• Home
  • MyECTS
  • Become a member
  • Contact us

Ectsoc

Ecstoc.org

MENUMENU
  • About
    • Mission & Vision
    • Governance & Transparency
    • Board of Directors
    • Annual General Meeting
    • Committees and Action Groups
      • Executive Committee
      • Communications Committee
      • Community Engagement Committee
      • ECTS Academy
      • Education Committee
      • Clinical Science Committee
      • Research Committee
      • Scientific Programme Committee 2022
    • ECTS Team
    • Membership
      • Individual Membership
      • Corporate Supporters
      • Join us
      • Affiliated Societies
  • ECTS 2023
  • Events
    • Upcoming Congresses
    • Past Congress
    • ECTS Academy Charity Event
    • ICCBH
    • Events
  • Grants & Awards
  • Education
    • Education Resource Center
    • Clinical Training Course in Metabolic Bone Diseases
    • ECTS-Mellanby Training Course
    • Bone Muscle & Beyond Webinars
    • East-meets-West Online Symposium
    • Rare Bone Diseases Webinars
    • PhD Training Course
    • Calendar ECTS Educational Events
  • ECTS Academy
    • About the ECTS Academy
    • ECTS Academy Members
    • Call for Applications - Basic Scientists
    • Call for Applications - Clinicians
    • ECTS Academy Activities
      • NI Conference Program
      • ECTS Academy Webinar Series
      • ECTS Academy Mentoring Options
      • ECTS Academy Charity Run
    • Visit the ECTS Academy website
  • News
    • ECTS Newsletter
    • News
    • Press Release
    • Image Library
    • Video Library
    • Job Advertisements
You are here: Home / GWAS studies in mice to understand periodontitis susceptibility – by Teun De Vries

GWAS studies in mice to understand periodontitis susceptibility – by Teun De Vries

Periodontitis, the bone loss disease of the bones that surround our teeth, is initiated by a bacterial  infection of the gums. Since the etiology in humans is not fully understood, one can make use of mouse models, such as genetically modified mice. Obvious benefits of such approaches, is the comparison with susceptibility of mice that have the exact genetic background apart from this one gene. A shortcoming is, of course, that humans are genetically very diverse, where two non-related individuals may differ every 250 base pairs of the DNA. In an attempt to account for genetic diversity, an admirable approach to hunt for periodontitis susceptibility genes, was presented in the August issue of the JBMR [link:  Genomewide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-Induced Periodontitis.

Hiyari S, Green E, Pan C, Lari S, Davar M, Davis R, Camargo PM, Tetradis S, Lusis AJ, Pirih FQ.

J Bone Miner Res. 2018 Aug;33(8):1450-1463. doi: 10.1002/jbmr.3440. Epub 2018 May 22]. Gums from no less than 104 genetically different mouse strains were injected with LPS from a periodontopathogen, a bacterial product that is known to contribute to periodontitis progression. These mouse strains were ranked on the  severity of periodontitis they developed, by simply measuring bone height of the bone that surrounded the teeth. With Genome wide analysis (GWAS), hotspots of suspect genes of the cxcl family were found on chromosome 5. Studies using a CXCR3 knock-out mouse, and studies using a CXCR3 agonist confirmed periodontitis susceptibility.

Use of such rigorous approaches may map genes associated with inflammation related bone loss.

Join ECTS or Renew your membership today!

Discount on annual congresses, exclusive advantages, training courses and so much more

Join or renew
Tweet
Copyright 2016 ECTS - Disclaimer - Cookies Policy - Privacy Policy - Privacy Centre - Terms of use - Contact us
This website uses cookies to improve user experience. Read about how we use cookies and how you can control them by clicking “Change Cookie Settings” or accept cookies by clicking “Accept Cookies”. Read more
Accept Cookies
Change Cookie Settings
Cookie Box Settings
Cookie Box Settings
Decide which cookies you want to allow. You can change cookie setting at any time. However, this can result in some functions no longer being available. Learn more about the cookies we use.

You can opt in by clicking on the cookie types below:

  • Block all
  • Essential
  • Functionality
  • Analytics
  • Advertising

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account

This website won

  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information
  • Remember your login details

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using

This website won

  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Remember your login details
  • Advertising: Gather personally identifiable information

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using

This website won

  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information
  • Remember your login details

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information

This website won

  • Remember your login details
Save & Close