Date & Time: 24 March 2022, 4 pm CET

Featuring: Dr Steve Stegen & Dr Fanxin Long

Chaired by: Maria-Bernadette Madel

Format:

• 5 min welcome & introductions
• 35 min presentation
• 20 min Q&A
• 15 min interactive coffee shop

Learning objectives:

• Learn about metabolic features of osteoblasts and osteoclasts.
• Examples of developmental signals regulating bone cell metabolism.
• Targeting of cellular metabolism as potential bone therapy.
• Understanding the role of amino acid metabolism in the developing growth plate
• The importance of chondrocytic amino acid metabolism during bone repair
• Linking metabolism with chondrocyte-associated transcription factors

Costs: Live webinar is free for ECTS members and non-members, but a registration is required. Recordings are accessible to ECTS members only.

Faculty:

Featuring Dr Steve Stegen

Dr. Steve Stegen is a postdoctoral research fellow in the Clinical & Experimental Endocrinology lab (Prof. Geert Carmeliet) at the KU Leuven in Leuven, Belgium. He currently holds a senior postdoctoral research grant from the Research Foundation Flanders (FWO).

Dr. Stegen obtained his PhD in Biomedical Sciences in 2016 studying the role of hypoxia signaling in skeletal cells and its application for bone tissue engineering. It was then that he developed his passion for cell metabolism, which he continued by investigating the role of amino acids in bone as a junior FWO postdoctoral research fellow. Currently, Steve focusses on the in-depth characterization of the metabolic needs of healthy and diseased skeletal cells. His expertise includes preclinical mouse models for fracture healing and osteoporosis, bone imaging/histology, primary skeletal cell isolation and mass spectrometry-based metabolomics.

Dr. Stegen is a member of several scientific societies such as ECTS, ECTS Academy and ASBMR, and he presented his findings at (inter)national meetings. His work received several awards, including the ASBMR Young Investigator Award, ECTS New Investigator Award and the Prize for Fundamental Research by the Belgian Royal Academy of Medicine.

Featuring Dr Fanxin Long

Dr. Long earned his doctorate in developmental biology from Tufts University, and completed postdoctoral training at Harvard University. He received a master’s degree in biochemistry and molecular biology from the University of California, Santa Barbara, and a bachelor’s degree in cell biology from Peking University. Dr. Long began his independent research at Washington University School of Medicine in St. Louis, and served there as Professor of Medicine, Developmental Biology and Orthopedic Surgery until 2018 when he was appointed William Wikoff Smith Endowed Chair in Pediatric Genomic Research at the Children’s Hospital of Philadelphia. He currently also serves as Professor of Orthopedic Surgery at University of Pennsylvania. Dr. Long served as program co-chair for American Society of Bone and Mineral Diseases, and chair for Gordon Conference on Bones and Teeth. He currently serves as consulting editor for Journal of Clinical Investigation and associate editor for PLoS Genetics.

In his research, Dr. Long seeks to understand the fundamental mechanisms underlying normal skeletal biology and the pathophysiology of bone diseases. His group has made major contributions to the understanding of Hh, Wnt and Notch signaling in skeletal development and homeostasis. They also pioneered the studies of osteogenic signals in regulating cellular metabolism.