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Meet the Professor

Theresa Guise (Charlottesville, USA)

Bone and cancer

Saturday 13 May 2006
13.00-14.00

Topics to be covered

  • Review skeletal complications of cancer and cancer treatment.
    Update on the current understanding of basic molecular mechanisms of solid tumor metastases to bone.
    1. Tumor-bone cell interactions: role of osteoclast and osteoblast in vicious cycle of tumor growth in bone
    2. Role of the bone microenvironment and how alterations in the bone microenvironment alter tumor growth in bone
    3. Role of other cell types: endothelial cells, platelets
  • Discuss current and emerging treatments for solid tumor metastases to bone.
  • Discuss emerging technology to assess bone metastases in humans and in animal models
  • Discuss the effect of cancer treatment on the skeleton.

 

Educational goals

  • To summarize current knowledge on the basic mechanisms of bone metastases.
  • To provide an update on emerging technologies for the assessment of bone metastases in humans and in animal models.
  • To discuss current and emerging treatment for solid tumor metastases to bone.

 

Teaching methods

  • A brief didactic overview of the basic biology of tumor metastases to bone.
  • Interactive discussion with audience on pathophysiology
  • Case presentations on skeletal complications of malignancy to involve audience participation to identify pathophysiology and potential targets

 

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