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The Cathederal, Zagreb

Saturday Sunday Monday Tuesday Wednesday

SUNDAY 26 May 2002

08:00 - 18:00 Registration

PLENARY SESSION 2

CELL BIOLOGY: OSTEOCLASTS

08:30 - 09:30 Main Auditorium

Chairs: Tim Arnett (London, UK), Anna Teti (L’Aquila, Italy)

08:30 I-3 Interactions between RANKL, TNF-alpha and TNF-beta in the regulation of osteoclast formation and function Tim Chambers (London, UK)

09:00 I-4 The mevalonate pathway in osteoclast signalling Mike Rogers (Aberdeen, UK)

ORAL PRESENTATIONS 2

CELL BIOLOGY: OSTEOCLASTS

09:30 - 10:18 Main Auditorium

Chairs: Tim Arnett (London, UK), Anna Teti (L’Aquila, Italy)

09:30 O-7 A PHOSPHONOCARBOXYLATE ANALOGUE OF RISEDRONATE (NE10790) INHIBITS RAB PRENYLATION IN OSTEOCLASTS IN VIVO AND DISRUPTS THE MEMBRANE LOCALIZATION OF RAB PROTEINS IN OSTEOCLASTS IN VITRO F. P. Coxon1*, E. Mules2, M. C. Seabra2, F. H. Ebetino3, M. J. Rogers1 1Department of Medicine & Therapeutics, University of Aberdeen, Aberdeen, UK; 2Department of Cell & Molecular Biology, Imperial College, London, UK; 3Procter & Gamble Pharmaceuticals, Mason, Ohio, USA

09:42 O-8 TGF-BETA INDUCES HUMAN OSTEOCLAST FORMATION AND BONE RESORPTION IN THE ABSENCE OF SOLUBLE RANKL I. Itonaga, A. Sabokbar, O. Kudo, N. A. Athanasou* Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK

09:54 O-9 PATTERNS OF EXPRESSION OF CHEMOKINES AND THEIR RECEPTORS IN OSTEOCLASTS  J. M. Lean*, C. Murphy, K. Fuller, T. J. Chambers St George's Hospital Medical School, London, UK

0:06 O-10 STIMULATION OF RANKL-DEPENDENT OSTEOCLAST FORMATION BY INFLAMMATORY (RHEUMATOID/ CRYSTAL) ARTHRITIS SYNOVIAL FLUIDL. Danks, A. Sabokbar, I. Itonaga, N. A. Athanasou*Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK

10:18 - 10:45 Coffee Break

PLENARY SESSION 3

RARE BONE DISEASES

10:45 - 12:15 Main Auditorium

Chairs: Darko Anticevic (Zagreb, Croatia),
Roger Smith (Oxford, UK)

10:45 I-5 Osteogenesis Imperfecta: pathophysiology and management Francis Glorieux (Montreal, Canada)

11:15 I-6 The mutational spectrum of human malignant autosomal recessive osteopetrosis Anna Villa (Segrate, Italy)

11:45 I-7 Fibrodysplasia Ossificans Progressiva: clues to the formation of a heterotopic skeleton Fred Kaplan (Philadelphia, USA)

12:15 - 14:00 Lunch and Poster Session 1

Between 12:15 and 13:15 posters with odd numbers will be attended by their presenting author.

PLENARY SESSION 4

HORMONES

14:00 - 15:00 Main Auditorium

Chairs: Mike Rogers (Aberdeen, UK),
Hans van Leeuwen (Rotterdam, The Netherlands)

14:00 I-8 11beta-hydroxysteroid dehydrogenase in glucocorticoid signalling in bone Martin Hewison (Birmingham, UK)

14:30 I-9 Analysis of the regulation of bone formation by leptin Gerard Karsenty (Houston TX, USA)

ORAL PRESENTATIONS 3

HORMONES

15:00 - 16:12 Main Auditorium

Chairs: Mike Rogers (Aberdeen, UK),
Hans van Leeuwen (Rotterdam, The Netherlands)

15:00 O-11 MET, A NOVEL MODULATOR OF ESTROGEN INDUCED TRANSCRIPTION S. M. Colley1*, A. Flynn2, M. Norman2, D. Wynick2, J. H. Tobias1 1Rheumatology Unit, Division of Medicine, University of Bristol, Bristol, UK; 2University Research Centre for Neuroendocrinology, University of Bristol, Bristol, UK

15:12 O-12 MODULATION OF HUMAN ER ALPHA F PROMOTER ACTIVITY BY A PROTEIN KINASE C - DEPENDENT MECHANISM IN HUMAN DIFFERENTIATED OSTEOBLAST-LIKE CELLS M. Longo1,3*, V. De Luca1,3, S. Denger2, G. F. Caselli3, F. Gannon2, A. Teti3, S. Migliaccio3,4 1Department of Histology & Medical Embryology, University 'La Sapienza', Rome, Italy; 2EMBL, Heidelberg, Germany; 3Department of Experimental Medicine, University of L'Aquila, Italy; 4Department of Medical Physiopathology, University 'La Sapienza', Rome, Italy

15:24 O-13 ACTIVATION OF THE BMP-6 PROMOTER BY THE ESTROGEN RECEPTOR S. M. Colley1*, D. B. Ong1, S. Kitazawa2, M. Norman3, D. Wynick3, J. H. Tobias1 1Rheumatology Unit, Division of Medicine, University of Bristol, Bristol, UK; 2Division of Molecular Pathology, Kobe University Graduate School of Medicine, Kobe, Japan; 3University Research Centre for Neuroendocrinology, University of Bristol, England

15:36 O-14 MICE DEFICIENT IN 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 LACK BONE MARROW ADIPOCYTES AND MAINTAIN NORMAL BONE FORMATION J. Justesen1*, L. I. Mosekilde3, K. Stenderup1, M. Holmes4, J. J. Mullins4, J. R. Seckl4, E. F. Eriksen1, M. Kassem1,2 1University Department of Endocrinology and Metabolism, University Hospital of Aarhus, Denmark; 2University Department of Endocrinology and Metabolism, University Hospital of Odense, Denmark; 3Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark; 4Molecular Medicine Centre, Western General Hospital, Edinburgh, UK

15:48 O-15 ROLE OF BETA-ARRESTINS IN THE REGULATION OF PARATHYROID HORMONE (PTH) ACTIVITY IN VITRO AND IN VIVO S. L. Ferrari1*, D. Sternlight2, D. Pierroz1, R. Lefkowitz3, M. Bouxsein2 1Div. of Bone Diseases, University Hospital, Geneva, Switzerland; 2Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC, USA

16:00 O-16 BONE MORPHOGENETIC PROTEIN-7 PROMOTES TENDON GRAFT INTEGRATION IN THE RECONSTRUCTION OF THE ANTERIOR CRUCIATE LIGAMENT R. Mihelic1*, V. Kusec2, D. Bobinac3, S. Zoricic3, M. Jelic4,5, M. Pecina5, S. Vukicevic4 1Orthopaedic Hospital, Lovran, Croatia; 2Clinical Institute of Laboratory Diagnosis, Clinical Hospital Centre Zagreb, Croatia; 3Department of Anatomy, School of Medicine, University of Rijeka, Croatia; 4Department of Anatomy, School of Medicine, University of Zagreb, Croatia; 5Department of Orthopaedic Surgery, School of Medicine, University of Zagreb, Croatia

16:12 - 16:30 Coffee Break

20:00 - 21:30 CULTURAL EVENT

Monday  27 May