SiSaf Vacancy: Biotechnologist / Cellular or Molecular Biologist

Job description is available here.  Applications should be submitted at bonesecr@strutture.univaq.it and should include a detailed CV with a complete list of publications and other relevant achievements.

Place of Work: University of L’Aquila, Italy, Department of Biotechnological and Applied Clinical Sciences, via Vetoio, Coppito 2, side B, 1° floor.

The “Unit of Pathogenesis and Treatment of Immune and Bone Diseases” lab, led by Anna Villa at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy is recruiting a highly motivated post-doctoral fellow with strong experience in hematopoietic stem cell biology and bone marrow niche.

Access announcement here.

The laboratory of molecular physiomedicine, team osteoimmunology, niches and inflammation is seeking a highly motivated post-doctoral researcher interested in osteo-immunology to join the team and work on the diversity of osteoclasts, the multinucleated monocytic cells involved in bone resorption.

We will pay special attention to candidates willing to develop their career in France and to apply for a permanent researcher position.

Deadline for application: March 15, 2022

More info available here.

Post-doctoral position, 1-year renewable
Inserm Laboratory UMR1229 RMeS “Regenerative medicine and skeleton”
Team: REGOS “Regenerative medicine of bone tissue”
Recruiting body: University of Nantes
Funding: Agence Nationale de Recherche (France)

The position is to be filled from the beginning of 2022

The host team’s long-term goal is to demonstrate the role of extracellular vesicles (EVs) of osteocytic origin in the maintenance and physiological repair of bone tissue. Recent observations indeed suggest that osteocytes produce EVs which could constitute a sophisticated mechanism of intercellular communication in bone. The increase in bone micro-fractures during aging could both participate in compromising the mechanical properties of bone, but also in altering this communication path between osteocytes and other bone cells. Our hypotheses are that 1 / these EVs released by osteocytes transport powerful signals to other bone cells, and control osteogenesis, 2 / these EVs are altered during aging either in quantity or in quality, and 3 / these EVs and their cargos constitute new tools for bone regeneration, based on the mobilization and activation of the healing potential of the host tissue.

The candidate’s mission will be to identify and analyze the cargos that are associated with EVs (transcriptomic and proteomic analysis) isolated from young and old mice in order to highlight the signals altered during aging. Finally, by using models of bone loss mastered in the laboratory, the candidate will participate in the demonstration of the regenerative capacities of the most promising cargos.

Candidate profile: The candidate should have solid skills in transcriptomic and / or proteomic analysis and cell biology (cells in culture, transfection). For this position, experience in animal experimentation is necessary, the animal experimentation certificate “Design or realization of procedures” would be a plus.
The candidate must be autonomous and motivated.

To apply, send a CV, list of publications, cover letter, letters of recommendation and contacts of recent referees.
Contact: valerie.geoffroy@inserm.fr
Deputy Director Inserm UMR_S 1229-RMeS REGOS team
https://rmes.univ-nantes.fr/
Faculty of dental surgery, 1 place Alexis Ricordeau, BP 84215, 44042 Nantes Cedex 1