Bone marrow fat imaging: technical basics and clinical applications
Live Webinar: 15 July 2021, 4 pm CET
Organised by ECTS
Date & Time: 15 July 2021, 4 pm CET
Featuring Xiaojuan Li, and moderated by Annegreet Veldhuis-Vlug
Costs: Live webinar is free for ECTS members and non-members, but a registration is required. Recordings are accessible to ECTS members only.
- 5 min welcome & introductions
- 35 min presentation on ” Bone marrow fat imaging: technical basics and clinical applications”
- 20 min Q&A
- Understand the basic principles, strengths, and weaknesses of different marrow fat imaging methods
- Gain knowledge of interpreting marrow fat imaging data
- Understand the role of marrow fat imaging in studying osteoporosis and other diseases
The Bone marrow fat imaging, Brussels, Belgium, 15-07-2021 has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 1 European CME credits (ECMEC®s).
Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.
Featuring Dr. Rachelle Johnson
Dr. Johnson earned her doctorate in Cancer Biology from Vanderbilt University, where she studied bone metastatic breast cancer with Drs. Gregory Mundy and Julie Sterling in the Vanderbilt Center for Bone Biology. She then relocated to Melbourne, Australia to pursue a post-doc with Drs. Natalie Sims and T. John (Jack) Martin in basic bone biology to better understand the physiological processes of skeletal homeostasis that may impact upon tumor cells. As a postdoc in Melbourne, she characterized the skeletal phenotype of several glycoprotein-130 (gp130) and SOCS3 (a gp130 downstream target) bone conditional knockout mouse models. She then joined Dr. Amato Giaccia’s laboratory as a Postdoctoral Scholar at Stanford University, where she examined the role for leukemia inhibitory factor (LIF) receptor (LIFR) in tumor dormancy. She returned to Vanderbilt University Medical Center as faculty in 2016, where her lab now studies mechanisms of tumor dormancy in bone. Dr. Johnson is an active member of and holds leadership positions in the American Society for Bone and Mineral Research (ASBMR) and the Cancer and Bone Society (CABS). She has received the ASBMR Young Investigator Award, AIMM-ASMBR John Haddad Young Investigator Award, ANZBMS Kaye Ibbertson Award for Bone and Mineral Medicine, and the ASBMR Harold M. Frost Young Investigator Award. She was also the recipient of an NIH Pathway to Independence Award from the National Institutes of Health (NIH)/NCI.
Her current work is focused on the mechanisms driving tumor cell dormancy in bone and the molecular processes that enable disseminated tumor cells to colonize the bone. In particular, she is interested in the role of leukemia inhibitory factor (LIF) signaling, parathyroid hormone-related protein (PTHrP), and hypoxia signaling in breast cancer dissemination and outgrowth in the bone marrow.
Moderated by Annegreet Veldhuis-Vlug
Breast cancer cells frequently disseminate to the bone marrow, where they may either enter a dormant state or colonize the bone and induce osteolysis. The mechanisms that regulate tumor cell entry and exit from dormancy in the bone are not well understood, but several factors have been identified. Previous work from our group found that leukemia inhibitory factor receptor (LIFR) promotes tumor dormancy when expressed on bone-disseminated tumor cells and that loss of LIFR enables otherwise dormant tumor cells to colonize the bone. Our lab has therefore examined how LIFR expression is regulated in breast cancer cells, with the hope that understanding its regulation might provide novel avenues to therapeutically target dormant disseminated tumor cells. Through these efforts we have found that LIFR is epigenetically regulated, and that histone deacetylase (HDAC) inhibitors, which are FDA-approved for several blood cancers, stimulate LIFR expression on breast cancer cells from all subtypes. This finding presents an interesting therapeutic opportunity to explore whether HDAC inhibitors may be used to promote a chronic state of tumor dormancy and prevent recurrence in bone. Our findings suggest that this may be feasible, but that the effects of histone deacetylase inhibitors on bone remodeling profoundly impact tumor colonization and must be combined with appropriate anti-resorptive therapies.