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Abstracts
Programme at a glance
Thursday Friday
Saturday Sunday Monday
Friday 9th May 2003
08:00 - 09:00 POSTERS
SYMPOSIUM 1
OSTEOBLASTS
Chairs: R. Civitelli (St. Louis MO, USA)
P. Marie (Paris, France)
09:00 - 10:00 Main Auditorium
09:00 I-2 Role of the Wnt/LRP5
pathway in regulation of bone mass and osteoblast function
M. Warman (Cleveland OH, USA)
09:30 I-3 The transcription
factor osterix is required for osteoblast differentiation and bone formation
B. de Crombrugghe (Houston TX, USA)
ORAL COMMUNICATIONS
OSTEOBLASTS 1
Chairs: R. Civitelli (St. Louis MO, USA)
P. Marie (Paris, France)
10:00 - 11:00 Main Auditorium
10:00 O-1SIGNALING VIA
BETA-CATENIN DIRECTS MESENCHYMAL LINEAGE ALLOCATION TOWARDS OSTEOGENESIS
G. Mbalaviele1,2, S. Sheikh1, C. Castro1, S-L. Cheng1,
J. Stains1, R. Civitelli1*
1Div. of Bone and Mineral Diseases, Washington University in St. Louis,
Missouri, USA
2Pharmacia Corp., St. Louis, Missouri, USA
10:12 O-2 FUNCTIONAL ROLE
OF CANONICAL WNT SIGNALLING DURING OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM
CELLS
S. L. Etheridge1*, G. J. Spencer1, D. Heath2,
P. G. Genever1
1Biomedical Tissue Research, University of York, York, UK
2Smith and Nephew GRC, York, UK
10:24 O-3 PLATELET-DERIVED
GROWTH FACTOR-D, A NOVEL BONE-ANABOLIC GROWTH FACTOR
S. Topouzis*, K. Lum, M. S. Holdren, J. Shin, C. Birks, D. Dong, S. D. Hughes, H. P. Ren,
T. Palmer, E. E. Moore
ZymoGenetics Inc., Seattle, USA
10:36 O-4 GENETIC
ABLATION OF PROLINE-RICH TRANSCRIPT OF THE BRAIN IS ASSOCIATED WITH INCREASED BONE MASS IN
MICE
D. W. Sommerfeldt1*, M. Priemel1, X. Wang2, T. Schinke1,
M. Amling1, S. Mansour2, J. M. Rueger1
1Dept. of Trauma and Reconstructive Surgery, Hamburg University Hospital,
Hamburg, Germany
2Dept. of Human Genetics, University of Utah, Salt Lake City, USA
10:48 O-5 DLK1 (EGF-LIKE
HOMEOTIC PROTEIN) OVEREXPRESSION INHIBITS MATURE ADIPOCYTE AND OSTEOBLAST FORMATION AND
MAINTAINS THE BIOPOTENTIAL DIFFERENTIATION CAPACITY OF HUMAN BONE MARROW STROMAL CELLS
B. M. Abdallah1*, C. H. Jensen2, G. Leslie2, T. B. Jensen3,
M. Kassem1,4
1Clinic for Molecular Endocrine Treatment KMEB, Odense University Hospital,
Odense, Denmark
2Institute of Medical Immunology, Univeristy of Southern Denmark, Odense,
Denmark
3Department of Human Genetics, University of Aarhus, Aarhus, Denmark
4Dept of Endocrinology M, Odense University Hospital, Odense, Denmark
11:00 - 12:00 Coffee & Posters
12:00 - 14:00 Lunch
WORKSHOP 1
NANOTECHNOLOGY
Chairs: P. Bianco (Rome, Italy)
K. Väänänen (Turku, Finland)
12:45 - 14:00 Room A
12:45 I-4 Nanotechnology -
where biology meets physics
W. Poon (Edinburgh, UK)
13:10 I-5 Probing bone cell
function with AFM
M. A. Horton (London, UK)
13:35 I-6 Nanotechnology of
collagen and bone: interaction and structure
P. K. Hansma (Santa Barbara, USA)
WORKSHOP 2
BONE QUALITY
Chairs: D. Dempster (New York NY, USA)
G. Mazzuoli (Rome, Italy)
12:45 - 14:00 Main Auditorium
12:45 I-7 How do we assess bone
quality?
C. H. Turner (Indianapolis, USA)
13:10 I-8 Role of bone
turnover in bone quality
P. Delmas (Lyon, France)
13:35 I-9 Importance of
mineralization for bone strength and response to therapeutic agents
P. J. Meunier (Lyon, France)
SYMPOSIUM 2
SEX HORMONES
Chairs: G. Isaia (Torino, Italy)
B. Langdahl (Aarhus, Denmark)
14:00 - 15:00 Main Auditorium
14:00 I-10 Modulation of
estrogen action by ER isoforms
J-Å. Gustafsson (Huddinge, Sweden)
14:30 I-11 Risks and
benefits of HRT and SERMS
E. Barrett-Connor (La Jolla, California, USA)
ORAL COMMUNICATIONS
SEX HORMONES
Chairs: G. Isaia (Torin, Italy)
B. Langdahl (Aarhus, Denmark)
15:00 - 16:00 Main Auditorium
15:00 O-6 SKELETAL
CHANGES IN TRANSGENIC MALE MICE OVEREXPRESSING HUMAN AROMATASE
Z. Q. Peng1*, X. D. Li2, M. Poutanen2, R. Santti1,
H. K. Väänänen1
1Dept. of Anatomy, Univ. of Turku, Finland
2Dept. of Physiology, Univ. of Turku, Finland
15:12 O-7 RALOXIFENE
INCREASES SERUM ESTRADIOL AND TESTOSTERONE AND DECREASES BIOCHEMICAL MARKERS OF BONE
TURNOVER IN MIDDLE AGED HEALTHY MEN WITH LOW BASELINE SEX STEROID SERUM VALUES
B. Uebelhart1*, F. Herrmann2, I. Pavo3, R. Rizzoli1
1Division of Bone Diseases, University Hospital, Geneva, Switzerland
2Department of Geriatrics, University Hospital, Geneva, Switzerland
3Eli Lilly, Vienna, Austria
15:24 O-8 SHORT COURSES
OF HORMONE REPLACEMENT TREATMENT IN HEALTHY WOMEN HAVE LONG-TERM PREVENTIVE EFFECTS ON
BONE MASS AND OSTEOPOROTIC FRACTURES
Y. Z. Bagger*, L. B. Tanko, P. Alexandersen, C. Christiansen
Center for Clinical and Basic Research, Ballerup, Denmark
15:36 O-9 POLYMORPHISMS
IN THE CYP19 AND ANDROGEN RECEPTOR GENES AND BONE MASS IN WOMEN WITH OR WITHOUT HORMONE
REPLACEMENT THERAPY. THE DANISH OSTEOPOROSIS PREVENTION STUDY
C. L. Tofteng1*, A. Kindmark2, H. Brandstrom2, B.
Abrahamsen3, S. Petersen1, F. Stiger2, L. S. Stilgren3,
J. E. B. Jensen1, P. Vestergaard, B. I. Langdahl4, L. Mosekilde4
1Osteoporosis Research Clinic, Hvidovre Hospital, Hvidovre, Denmark
2Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
3Department of Endocrinology, Odense University Hospital, Odense, Denmark
4Department of Endocrinology, Aarhus County Hospital, Aarhus, Denmark
15:48 O-10 GENDER
DIFFERENCES IN ASSOCIATION OF 5' ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISMS WITH BONE
PARAMETERS, HEIGHT AND FRACTURE RISK
S. C. E. Schuit1,2*, J. B. J. van Meurs1,2, A. E. A. M. Weel1,
M. van der Klift2, A. P. Bergink1,2, Y. Fang1, P. P. Arp1,
J. P. T. M. van Leeuwen1, H. A. P. Pols1,2, A. G. Uitterlinden1
1Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
2Department of Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The
Netherlands
16:00 - 16:20 Coffee
ORAL COMMUNICATIONS
OSTEOBLASTS 2
Chairs: E. Bonucci (Rome, Italy)
H. van Leeuwen (Rotterdam, Netherlands)
16:20 - 17:20 Main Auditorium
16:20 O-11 NEW INSIGHTS
INTO CALCINEURIN ALPHA FUNCTION AND SIGNALING
E. Abe1, X. B. Wu1, M. Lu1, X. Zhang1, B. S.
Moonga1, S. Epstein1, H. C. Blair2, L. Sun1,
M. Zaidi1*
1The Mount Sinai Bone Program and Bronx VA GRECC, New York, NY. USA
2University of Pittsburgh, Pittsburgh, PA. USA
16:32 O-12 WNT-MEDIATED
TCF GENE TRANSCRIPTION IN OSTEOBLASTS: A NOVEL EFFECTOR OF OSTEOTROPIC HORMONES AND
CYTOKINES?
G. J. Spencer*, S. L. Etheridge, P. G. Genever
Biomedical Tissue Research, University of York, York, UK
16:44 O-13FIBROBLAST
GROWTH FACTOR-2 ENHANCES HUMAN OSTEOBLAST SURVIVAL THROUGH ACTIVATION OF THE PI3K AND
GSK-3 SIGNALING PATHWAY
F. Debiais1*, S. Lemée1, G. Lefèvre2, F. Mascarelli2,
P. J. Marie1
1Inserm U349, Paris, France
2Inserm U403, Paris, France
16:56 O-14 ACTIVATION
OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA INHIBITS THE RUNX2-MEDIATED
TRANSCRIPTION OF OSTEOCALCIN IN OSTEOBLASTS
C. S. Shin1,2*, M. J. Jeon2, S. H. Kwon1, J. A. Kim2,
S. W. Kim1, S. Y. Kim1,2
1Department of Internal Medicine, Seoul National University College of
Medicine, Seoul, Korea
2Seoul National University Hospital Clinical Research Institute, Seoul, Korea
17:08 O-15 IDENTIFICATION
OF TWO EPITHELIAL CALCIUM CHANNELS, TRPV5 AND 6, ALONG WITH OTHER PROTEINS INVOLVED IN
CALCIUM TRANSPORT IN HUMAN OSTEOBLASTS, IN VITRO AND VIVO
B. C. J. van der Eerden1*, M. Eijken1, H. Jahr1,2, J.
G. J. Hoenderop3, H. A. P. Pols1, R. J. M. Bindels3, J.
P. T. M. van Leeuwen1
1Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
2Department of Orthopedics, Erasmus MC, Rotterdam, The Netherlands
3Department of Cell Physiology, University Medical Center, Nijmegen, The
Netherlands
17:20 - 17:40 Coffee
SATELLITE SYMPOSIUM
BONE QUALITY: A NEW
PERSPECTIVE IN THE MANAGEMENT OF OSTEOPOROSIS
Supported by Eli Lilly & Co
Chair: S. Adami
17:40 - 19:40 Main Auditorium
A brief Question & Answer session will follow each presentation.
17:40 -17:50 Opening Remarks
Silvano Adami
17:50 -18:25 Bone Quality: Shifting the
Osteoporosis Paradigm
Ego Seeman
18:25 -19:00 The Role of Antiresorptive Agents on Bone Quality
Pierre Delmas
19:00 -19:35 Innovative Effects of Bone Formation Agents on Bone
Quality
David Dempster
19:35 -19:40 Closing Remarks
20:00 ECTS COPPA ITALIA
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