease - P692 - P696

P692-Mo CHANGES IN GENE EXPRESSION IN PAGETIC OSTEOBLASTS AND STROMAL CELLS

U. Bava¹, D. Naot¹, K. E. Callon¹, G. D. Gamble¹, D. Wattie¹, I. R. Reid¹, R. P. Pitto², S. A. McCowan³, T. Cundy¹, J. Cornish¹

¹Medicine, ²Surgery, University of Auckland, ³Orthopaedics, Auckland Hospital, Auckland, New Zealand

P693-Tu BISPHOSPHONATE TREATMENT PARTIALLY RESTORES TRABECULAR ARCHITECTURE IN JUVENILE PAGET’S DISEASE

P. L. Salmon¹, T. Cundy²

¹Application Science, Skyscan NV, Aartselaar, Belgium, ²Dept. of Medicine, Auckland University, Auckland, New Zealand

P694-Su PAGET'S DISEASE: CLINICAL PROFILE OF 19 PATIENTS FROM INDIA

S. Bhadada¹, A. Bhansali¹, R. Khadgawat², A. Unnikrishnan³, S. K. Singh⁴, K. Suryanarayanan⁵, A. Bhattacharya⁶, A. Mithal⁷

¹Endocrinology, PGIMER, Chandigarh, ²Endocrinology, AIIMS, Delhi, ³Endocrinology, AIMS, Cochin, ⁴Endocrinology, BHU, Varanasi, ⁵Endocrinology, Army Hospital, Delhi, ⁶Endocrinology, Manipal Hospital, Bangalore, ⁷Endocrinology, Indraprastha Apollo Hospital, Delhi, India

P695-Mo ZOLEDRONIC ACID SHOWS SUPERIOR EFFECT ON PAGET’S DISEASE ACTIVITY THAT IS NOT BLUNTED BY PREVIOUS TREATMENT STATUS: A RANDOMIZED CONTROLLED COMPARISON WITH RISEDRONATE

I. R. Reid¹, K. W. Lyles², P. D. Miller³, J. P. Brown⁴, W. D. Fraser⁵, Y. Saidi⁶, J. Pak⁷, P. Mesenbrink⁸, G. Su⁸, K. Zelenakas⁷, J. Krasnow⁷, D. J. Hosking⁹

¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²Duke University Medical and VA Centers, Durham, NC, ³Colorado Center for Bone Research, Lakewood, CO, United States, ⁴Le Centre hospitalier universitaire de Quebec, Sainte-Foy, Quebec, Canada, ⁵Department of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, United Kingdom, ⁶Clinical Development and Medical Affairs, Novartis Pharma AG, Basel, Switzerland, ⁷Clinical Development and Medical Affairs, ⁸Biostatistics, Novartis Pharmaceuticals Corporation, NJ, United States, ⁹Division of Bone and Mineral Metabolism, Nottingham City Hospital, Nottingham, United Kingdom

P696-Tu EFFECT OF BISPHOSPHONATE TREATMENT IN PAGETIC PATIENTS WITH SKULL INVOLVEMENT.

P. Peris¹, L. Alvarez², S. Vidal³, A. Monegal¹, A. Martinez¹, C. Moll¹, H. Solberg⁴, P. A. C. Cloos⁴, F. Pons³, J. L. Bedini², N. Guañabens¹

¹Rheumatology, ²Biochemistry, ³Nuclear Medicine, Hospital Clinic, Barcelona, Spain, ⁴, Nordic Bioscience, Herlev, Denmark

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Peptides PTH/PTHrP PTH/PTHrP Receptor - P697 - P700

P697-Su C-TERMINAL PARATHYROID HORMONE-RELATED PROTEIN (107-139) EXERTS ANTIAPOPTOTIC EFFECTS ON HUMAN OSTEOBLASTIC CELLS IN VITRO

A. R. De Gortázar¹, M. V. Alvarez-Arroyo², V. Alonso¹, P. Esbrit¹

¹Bone and Mineral Metabolism Laboratory, ²Renovascular Metabolism Laboratory, Fundación Jiménez Díaz, Madrid, Spain

P698-Mo PTH activation of ERKs is mediated through both PTH/PTHrP receptor C-terminus and Gq proteins and is modulated by ß-arrestins

A. Rey¹, D. Manen¹, J. Caverzasio¹, R. Rizzoli¹, S. Ferrari¹

¹Service of Bone Diseases, Geneva University Hospital, Geneva, Switzerland

P699-Tu ESSENTIAL AND DISTINCT ROLES OF MAP KINASES IN ACTIVATION OF OSTEOBLASTIC CELLS BY PARATHYROID HORMONE

A. F. Rey¹, D. Manen¹, S. Ferrari¹, R. Rizzoli¹, J. Caverzasio¹

¹Rehabilitation and Geriatrics, Service of Bone Diseases, Geneva, Switzerland

P700-Su DOSE-DEPENDENT EFFECTS OF PARATHYROID HORMONE 1-84 AND TERIPARATIDE ON BLOOD PRESSURE IN RATS

J. Fox¹, K. R. Scott¹

¹Discovery Research, NPS Pharmaceuticals, Salt Lake City, United States

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Phosphatonins and Phosphate Homeostasis - P701 - P702

P701-Mo DOWN-REGULATION BY FIBROBLAST GROWTH FACTOR 23 OF HUMAN 25-HYDROXYVITAMIN D3 1ALPHA-HYDROXYLASE PROMOTER ACTIVITY

R. Ebert¹, D. Schneider¹, J. Meissner-Weigl¹, S. Zeck¹, J. Seufert², J. Adamski³, F. Jakob¹

¹Orthopedic Department, ²Division of Metabolism, Endocrinology and Molecular Medicine, Medical Policlinic, University of Wuerzburg, Wuerzburg, ³Institute of Experimental Genetics, GSF-National Research Center for Environment and Health, Neuherberg, Germany

P702-Tu THE EFFECT OF PHOSPHATE INGESTION ON SERUM FIBROBLAST GROWTH FACTOR AND INDICES OF PHOSPHATE HOMEOSTASIS

B. H. Durham¹, F. Joseph², A. M. Ahmad², J. P. Vora², W. D. Fraser³

¹Metabolic Bone Disease Unit, Dept of Clinical Biochemistry and Metabolic Medicine, ²Endocrinology, Royal Liverpool University Hospital, ³Metabolic Bone Disease Unit, Department of Clinical Biochemistry and Metabolic Medicine, Liverpool, United Kingdom

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Renal Disease - P703 - P706

P703-Su PREVALENCE AND CAUSES OF OSTEOPENIA IN END-STAGE RENAL DISEASE PATIENTS ASSESSED BY QUANTITATIVE ULTRASONOMETRY

I. Adamsone¹, D. Babarykin¹, D. Amerika¹, I. Folkmane¹, R. Rosental¹

¹Department of Dialysis and Transplantation, Medical Academy of Latvia, Riga, Latvia

P704-Mo QUANTITATIVE ULTRASOUND IN ADULTS WITH END-STAGE RENAL FAILURE: A LONGITUDINAL STUDY

W. Pluskiewicz¹, J. Przedlacki², B. Drozdzowska³, D. Wlodarczyk², J. Matuszkiewicz-Rowinska², P. Adamczyk⁴

¹Metabolic Bone Diseases Unit, Department and Clinic of Internal Diseases, Diabetology and Nephrology, Silesian School of Medicine in Katowice, Zabrze, ²Department and Clinic of Internal Diseases and Nephrology, Medical University in Warsaw, Warsaw, ³Department and Chair of Pathomorphology, ⁴Department and Clinic of Pediatrics, Pediatric Nephrology and Endocrinology, Silesian School of Medicine in Katowice, Zabrze, Poland

P705-Tu BONE LOSS IN KIDNEY RECIPIENTS IS DUE TO INCREASED BONE RESORPTION

R. Smalcelj¹, V. Kusec², P. Kes¹

¹Dept of Dialysis, ²Clin Inst Lab Diagnosis, Clinical Hospital Centre Zagreb, Zagreb, Croatia

P706-Su BONE MINERAL DENSITY AND OSTEOPROTEGERIN IN HAEMODIALYSIS PATIENTS

A. Crisafulli¹, S. Mondello², A. Romeo², G. D'Anneo³, C. Aloisi², M. Buemi²

¹Department of Experimental Medicine and Pharmacology, Policlinico G. Martino, University of Messina, ²Department of Internal Medicine, Policlinico "G. Martino", University of Messina, ³Department of Internal Medicine, Azienda Ospedaliera Papardo, Messina, Italy

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Steroids Retinoids and Related Hormones - P707

P707-Mo DEXAMETHASONE STIMULATES ODONTOBLAST-LIKE CELL DIFFERENTIATION IN HUMAN DENTAL PULP CULTURES

B. Alliot-Licht¹, G. Bluteau¹, D. Magne¹, S. Lopez-Cazaux¹, B. Lieubeau¹, G. Daculsi¹, J. J. Guicheux¹

¹INSERM EMI 9903, School of dental surgery, Nantes, France

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Transforming Growth Factor - P708

P708-Tu EFFECT OF ENAMEL MATRIX DERIVATIVE ON OSTEOBLASTIC DIFFERENTIATION OF RAT CALVARIA CELLS IN CULTURE

H. Hama¹, H. Azuma¹, H. Seto¹, T. Nagata¹

¹Periodontology and Endodontology, Health of Biosciences, University of Tokushima Graduate School, Tokushima city, Japan

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Vitamin D : Measurement and Identification - P709 - P715

P709-Su SERUM 25-HYDROXYVITAMIN D LEVEL IN TYPE 2 DIABETES MELLITUS: ASSOCIATION WITH MICROVASCULAR COMPLICATIONS AND TYPE OF TREATMENT

A. Suzuki¹, M. Kotake¹, Y. Ono¹, K. Nishiwaki-Yasuda¹, T. Matsumoto¹, S. Imamura¹, T. Kato¹, M. Nagata¹, N. Hayakawa¹, N. Oda¹, M. Itoh¹

¹Division of Endocrinology, Department of Internal Medicine, Fujita Health University, Toyoake, Japan

P710-Mo THE LEVELS OF 25 HYDROXY VITAMIN D AND PTH IN 834 WOMEN WITH OSTEOPOROSIS ATTENDING AN OSTEOPOROSIS CENTER

D. Grigorie¹, E. Neacsu², M. I. Marinescu², L. Dumitrache³, A. Grecu³, O. M. Popa⁴

¹Endocrinology-Osteoporosis Center, Carol Davila University of Medicine and C.I.Parhon Institute of Endocrinology, ²Endocrinology-Osteoporosis Center, ³Endocrinology, ⁴Osteoporosis Center, C.I.Parhon Institute of Endocrinology, Bucharest, Romania

P711-Tu GLOBAL PREVALENCE OF VITAMIN D INADEQUACY AMONG COMMUNITY DWELLING WOMEN WITH OSTEOPOROSIS

P. Lips¹, H. Shimizu², J. Chandler³, J. Turpin³, G. Maalouf⁴, K. Lippuner⁵, R. Rizzoli⁶

¹Endocrinology, Vrije Universiteit Medical Center, Amsterdam, Netherlands, ²Orthopedic Surgery, Shimizu Orthopedic Surgery, Fukui, Japan, ³Epidemiology, Merck Research Laboratories, Blue Bell, PA, United States, ⁴Endocrinology, St. Georges Hospital, Beirut, Lebanon, ⁵Osteoporosis Policlinic, University Hospital of Berne, Berne, ⁶Rehabilitation and Geriatrics, Hôpital cantonal universitaire de Genève, Geneva, Switzerland

P712-Su A PRECISE AND SENSITIVE METHOD FOR THE DETERMINATION OF 25-HYDROXYVITAMIN D IN HUMAN PLASMA USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

T. Okano¹, N. Tsugawa¹, Y. Suhara¹, M. Kamao¹

¹Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan

P713-Mo VITAMIN D STATUS, PARATHYROID FUNCTION AND BONE MINERAL DENSITY IN JAPANESE ADOLESCENT MALES AND FEMALES

N. Tsugawa¹, K. Uenishi², H. Ishida³, T. Okano¹

¹Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, ²Laboratory of Physiology, ³Laboratory of Administrative Dietetics, Kagawa Nutrition University, Sakado, Japan

P714-Tu A NEW, COMMERCIAL, NON-ISOTOPIC METHOD FOR THE MEASUREMENT OF 1,25-DIHYDROXYVITAMIN D IN HUMAN SERUM AND PLASMA

M. J. Chard¹, A. K. Barnes¹, M. J. Gardner¹, D. Laurie¹

¹Research and Development, IDS LTD, BOLDON, United Kingdom

P715-Su A SIMPLE METHOD FOR MEASUREMENT OF VITAMIN D BINDING PROTEIN CAPACITY (DBPC) IN SERUM

M. J. Gardner¹, D. Laurie¹

¹Research and Development, IDS LTD, Boldon, United Kingdom

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Vitamin D Action - P716 - P717

P716-Mo HYPERVITAMINOSIS D AS A CAUSE OF CALCINOSIS CUTIS

S. C. Loke¹, A. W. H. Tan², M. K. S. Leow¹

¹Department of Endocrinology, Tan Tock Seng Hospital, ²Department of Dermatology, National Skin Centre, Singapore, Singapore

P717-Tu VITAMIN D INADEQUACY: GLOBAL PREVALENCE AND SKELETAL IMPLICATIONS

J. Reginster¹, F. Richy¹, V. Rabenda¹, A. Tancredi¹

¹Department of Epidemiology, Public Health and Health Economics, University of Liege and WHO Collaborating Center for Public Health Aspects of Rheumatic Diseases, Liege, Belgium

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Vitamin D Receptors - P718

P718-Su 1,25(OH)2D3 SUPPRESSION OF Sp1/NF-Y TRANSACTIVATION OF THE HUMAN PTH PROMOTER REQUIRES AN INTACT AF-2 DOMAIN

N. J. Koszewski¹, A. P. Alimov¹, O. Park-Sarge², K. D. Sarge³, H. H. Malluche¹

¹Division of Nephrology, Bone and Mineral Metabolism, ²Department of Physiology, ³Department of Molecular and Cellular Biochemistry, University of Kentucky Medical Center, Lexington, United States

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Late Posters - P719 - P725

P719-Mo FULVESTRANT, AN OESTROGEN RECEPTOR ANTAGONIST, BLOCKS PROLIFERATION AND DIFFERENTIATION OF CULTURED PRIMARY HUMAN OSTEOBLASTS.

L. Filgueira¹, J. Meagher¹, M. Al-Mushaiqri¹, A. P. Skirving², R. Zellweger²

¹School of Anatomy and Human Biology, University of Western Australia, Crawley, ²Department of Orthopaedic Surgery, Royal Perth Hostpital, Perth, Australia

P720-Tu THE PROTECTIVE EFFECT OF BODY MASS INDEX ON OSTEOPOROSIS

S. Aki¹, N. Bolukbasi¹, I. Ural¹, N. Eskiyurt¹

¹Department of Physical Medicine and Rehabilitation, Istanbul Medical Faculty, Istanbul, Turkey

P721-Su THE OSTEOGENIC POTENTIAL OF SULFATED GLYCOSAMINOGLYCANS

L. Ling¹, M. Sadasivam¹, V. Nurcombe^1,2, S. Cool¹^,3

¹Laboratory of Stem Cells and Tissue Repair, Institute of Molecular and Cell Biology, Proteos, ²Department of Anatomy, ³Department of Orthopaedic Surgery, National University of Singapore, Singapore, Singapore

P722-Mo INTRA ARTICULAR MAL UNION OF DISTAL RADIUS TREATED BY CHONDRO COSTAL GRAFT

L. Obert¹, D. Lepage¹, Y. Tropet¹, P. Garbuio¹

¹Orthopedic Unit CHRU Besançon, Hop J Minjoz, Besançon, France

P723-Tu DISTAL RADIUS FRACTURE AND INJECTABLE CEMENT: USEFUL OR NOT?

L. Obert¹, G. Leclerc¹, D. Lepage¹, P. Clappaz¹, Y. Tropet¹, P. Garbuio¹

¹Orthopedic Unit CHRU Besançon, Hop J Minjoz, Besançon, France

P724-Su SEPTIC NON UNION OF TIBIA SOLVED BY FREE FLAP AND INDUCED MEMBRANE

L. Obert¹, F. Gindraux¹, F. Deschaseaux¹, V. Lapierre¹, P. Tiberghien¹, P. Hervé¹, Y. Tropet¹, P. Garbuio¹

¹Orthopedic Unit, University Hospital Jean Minjoz, Besançon Inserm U645 and Ingénierie de Biologie Cellulaire et Tissulaire IFR 133, Besançon, France

P725-Tu Physician and Patient Satisfaction, Tolerability and Safety during Raloxifene Treatment in PM Women

P. Pancaldi¹, M. Wagener²

¹Muralto, ²Eli Lilly Suisse, Vernier, Switzerland