Dr Isabel Orriss obtained a first class degree in Biochemistry from the University of Southampton in 2001. She completed her PhD, which focussed on the regulation of bone cell function by extracellular nucleotides at University College London in 2005 under the supervision of Professors Tim Arnett and Geoff Burnstock. Her post-doctoral work continued to develop this research, with support from Arthritis Research UK and the ‘ATPbone’ Europe-wide collaboration. Isabel obtained a 5-year Career Development Fellowship from Arthritis Research UK in 2010 to continue her work in the Bone Biology laboratory at UCL. In 2013, Dr Orriss transferred her fellowship to the Royal Veterinary College (RVC) to join skeletal biology as a new group leader. At the end of her fellowship, Isabel was taken on by the RVC as a lecturer and promoted to senior lecturer in 2019. Her research interests primarily focus on the regulation of bone cell function and vascular calcification by local signalling systems. To date she has published 48 papers, reviews and book chapters, over 30 of which as first or last author. Following a period as the new investigator representative and an elected committee member, Isabel is currently the secretary of the UK Bone Research Society.