Topic: Early-Onset Osteoporosis: Genetics, Filtering, and Functional Modelling
Organised by the Rare bone diseases action group
Chairs: Dr Adalbert Raimann, Medical University of Vienna, Vienna, Austria and Dr Felix von Brackel, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Speakers: Pr Dr Melissa Formosa, University of Malta, Msida, Malta and Pr Dr Ralf Oheim, University Medical Center Hamburg, Hamburg, Germany
Date & Time: Thursday, 16 October 2025 from 16.00-17.00hrs CET
Format: Live Interactive Webinar. On-demand recording to be available for ECTS full tier members after the event

Registration

The live webinar is free and open to everyone with an interest in the field.

Register

Learning objectives:

• Describe the key steps in analysing early-onset osteoporosis, from recruitment and deep phenotyping to sample collection and data preparation.
• Understand the application of high-throughput sequencing coupled with stepwise variant filtering strategies to identify potential causal genetic factors.
• Assess the translational value of genetic findings through functional studies in cellular and animal models.

Agenda:

Introduction by Dr von Brackel (3 min)
Presentation on “Early-Onset Osteoporosis: Genetics, Filtering, and Functional Modelling” by Pr Dr Formosa and Pr Dr Oheim (40 min)
Live Q&A from the audience, moderated by Dr Raimann (15 min)
Conclusion and key messages by Dr Raimann (2 min)