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Meet the Professor

Pam Robey (Bethesda, USA)

Matrix biology

Friday 12 May 2006
13.00-14.00

Topics to be covered

  • Classes of molecules found in the extracellular matrix of bone
  • Expression of matrix proteins as a function of osteogenic differentiation
  • Contributions of matrix proteins to biomineralization
  • Non-structural roles of matrix proteins
  • Changes in matrix proteins as a function of aging and in disease states
     

Educational Goals

  • To become familiar with components of the extracellular matrix of bone
  • To understand the role that they play not only as structural elements, controlling biomineralization, but in regulating cell activity
  • To recognize that changes in extracellular matrix in genetic and acquired disease states impact on bone quality
     

Teaching Methods

  • A brief didactic overview of matrix biology
  • Discussion of factors that control expression of matrix proteins, thereby controlling biomineralization
  • Presentation and discussion of examples in which bone matrix is disrupted

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