• Home
  • MyECTS
  • Become a member
  • Contact us

Ectsoc

Ecstoc.org

MENUMENU
  • About
    • Mission & Vision
    • Governance & Transparency
    • Board of Directors
    • Annual General Meeting
    • Committees and Action Groups
      • Executive Committee
      • Communications Committee
      • Community Engagement Committee
      • ECTS Academy
      • Education Committee
      • Clinical Science Committee
      • Research Committee
      • Scientific Programme Committee 2022
    • ECTS Team
    • Membership
      • Individual Membership
      • Corporate Supporters
      • Join us
      • Affiliated Societies
  • ECTS 2023
  • Events
    • Upcoming Congresses
    • Past Congress
    • ECTS Academy Charity Event
    • ICCBH
    • Events
  • Grants & Awards
  • Education
    • Education Resource Center
    • Clinical Training Course in Metabolic Bone Diseases
    • ECTS-Mellanby Training Course
    • Bone Muscle & Beyond Webinars
    • East-meets-West Online Symposium
    • Rare Bone Diseases Webinars
    • PhD Training Course
    • Calendar ECTS Educational Events
  • ECTS Academy
    • About the ECTS Academy
    • ECTS Academy Members
    • Call for Applications - Basic Scientists
    • Call for Applications - Clinicians
    • ECTS Academy Activities
      • NI Conference Program
      • ECTS Academy Webinar Series
      • ECTS Academy Mentoring Options
      • ECTS Academy Charity Run
    • Visit the ECTS Academy website
  • News
    • ECTS Newsletter
    • News
    • Press Release
    • Image Library
    • Video Library
    • Job Advertisements
You are here: Home / New investigators / Newsletter / News from the world: Gastric bypass alters bone marrow adipose tissue composition of the vertebrae but not the tibia. By Antonia Sophocleous

News from the world: Gastric bypass alters bone marrow adipose tissue composition of the vertebrae but not the tibia. By Antonia Sophocleous

People with type 2 diabetes have an increased risk of bone fractures, which may be partly because of altered bone marrow adipose tissue (BMAT) composition. A recent manuscript, published by Kim et al. in the latest issue of Bone Reports, went on to investigate whether the Roux-en-Y gastric bypass (RYGB) surgery, which is known to improve the glycemic status of patients, alters the unsaturated lipid composition of bone marrow, and whether these changes differ by diabetes status or by anatomic skeletal location.

Thirty obese adult women (>25 years of age) that were scheduled for an upcoming gastric bypass procedure, were recruited from two academic bariatric surgery centres in San Francisco. Enrolment was stratified by diabetes status and bone marrow adipose tissue (BMAT) was measured by magnetic resonance spectroscopy at the spine (n=30) and tibia (n=19). The total marrow fat content as well as the unsaturated lipid index were calculated. Bone mineral density, BMI, whole body fat, lean mass, visceral adipose tissue area and serum levels for haemoglobin A1c (HbA1c), 25 hydroxyvitamin D and sclerostin, were also measured at baseline and 6 months after gastric bypass.

Findings showed that although at baseline BMAT parameters were similar between those with and without diabetes, six months after RYGB surgery there was a significant interaction between diabetes status and changes in both vertebral marrow fat content (p = 0.02) and the unsaturated lipid index (p < 0.01). In diabetic patients, there was a trend towards a decline in marrow fat content (-4.3 % ± 8.2 %, p = 0.09) and a significant increase in the unsaturated lipid index (+1.1 % ± 1.5 %, p = 0.02). No significant changes in BMAT parameters were observed in women without diabetes. Furthermore, no differences were observed between women with and without diabetes at the tibial marrow fat content or composition. Finally, changes in the unsaturated lipid index were inversely correlated with haemoglobin A1c changes (r = -0.47, p = 0.02), regardless of diabetes status.

Authors concluded that gastric bypass-induced weight loss led to longitudinal changes in the vertebral but not tibial, BMAT content and composition and that these changes were different for women with versus without diabetes. They also noted that changes in the unsaturated lipid index at the spine correlated with glycemic improvements.

Read the Article

Join ECTS or Renew your membership today!

Discount on annual congresses, exclusive advantages, training courses and so much more

Join or renew
Tweet
Copyright 2016 ECTS - Disclaimer - Cookies Policy - Privacy Policy - Privacy Centre - Terms of use - Contact us
This website uses cookies to improve user experience. Read about how we use cookies and how you can control them by clicking “Change Cookie Settings” or accept cookies by clicking “Accept Cookies”. Read more
Accept Cookies
Change Cookie Settings
Cookie Box Settings
Cookie Box Settings
Decide which cookies you want to allow. You can change cookie setting at any time. However, this can result in some functions no longer being available. Learn more about the cookies we use.

You can opt in by clicking on the cookie types below:

  • Block all
  • Essential
  • Functionality
  • Analytics
  • Advertising

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account

This website won

  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information
  • Remember your login details

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using

This website won

  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Remember your login details
  • Advertising: Gather personally identifiable information

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using

This website won

  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information
  • Remember your login details

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Functionality: Remember language version you selected
  • Functionality: Identify device you are using
  • Analytics: Keep track of your visited pages
  • Analytics: Keep track about your location and region based on your IP address
  • Analytics: Keep track on the time spent on each page
  • Analytics: Identify device you are using
  • Advertising: Allow you to connect to social sites
  • Advertising: Gather personally identifiable information

This website won

  • Remember your login details
Save & Close