ECTS Newsletter | September 2021

Your monthly news & updates

Announcements and Events

Society’s life:

Be part of ECTS in 2021: become member of a dynamic community in the musculoskeletal field and take advantage from a wide range of benefits. – Join or renew your membership now – View the membership benefit
Let us know if you would like to be actively involved in ECTS activities and you may be called to be part in one of our committees or action groups. Become an ECTS member here and complete an online form here
ECTS Clinical and Basic Research Fellowship: apply now until 31 October for the two calls.
Join the ECTS Academy: applications are now open to select top young researchers and clinicians in the musculoskeletal field. Check eligibility criteria and application process here.

Education and Events:

NEW: Webinar Series on Rare Bone Diseases! First webinar on Hereditary Hypophosphatemia to be held on 20 October. Learn more about the series and register here.
Webinar Series: Bone, Muscle & Beyond: next on 9 September: Hypophosphatasia: diagnosis, symptoms and management by Carola Zillikens. Register here.
Bone, Muscle & Beyond Webinars: 2021 calendar – Check it out & register

Other Announcements and Events :

9th Seoul International Congress of Endocrinology and Metabolism in conjunction with the 40th Annual Scientific Meeting of the Korean Endocrine Society (SICEM 2021), 28-30 October 2021. Abstract submission deadline 9 September 2021. Check the programme and submit your abstract here.
4th International Congress of Osteoporosis 2021 will be held from November 5th to 7th, 2021 in Seoul, Republic of Korea. Read more here.
1st Athens Foot and Ankle Arthroscopy Symposium, 25 – 26 September 2021. More info here.
ESA-SRB-ANZBMS 2021 Annual Scientific Meetings, 21-24 November 2021. Check the programme here.
14th International Conference on Osteogenesis Imperfecta, Sheffield, UK, 30 August – 2 September 2022
ICCBH Bone School, Dublin, Ireland, 29 June – 1 July 2022 – More info here
10th International Conference on Children’s Bone Health, Dublin, Ireland, 2 -5 July 2022 – More info here

The Official Open Access Journal of the ECTS

20% discount on Article Publishing Charge (APC) for ECTS members

September 2021 Article Selection

Protein phosphatase 1 regulatory subunit 18 suppresses the transcriptional activity of NFATc1 via regulation of c-fos. Download PDF
Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study. Download PDF

Greetings on behalf of the 2021 Board of Directors of the ECTS. By Bo Abrahamsen, ECTS president

September and a new academic year is almost here. As you know, the members of the Board are elected by the Annual General Meeting of the ECTS and election is for a three year period with the possibility of standing for re-election. Many thanks for contributing actively to the election process and for supporting the ECTS.

All members of the Board of Directors have individually assigned responsibilities to take of in the ECTS in addition to being the official representatives of the organisation. I would like to briefly go through what these tasks are and how they are filled by individual Board members so that you have a better idea how the daily running of the ECTS work and who is the elective representative in charge of each aspect of what we do.

Congratulation to the 2021 ECTS Fellowship awardees! By Cristiana Cipriani

Two fellowships have been assigned in 2021 to young investigators working in clinical and basic/translational research. They are Dr Maria Papageorgiou from the University of Geneve and Dr Biagio Palmisano from Sapienza University of Rome. Here we have the pleasure to report a brief summary of their project and their own feelings about having been awarded with such a grant.

Background and vision of the new co-Chair of the ECTS Academy. By Ciro Menale

It is an enormous privilege for me to contribute to the ECTS Academy activities as the newly elected ECTS Academy co-Chair and to collaborate with the current Chair Annegreet Vlug.

I am a Research Associate and Lecturer in Physiology at University of Naples “Federico II” Medical School, Naples, Italy. During the last years, I have conducted my research in the laboratories headed by Dr. Anna Villa and Dr. Cristina Sobacchi at IRGB-CNR and Humanitas Research Center in Milan, Italy. I focused on novel therapeutic approaches for the RANKL-dependent osteopetrosis by exploiting gene therapy and 3D culture models. I also contributed to the dissection of the anabolic role of RANKL in bone physiology. At the same time, I investigated the interaction of bone and immune cells focusing on bone loss and immune system defects driven by oxidative stress. Nowadays, in the laboratory directed by Prof. Sabrina Diano, my attention is aimed at dissecting bone cell metabolism, investigating the role of nutrient availability in the regulation of bone cells function. To further elucidate cellular and physiological basis of bone homeostasis, I am also interested in the local and hypothalamic regulation of energy metabolism, connecting bone diseases and metabolic disorders.

Taking advantage of this great opportunity, I would like to invite young researchers and clinicians in the musculoskeletal field in Europe to join us by applying to ECTS Academy 2022 basic/translational and clinical calls released in September 2021 (deadline October 31^st2021).

Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4. By Antonio Maurizi

In recent years many studies demonstrated the beneficial effect of mechanical loading on bone metabolism and body homeostasis. Indeed, bone mechanical loading produces local and systemic signals able to affect different target cells and tissues beyond the bone. In particular, increasing interest is arising around the role of bone mechanical loading in pathological conditions such as the development of cancer-associated osteolytic lesions. In this regard, it has been demonstrated that the mechanical loading suppresses the tumor-induced tibia osteolysis in a model of breast cancer, in an intensity-dependent manner. Little is currently known about the effect of mechanical loading on the development of breast cancer-associated metastases in non-skeletal tissues.

In this article, the authors focused on the effect of bone mechanical loading on breast cancer-associated brain tumors. Indeed, about 15% of women with breast cancer develop brain metastases and the latter are difficult to be targeted because of the blood-brain barrier. Here the authors showed that the bone mechanical loading alone or in combination with the FDA-approved dopamine modulator Fluphenazine (FP) contributes to the suppression of brain tumors acting on the dopamine-Lrp5-CCN4 axis. In particular, they demonstrated the existence of remote mechanotransduction “from bone to brain”, suggesting that the bone mechanical loading can be used as adjuvant therapy for treating breast cancer-associated brain tumors.

Announcements and Events

Society’s life:

Be part of ECTS in 2021: become member of a dynamic community in the musculoskeletal field and take advantage from a wide range of benefits. – Join or renew your membership now – View the membership benefit
Let us know if you would like to be actively involved in ECTS activities and you may be called to be part in one of our committees or action groups. Become an ECTS member here and complete an online form here
ECTS Clinical and Basic Research Fellowship: apply now until 31 October for the two calls.
Join the ECTS Academy: applications are now open to select top young researchers and clinicians in the musculoskeletal field. Check eligibility criteria and application process here.

Education and Events:

NEW: Webinar Series on Rare Bone Diseases! First webinar on Hereditary Hypophosphatemia to be held on 20 October. Learn more about the series and register here.
Webinar Series: Bone, Muscle & Beyond: next on 9 September: Hypophosphatasia: diagnosis, symptoms and management by Carola Zillikens. Register here.
Bone, Muscle & Beyond Webinars: 2021 calendar – Check it out & register

Other Announcements and Events :

9th Seoul International Congress of Endocrinology and Metabolism in conjunction with the 40th Annual Scientific Meeting of the Korean Endocrine Society (SICEM 2021), 28-30 October 2021. Abstract submission deadline 9 September 2021. Check the programme and submit your abstract here.
4th International Congress of Osteoporosis 2021 will be held from November 5th to 7th, 2021 in Seoul, Republic of Korea. Read more here.
1st Athens Foot and Ankle Arthroscopy Symposium, 25 – 26 September 2021. More info here.
ESA-SRB-ANZBMS 2021 Annual Scientific Meetings, 21-24 November 2021. Check the programme here.
14th International Conference on Osteogenesis Imperfecta, Sheffield, UK, 30 August – 2 September 2022
ICCBH Bone School, Dublin, Ireland, 29 June – 1 July 2022 – More info here
10th International Conference on Children’s Bone Health, Dublin, Ireland, 2 -5 July 2022 – More info here

The Official Open Access Journal of the ECTS

20% discount on Article Publishing Charge (APC) for ECTS members

September 2021 Article Selection

Protein phosphatase 1 regulatory subunit 18 suppresses the transcriptional activity of NFATc1 via regulation of c-fos. Download PDF
Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study. Download PDF

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ECTS is thankful to its Corporate Members and other companies that have supported ECTS activities through unrestricted educational grants. These sponsors have in no way contributed to or influenced the content.

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