Date & Time: 18 August 2022, 4 pm CET

Featuring Claudine Blin and moderated by Maria-Bernadette Madel

Format:

• 5 min welcome & introductions
• 35 min presentation
• 20 min Q&A
• 15 min Coffee Shop for more interactive and informal discussions

Learning objectives:

• The principles of the connection between the bone and the immune system.
• The principles of monocytic cell function
• How to understand diversity within a cell population
  

Followed by a Coffee Shop

Costs: Live webinar is free for ECTS members and non-members, but a registration is required. Recordings are accessible to ECTS members only.

WATCH RECORDINGS

Faculty:

Claudine Blin

Claudine Blin is research director and head of the team “Osteoimmunology, Niches and Inflammation” at the Laboratory of Molecular Physiomedicine, Nice, France. She obtained her PhD from the University Paris Diderot in 1995. In 2003, she established her independent research group on osteoimmunology in Nice. Her team projects are at the interface between osteology, immunology and stem cell biology, mostly in the context of chronic inflammatory diseases. She has a special interest in the heterogeneity and innate immune function of osteoclasts, their interaction with immune cells, and their contribution in inflammatory bone destruction. Claudine Blin has been secretary and is president elect of the French Society of Mineral Tissue Biology (SFBTM) and member of the ECTS Board of Directors. She is also a member of the scientific board of the French Arthritis Fondation and a member of the scientific and educational committee of the Life University School of Research, University Cote d’Azur.

Date & Time: 21 July 2022, 4 pm CET

Featuring Prof Carola Zillikens

Format:

• 5 min welcome & introductions
• 35 min presentation
• 20 min Q&A

Followed by a Coffee Shop

Costs: Live webinar is free for ECTS members and non-members, but a registration is required. Recordings are accessible to ECTS members only.

WATCH RECORDINGS

Faculty:

Featuring Dr Carola Zillikens

Carola Zillikens, MD, PhD, is Professor and staff member at the Department of Internal Medicine, section Endocrinology, of Erasmus MC,

University Medical Center Rotterdam, the Netherlands. She founded and heads the Erasmus MC Bone Center, a multidisciplinary

expertise center for patients with common and rare disorders of calcium and bone metabolism. She is past President of the Dutch Society

for Calcium and Bone Metabolism and a past Board Member of ECTS (2015-2021) where she chaired the Professional Practice Committee. She is a member of the Steering committee of the European Reference Network for rare bone disorders, BOND since 2015. Her research topics concern the (genetic) background of unexplained familial osteoporosis, rare disorders of calcium, phosphate and bone metabolism, atypical femur fractures and the relation of osteoporosis with chronic diseases and mortality and the role of Advanced Glycation End products (AGEs) in this association. She is coordinating a Dutch national registry for chronic hypophosphatemia, including XLH. She has co-authored over 260 papers.

Date & Time: 19 May 2022, 4 pm CET

Featuring Dr Rowan Hardy and Chaired by Dr Lars Folkestad

Format:

• 5 min welcome & introductions
• 35 min presentation
• 20 min Q&A
• 15 min coffee shop

Learning objectives:

• Understand mechanisms of inflammatory bone loss 
• Understand mechanisms of glucocorticoid induced osteoporosis
• Appreciate how inflammation and therapeutic glucocorticoids interact to regulate bone metabolism
• Understand the role that steroid metabolism plays in these processes

Costs: Live webinar is free for ECTS members and non-members, but a registration is required. Recordings are accessible to ECTS members only.

Date & Time: 21 April 2022, 4 pm CET

Featuring Dr Morten Frost

Format:

• 5 min welcome & introductions
• 35 min presentation
• 20 min Q&A
• 15 min interactive coffee shop

Learning objectives:

• Gastrointestinal peptide (GIP) impairs bone resorption and may increase bone formation
• Glucagon-like peptide 2 has antiresorptive properties 
• Glucagon-like peptide 1 acutely decreases bone resorption – and commonly used GLP1 receptor agonists may prevent bone loss despite decreasing body weight 

Costs: Live webinar is free for ECTS members and non-members, but a registration is required. Recordings are accessible to ECTS members only.

Faculty:

Featuring Dr Morten Frost

Morten Frost is professor of metabolic bone diseases at the Endocrine Research Unit and Steno Diabetes Centre Odense, University of Southern Denmark, and a consultant endocrinologist at the department of endocrinology, Odense University Hospital (DK). His current research involves effects of gut secreted hormones on bone metabolism, the impact of mitochondrial function on bone cell activity, and mechanisms behind skeletal fragility in type 1 and 2 diabetes. He is a member of the ECTS Academy and chairs the Danish Medicines Council’s committee on treatment of metabolic bone diseases.  

Date & Time: 24 March 2022, 4 pm CET

Featuring: Dr Steve Stegen & Dr Fanxin Long

Chaired by: Maria-Bernadette Madel

Format:

• 5 min welcome & introductions
• 35 min presentation
• 20 min Q&A
• 15 min interactive coffee shop

Learning objectives:

• Learn about metabolic features of osteoblasts and osteoclasts.
• Examples of developmental signals regulating bone cell metabolism.
• Targeting of cellular metabolism as potential bone therapy.
• Understanding the role of amino acid metabolism in the developing growth plate
• The importance of chondrocytic amino acid metabolism during bone repair
• Linking metabolism with chondrocyte-associated transcription factors

Costs: Live webinar is free for ECTS members and non-members, but a registration is required. Recordings are accessible to ECTS members only.

Faculty:

Featuring Dr Steve Stegen

Dr. Steve Stegen is a postdoctoral research fellow in the Clinical & Experimental Endocrinology lab (Prof. Geert Carmeliet) at the KU Leuven in Leuven, Belgium. He currently holds a senior postdoctoral research grant from the Research Foundation Flanders (FWO).

Dr. Stegen obtained his PhD in Biomedical Sciences in 2016 studying the role of hypoxia signaling in skeletal cells and its application for bone tissue engineering. It was then that he developed his passion for cell metabolism, which he continued by investigating the role of amino acids in bone as a junior FWO postdoctoral research fellow. Currently, Steve focusses on the in-depth characterization of the metabolic needs of healthy and diseased skeletal cells. His expertise includes preclinical mouse models for fracture healing and osteoporosis, bone imaging/histology, primary skeletal cell isolation and mass spectrometry-based metabolomics.

Dr. Stegen is a member of several scientific societies such as ECTS, ECTS Academy and ASBMR, and he presented his findings at (inter)national meetings. His work received several awards, including the ASBMR Young Investigator Award, ECTS New Investigator Award and the Prize for Fundamental Research by the Belgian Royal Academy of Medicine.

Featuring Dr Fanxin Long

Dr. Long earned his doctorate in developmental biology from Tufts University, and completed postdoctoral training at Harvard University. He received a master’s degree in biochemistry and molecular biology from the University of California, Santa Barbara, and a bachelor’s degree in cell biology from Peking University. Dr. Long began his independent research at Washington University School of Medicine in St. Louis, and served there as Professor of Medicine, Developmental Biology and Orthopedic Surgery until 2018 when he was appointed William Wikoff Smith Endowed Chair in Pediatric Genomic Research at the Children’s Hospital of Philadelphia. He currently also serves as Professor of Orthopedic Surgery at University of Pennsylvania. Dr. Long served as program co-chair for American Society of Bone and Mineral Diseases, and chair for Gordon Conference on Bones and Teeth. He currently serves as consulting editor for Journal of Clinical Investigation and associate editor for PLoS Genetics.

In his research, Dr. Long seeks to understand the fundamental mechanisms underlying normal skeletal biology and the pathophysiology of bone diseases. His group has made major contributions to the understanding of Hh, Wnt and Notch signaling in skeletal development and homeostasis. They also pioneered the studies of osteogenic signals in regulating cellular metabolism.