• Home
  • MyECTS
  • Become a member
  • Contact us

Ectsoc

Ecstoc.org

MENUMENU
  • About
    • Mission & Vision
    • Governance & Transparency
    • Board of Directors
    • Annual General Meeting
    • Committees and Action Groups
      • Executive Committee
      • Communications Committee
      • Community Engagement Committee
      • ECTS Academy
      • Education Committee
      • Clinical Science Committee
      • Research Committee
      • Scientific Programme Committee 2022
    • ECTS Team
    • Membership
      • Individual Membership
      • Corporate Supporters
      • Join us
      • Affiliated Societies
  • ECTS 2023
  • Events
    • Upcoming Congresses
    • Past Congress
    • ECTS Academy Charity Event
    • ICCBH
    • Events
  • Grants & Awards
  • Education
    • Education Resource Center
    • Clinical Training Course in Metabolic Bone Diseases
    • ECTS-Mellanby Training Course
    • Bone Muscle & Beyond Webinars
    • East-meets-West Online Symposium
    • Rare Bone Diseases Webinars
    • PhD Training Course
    • Calendar ECTS Educational Events
  • ECTS Academy
    • About the ECTS Academy
    • ECTS Academy Members
    • Call for Applications - Basic Scientists
    • Call for Applications - Clinicians
    • ECTS Academy Activities
      • NI Conference Program
      • ECTS Academy Webinar Series
      • ECTS Academy Mentoring Options
      • ECTS Academy Charity Run
    • Visit the ECTS Academy website
  • News
    • ECTS Newsletter
    • News
    • Press Release
    • Image Library
    • Video Library
    • Job Advertisements
You are here: Home / New investigators / Newsletter / News from the World: Cdk5 – a potential new therapeutic target for the treatment of osteoporosis. By Barbara Hauser

News from the World: Cdk5 – a potential new therapeutic target for the treatment of osteoporosis. By Barbara Hauser

Osteoporosis and accelerated systemic bone loss is a result of dysregulated bone turnover in form of reduced bone resorption and increased bone formation. Osteoblasts are bone forming cells that build extracellular matrix and help mineralization. Knowledge about key signaling pathways and proteins influencing bone formation, such as sclerostin and parathyroid hormone, has been translated into anabolic osteoporosis treatments.

A recent paper (“Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing”) by Ahmad et al describes a novel cell based RNAi high content method which screens RNAi libraries of kinases in primary murine calvarial osteoblasts to look for potential novel bone formation regulators. Using this method, the research group has identified cyclin-dependant kinase 5 (Cdk5) as suppressor of osteoblast differentiation and mineralization in murine and human preosteoblastic cells. Roscovitine, a small molecule, inhibits Cdk5 and was shown to increase osteoblast formation in vitro and in vivo. Micro-CT analyses showed that mice, treated with roscovitine had enhanced bone mass and better fracture healing properties after femur osteotomy than vehicle treated mice. Importantly Cdk5 inhibition did not seem to influence osteoclastogenesis in vivo. Further analyses looking into the mechanism of Cdk5 modulation suggests that Cdk5 regulates osteoblast differentiation through MAP kinase pathway modulation.

These new findings may be of great clinical importance as Cdk5 could be a potential therapeutic target to treat osteoporosis and/or enhance fracture healing in future.

Read the article

Join ECTS or Renew your membership today!

Discount on annual congresses, exclusive advantages, training courses and so much more

Join or renew
Tweet
Copyright 2016 ECTS - Disclaimer - Cookies Policy - Privacy Policy - Privacy Centre - Terms of use - Contact us
This website uses cookies to improve user experience. Read about how we use cookies and how you can control them by clicking “Change Cookie Settings” or accept cookies by clicking “Accept Cookies”. Read more
Accept Cookies
Change Cookie Settings
Cookie Box Settings
Cookie Box Settings
Decide which cookies you want to allow. You can change cookie setting at any time. However, this can result in some functions no longer being available. Learn more about the cookies we use.

You can opt in by clicking on the cookie types below:

  • Block all
  • Essential
  • Functionality
  • Analytics
  • Advertising

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account

This website won

  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information
  • Remember your login details

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using

This website won

  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Remember your login details
  • Advertising: Gather personally identifiable information

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using

This website won

  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information
  • Remember your login details

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information

This website won

  • Remember your login details
Save & Close