• Home
  • MyECTS
  • Become a member
  • Contact us

Ectsoc

Ecstoc.org

MENUMENU
  • About
    • Mission & Vision
    • Governance & Transparency
    • Board of Directors
    • Annual General Meeting
    • Committees and Action Groups
      • Executive Committee
      • Communications Committee
      • Community Engagement Committee
      • ECTS Academy
      • Education Committee
      • Clinical Science Committee
      • Research Committee
      • Scientific Programme Committee 2025
    • ECTS Team
    • Membership
      • Individual Membership
      • Corporate Supporters
      • Join us
      • Affiliated Societies
  • ECTS 2025
  • Events
    • Upcoming Congresses
    • Past Congress
    • ECTS Academy Charity Event
    • ICCBH
    • Events
  • Grants & Awards
  • Education
    • PhD Training Course
    • Clinical Training Course in Metabolic Bone Diseases
    • Rare Bone Diseases Webinars
    • Education Resource Center
    • Bone Muscle & Beyond Webinars
    • ECTS-Mellanby Training Course
    • Calendar ECTS Educational Events
  • ECTS Academy
    • About the ECTS Academy
    • ECTS Academy – Members
    • Call for Applications - Basic Scientists
    • Call for Applications - Clinicians
    • ECTS Academy Activities
      • NI Conference Program
      • ECTS Academy Webinar Series
      • ECTS Academy Mentoring Options
      • ECTS Academy Charity Run
    • Visit the ECTS Academy website
  • News
    • ECTS Newsletter
    • News
    • Press Release
    • Image Library
    • Video Library
    • Job Advertisements
You are here: Home / New investigators / Newsletter / News from the world: Vitamin D supplementation in COVID-19. By Cristiana Cipriani

News from the world: Vitamin D supplementation in COVID-19. By Cristiana Cipriani

Since the beginning of the pandemic, many researchers focused on the possible effect of vitamin D deficiency on the pathophysiology, clinical manifestation and outcomes of Sars-CoV-2 infection. Evidence gleaned from retrospective and observational studies reported an inverse relationship between serum vitamin D levels and COVID-19. Possible mutual relationships between perturbation of vitamin D metabolism and immunological mechanisms associated with COVID-19 have been described, as well.

In the attempt of best defining this interesting topic, randomized controlled trials have been carrying out with the rationale of a beneficial effect of vitamin D supplementation on several outcomes related to Sars-CoV-2 infection.

The article by Villasis-Keever et al. is a recent interesting contribution in the field. The authors employed a daily 4,000 IU dose of cholecalciferol as a preventive measure that was administered to 94 Sars-Cov-2-negative healthcare workers for 30 days. A placebo group of 98 subjects was assessed. All were high risk subjects, as they were employed in Covid 19 wards. Results demostrated that vitamin D administration was associated with lower risk of Sars-CoV-2 infection independently of baseline serum vitamin D levels. Interestingly, the increase in vitamin D levels was found to be a significant predictor of the risk of infection. Results were confirmed after adjustment for age and comorbidities.

Notwithstanding the limit of a study that showed high rate of discontinuation (56 in the vitamin D and 54 in the placebo group) and whose evaluation of confounding factors should be more deeply discussed, the article opens new and interesting questions on how vitamin D may be effectively empolyed on a regular basis for disease prevention and which could be the pathophysiological mechanisms of protection from Sars-Cov-2 infection associated with vitamin D administration. Finally, is there any space for an eventual protection from other infective respiratory disease offered by vitamin D repletion?

Join ECTS or Renew your membership today!

Discount on annual congresses, exclusive advantages, training courses and so much more

Join or renew
Tweet
Copyright 2016 ECTS - Disclaimer - Cookies Policy - Privacy Policy - Privacy Centre - Terms of use - Contact us